Detailed information for compound 172403

Basic information

Technical information
  • TDR Targets ID: 172403
  • Name: (E)-1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en -1-one
  • MW: 240.254 | Formula: C15H12O3
  • H donors: 2 H acceptors: 3 LogP: 3.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(c(c1)O)C(=O)/C=C/c1ccccc1
  • InChi: 1S/C15H12O3/c16-12-7-8-13(15(18)10-12)14(17)9-6-11-4-2-1-3-5-11/h1-10,16,18H/b9-6+
  • InChiKey: JUMSUVHHUVPSOY-RMKNXTFCSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • (E)-1-(2,4-dihydroxyphenyl)-3-phenyl-prop-2-en-1-one
  • (E)-1-(2,4-dihydroxyphenyl)-3-phenyl-2-propen-1-one
  • 2',4'-dihydroxychalcone
  • 1-(2,4-dihydroxyphenyl)-3-phenylprop-2-en-1-one
  • 1-(2,4-dihydroxyphenyl)-3-phenyl-prop-2-en-1-one
  • 25515-43-9
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-
  • NSC401492
  • CHALCONE, 2',4'-DIHYDROXY-
  • ST5308968
  • NCGC00096022-01
  • 2-Propen-1-one, 1-(2,4-dihydroxyphenyl)-3-phenyl-, (E)-
  • SPECTRUM1505132

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Rattus norvegicus Aldose reductase Starlite/ChEMBL No references
Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Plasmodium falciparum fructose-bisphosphate aldolase Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii Fructose-bisphosphate aldolase class-I Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K01623 fructose-bisphosphate aldolase, class I [EC4.1.2.13A], putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium falciparum fructose-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus fructose bisphosphate aldolase class I Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Fructose-bisphosphate aldolase (EC 4.1.2.13), related Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei gambiense fructose-bisphosphate aldolase, glycosomal putative Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis fructose-1,6-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium knowlesi fructose-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative Get druggable targets OG5_127143 All targets in OG5_127143
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus fructose 16 bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei fructose-bisphosphate aldolase 2 Get druggable targets OG5_127143 All targets in OG5_127143
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni fructose 16-bisphosphate aldolase Get druggable targets OG5_127143 All targets in OG5_127143
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Aldose reductase   316 aa 314 aa 37.3 %
Plasmodium falciparum steroid dehydrogenase, putative hydroxyprostaglandin dehydrogenase 15-(NAD) 266 aa 216 aa 22.2 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 335 aa 24.2 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 320 aa 19.7 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 40.3 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 309 aa 26.9 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 329 aa 19.8 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 334 aa 24.3 %
Leishmania braziliensis aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   316 aa 267 aa 27.3 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 296 aa 26.7 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 295 aa 21.4 %
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0038 0.0232 0.0232
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0138 0.1119 0.1119
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0138 0.1119 0.1119
Leishmania major heat shock protein, putative 0.006 0.0428 0.0406
Giardia lamblia Grp94/Hsp90 0.0117 0.0935 0.7443
Loa Loa (eye worm) heat shock protein 90 0.0147 0.1201 0.1201
Trichomonas vaginalis heat shock protein, putative 0.0147 0.1201 1
Schistosoma mansoni loxhd1 0.0024 0.0103 0.0103
Plasmodium vivax DNA topoisomerase II, putative 0.003 0.0158 0.0056
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.7297 0.7297
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.003 0.0158 0.3696
Brugia malayi Cytochrome P450 family protein 0.0015 0.0024 0.0024
Trypanosoma cruzi heat shock protein 90, putative 0.0147 0.1201 0.1181
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1137 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1137 1 1
Trichomonas vaginalis endoplasmin, putative 0.009 0.0695 0.5145
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0103 0.0103
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Entamoeba histolytica 90 kDa heat shock protein, putative 0.006 0.0428 0.2588
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.0866 0.0845
Giardia lamblia Heat shock protein HSP 90-alpha 0.0117 0.0935 0.7443
Trypanosoma brucei developmentally regulated phosphoprotein 0.003 0.0158 0.0135
Brugia malayi fructose-bisphosphate aldolase 2 0.011 0.0866 0.0866
Echinococcus multilocularis aldo keto reductase 0.0038 0.0232 0.0232
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0158
Onchocerca volvulus DNA topoisomerase 2 homolog 0.003 0.0158 0.3696
Echinococcus multilocularis heat shock protein 90 0.0117 0.0935 0.0935
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.003 0.0158 0.0256
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0024 0.0024
Mycobacterium ulcerans DNA gyrase subunit B 0.003 0.0158 0.123
Onchocerca volvulus 0.0038 0.0232 0.5406
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.0866 0.0866
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1201 0.1181
Echinococcus multilocularis RUN 0.0024 0.0103 0.0103
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0117 0.0935 0.0935
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0138 0.1119 0.1119
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0232 0.0232
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.006 0.0428 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0484 0.0484
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0484 0.0484
Trypanosoma brucei heat shock protein 90, putative 0.0147 0.1201 0.1181
Trypanosoma cruzi heat shock protein 90, putative 0.0087 0.0665 0.0643
Toxoplasma gondii aldose reductase, putative 0.0038 0.0232 0.0074
Plasmodium falciparum heat shock protein 90, putative 0.006 0.0428 0.0328
Entamoeba histolytica heat shock protein 90, putative 0.0147 0.1201 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0232 0.0208
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Trypanosoma brucei Heat shock protein 83, putative 0.0147 0.1201 0.1181
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.003 0.0158 0.0158
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.011 0.0866 0.072
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.0866 0.0845
Echinococcus granulosus heat shock protein 0.0147 0.1201 0.1201
Entamoeba histolytica tartrate dehydrogenase, putative 0.0138 0.1119 0.9214
Schistosoma mansoni rab6-interacting 0.0024 0.0103 0.0103
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.0866 0.0845
Plasmodium vivax endoplasmin, putative 0.0147 0.1201 0.111
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Trypanosoma brucei heat shock protein 84, putative 0.006 0.0428 0.0406
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1137 1 1
Onchocerca volvulus 0.0038 0.0232 0.5406
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.003 0.0158 0.0135
Schistosoma mansoni endoplasmin 0.0147 0.1201 0.1201
Brugia malayi Doublecortin family protein 0.0024 0.0103 0.0103
Trichomonas vaginalis heat shock protein, putative 0.0117 0.0935 0.7443
Loa Loa (eye worm) CYP4Cod1 0.0015 0.0024 0.0024
Schistosoma mansoni aldo-keto reductase 0.0038 0.0232 0.0232
Loa Loa (eye worm) cytochrome P450 family protein 0.0015 0.0024 0.0024
Entamoeba histolytica heat shock protein 90, putative 0.0147 0.1201 1
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Loa Loa (eye worm) hypothetical protein 0.0138 0.1119 0.1119
Plasmodium vivax heat shock protein 90, putative 0.006 0.0428 0.0328
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.0866 0.0866
Toxoplasma gondii isocitrate dehydrogenase 0.1137 1 1
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.003 0.0158 0.0135
Echinococcus granulosus heat shock protein 90 0.0117 0.0935 0.0935
Brugia malayi DNA topoisomerase II, alpha isozyme 0.003 0.0158 0.0158
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Leishmania major fructose-1,6-bisphosphate aldolase 0.011 0.0866 0.0845
Trypanosoma cruzi DNA topoisomerase II, putative 0.003 0.0158 0.0135
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0232 0.0232
Loa Loa (eye worm) oxidoreductase 0.0038 0.0232 0.0232
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0138 0.1119 0.1119
Schistosoma mansoni DNA topoisomerase II 0.003 0.0158 0.0158
Trypanosoma cruzi heat shock protein, putative 0.006 0.0428 0.0406
Schistosoma mansoni aldo-keto reductase 0.0038 0.0232 0.0232
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Echinococcus granulosus heat shock protein 90 0.0147 0.1201 0.1201
Mycobacterium ulcerans two component regulator - sensor kinase 0.003 0.0158 0.123
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Echinococcus multilocularis heat shock protein 0.0147 0.1201 0.1201
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.011 0.0866 0.072
Echinococcus granulosus fructose bisphosphate aldolase class I 0.011 0.0866 0.0866
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1137 1 1
Mycobacterium ulcerans two component sensor kinase MprB 0.003 0.0158 0.123
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0117 0.0935 0.8127
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0232 0.0702
Leishmania major hypothetical protein, conserved 0.003 0.0158 0.0135
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Brugia malayi Endoplasmin precursor 0.0147 0.1201 0.1201
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0138 0.1119 0.0977
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0232 0.0232
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.003 0.0158 0.0056
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0138 0.1119 0.1119
Trichomonas vaginalis heat shock protein, putative 0.006 0.0428 0.2588
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.0866 0.0845
Loa Loa (eye worm) oxidoreductase 0.0038 0.0232 0.0232
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0138 0.1119 0.1119
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.003 0.0158 0.0158
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0158
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0232 0.0074
Schistosoma mansoni isocitrate dehydrogenase 0.0138 0.1119 0.1119
Brugia malayi hypothetical protein 0.0024 0.0103 0.0103
Plasmodium falciparum DNA topoisomerase 2 0.003 0.0158 0.0056
Loa Loa (eye worm) oxidoreductase 0.0038 0.0232 0.0232
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Trypanosoma cruzi Heat shock protein 83, putative 0.0147 0.1201 0.1181
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.003 0.0158 0.123
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Entamoeba histolytica aldose reductase, putative 0.0038 0.0232 0.0702
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1137 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.011 0.0866 0.0866
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.003 0.0158 0.0135
Brugia malayi fructose-bisphosphate aldolase 1 0.011 0.0866 0.0866
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0138 0.1119 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.003 0.0158 0.0158
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Trichomonas vaginalis heat shock protein, putative 0.0117 0.0935 0.7443
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Giardia lamblia Aldose reductase 0.0038 0.0232 0.0702
Echinococcus multilocularis aldehyde reductase 0.0027 0.0133 0.0133
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0138 0.1119 0.9214
Onchocerca volvulus 0.0024 0.0103 0.2408
Brugia malayi Probable isocitrate dehydrogenase 0.0138 0.1119 0.1119
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.0866 0.0866
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.011 0.0866 0.0771
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0232 0.0208
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Plasmodium falciparum endoplasmin, putative 0.009 0.0695 0.0598
Mycobacterium leprae Probable two component sensor kinase MprB 0.003 0.0158 0.0256
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.003 0.0158 0.0135
Schistosoma mansoni lipoxygenase 0.0067 0.0484 0.0484
Loa Loa (eye worm) hypothetical protein 0.003 0.0158 0.0158
Plasmodium falciparum heat shock protein 90 0.0147 0.1201 0.111
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Plasmodium vivax heat shock protein, putative 0.006 0.0428 0.0328
Trypanosoma brucei DNA topoisomerase ii 0.003 0.0158 0.0135
Echinococcus granulosus endoplasmin 0.0117 0.0935 0.0935
Brugia malayi Isocitrate dehydrogenase 0.1137 1 1
Treponema pallidum heat shock protein 90 0.0117 0.0935 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.003 0.0158 0.0158
Mycobacterium leprae Probable two-component sensor kinase 0.003 0.0158 0.0256
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Schistosoma mansoni heat shock protein 0.006 0.0428 0.0428
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0232 0.0702
Plasmodium falciparum fructose-bisphosphate aldolase 0.011 0.0866 0.0771
Brugia malayi heat shock protein 90 0.0147 0.1201 0.1201
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0103
Leishmania major mitochondrial DNA topoisomerase II 0.003 0.0158 0.0135
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0103 0.0103
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0138 0.1119 1
Brugia malayi hypothetical protein 0.0024 0.0103 0.0103
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0103 0.0103
Loa Loa (eye worm) heat shock protein 75 0.006 0.0428 0.0428
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Loa Loa (eye worm) TOPoisomerase family member 0.003 0.0158 0.0158
Toxoplasma gondii heat shock protein 75, putative 0.006 0.0428 0.0274
Plasmodium falciparum DNA gyrase subunit B 0.003 0.0158 0.0056
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.003 0.0158 0.0158
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.006 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0038 0.0232 0.0232
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.003 0.0158 0.123
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Onchocerca volvulus 0.0038 0.0232 0.5406
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0103
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0103 0.0103
Schistosoma mansoni rab6-interacting 0.0024 0.0103 0.0103
Schistosoma mansoni unc-13 (munc13) 0.0138 0.1119 0.1119
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0117 0.0935 0.8077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1137 1 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.003 0.0158 0.0135
Schistosoma mansoni pol-related 0.0038 0.0232 0.0232
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0232 0.0208
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.011 0.0866 0.072
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0117 0.0935 0.0789
Leishmania major DNA topoisomerase ii 0.003 0.0158 0.0135
Loa Loa (eye worm) oxidoreductase 0.0038 0.0232 0.0232
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.011 0.0866 0.0866
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0117 0.0935 0.0913
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0138 0.1119 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Onchocerca volvulus 0.0038 0.0232 0.5406
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0232 0.0208
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Echinococcus granulosus RUN 0.0024 0.0103 0.0103
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0138 0.1119 0.1119
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1137 1 1
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.003 0.0158 0.123
Mycobacterium ulcerans putative regultory protein 0.003 0.0158 0.123
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.003 0.0158 0.0135
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0232 0.0208
Trypanosoma brucei heat shock protein 90, putative 0.0147 0.1201 0.1181
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1201 0.1181
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Echinococcus granulosus microtubule associated protein 2 0.0833 0.7297 0.7297
Schistosoma mansoni pyruvate dehydrogenase 0.003 0.0158 0.0158
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Schistosoma mansoni lipoxygenase 0.0024 0.0103 0.0103
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Plasmodium falciparum heat shock protein 90, putative 0.006 0.0428 0.0328
Schistosoma mansoni endoplasmin 0.0147 0.1201 0.1201
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1137 1 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0147 0.1201 1
Chlamydia trachomatis DNA gyrase subunit B 0.003 0.0158 0.5
Onchocerca volvulus 0.0038 0.0232 0.5406
Brugia malayi Probable isocitrate dehydrogenase 0.0138 0.1119 0.1119
Brugia malayi Hsp90 protein 0.006 0.0428 0.0428
Echinococcus granulosus aldo keto reductase 0.0038 0.0232 0.0232
Toxoplasma gondii heat shock protein HSP90 0.0147 0.1201 0.106
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.003 0.0158 0.0256
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.003 0.0158 0.123
Toxoplasma gondii Hsp90 domain-containing protein 0.006 0.0428 0.0274
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.011 0.0866 0.0866
Trypanosoma brucei DNA topoisomerase II beta, putative 0.003 0.0158 0.0135
Schistosoma mansoni heat shock protein 0.0147 0.1201 0.1201
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0232 0.0998
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0138 0.1119 0.1119
Entamoeba histolytica aldose reductase, putative 0.0038 0.0232 0.0702
Brugia malayi kinase, mitochondrial precursor 0.003 0.0158 0.0158
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0232 0.0702
Toxoplasma gondii heat shock protein 90, putative 0.0147 0.1201 0.106
Schistosoma mansoni heat shock protein 0.0147 0.1201 0.1201
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1137 1 1
Trichomonas vaginalis heat shock protein, putative 0.0117 0.0935 0.7443
Leishmania major aldo-keto reductase-like protein 0.0038 0.0232 0.0208
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.7297 0.7297
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Plasmodium vivax heat shock protein 86, putative 0.0147 0.1201 0.111
Entamoeba histolytica aldose reductase, putative 0.0038 0.0232 0.0702
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.011 0.0866 0.0866
Trichomonas vaginalis heat shock protein, putative 0.009 0.0695 0.5145
Echinococcus multilocularis aldo keto reductase 0.0038 0.0232 0.0232
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.003 0.0158 0.123
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1137 1 1
Chlamydia trachomatis DNA gyrase subunit B 0.003 0.0158 0.5
Echinococcus granulosus aldo keto reductase 0.0038 0.0232 0.0232
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Mycobacterium ulcerans oxidoreductase 0.0038 0.0232 0.1898
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1137 1 1
Mycobacterium ulcerans heat shock protein 90 0.0117 0.0935 0.8314
Echinococcus granulosus DNA topoisomerase 2 alpha 0.003 0.0158 0.0158
Echinococcus multilocularis aldo keto reductase 0.0038 0.0232 0.0232
Plasmodium vivax hypothetical protein, conserved 0.003 0.0158 0.0056
Schistosoma mansoni hypothetical protein 0.0024 0.0103 0.0103
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0232 0.0232
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0232 0.0232
Giardia lamblia Aldose reductase 0.0038 0.0232 0.0702
Onchocerca volvulus 0.0024 0.0103 0.2408
Loa Loa (eye worm) endoplasmin 0.0147 0.1201 0.1201
Loa Loa (eye worm) oxidoreductase 0.0038 0.0232 0.0232
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0232 0.0702
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Leishmania major developmentally regulated phosphoprotein-like protein 0.003 0.0158 0.0135
Leishmania major isocitrate dehydrogenase, putative 0.0138 0.1119 0.1098
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0138 0.1119 0.1119
Plasmodium vivax DNA gyrase subunit B, putative 0.003 0.0158 0.0056
Brugia malayi Probable DNA topoisomerase II 0.003 0.0158 0.0158
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.0866 0.0866
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.011 0.0866 0.0866
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.011 0.0866 0.0866
Echinococcus multilocularis isocitrate dehydrogenase 0.1137 1 1
Trypanosoma cruzi heat shock protein 85, putative 0.0117 0.0935 0.0913
Loa Loa (eye worm) isocitrate dehydrogenase 0.1137 1 1
Leishmania major prostaglandin f synthase, putative 0.0038 0.0232 0.0208
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0232 0.0702
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.003 0.0158 0.123
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.011 0.0866 0.0845
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.006 0.0428 0.0428
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.003 0.0158 0.123
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1137 1 1
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0232 0.0208
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.003 0.0158 0.123
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1137 1 1
Onchocerca volvulus 0.0038 0.0232 0.5406
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Echinococcus granulosus aldehyde reductase 0.0027 0.0133 0.0133
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0103 0.0103
Echinococcus multilocularis heat shock protein 90 0.0147 0.1201 0.1201
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0232 0.0232
Brugia malayi Cytochrome P450 family protein 0.0015 0.0024 0.0024
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0103 0.0103
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1137 1 1
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0103 0.0103
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.003 0.0158 0.0135
Trypanosoma brucei heat shock protein, putative 0.0147 0.1201 0.1181
Toxoplasma gondii isocitrate dehydrogenase 0.1137 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0232 0.0702
Echinococcus granulosus aldo keto reductase 0.0038 0.0232 0.0232
Onchocerca volvulus DNA topoisomerase 2 homolog 0.003 0.0158 0.3696
Trypanosoma cruzi heat shock protein 90, putative 0.0117 0.0935 0.0913
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Echinococcus granulosus hypothetical protein 0.0038 0.0232 0.0232
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.003 0.0158 0.5
Trypanosoma cruzi heat shock protein 85, putative 0.0147 0.1201 0.1181
Schistosoma mansoni polycystin 1-related 0.0024 0.0103 0.0103
Echinococcus multilocularis endoplasmin 0.0117 0.0935 0.0935
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.011 0.0866 0.0866
Leishmania major heat shock protein 83-1 0.0147 0.1201 0.1181
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0232 0.0702

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 273 mg/dl Antidiabetic activity in mouse 3T3L1 cells assessed as decrease in glucose consumption from cell culture medium using 450 mg/dL D-glucose at 30 ug/mL after 24 hrs (Rvb = 310 +/- 4 mg/dl) ChEMBL. 22608392
CD100 (functional) > 100 uM Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs ChEMBL. 17950610
CD100 (functional) > 100 uM Cytotoxicity against human PANC1 cells in nutrient deprived medium after 24 hrs ChEMBL. 17950610
IC50 (binding) Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysis ChEMBL. 26762836
IC50 (binding) Inhibition of human BCRP expressed in MDCK2 cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by fluorimetry ChEMBL. 22112540
IC50 (binding) Inhibition of BCRP in human MCF7/MX cells assessed as Hoechst 33342 accumulation preincubated for 30 mins by Fluorometry ChEMBL. 22112540
IC50 (binding) = 1.01 uM Inhibition of Rattus norvegicus (rat) lens aldose reductase ChEMBL. No reference
IC50 (functional) > 10 uM Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by MTT assay ChEMBL. 26690274
IC50 (functional) = 16.3 uM The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells ChEMBL. 11720850
IC50 (functional) = 16.3 uM The compound was tested for antiproliferative activity against MCF-7 human breast cancer cells ChEMBL. 11720850
IC50 (functional) = 17 uM Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay ChEMBL. 19689125
IC50 (functional) = 23.1 uM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay ChEMBL. 18440233
IC50 (functional) = 23.2 uM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 19689125
IC50 (functional) = 23.8 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 assessed as growth inhibition after 24 to 168 hrs by microplate resazurin assay ChEMBL. 26473275
IC50 (functional) = 24.4 uM Cytotoxicity against human HeLa cells after 72 hrs by MTT assay ChEMBL. 19689125
IC50 (functional) = 34 uM Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay ChEMBL. 18440233
IC50 (functional) = 41.6 uM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 18440233
IC50 (functional) = 75 uM Cytotoxicity against human SK-MEL-28 cells after 72 hrs by MTT assay ChEMBL. 21696954
IC50 (ADMET) = 80.2 uM Cytotoxicity against human U937 cells ChEMBL. 20035557
IC50 (functional) = 81 uM Cytotoxicity against human LoVo cells after 72 hrs by MTT assay ChEMBL. 21696954
IC50 (functional) > 100 uM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 21696954
IC50 (functional) > 100 uM Cytotoxicity against human PC3 cells after 72 hrs by MTT assay ChEMBL. 21696954
IC50 (ADMET) = 109 uM Cytotoxicity against human HEK293 cells assessed as cell viability after 24 hrs by cell titer-blue assay ChEMBL. 26473275
IC50 (binding) = 280 uM Inhibition of Prostaglandin G/H synthase activity in sheep seminal vesicle was determined ChEMBL. 8254620
IC50 (binding) = 400 uM In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined ChEMBL. 8254620
IC50 (binding) = 400 uM In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined ChEMBL. 8254620
IC50 (binding) = 400 uM Inhibition of 5-lipoxygenase in rat RBL1 cells ChEMBL. No reference
Inhibition (binding) Inhibition of MRP1 overexpressed in human 2008 MRP1 cells assessed as calcein AM accumulation at 10 uM by fluorimetry ChEMBL. 22112540
Inhibition (binding) Inhibition of MDR1 in human A2780adr cells assessed as calcein AM accumulation at 10 uM by fluorimetry ChEMBL. 22112540
Inhibition (binding) Inhibition of Mycobacterium tuberculosis mycothiol disulfide reductase assessed as NADPH oxidation at 800 uM by Ellmans reagent method ChEMBL. 20035557
Inhibition (functional) = 5 % Inhibition of lipid peroxidation in rat liver microsomes at 1 microM ChEMBL. 8254620
Inhibition (binding) < 20 % Inhibition of mushroom tyrosinase at 400 uM ChEMBL. 17267225
Inhibition (binding) < 20 % Inhibition of mushroom tyrosinase at 400 uM ChEMBL. 17267225
Inhibition (functional) = 40.1 % Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of lipopolysaccharide-induced nitric oxide production at 50 uM pre-incubated for 4 hrs before LPS challenge for 24 hrs by Griess assay ChEMBL. 22775441
Inhibition (functional) = 99.5 % Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells at MBC by radiometric method ChEMBL. 20035557
MBC (functional) = 416.5 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells by radiometric method ChEMBL. 20035557
MIC (functional) = 6.25 ug ml-1 Antifungal activity against Colletotrichum truncatum CE175 ChEMBL. 17112640
MIC (functional) = 6.25 ug ml-1 Antifungal activity against Phomopsis longicolla Hobbs CE117 ChEMBL. 17112640
MIC (functional) = 195.3 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv by radiometric method ChEMBL. 20035557
MIC (functional) = 195.3 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in human U937 cells by radiometric method ChEMBL. 20035557
MIC>90 (functional) = 104 uM Antimycobacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 assessed as growth inhibition after 24 to 168 hrs by microplate resazurin assay ChEMBL. 26473275
PC50 (functional) = 19 uM Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay ChEMBL. 19689125
Potency (ADMET) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (ADMET) = 1.5849 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4. (Class of assay: confirmatory) [Related pubchem assays: 410 ] ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: Inhibitors of USP1/UAF1: Pilot qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504878] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 11720850

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

7 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.