Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | neuropeptide Y receptor Y5 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tubulin alpha 1C chain | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0196 | 0.6486 | 0.5571 |
Brugia malayi | Tubulin alpha-2 chain | 0.0196 | 0.6486 | 0.6486 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0196 | 0.6486 | 0.6486 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma brucei | epsilon tubulin | 0.0141 | 0.3392 | 0.3392 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0196 | 0.6486 | 0.5571 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0135 | 0.3094 | 0.3094 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | tubulin subunit TubB | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0196 | 0.6486 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0196 | 0.6486 | 0.5571 |
Schistosoma mansoni | tubulin subunit alpha | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Schistosoma mansoni | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Schistosoma mansoni | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0135 | 0.3094 | 0.1296 |
Schistosoma mansoni | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0196 | 0.6486 | 0.6486 |
Echinococcus multilocularis | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0135 | 0.3094 | 0.1296 |
Trypanosoma brucei | alpha tubulin | 0.0196 | 0.6486 | 0.6486 |
Plasmodium falciparum | alpha tubulin 2 | 0.0196 | 0.6486 | 0.4682 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0117 | 0.2066 | 0.2066 |
Brugia malayi | Tubulin alpha-2 chain | 0.0196 | 0.6486 | 0.6486 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0141 | 0.3392 | 0.3392 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0196 | 0.6486 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0141 | 0.3392 | 0.3392 |
Echinococcus granulosus | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.6486 | 0.5571 |
Plasmodium falciparum | alpha tubulin 1 | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0141 | 0.3392 | 0.1672 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0196 | 0.6486 | 0.5571 |
Trypanosoma brucei | tubulin gamma chain | 0.0141 | 0.3392 | 0.3392 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0141 | 0.3392 | 0.3392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0196 | 0.6486 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0196 | 0.6486 | 0.6486 |
Giardia lamblia | Alpha-tubulin | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma brucei | beta tubulin | 0.0141 | 0.3392 | 0.3392 |
Trypanosoma brucei | epsilon tubulin | 0.0141 | 0.3392 | 0.3392 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0248 | 0.9345 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.3094 | 0.1296 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0196 | 0.6486 | 0.6486 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0135 | 0.3094 | 0.1296 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0196 | 0.6486 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0196 | 0.6486 | 0.6486 |
Trypanosoma brucei | epsilon tubulin | 0.0141 | 0.3392 | 0.3392 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Brugia malayi | Tubulin gamma chain | 0.0141 | 0.3392 | 0.3392 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0196 | 0.6486 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0196 | 0.6486 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0196 | 0.6486 | 0.6486 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0196 | 0.6486 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0196 | 0.6486 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0196 | 0.6486 | 0.6486 |
Brugia malayi | Tubulin alpha chain | 0.0196 | 0.6486 | 0.6486 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0196 | 0.6486 | 0.4682 |
Leishmania major | alpha tubulin | 0.0196 | 0.6486 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 nM | Displacement of [125I]PYY from mouse NPY Y5 receptor | ChEMBL. | 23025998 |
INH (ADMET) | = 17 uM | Inhibition of CYP2C19 | ChEMBL. | 23025998 |
INH (ADMET) | > 20 uM | Inhibition of CYP1A2 | ChEMBL. | 23025998 |
INH (ADMET) | > 20 uM | Inhibition of CYP2C9 | ChEMBL. | 23025998 |
INH (ADMET) | > 20 uM | Inhibition of CYP2D6 | ChEMBL. | 23025998 |
INH (ADMET) | > 20 uM | Inhibition of CYP3A4 | ChEMBL. | 23025998 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.