Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.54 nM | Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate | ChEMBL. | 11714608 |
Ki (binding) | = 1.54 nM | Ability to displace [3H]- beta-CIT from Dopamine transporter in rat striatal homogenate | ChEMBL. | 11714608 |
Ki (binding) | = 1.65 nM | Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate | ChEMBL. | 11714608 |
Ki (binding) | = 1.65 nM | Ability to displace [3H]- paroxetine from Serotonin transporter in rat cerebral cortical homogenate | ChEMBL. | 11714608 |
Ki (binding) | = 173 nM | Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate | ChEMBL. | 11714608 |
Ki (binding) | = 173 nM | Ability to displace [3H]- nisoxetin from Norepinephrine transporter in rat cerebral cortical homogenate | ChEMBL. | 11714608 |
Selectivity ratio (binding) | = 1.1 | Selectivity for DAT determined as ratio of binding affinity for SERT to that for DAT | ChEMBL. | 11714608 |
Selectivity ratio (binding) | = 112 | Selectivity for DAT determined as ratio of binding affinity for NET to that for DAT | ChEMBL. | 11714608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.