TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 417.869 | Formula: C18H16ClN5O3S
H donors: 2 H acceptors: 5 LogP: 2.66 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1c[nH]c2c1c(nc(n2)SCC(=O)N(C)C)c1cc(O)c(cc1Cl)OC
InChi: 1S/C18H16ClN5O3S/c1-24(2)14(26)8-28-18-22-16(15-9(6-20)7-21-17(15)23-18)10-4-12(25)13(27-3)5-11(10)19/h4-5,7,25H,8H2,1-3H3,(H,21,22,23)
InChiKey: CNCOWHMBYWEBGS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	heat shock protein 90kDa alpha (cytosolic), class B member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	Endoplasmin precursor	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90, related	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	heat shock protein 86, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	IPR003367,Thrombospondin type 3 repeat;IPR002048,Calcium-binding EF-hand,domain-containing	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-alpha, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Theileria parva	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium knowlesi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Heat shock protein HSP 90-alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	heat shock 90 kDa protein homolog	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium vivax	endoplasmin, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium falciparum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania infantum	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium ulcerans	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium hominis	heat shock protein 83	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Treponema pallidum	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K09487 heat shock protein 90kDa beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	hypothetical protein	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	ko:K04079 molecular chaperone HtpG, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Candida albicans	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus granulosus	heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania mexicana	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma mansoni	endoplasmin	Get druggable targets OG5_126623	All targets in OG5_126623
Schistosoma japonicum	Heat shock protein HSP 90-beta, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Babesia bovis	hsp90 protein	Get druggable targets OG5_126623	All targets in OG5_126623
Toxoplasma gondii	heat shock protein HSP90	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium berghei	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania donovani	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Cryptosporidium parvum	Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma congolense	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trichomonas vaginalis	heat shock protein, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Echinococcus multilocularis	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania braziliensis	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Plasmodium yoelii	putative heat shock protein 81-2	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Giardia lamblia	Grp94/Hsp90	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	Heat shock protein 83, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Leishmania major	heat shock protein 83-1	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma brucei gambiense	heat shock protein 83,heat shock protein	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Trypanosoma cruzi	heat shock protein 85, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Entamoeba histolytica	heat shock protein 90, putative	Get druggable targets OG5_126623	All targets in OG5_126623
Neospora caninum	HSP90-like protein, related	Get druggable targets OG5_126623	All targets in OG5_126623
Loa Loa (eye worm)	heat shock protein 90	Get druggable targets OG5_126623	All targets in OG5_126623
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	Get druggable targets OG5_126623	All targets in OG5_126623

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	heat shock protein 90, putative	heat shock protein 90kDa alpha (cytosolic), class B member 1	724 aa	725 aa	35.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1556	0.3599
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	natriuretic peptide receptor 1	0.0064	0.4324	0.4324
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus granulosus	hypothetical protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase HCK	0.0064	0.4324	0.4324
Leishmania major	protein kinase, putative	0.0064	0.4324	1
Onchocerca volvulus		0.0063	0.4227	0.4227
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Brugia malayi	hypothetical protein	0.0063	0.4227	0.4227
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0063	0.4227	0.4227
Schistosoma mansoni	protein tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0063	0.4227	0.4227
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0064	0.4324	0.4324
Echinococcus granulosus	receptor type guanylyl cyclase	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0064	0.4324	1
Onchocerca volvulus		0.0063	0.4227	0.4227
Echinococcus multilocularis	tyrosine protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	integrin linked protein kinase	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trypanosoma cruzi	protein kinase, putative	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0063	0.4227	0.4227
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0064	0.4324	0.4324
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	kinase suppressor of Ras 1	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	epidermal growth factor receptor	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Mycobacterium ulcerans	heat shock protein 90	0.0031	0.1367	0.5
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Trypanosoma brucei	Pseudokinase, putative	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.1768	0.1768
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.2088	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	heat shock protein 90	0.0031	0.1367	0.1367
Plasmodium falciparum	protein kinase, putative	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	heat shock protein	0.0039	0.2088	0.2088
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.2088	0.4828
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0063	0.4227	0.4227
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0064	0.4324	0.4324
Entamoeba histolytica	receptor protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	signal transduction protein lnk realted	0.0063	0.4227	0.4227
Leishmania major	hypothetical protein, conserved	0.0064	0.4324	1
Echinococcus granulosus	insulin receptor	0.0064	0.4324	0.4324
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Giardia lamblia	Kinase, NEK	0.0064	0.4324	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0063	0.4227	0.4227
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	ephrin receptor	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	SH2 motif	0.0063	0.4227	0.4227
Echinococcus granulosus	ephrin type A receptor 4 A	0.0064	0.4324	0.4324
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0036	0.1768	0.1768
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.2088	0.2088
Entamoeba histolytica	protein kinase, putative	0.0063	0.4227	0.4227
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0064	0.4324	0.4324
Schistosoma mansoni	endoplasmin	0.0039	0.2088	0.2088
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0064	0.4324	0.4324
Echinococcus multilocularis	SH2 motif	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0033	0.1556	0.3599
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Plasmodium vivax	protein kinase, putative	0.0064	0.4324	1
Brugia malayi	ephrin receptor 1 precursor	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	suppressor of cytokine signaling	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0036	0.1768	0.1768
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	NCK adaptor protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	heat shock protein 70	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0064	0.4324	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0063	0.4227	0.4227
Schistosoma mansoni	ephrin receptor	0.0064	0.4324	0.4324
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Echinococcus granulosus	SH2 motif	0.0063	0.4227	0.4227
Echinococcus multilocularis	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.1367	0.3162
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.1367	0.3162
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	heat shock protein 90	0.0039	0.2088	0.2088
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Leishmania major	protein kinase, putative	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.4227	0.4227
Plasmodium falciparum	heat shock protein 90	0.0039	0.2088	0.4828
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0064	0.4324	0.4324
Schistosoma mansoni	tensin	0.0063	0.4227	0.4227
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0063	0.4227	0.4227
Echinococcus granulosus	epidermal growth factor receptor	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Brugia malayi	Tyrosine-protein kinase PR2	0.0064	0.4324	0.4324
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0063	0.4227	0.4227
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/ROR protein kinase	0.0064	0.4324	0.4324
Giardia lamblia	Heat shock protein HSP 90-alpha	0.0039	0.2088	0.2436
Schistosoma mansoni	endoplasmin	0.0039	0.2088	0.2088
Schistosoma mansoni	shc transforming protein	0.0063	0.4227	0.4227
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Onchocerca volvulus		0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.2064	0.2064
Entamoeba histolytica	ankyrin repeat protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0063	0.4227	0.4227
Plasmodium vivax	endoplasmin, putative	0.0039	0.2088	0.4828
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Plasmodium falciparum	protein kinase, putative	0.0064	0.4324	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0063	0.4227	0.4227
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus multilocularis		0.0063	0.4227	0.4227
Echinococcus granulosus	growth factor receptor bound protein 2	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0063	0.4227	0.4227
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	GTPase activating protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	heat shock protein 90	0.0039	0.2088	0.2088
Trypanosoma brucei	protein kinase, putative	0.0064	0.4324	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	endoplasmin	0.0039	0.2088	0.2088
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Giardia lamblia	Protein 21.1	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Toxoplasma gondii	protein kinase domain-containing protein	0.0064	0.4324	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Brugia malayi	Sex muscle abnormal protein 5	0.0063	0.4227	0.4227
Echinococcus granulosus	protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0063	0.4227	0.4227
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Echinococcus granulosus	protein tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Trypanosoma brucei	Heat shock protein 83, putative	0.0039	0.2088	0.4828
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0063	0.4227	0.4227
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	AGC family protein kinase	0.0064	0.4324	1
Treponema pallidum	heat shock protein 90	0.0031	0.1367	0.5
Echinococcus multilocularis	SH2 domain containing protein 7	0.0063	0.4227	0.4227
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Entamoeba histolytica	heat shock protein 90, putative	0.0039	0.2088	0.2088
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Onchocerca volvulus		0.0063	0.4227	0.4227
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0063	0.4227	0.4227
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Onchocerca volvulus	Tyrosine kinase homolog	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	endoplasmin	0.0031	0.1367	0.1367
Echinococcus granulosus	SH2 domain containing protein 7	0.0063	0.4227	0.4227
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0064	0.4324	0.4324
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0064	0.4324	1
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0064	0.4324	0.4324
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Schistosoma mansoni	nck2/grb4	0.0063	0.4227	0.4227
Schistosoma mansoni	tensin-related	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0064	0.4324	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0063	0.4227	0.4227
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0064	0.4324	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.2088	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0063	0.4227	0.4227
Trypanosoma cruzi	protein kinase, putative	0.0064	0.4324	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	SH2 motif	0.0063	0.4227	0.4227
Echinococcus multilocularis	FL cytokine receptor	0.0064	0.4324	0.4324
Schistosoma mansoni	adapter molecule crk	0.0063	0.4227	0.4227
Echinococcus multilocularis	heat shock protein 90	0.0031	0.1367	0.1367
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Echinococcus multilocularis	endoplasmin	0.0031	0.1367	0.1367
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Brugia malayi	hypothetical protein	0.0064	0.4324	0.4324
Trypanosoma cruzi	heat shock protein 90, putative	0.0023	0.0638	0.1476
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0063	0.4227	0.4227
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Brugia malayi	C-terminal src kinase protein 1	0.0064	0.4324	0.4324
Echinococcus granulosus	tyrosine protein kinase	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	ankyrin repeat protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Giardia lamblia	Kinase	0.0064	0.4324	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Brugia malayi	Receptor family ligand binding region containing protein	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0064	0.4324	0.4324
Plasmodium falciparum	tyrosine kinase-like protein	0.0064	0.4324	1
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	STE family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	receptor protein kinase, putative	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0064	0.4324	0.4324
Echinococcus multilocularis	insulin receptor	0.0064	0.4324	0.4324
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	activated cdc42 kinase 1	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trypanosoma cruzi	heat shock protein 85, putative	0.0031	0.1367	0.3162
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Trypanosoma cruzi	Heat shock protein 83, putative	0.0039	0.2088	0.4828
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	expressed conserved protein	0.0063	0.4227	0.4227
Toxoplasma gondii	heat shock protein HSP90	0.0039	0.2088	0.4828
Loa Loa (eye worm)	TK/Met protein kinase	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Plasmodium falciparum	tyrosine kinase-like protein	0.0064	0.4324	1
Trichomonas vaginalis	heat shock protein, putative	0.0031	0.1367	0.3162
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0063	0.4227	0.4227
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.4227	0.4227
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	activated cdc42 kinase 1	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/INSR protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0063	0.4227	0.4227
Schistosoma mansoni	hypothetical protein	0.0063	0.4227	0.4227
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Mycobacterium leprae	PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G)	0.0031	0.1367	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0063	0.4227	0.4227
Echinococcus granulosus	SH2 motif	0.0063	0.4227	0.4227
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Echinococcus granulosus	SHC transforming protein 3	0.0063	0.4227	0.4227
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0064	0.4324	0.4324
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	TK/EPH protein kinase	0.0064	0.4324	0.4324
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0064	0.4324	1
Schistosoma mansoni	vav2	0.0063	0.4227	0.4227
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0064	0.4324	0.4324
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Echinococcus granulosus	tensin	0.0063	0.4227	0.4227
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	SH2 domain-containing protein	0.0063	0.4227	0.4227
Entamoeba histolytica	tyrosin kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0064	0.4324	0.4324
Echinococcus granulosus	heat shock protein heat shock protein 90 alpha	0.0031	0.1367	0.1367
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	integrin-linked kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein 90, putative	0.0039	0.2088	0.4828
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	voltage-gated potassium channel	0.0039	0.2064	0.2064
Brugia malayi	hypothetical protein	0.0064	0.4324	0.4324
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Schistosoma mansoni	tensin	0.0063	0.4227	0.4227
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0063	0.4227	0.4227
Mycobacterium tuberculosis	Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G)	0.0031	0.1367	0.5
Echinococcus multilocularis	protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	N chimaerin	0.0063	0.4227	0.4227
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0063	0.4227	0.4227
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/FAK protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	heat shock protein 90	0.0039	0.2088	0.2088
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	protein tyrosine kinase	0.0064	0.4324	0.4324
Trypanosoma cruzi	heat shock protein 85, putative	0.0039	0.2088	0.4828
Schistosoma mansoni	heat shock protein	0.0039	0.2088	0.2088
Echinococcus granulosus	epidermal growth factor receptor	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0063	0.4227	0.4227
Loa Loa (eye worm)	TK/ACK protein kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	NCK adaptor protein	0.0063	0.4227	0.4227
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Trypanosoma cruzi	heat shock protein 90, putative	0.0039	0.2088	0.4828
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Echinococcus granulosus	activated cdc42 kinase 1	0.0064	0.4324	0.4324
Brugia malayi	Variant SH3 domain containing protein	0.0063	0.4227	0.4227
Schistosoma mansoni	serine/threonine protein kinase	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0064	0.4324	0.4324
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TK family protein kinase	0.0064	0.4324	1
Echinococcus granulosus	tyrosine kinase	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0064	0.4324	0.4324
Echinococcus multilocularis	transfer RNA-Thr	0.0064	0.4324	0.4324
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trypanosoma cruzi	heat shock protein 90, putative	0.0031	0.1367	0.3162
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Plasmodium vivax	heat shock protein 86, putative	0.0039	0.2088	0.4828
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0063	0.4227	0.4227
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0064	0.4324	0.4324
Trichomonas vaginalis	endoplasmin, putative	0.0024	0.072	0.1666
Loa Loa (eye worm)	hypothetical protein	0.0031	0.1343	0.1343
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0063	0.4227	0.4227
Toxoplasma gondii	protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Onchocerca volvulus		0.0063	0.4227	0.4227
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	cysteine surface protein, putative	0.0064	0.4324	0.4324
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0064	0.4324	1
Trichomonas vaginalis	CAMK family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	hypothetical protein	0.0064	0.4324	0.4324
Schistosoma mansoni	hypothetical protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0064	0.4324	0.4324
Toxoplasma gondii	STE kinase	0.0064	0.4324	1
Brugia malayi	Endoplasmin precursor	0.0039	0.2088	0.2088
Loa Loa (eye worm)	TK/ALK protein kinase	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	heat shock protein, putative	0.0024	0.072	0.1666
Schistosoma mansoni	growth factor receptor-bound protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0063	0.4227	0.4227
Entamoeba histolytica	SH2 domain containing protein	0.0063	0.4227	0.4227
Schistosoma mansoni	tensin-related	0.0063	0.4227	0.4227
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Echinococcus granulosus	N chimaerin	0.0063	0.4227	0.4227
Schistosoma mansoni	suppressor of cytokine signaling	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0064	0.4324	0.4324
Brugia malayi	heat shock protein 90	0.0039	0.2088	0.2088
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0064	0.4324	0.4324
Schistosoma mansoni	SH2A	0.0063	0.4227	0.4227
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0064	0.4324	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/DDR protein kinase	0.0064	0.4324	0.4324
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0064	0.4324	1
Plasmodium falciparum	endoplasmin, putative	0.0024	0.072	0.1666
Brugia malayi	Guanylyl cyclase protein 23	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Plasmodium falciparum	protein kinase, putative	0.0064	0.4324	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	SH2 domain containing protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0064	0.4324	1
Schistosoma mansoni	tyrosine protein kinase	0.0064	0.4324	0.4324
Brugia malayi	Tensin	0.0063	0.4227	0.4227
Toxoplasma gondii	heat shock protein 90, putative	0.0039	0.2088	0.4828
Echinococcus multilocularis	epidermal growth factor receptor	0.0064	0.4324	0.4324
Brugia malayi	RhoGAP domain containing protein	0.0063	0.4227	0.4227
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0064	0.4324	0.4324
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0064	0.4324	1
Trypanosoma brucei	heat shock protein, putative	0.0039	0.2088	0.4828
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0064	0.4324	1
Echinococcus granulosus	heat shock protein	0.0039	0.2088	0.2088
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0063	0.4227	0.4227
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Echinococcus granulosus	tyrosine protein kinase pr2	0.0064	0.4324	0.4324
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Echinococcus multilocularis	SHC transforming protein 3	0.0063	0.4227	0.4227
Wolbachia endosymbiont of Brugia malayi	heat shock protein 90	0.0031	0.1367	0.5
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0064	0.4324	1
Echinococcus multilocularis	activin receptor type	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Loa Loa (eye worm)	STAT protein	0.0063	0.4227	0.4227
Trichomonas vaginalis	heat shock protein, putative	0.0039	0.2088	0.4828
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Onchocerca volvulus		0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Entamoeba histolytica	hypothetical protein, conserved	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0064	0.4324	0.4324
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0064	0.4324	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0064	0.4324	1
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus granulosus	activin receptor type	0.0064	0.4324	0.4324
Entamoeba histolytica	hypothetical protein	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein kinase csk	0.0064	0.4324	0.4324
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0063	0.4227	0.4227
Loa Loa (eye worm)	TK protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	tensin	0.0063	0.4227	0.4227
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	signal transduction protein lnk-related	0.0063	0.4227	0.4227
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0036	0.1768	0.1768
Echinococcus multilocularis	heat shock protein	0.0039	0.2088	0.2088
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	signal transduction protein lnk realted	0.0063	0.4227	0.4227
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0063	0.4227	0.4227
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	serine/threonine protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	tensin	0.0063	0.4227	0.4227
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	protein kinase	0.0064	0.4324	0.4324
Schistosoma mansoni	serine/threonine RGC	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Echinococcus multilocularis	integrin linked protein kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Schistosoma mansoni	protein kinase	0.0064	0.4324	0.4324
Leishmania major	lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative	0.0031	0.1367	0.3162
Entamoeba histolytica	protein kinase domain containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	serine/threonine kinase, putative	0.0064	0.4324	0.4324
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Giardia lamblia	Kinase, NEK	0.0064	0.4324	1
Entamoeba histolytica	tyrosine kinase, putative	0.0064	0.4324	0.4324
Leishmania major	heat shock protein 83-1	0.0039	0.2088	0.4828
Loa Loa (eye worm)	hypothetical protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein kinase, putative	0.0064	0.4324	0.4324
Loa Loa (eye worm)	hypothetical protein	0.0063	0.4227	0.4227
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0064	0.4324	0.4324
Brugia malayi	Raf kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0064	0.4324	1
Trichomonas vaginalis	TKL family protein kinase	0.0064	0.4324	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0064	0.4324	0.4324
Echinococcus multilocularis	tensin	0.0063	0.4227	0.4227
Echinococcus multilocularis	tyrosine kinase	0.0064	0.4324	0.4324
Trichomonas vaginalis	conserved hypothetical protein	0.0064	0.4324	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Brugia malayi	Protein kinase domain containing protein	0.0064	0.4324	0.4324
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0064	0.4324	0.4324
Schistosoma mansoni	tyrosine kinase	0.0064	0.4324	0.4324

Activities

Activity type	Activity value	Assay description	Source	Reference
Cmax (ADMET)	= 31 ng/ml	Cmax in Balb-C mouse kidney at 5 mg/kg, po	ChEMBL.	23018093
GI50 (functional)	= 23 nM	Antiproliferative activity against human MDA-MB-468 cells after 4 days by SRB method	ChEMBL.	23018093
IC50 (binding)	> 30 uM	Inhibition of human ERG expressed in HEK293 cells by voltage-clamp method	ChEMBL.	23018093
IC50 (binding)	> 30 uM	Displacement of [3H]-dofetilide from human ERG	ChEMBL.	23018093
Inhibition (binding)		Inhibition of HSP90 in human BT474 cells assessed as depletion of pAKT protein level at 0.1 to 1 uM after 24 hrs by Western blot method	ChEMBL.	23018093
Inhibition (binding)		Inhibition of HSP90 in human BT474 cells assessed as depletion of Her2 protein level at 0.1 to 1 uM after 24 hrs by Western blot method	ChEMBL.	23018093
Inhibition (binding)		Inhibition of HSP90 in human BT474 cells assessed as depletion of AKT protein level at 0.1 to 1 uM after 24 hrs by Western blot method	ChEMBL.	23018093
Inhibition (binding)		Inhibition of HSP90 in human BT474 cells assessed as induction of HSP70 at 0.1 to 1 uM after 24 hrs by Western blot method	ChEMBL.	23018093
Inhibition (binding)		Inhibition of HSP90 in human BT474 cells assessed as depletion of pHer2 protein level at 0.1 to 1 uM after 24 hrs by Western blot method	ChEMBL.	23018093
Ki (binding)	< 1 nM	Inhibition of fluorescently labeled VER51001 binding to full length human HSP90beta after 30 mins by fluorescence polarization assay	ChEMBL.	23018093

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2158561

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1724068