Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protein kinase C, alpha | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, beta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, eta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, epsilon | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, delta | Starlite/ChEMBL | References |
Homo sapiens | protein kinase C, theta | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine threonine protein kinase | 0.0168 | 0.2397 | 0.381 |
Echinococcus multilocularis | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0168 | 0.2388 | 0.3795 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Echinococcus granulosus | protein kinase C gamma type | 0.0168 | 0.2397 | 0.381 |
Loa Loa (eye worm) | hypothetical protein | 0.0143 | 0.1555 | 0.1555 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0381 | 0.9356 | 0.9356 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0287 | 0.6292 | 1 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Brugia malayi | protein kinase C II. | 0.0287 | 0.6292 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0287 | 0.6292 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Onchocerca volvulus | 0.0333 | 0.7801 | 0.5 | |
Echinococcus granulosus | protein kinase c iota type | 0.0115 | 0.0633 | 0.1006 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0168 | 0.2388 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0216 | 0.3952 | 0.5865 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0216 | 0.3952 | 0.6281 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 0.7801 | 0.7801 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0287 | 0.6292 | 0.6292 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0103 | 0.0246 | 0.0246 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0234 | 0.4539 | 0.7214 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2.7 nM | Inhibition of PKCdelta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 3.8 nM | Inhibition of PKCtheta by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 7.8 nM | Inhibition of PKCbeta-1 by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 11 nM | Inhibition of PKCalpha by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 11 nM | Inhibition of PKCepsilon by scintillation proximity assay | ChEMBL. | 21797275 |
IC50 (binding) | = 11 nM | Inhibition of PKCeta by scintillation proximity assay | ChEMBL. | 21797275 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.