Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0231 | 0.4798 | 0.4721 |
Echinococcus multilocularis | acetylcholinesterase | 0.0231 | 0.4798 | 0.4798 |
Loa Loa (eye worm) | carboxylesterase | 0.0231 | 0.4798 | 0.4721 |
Echinococcus multilocularis | acetylcholinesterase | 0.0231 | 0.4798 | 0.4798 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.3299 | 0.32 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0231 | 0.4798 | 0.4798 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4798 | 0.4721 |
Echinococcus granulosus | acetylcholinesterase | 0.0231 | 0.4798 | 0.4721 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0145 | 0.0145 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0231 | 0.4798 | 0.4721 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.3217 | 0.3117 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.4798 | 0.4721 |
Echinococcus granulosus | carboxylesterase 5A | 0.0231 | 0.4798 | 0.4721 |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0145 | 0.0145 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0231 | 0.4798 | 0.4721 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.3299 | 0.32 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.3299 | 0.3299 |
Brugia malayi | Carboxylesterase family protein | 0.0231 | 0.4798 | 0.4721 |
Echinococcus granulosus | acetylcholinesterase | 0.0231 | 0.4798 | 0.4721 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.44 uM | Antiproliferative activity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 23391364 |
IC50 (binding) | = 0.35 uM | Inhibition of recombinant EGFR cytoplasmic domain (645 to 1186) (unknown origin) autophosphorylation after 1 hr | ChEMBL. | 23391364 |
IC50 (binding) | = 1.21 uM | Inhibition of human recombinant HER-2 cytoplasmic domain (676 to 1245) autophosphorylation after 1 hr | ChEMBL. | 23391364 |
Ratio IC50 (binding) | = 3.46 | Selectivity ratio of IC50 for human HER2 cytoplasmic domain (676 to 1245) to IC50 for recombinant EGFR cytoplasmic domain (645 to 1186) (unknown origin) | ChEMBL. | 23391364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.