Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | PHD-finger family protein | 0.0027 | 0.0041 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.0842 | 0.104 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0206 | 0.1315 | 0.1599 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0035 | 0.0101 | 0.0189 | |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1064 | 0.1064 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0131 | 0.0131 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.0101 | 0.0101 |
Trichomonas vaginalis | set domain proteins, putative | 0.0495 | 0.3376 | 1 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0139 | 0.0842 | 0.1007 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0139 | 0.0842 | 0.1007 |
Echinococcus multilocularis | geminin | 0.0171 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0435 | 0.2948 | 0.3665 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0313 | 0.038 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0131 | 0.0326 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1148 | 0.8028 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0065 | 0.031 | 0.031 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0107 | 0.0107 |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0036 | 0.0108 | 0.0017 |
Brugia malayi | Inositol-1 | 0.004 | 0.0131 | 0.0117 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.0095 | 0.0108 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0139 | 0.0842 | 0.0842 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0101 | 0.0007 |
Schistosoma mansoni | lamin | 0.0026 | 0.0038 | 0.0038 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0081 | 0.0425 | 0.0425 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0107 | 0.0107 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0081 | 0.0425 | 0.0425 |
Brugia malayi | Pre-SET motif family protein | 0.0435 | 0.2948 | 0.3642 |
Onchocerca volvulus | 0.0062 | 0.0293 | 0.0766 | |
Schistosoma mansoni | unc-13 (munc13) | 0.0139 | 0.0842 | 0.0842 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0139 | 0.0842 | 0.0842 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0293 | 0.0293 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0024 | 0.0023 | 0.0023 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0507 | 0.0507 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0065 | 0.0313 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.0178 | 0.0212 |
Echinococcus granulosus | lamin | 0.0026 | 0.0038 | 0.0038 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0023 | 0.0023 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0038 | 0.0038 |
Schistosoma mansoni | microtubule-associated protein tau | 0.1424 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0022 | 0.0008 | 0.0008 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0313 | 0.0313 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0126 | 0.0126 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.006 | 0.0277 | 0.0277 |
Brugia malayi | hypothetical protein | 0.012 | 0.0706 | 0.0836 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0139 | 0.0842 | 0.104 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.0095 | 0.0072 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0062 | 0.0293 | 0.0293 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0062 | 0.0293 | 0.0293 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0038 | 0.0038 |
Brugia malayi | Pre-SET motif family protein | 0.0062 | 0.0293 | 0.032 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0131 | 0.0045 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0313 | 0.0313 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0131 | 0.0131 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0065 | 0.031 | 0.031 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0313 | 0.0313 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0507 | 0.0507 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0507 | 0.0507 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0095 | 0.0095 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1148 | 0.8028 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0038 | 0.0037 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0081 | 0.0425 | 0.0425 |
Echinococcus multilocularis | sodium channel protein | 0.0036 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0065 | 0.0313 | 0.038 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.1424 | 1 | 1 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0139 | 0.0842 | 0.0842 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0107 | 0.0087 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0101 | 0.0079 |
Schistosoma mansoni | hypothetical protein | 0.0141 | 0.0851 | 0.0851 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0163 | 0.0193 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0038 | 0.0038 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0101 | 0.0001 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0131 | 0.0045 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0313 | 0.0313 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.0101 | 0.0079 |
Echinococcus granulosus | geminin | 0.0171 | 0.1064 | 0.1064 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0062 | 0.0293 | 0.025 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0065 | 0.0313 | 0.0313 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0139 | 0.0842 | 0.1007 |
Onchocerca volvulus | 0.0035 | 0.0101 | 0.0189 | |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0139 | 0.0842 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0851 | 0.1051 |
Brugia malayi | beta-lactamase | 0.0035 | 0.0101 | 0.0079 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0038 | 0.0037 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0131 | 0.0045 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1148 | 0.8028 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.0101 | 0.0079 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0036 | 0.0108 | 0.0108 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0038 | 0.0038 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0139 | 0.0842 | 0.1007 |
Echinococcus granulosus | sodium channel protein | 0.0036 | 0.0108 | 0.0108 |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.0425 | 0.052 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.0101 | 0.0115 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0101 | 0.0007 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0101 | 0.0101 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0139 | 0.0842 | 0.0842 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Brugia malayi | Isocitrate dehydrogenase | 0.1148 | 0.8028 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.0101 | 0.0007 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0139 | 0.0842 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0206 | 0.1315 | 0.163 |
Brugia malayi | Bromodomain containing protein | 0.0081 | 0.0428 | 0.0488 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0131 | 0.0131 |
Mycobacterium tuberculosis | Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) | 0.0139 | 0.0842 | 0.0936 |
Schistosoma mansoni | lamin | 0.0026 | 0.0038 | 0.0038 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1148 | 0.8028 | 1 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0139 | 0.0842 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0507 | 0.0622 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0507 | 0.0588 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0038 | 0.0038 |
Echinococcus granulosus | GPCR family 2 | 0.0065 | 0.0313 | 0.0313 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.0101 | 0.0101 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.0706 | 0.2002 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0034 | 0.0032 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0226 | 0.1458 | 0.1712 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0139 | 0.0842 | 0.0842 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0131 | 0.0131 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0507 | 0.0507 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0101 | 0.0007 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1148 | 0.8028 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.1148 | 0.8028 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0131 | 0.0408 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0131 | 0.0092 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1148 | 0.8028 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0065 | 0.0313 | 0.0313 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0206 | 0.1315 | 0.1599 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0095 | 0.0095 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1148 | 0.8028 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0065 | 0.0313 | 0.0345 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0706 | 0.087 |
Schistosoma mansoni | hypothetical protein | 0.0171 | 0.1064 | 0.1064 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0139 | 0.0842 | 0.2265 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0131 | 0.0092 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0139 | 0.0842 | 0.0842 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0141 | 0.0851 | 0.1018 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0139 | 0.0842 | 0.1007 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Leishmania major | isocitrate dehydrogenase, putative | 0.0139 | 0.0842 | 0.0942 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.0101 | 0.0007 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0507 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0206 | 0.1315 | 0.163 |
Onchocerca volvulus | 0.0495 | 0.3376 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.0101 | 0.0115 |
Schistosoma mansoni | bromodomain containing protein | 0.0069 | 0.0337 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0145 | 0.0171 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1148 | 0.8028 | 1 |
Onchocerca volvulus | 0.0035 | 0.0101 | 0.0189 | |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0101 | 0.0009 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0131 | 0.0153 |
Onchocerca volvulus | Huntingtin homolog | 0.012 | 0.0706 | 0.2002 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0131 | 0.0092 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0139 | 0.0842 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0131 | 0.0045 |
Echinococcus multilocularis | GPCR, family 2 | 0.0065 | 0.0313 | 0.0313 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.0395 | 0.0482 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0038 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0101 | 0.0115 |
Plasmodium vivax | SET domain protein, putative | 0.0062 | 0.0293 | 0.025 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0507 | 0.0507 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0081 | 0.0425 | 0.0425 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0101 | 0.0007 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0024 | 0.0023 | 0.0023 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.0706 | 0.087 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0313 | 0.0313 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0507 | 0.0507 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0131 | 0.0045 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1148 | 0.8028 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0041 | 0.0144 | 0.0134 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0039 | 0.0126 | 0.0126 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0038 | 0.0038 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0107 | 0.0107 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1148 | 0.8028 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1148 | 0.8028 | 0.8028 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1148 | 0.8028 | 0.8028 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1148 | 0.8028 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | ~ 100 uM | Inhibition of farnesyl transferase | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.