Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | tubulin gamma chain | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | alpha-tubulin | 0.0236 | 0.6661 | 0.6291 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0236 | 0.6661 | 1 |
Leishmania major | gamma-tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Giardia lamblia | Gamma tubulin | 0.0236 | 0.6661 | 0.5 |
Entamoeba histolytica | tubulin family protein | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0236 | 0.6661 | 1 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0236 | 0.6661 | 1 |
Onchocerca volvulus | 0.0133 | 0.0997 | 0.5 | |
Toxoplasma gondii | tubulin/FtsZ family, GTPase domain-containing protein | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0236 | 0.6661 | 0.6291 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0236 | 0.6661 | 1 |
Plasmodium vivax | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0236 | 0.6661 | 0.6291 |
Trypanosoma brucei | alpha tubulin | 0.0236 | 0.6661 | 1 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | epsilon tubulin | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0236 | 0.6661 | 1 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Loa Loa (eye worm) | alpha-tubulin | 0.0236 | 0.6661 | 0.6291 |
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0236 | 0.6661 | 0.6291 |
Brugia malayi | Tubulin alpha chain | 0.0236 | 0.6661 | 0.6291 |
Loa Loa (eye worm) | tubulin beta chain | 0.0236 | 0.6661 | 0.6291 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0236 | 0.6661 | 1 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0236 | 0.6661 | 0.5 |
Toxoplasma gondii | beta-tubulin, putative | 0.0236 | 0.6661 | 0.5 |
Brugia malayi | Tubulin alpha-2 chain | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0236 | 0.6661 | 0.6291 |
Plasmodium falciparum | alpha tubulin 1 | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0236 | 0.6661 | 1 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0236 | 0.6661 | 1 |
Brugia malayi | tubulin alpha chain - mouse | 0.0236 | 0.6661 | 0.6291 |
Trypanosoma brucei | epsilon tubulin | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0236 | 0.6661 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0236 | 0.6661 | 0.5 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | tubulin gamma chain | 0.0236 | 0.6661 | 1 |
Giardia lamblia | Alpha-tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin, putative | 0.0236 | 0.6661 | 1 |
Trypanosoma brucei | beta tubulin | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 1 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 1 |
Plasmodium vivax | tubulin gamma chain, putative | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0236 | 0.6661 | 1 |
Giardia lamblia | Beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Toxoplasma gondii | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Giardia lamblia | Alpha-tubulin | 0.0236 | 0.6661 | 0.5 |
Plasmodium vivax | tubulin beta chain, putative | 0.0236 | 0.6661 | 0.5 |
Brugia malayi | Tubulin gamma chain | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0236 | 0.6661 | 1 |
Brugia malayi | alpha-tubulin | 0.0236 | 0.6661 | 0.6291 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0236 | 0.6661 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0236 | 0.6661 | 0.6291 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Plasmodium falciparum | alpha tubulin 2 | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma cruzi | tubulin gamma chain | 0.0236 | 0.6661 | 1 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0236 | 0.6661 | 1 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | alpha tubulin, putative | 0.0133 | 0.0997 | 0.1496 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0236 | 0.6661 | 0.6291 |
Brugia malayi | Tubulin alpha-2 chain | 0.0236 | 0.6661 | 0.6291 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0236 | 0.6661 | 0.6291 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0236 | 0.6661 | 0.5 |
Plasmodium falciparum | tubulin epsilon chain, putative | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0236 | 0.6661 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0236 | 0.6661 | 1 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | epsilon tubulin, putative | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | beta tubulin | 0.0236 | 0.6661 | 1 |
Entamoeba histolytica | tubulin gamma chain | 0.0236 | 0.6661 | 0.5 |
Giardia lamblia | Beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0236 | 0.6661 | 0.6291 |
Plasmodium falciparum | tubulin beta chain | 0.0236 | 0.6661 | 0.5 |
Trypanosoma brucei | alpha tubulin | 0.0236 | 0.6661 | 1 |
Brugia malayi | tubulin alpha-2 chain | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0236 | 0.6661 | 0.6291 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Leishmania major | beta tubulin | 0.0236 | 0.6661 | 0.5 |
Trypanosoma cruzi | epsilon tubulin, putative | 0.0236 | 0.6661 | 1 |
Brugia malayi | Tubulin beta-1 chain | 0.0236 | 0.6661 | 0.6291 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0236 | 0.6661 | 0.5 |
Leishmania major | alpha tubulin | 0.0236 | 0.6661 | 0.5 |
Loa Loa (eye worm) | beta-tubulin | 0.0236 | 0.6661 | 0.6291 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 58 nM | Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassay | ChEMBL. | 24900409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.