Detailed information for compound 1723800

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 342.818 | Formula: C16H23ClN2O4
  • H donors: 0 H acceptors: 2 LogP: 2.83 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(C(=O)Oc1cccc2c1CCN2CCC(=O)OC)C.Cl
  • InChi: 1S/C16H22N2O4.ClH/c1-4-17(2)16(20)22-14-7-5-6-13-12(14)8-10-18(13)11-9-15(19)21-3;/h5-7H,4,8-11H2,1-3H3;1H
  • InChiKey: QAXOVWJBIIWDPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Acetylcholinesterase Starlite/ChEMBL References
Equus caballus Butyrylcholinesterase Starlite/ChEMBL References
Equus caballus Cholinesterase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Putative nuclear protein Acetylcholinesterase   613 aa 572 aa 41.6 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 561 aa 24.6 %
Echinococcus multilocularis neuroligin Acetylcholinesterase   613 aa 534 aa 23.2 %
Brugia malayi Carboxylesterase family protein Cholinesterase   574 aa 538 aa 31.4 %
Onchocerca volvulus Carnitine O-palmitoyltransferase 2, mitochondrial homolog Acetylcholinesterase   613 aa 511 aa 39.9 %
Onchocerca volvulus Molybdopterin synthase catalytic subunit homolog Acetylcholinesterase   613 aa 564 aa 30.3 %
Onchocerca volvulus Acetylcholinesterase   613 aa 565 aa 26.0 %
Schistosoma mansoni gliotactin Butyrylcholinesterase   602 aa 587 aa 28.1 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 491 aa 26.7 %
Loa Loa (eye worm) hypothetical protein Acetylcholinesterase   613 aa 573 aa 26.5 %
Onchocerca volvulus Galectin homolog Cholinesterase   574 aa 531 aa 39.7 %
Echinococcus multilocularis BC026374 protein (S09 family) Acetylcholinesterase   613 aa 627 aa 33.8 %
Drosophila melanogaster CG10175 gene product from transcript CG10175-RE Acetylcholinesterase   613 aa 527 aa 32.3 %
Echinococcus granulosus BC026374 protein S09 family Acetylcholinesterase   613 aa 627 aa 34.0 %
Schistosoma japonicum ko:K01050 cholinesterase [EC3.1.1.8], putative Cholinesterase   574 aa 577 aa 36.9 %
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Acetylcholinesterase   613 aa 601 aa 23.6 %
Onchocerca volvulus Acetylcholinesterase   613 aa 613 aa 26.8 %
Brugia malayi Carboxylesterase family protein Acetylcholinesterase   613 aa 569 aa 31.3 %
Echinococcus granulosus neuroligin Butyrylcholinesterase   602 aa 492 aa 24.2 %
Onchocerca volvulus Acetylcholinesterase   613 aa 552 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0039 0.0325 0.0919
Loa Loa (eye worm) hypothetical protein 0.0099 0.1006 0.2114
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0174 0.048
Mycobacterium tuberculosis Carboxylesterase LipT 0.0041 0.0354 0.0382
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0043 0.012
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0174 0.1591
Onchocerca volvulus 0.0041 0.0354 0.1649
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0032 0.0249 0.0524
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0013 0.0033 0.0305
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0145 0.1526 0.3207
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0029 0.0208 0.0436
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0285 0.3122 0.3369
Mycobacterium tuberculosis Probable aminotransferase 0.0329 0.3619 0.3906
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0046 0.0402 0.0402
Plasmodium vivax glutathione reductase, putative 0.0112 0.116 0.8584
Treponema pallidum exodeoxyribonuclease (exoA) 0.0013 0.0033 0.1025
Loa Loa (eye worm) beta-lactamase 0.0129 0.1351 0.284
Leishmania major mitochondrial DNA polymerase beta 0.0322 0.3538 1
Brugia malayi beta-lactamase 0.0129 0.1351 0.284
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0039 0.0325 0.2406
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0129 0.1351 0.1458
Echinococcus multilocularis GPCR, family 2 0.0046 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Schistosoma mansoni microtubule-associated protein tau 0.0542 0.6036 0.6036
Echinococcus multilocularis acetylcholinesterase 0.0246 0.2673 0.2673
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0033
Schistosoma mansoni ap endonuclease 0.0013 0.0033 0.0033
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0113 0.0113
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0024 0.0155 0.0155
Plasmodium vivax SET domain protein, putative 0.0026 0.0181 0.1342
Trichomonas vaginalis esterase, putative 0.0129 0.1351 0.3734
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0249 0.0249
Echinococcus multilocularis geminin 0.0326 0.3586 0.3586
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0113 0.0113
Trichomonas vaginalis spcc417.12 protein, putative 0.0041 0.0354 0.0978
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0047 0.0414 0.1143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0046 0.0402 0.0846
Schistosoma mansoni transcription factor LCR-F1 0.0107 0.1093 0.1093
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0246 0.2673 0.2673
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.01 0.0108
Mycobacterium ulcerans hypothetical protein 0.0169 0.1808 0.4996
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0174 0.1591
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0013 0.0033 0.0094
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0039 0.0325 0.0351
Schistosoma mansoni acetylcholinesterase 0.0041 0.0354 0.0354
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0013 0.0033 0.0033
Onchocerca volvulus 0.0129 0.1351 0.6298
Schistosoma mansoni inositol monophosphatase 0.0031 0.0233 0.0233
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0129 0.1351 0.1458
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Brugia malayi Thioredoxin reductase 0.0112 0.116 0.2438
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.01 0.0742
Brugia malayi beta-lactamase family protein 0.0129 0.1351 0.284
Echinococcus granulosus acetylcholinesterase 0.0246 0.2673 0.2673
Echinococcus granulosus Aminotransferase class III 0.0047 0.0414 0.0414
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0013 0.0033 0.0033
Loa Loa (eye worm) acetylcholinesterase 1 0.0246 0.2673 0.5616
Mycobacterium ulcerans esterase/lipase LipP 0.0129 0.1351 0.3734
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0039 0.0325 0.0919
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0012 0.0018 0.0051
Toxoplasma gondii histone lysine methyltransferase SET1 0.0119 0.1239 0.3661
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0013 0.0033 0.0094
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0329 0.3619 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0256 0.2796 0.3018
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0325 0.0919
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0033 0.0287
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Onchocerca volvulus 0.0041 0.0354 0.1649
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0256 0.2796 0.7727
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0152 0.1613 0.4558
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0174 0.048
Mycobacterium leprae conserved hypothetical protein 0.0129 0.1351 0.3734
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0129 0.1351 0.284
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0047 0.0414 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0898
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0039 0.0325 0.2406
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0047 0.0414 0.1143
Trichomonas vaginalis inositol monophosphatase, putative 0.0031 0.0233 0.0644
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0013 0.0033 0.0805
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Brugia malayi Inositol-1 0.0031 0.0233 0.049
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0046 0.0402 0.0402
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0088 0.0877 0.1843
Schistosoma mansoni hypothetical protein 0.0099 0.1006 0.1006
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0174 0.0188
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Echinococcus granulosus survival motor neuron protein 1 0.0429 0.4759 0.4759
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0113 0.1166 0.1166
Brugia malayi isocitrate dehydrogenase 0.0012 0.0018 0.0038
Onchocerca volvulus 0.0199 0.2146 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0012 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0174 0.1591
Loa Loa (eye worm) hypothetical protein 0.0046 0.0402 0.0846
Echinococcus granulosus geminin 0.0326 0.3586 0.3586
Brugia malayi hypothetical protein 0.0429 0.4759 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0046 0.0402 0.0402
Echinococcus multilocularis cpg binding protein 0.0066 0.0633 0.0633
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0256 0.2796 0.3018
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0329 0.3619 0.3906
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1613 0.4558
Schistosoma mansoni hypothetical protein 0.0088 0.0877 0.0877
Brugia malayi hypothetical protein 0.0041 0.0354 0.0744
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0032 0.0249 0.0249
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0129 0.1351 0.1351
Brugia malayi Carboxylesterase family protein 0.0246 0.2673 0.5616
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0033 0.0092
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0174 0.048
Schistosoma mansoni hypothetical protein 0.0326 0.3586 0.3586
Brugia malayi hypothetical protein 0.0062 0.0589 0.1238
Giardia lamblia NADH oxidase lateral transfer candidate 0.0039 0.0325 0.0961
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0039 0.0325 0.0961
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0256 0.2796 0.3018
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Onchocerca volvulus 0.0041 0.0354 0.1649
Echinococcus multilocularis carboxylesterase 5A 0.0246 0.2673 0.2673
Brugia malayi beta-lactamase family protein 0.0129 0.1351 0.284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0032 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0107 0.1093 0.1093
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0026 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Loa Loa (eye worm) carboxylesterase 0.0041 0.0354 0.0744
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0028 0.0196 0.0542
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0047 0.0414 0.0446
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0012 0.0018 0.0019
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0047 0.0414 0.1223
Plasmodium vivax ornithine aminotransferase, putative 0.0047 0.0414 0.3062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni eyes absent homolog 0.0062 0.0589 0.0589
Echinococcus granulosus BC026374 protein S09 family 0.0041 0.0354 0.0354
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0174 0.048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0233 0.0644
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni survival motor neuron protein 0.0088 0.0877 0.0877
Mycobacterium tuberculosis Probable dehydrogenase 0.0256 0.2796 0.3018
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0047 0.0414 0.1143
Echinococcus multilocularis BC026374 protein (S09 family) 0.0041 0.0354 0.0354
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Mycobacterium tuberculosis Probable oxidoreductase 0.0285 0.3122 0.3369
Onchocerca volvulus 0.0041 0.0354 0.1649
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0026 0.0181 0.0181
Echinococcus granulosus inositol monophosphatase 1 0.0031 0.0233 0.0233
Brugia malayi hypothetical protein 0.0123 0.1279 0.2688
Echinococcus multilocularis beta LACTamase domain containing family member 0.0129 0.1351 0.1351
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0069
Onchocerca volvulus 0.0026 0.0174 0.081
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0013 0.0033 0.0247
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Loa Loa (eye worm) carboxylesterase 0.0246 0.2673 0.5616
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0041 0.0354 0.0978
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0174 0.048
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0032 0.0249 0.0524
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0039 0.0325 0.0898
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Echinococcus multilocularis para nitrobenzyl esterase 0.0041 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0145 0.1526 0.3207
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Onchocerca volvulus 0.0026 0.0181 0.0845
Brugia malayi follicle stimulating hormone receptor 0.0182 0.1948 0.4093
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Plasmodium vivax thioredoxin reductase, putative 0.0112 0.116 0.8584
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Loa Loa (eye worm) thioredoxin reductase 0.0112 0.116 0.2438
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Trichomonas vaginalis penicillin-binding protein, putative 0.0129 0.1351 0.3734
Brugia malayi hypothetical protein 0.0107 0.1093 0.2297
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0414 0.0414
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0026 0.0181 0.0536
Onchocerca volvulus 0.0041 0.0354 0.1649
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.01 0.0277
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0031 0.0233 0.0658
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0026 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0246 0.2673 0.5616
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.1351 0.3819
Loa Loa (eye worm) hypothetical protein 0.0026 0.0174 0.0365
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Echinococcus multilocularis acetylcholinesterase 0.0246 0.2673 0.2673
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Echinococcus granulosus histone lysine methyltransferase setb 0.0026 0.0181 0.0181
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0593 0.1246
Mycobacterium ulcerans hypothetical protein 0.0026 0.0174 0.048
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0134 0.14 0.14
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0329 0.3619 1
Echinococcus multilocularis Aminotransferase class III 0.0047 0.0414 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0046 0.0402 0.0846
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0013 0.0033 0.0036
Trichomonas vaginalis set domain proteins, putative 0.0199 0.2146 0.5929
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0016 0.0069 0.0069
Onchocerca volvulus 0.0088 0.0877 0.4087
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Schistosoma mansoni neuroligin 3 (S09 family) 0.0041 0.0354 0.0354
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Brugia malayi CXXC zinc finger family protein 0.0063 0.0593 0.1246
Toxoplasma gondii NADPH-glutathione reductase 0.0039 0.0325 0.0961
Echinococcus granulosus acetylcholinesterase 0.0246 0.2673 0.2673
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0107 0.1093 0.1093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0046 0.0402 0.0846
Brugia malayi Pre-SET motif family protein 0.0026 0.0181 0.0381
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0016 0.0069 0.0069
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3538 1
Echinococcus multilocularis survival motor neuron protein 1 0.0429 0.4759 0.4759
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0246 0.2673 0.5616
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0039 0.0325 0.2803
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0013 0.0033 0.0092
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0129 0.1351 0.1458
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0012 0.0018 0.0018
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0039 0.0325 0.0898
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Loa Loa (eye worm) hypothetical protein 0.0062 0.0589 0.1238
Echinococcus granulosus GPCR family 2 0.0046 0.0402 0.0402
Plasmodium falciparum glutathione reductase 0.0112 0.116 1
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0047 0.0414 0.1143
Mycobacterium leprae Probable lipase LipE 0.0129 0.1351 0.3734
Schistosoma mansoni hypothetical protein 0.0326 0.3586 0.3586
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.01 0.2423
Echinococcus granulosus neuroligin 0.0041 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Schistosoma mansoni hypothetical protein 0.0107 0.1093 0.1093
Toxoplasma gondii hypothetical protein 0.0052 0.0472 0.1396
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0029 0.0208 0.0436
Brugia malayi Pre-SET motif family protein 0.0175 0.1873 0.3936
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0041 0.0354 0.0354
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0039 0.0325 0.0683
Schistosoma mansoni cpg binding protein 0.0063 0.0593 0.0593
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0129 0.1351 0.3734
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0088 0.0095
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Echinococcus granulosus ornithine aminotransferase 0.0047 0.0414 0.0414
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Brugia malayi Isocitrate dehydrogenase 0.0012 0.0018 0.0038
Schistosoma mansoni BC026374 protein (S09 family) 0.0041 0.0354 0.0354
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0174 0.0188
Mycobacterium tuberculosis Conserved protein 0.0129 0.1351 0.1458
Mycobacterium ulcerans beta-lactamase 0.0129 0.1351 0.3734
Brugia malayi exodeoxyribonuclease III family protein 0.0013 0.0033 0.007
Brugia malayi latrophilin 2 splice variant baaae 0.0099 0.1006 0.2114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0285 0.3122 0.8625
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0013 0.0033 0.0098
Echinococcus granulosus para nitrobenzyl esterase 0.0041 0.0354 0.0354
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0039 0.0325 0.2803
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0129 0.1351 0.1351
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0256 0.2796 0.3018
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0041 0.0354 0.0382
Brugia malayi glutathione reductase 0.0112 0.116 0.2438
Mycobacterium ulcerans carboxylesterase, LipT 0.0041 0.0354 0.0978
Plasmodium vivax hypothetical protein, conserved 0.0129 0.1351 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0031 0.0233 0.0644
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.01 0.0864
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0045 0.0397 0.1121
Echinococcus multilocularis microtubule associated protein 2 0.0542 0.6036 0.6036
Trichomonas vaginalis ap endonuclease, putative 0.0013 0.0033 0.0092
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0013 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Mycobacterium tuberculosis Probable reductase 0.0256 0.2796 0.3018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0169 0.1808 0.1951
Toxoplasma gondii ABC1 family protein 0.0129 0.1351 0.3994
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0039 0.0325 0.7859
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0129 0.1351 0.284
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0012 0.0018 0.0051
Trichomonas vaginalis mercuric reductase, putative 0.0039 0.0325 0.0898
Echinococcus granulosus carboxylesterase 5A 0.0246 0.2673 0.2673
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0031 0.0233 0.0644
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Onchocerca volvulus 0.0123 0.1279 0.5961
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0308 0.3383 0.3383
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0028 0.0196 0.0212
Loa Loa (eye worm) hypothetical protein 0.0026 0.0181 0.0381
Leishmania major trypanothione reductase 0.0112 0.116 0.3278
Onchocerca volvulus 0.0129 0.1351 0.6298
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0174 0.0491
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0249 0.0249
Mycobacterium ulcerans lipase LipD 0.0129 0.1351 0.3734
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0182 0.1948 0.4093
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Mycobacterium tuberculosis Probable esterase LipL 0.0129 0.1351 0.1458
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0039 0.0325 0.0919
Echinococcus granulosus thioredoxin glutathione reductase 0.0113 0.1166 0.1166
Plasmodium falciparum glutathione reductase 0.0039 0.0325 0.2803
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0174 0.0365
Trypanosoma brucei hypothetical protein, conserved 0.0129 0.1351 0.3819
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Loa Loa (eye worm) carboxylesterase 0.0041 0.0354 0.0744
Mycobacterium ulcerans hypothetical protein 0.0129 0.1351 0.3734
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0013 0.0033 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0285 0.3122 0.3369
Loa Loa (eye worm) hypothetical protein 0.0123 0.1279 0.2688
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0308 0.3383 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0174 0.048
Echinococcus granulosus microtubule associated protein 2 0.0542 0.6036 0.6036
Plasmodium falciparum thioredoxin reductase 0.0112 0.116 1
Plasmodium falciparum ornithine aminotransferase 0.0047 0.0414 0.3567
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.1613 0.4558
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0047 0.0414 0.0446
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.011 0.0231
Loa Loa (eye worm) hypothetical protein 0.0062 0.0589 0.1238
Echinococcus multilocularis isocitrate dehydrogenase 0.0012 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0043 0.012
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0047 0.0414 0.0446
Trichomonas vaginalis helicase, putative 0.0014 0.0043 0.012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0325 0.7859
Onchocerca volvulus 0.0063 0.0593 0.2763
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0047 0.0414 0.1143
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0047 0.0414 0.0869
Brugia malayi Carboxylesterase family protein 0.0246 0.2673 0.5616
Schistosoma mansoni hypothetical protein 0.0046 0.0402 0.0402
Loa Loa (eye worm) hypothetical protein 0.0041 0.0354 0.0744
Loa Loa (eye worm) hypothetical protein 0.0429 0.4759 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0145 0.1526 0.3207
Trypanosoma cruzi trypanothione reductase, putative 0.0112 0.116 0.3278
Echinococcus multilocularis ornithine aminotransferase 0.0047 0.0414 0.0414
Mycobacterium ulcerans L-lysine aminotransferase 0.0047 0.0414 0.1143
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0031 0.0233 0.0689
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Loa Loa (eye worm) inositol-1 0.0031 0.0233 0.049
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0329 0.3619 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0308 0.3383 0.3383
Mycobacterium ulcerans hypothetical protein 0.0329 0.3619 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0012 0.0018 0.0038
Schistosoma mansoni cpg binding protein 0.0066 0.0633 0.0633
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0047 0.0414 0.0446
Mycobacterium tuberculosis Probable lipase LipE 0.0129 0.1351 0.1458
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0041 0.0354 0.0354
Schistosoma mansoni cpg binding protein 0.0066 0.0633 0.0633
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0308 0.3383 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0013 0.0033 0.007
Echinococcus granulosus cpg binding protein 0.0066 0.0633 0.0633
Entamoeba histolytica hypothetical protein 0.0107 0.1093 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0012 0.0018 0.0051
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0039 0.0325 0.7859
Plasmodium falciparum thioredoxin reductase 0.0039 0.0325 0.2803
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0012 0.0018 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0018 0.0053
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0031 0.0233 0.5631
Onchocerca volvulus 0.0129 0.1351 0.6298
Loa Loa (eye worm) hypothetical protein 0.0129 0.1351 0.284
Trypanosoma cruzi hypothetical protein, conserved 0.0129 0.1351 0.3819
Treponema pallidum NADH oxidase 0.0039 0.0325 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0026 0.0181 0.0181
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0041 0.0354 0.0382
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0045 0.0397 0.1121
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0047 0.0414 0.0414
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0322 0.3538 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0043 0.012
Toxoplasma gondii exonuclease III APE 0.0013 0.0033 0.0098
Toxoplasma gondii isocitrate dehydrogenase 0.0012 0.0018 0.0053
Trichomonas vaginalis glutathione reductase, putative 0.0039 0.0325 0.0898
Trypanosoma brucei trypanothione reductase 0.0112 0.116 0.3278
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0308 0.3383 0.711
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Trichomonas vaginalis penicillin-binding protein, putative 0.0129 0.1351 0.3734
Trichomonas vaginalis D-aminoacylase, putative 0.0129 0.1351 0.3734
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Echinococcus multilocularis inositol monophosphatase 1 0.0031 0.0233 0.0233
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0322 0.3538 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.01 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0041 0.0354 0.0354
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0174 0.048
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0826 0.9267 1
Mycobacterium tuberculosis Probable hydrolase 0.0129 0.1351 0.1458
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0046 0.0402 0.0402
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0039 0.0325 0.0919
Schistosoma mansoni gliotactin 0.0041 0.0354 0.0354
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0112 0.116 0.1252
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0919
Toxoplasma gondii thioredoxin reductase 0.0112 0.116 0.3428
Mycobacterium tuberculosis Probable lipase LipD 0.0129 0.1351 0.1458
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0031 0.0233 0.2131
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0414 0.1143
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0308 0.3383 0.711
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0047 0.0414 1
Leishmania major hypothetical protein, conserved 0.0129 0.1351 0.3819
Mycobacterium ulcerans acetylornithine aminotransferase 0.0047 0.0414 0.1143
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0039 0.0325 0.0919
Echinococcus granulosus mixed lineage leukemia protein mll 0.0016 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0308 0.3383 0.711
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0047 0.0414 0.1143
Echinococcus multilocularis neuroligin 0.0041 0.0354 0.0354
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0325 0.0919
Schistosoma mansoni inositol monophosphatase 0.0031 0.0233 0.0233
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0043 0.012
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0145 0.1526 0.3207
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0039 0.0325 0.0919
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0175 0.1873 0.3936
Loa Loa (eye worm) histone methyltransferase 0.002 0.0113 0.0237
Loa Loa (eye worm) glutathione reductase 0.0112 0.116 0.2438
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0055 0.0509 0.1439
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0032 0.0249 0.0249
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0012 0.0018 0.0132
Brugia malayi Carboxylesterase family protein 0.0041 0.0354 0.0744
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0012 0.0018 0.0018
Echinococcus granulosus beta LACTamase domain containing family member 0.0129 0.1351 0.1351

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.7 uM Inhibition of equine BuChE after 120 mins by Ellman's method ChEMBL. 23151013
IC50 (binding) = 0.7 uM Inhibition of BuChE in equine serum using butylthiocholine iodide as substrate by Ellman's method ChEMBL. 24731278
IC50 (binding) = 5.6 uM Inhibition of bovine AChE after 120 mins by Ellman's method ChEMBL. 23151013
IC50 (binding) = 5.6 uM Inhibition of AChE in bovine erythrocytes using acetylthiocholine iodide as substrate by Ellman's method ChEMBL. 24731278

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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