Detailed information for compound 1724342

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 750.33 | Formula: C38H52ClN9O5
  • H donors: 7 H acceptors: 5 LogP: 4.22 Rotable bonds: 25
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1ccn(c1)c1ccc(cc1)Cl)CCCNC(=N)N)CC(C)C)C
  • InChi: 1S/C38H52ClN9O5/c1-5-24(4)32(37(53)45-30(33(40)49)21-25-10-7-6-8-11-25)47-36(52)31(20-23(2)3)46-35(51)29(12-9-18-43-38(41)42)44-34(50)26-17-19-48(22-26)28-15-13-27(39)14-16-28/h6-8,10-11,13-17,19,22-24,29-32H,5,9,12,18,20-21H2,1-4H3,(H2,40,49)(H,44,50)(H,45,53)(H,46,51)(H,47,52)(H4,41,42,43)/t24-,29-,30-,31-,32-/m0/s1
  • InChiKey: IAVITXXIEGZFAG-PYHODHCZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor RXR 0.0048 0.0045 0.0045
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0642 0.2298 0.2298
Echinococcus multilocularis carbonic anhydrase 0.0269 0.0885 0.0885
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Schistosoma mansoni nuclear hormone receptor 0.0125 0.0336 0.0336
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0045 0.0045
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0077 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0065 0.0108 0.0108
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.0336 0.0336
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0269 0.0885 0.0885
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi TAR-binding protein 0.0042 0.0023 0.0023
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0116 0.0304 0.0304
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0125 0.0336 0.0336
Echinococcus multilocularis sodium channel protein 0.0225 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0642 0.2298 1
Echinococcus granulosus calcium activated potassium channel 0.0108 0.0274 0.0274
Brugia malayi hypothetical protein 0.0089 0.02 0.02
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0116 0.0304 0.0494
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0108 0.0274 0.0274
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0642 0.2298 0.2298
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0045 0.0041
Echinococcus multilocularis conserved hypothetical protein 0.0108 0.0274 0.0274
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0045 0.0045
Onchocerca volvulus 0.0048 0.0045 0.0041
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0154 0.0445 0.0844
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0125 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0153 0.0442 0.0442
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Brugia malayi Nuclear hormone receptor-like 1 0.0125 0.0336 0.0336
Schistosoma mansoni two-pore calcium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis two pore calcium channel protein 1 0.0108 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.018 0.0544 0.0544
Echinococcus granulosus potassium voltage gated channel protein 0.0108 0.0274 0.0274
Echinococcus granulosus chromobox protein 1 0.0074 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0116 0.0304 0.0148
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0125 0.0336 0.0336
Schistosoma mansoni RAR-like nuclear receptor 0.0125 0.0336 0.0336
Schistosoma mansoni carbonic anhydrase-related 0.0269 0.0885 0.0885
Schistosoma mansoni carbonic anhydrase-related 0.0269 0.0885 0.0885
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0336 0.0336
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0125 0.0336 0.0336
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0269 0.0885 0.0885
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0108 0.0274 0.0274
Echinococcus granulosus hyperpolarization activated cyclic 0.0108 0.0274 0.0274
Echinococcus multilocularis geminin 0.018 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.018 0.0544 0.0544
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0274 0.0274
Echinococcus granulosus potassium voltage gated channel protein 0.0225 0.0716 0.0716
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0108 0.0274 0.0411
Schistosoma mansoni coup transcription factor 0.0125 0.0336 0.0336
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0116 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0153
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0116 0.0304 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.0336 0.0336
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0108 0.0274 0.0274
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0116 0.0304 0.0304
Brugia malayi steroid hormone receptor 0.0125 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.1674 0.6213 0.6213
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0116 0.0304 0.0304
Echinococcus granulosus two pore calcium channel protein 2 0.0108 0.0274 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0023 0.0023
Onchocerca volvulus 0.0116 0.0304 0.0459
Schistosoma mansoni voltage-dependent calcium channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0042 0.0023 0.0023
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0225 0.0716 0.0716
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0116 0.0304 0.0304
Loa Loa (eye worm) RNA binding protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0154 0.0445 0.0844
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0153
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0116 0.0304 0.0304
Echinococcus multilocularis carbonic anhydrase 0.0269 0.0885 0.0885
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Brugia malayi Cyclic-nucleotide gated cation channel 0.0108 0.0274 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0032 0.0468
Brugia malayi nuclear receptor NHR-88 0.0048 0.0045 0.0045
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0116 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0108 0.0274 0.0274
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0114 0.0295 0.0335
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0108 0.0274 0.0274
Trypanosoma brucei potassium voltage-gated channel, putative 0.0116 0.0304 0.0836
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0045 0.0045
Schistosoma mansoni carbonic anhydrase 0.0269 0.0885 0.0885
Echinococcus granulosus ecdysone induced protein 78C 0.0125 0.0336 0.0336
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0108 0.0274 0.0274
Onchocerca volvulus 0.0116 0.0304 0.0459
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Onchocerca volvulus 0.0048 0.0045 0.0041
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Schistosoma mansoni zinc finger protein 0.0048 0.0045 0.0045
Echinococcus multilocularis ecdysone induced protein 78C 0.0125 0.0336 0.0336
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0225 0.0716 0.0716
Echinococcus granulosus voltage gated potassium channel 0.0108 0.0274 0.0274
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0108 0.0274 0.0274
Onchocerca volvulus Protein ultraspiracle homolog 0.0125 0.0336 0.0511
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.027 0.0886 0.0886
Echinococcus multilocularis hyperpolarization activated cyclic 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0089 0.02 0.02
Echinococcus multilocularis chromobox protein 1 0.0074 0.0143 0.0143
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0045 0.0045
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Echinococcus granulosus carbonic anhydrase 0.0269 0.0885 0.0885
Echinococcus multilocularis FTZ F1 alpha 0.0125 0.0336 0.0336
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0125 0.0336 0.0336
Brugia malayi RNA binding protein 0.0042 0.0023 0.0023
Schistosoma mansoni retinoic acid receptor RXR 0.0125 0.0336 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0274 0.0274
Schistosoma mansoni voltage-gated potassium channel 0.0116 0.0304 0.0304
Loa Loa (eye worm) ryanodine receptor 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0045 0.0045
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0108 0.0274 0.0274
Loa Loa (eye worm) TAR-binding protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0125 0.0336 0.0336
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0274 0.0274
Brugia malayi ecdysone receptor 0.0048 0.0045 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.0336 0.0336
Onchocerca volvulus 0.0116 0.0304 0.0459
Brugia malayi photoreceptor-specific nuclear receptor 0.0125 0.0336 0.0336
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0108 0.0274 0.0274
Loa Loa (eye worm) calcium channel 0.0108 0.0274 0.0274
Echinococcus granulosus hyperpolarization activated cyclic 0.0108 0.0274 0.0274
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.027 0.0886 0.0886
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0108 0.0274 0.0274
Brugia malayi nuclear receptor RXR 0.0077 0.0153 0.0153
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0125 0.0336 0.0336
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.2556 0.9559 0.9559
Schistosoma mansoni voltage-gated potassium channel 0.0116 0.0304 0.0304
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0108 0.0274 0.0274
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0108 0.0274 0.0274
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0108 0.0274 0.0274
Echinococcus granulosus potassium voltage gated channel protein 0.0108 0.0274 0.0274
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0045 0.0032 0.0019
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0045 0.0045
Echinococcus granulosus carbonic anhydrase II 0.0642 0.2298 0.2298
Brugia malayi prolyl oligopeptidase family protein 0.027 0.0886 0.0886
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0045 0.0045
Echinococcus multilocularis tar DNA binding protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0225 0.0716 0.0716
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0108 0.0274 0.0274
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0125 0.0336 0.0336
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0225 0.0716 0.0716
Leishmania major potassium voltage-gated channel, putative 0.0116 0.0304 0.0148
Schistosoma mansoni voltage-gated ion channel 0.0108 0.0274 0.0274
Brugia malayi Steroid receptor seven-up type 2 0.0125 0.0336 0.0336
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0642 0.2298 0.2298
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0045 0.0045
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0116 0.0304 0.0304
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.0336 0.0336
Echinococcus granulosus TRP transient receptor potential channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0108 0.0274 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0045 0.0032 0.0468
Echinococcus granulosus hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0125 0.0336 0.0336
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0153
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0154 0.0445 0.0844
Loa Loa (eye worm) hypothetical protein 0.0116 0.0304 0.0304
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0116 0.0304 0.0836
Echinococcus granulosus short transient receptor potential channel 6 0.0108 0.0274 0.0274
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Schistosoma mansoni carbonic anhydrase-related 0.0269 0.0885 0.0885
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.0336 0.0336
Echinococcus granulosus ryanodine receptor 44f 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Brugia malayi K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.0304
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0125 0.0336 0.0511
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0253 0.0821 0.0821
Loa Loa (eye worm) voltage-gated calcium channel 0.0108 0.0274 0.0274
Schistosoma mansoni 60S ribosomal protein L21 0.0108 0.0274 0.0274
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0108 0.0274 0.0274
Leishmania major hypothetical protein, conserved 0.0116 0.0304 0.0148
Echinococcus granulosus potassium voltage gated channel protein 0.0225 0.0716 0.0716
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0125 0.0336 0.0336
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0077 0.0153 0.0153
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0108 0.0274 0.0274
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0108 0.0274 0.0274
Echinococcus granulosus geminin 0.018 0.0544 0.0544
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0642 0.2298 1
Echinococcus granulosus sodium channel protein 0.0225 0.0716 0.0716
Onchocerca volvulus 0.0116 0.0304 0.0459
Trypanosoma brucei btb/poz domain containing protein, putative 0.0116 0.0304 0.0836
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0143 0.4837
Echinococcus granulosus voltage gated potassium channel 0.0225 0.0716 0.0716
Echinococcus granulosus sodium leak channel non selective protein 0.0108 0.0274 0.0274
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0225 0.0716 0.0716
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0108 0.0274 1
Echinococcus multilocularis carbonic anhydrase 0.0269 0.0885 0.0885
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0108 0.0274 0.0698
Brugia malayi prolyl oligopeptidase family protein 0.0154 0.0445 0.0445
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0172 0.0515 0.0515
Loa Loa (eye worm) voltage-dependent calcium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis calcium activated potassium channel 0.0108 0.0274 0.0274
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0154 0.0445 0.1483
Echinococcus granulosus voltage gated hydrogen channel 1 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi ecdysteroid receptor 0.1674 0.6213 0.6213
Trypanosoma brucei potassium voltage-gated channel, putative 0.0116 0.0304 0.0836
Brugia malayi Heterochromatin protein 1 0.0074 0.0143 0.0143
Schistosoma mansoni hypothetical protein 0.0068 0.0122 0.0122
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0108 0.0274 0.0274
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0077 0.0153 0.0153
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0108 0.0274 0.0274
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0269 0.0885 0.0885
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0108 0.0274 0.0274
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0125 0.0336 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0108 0.0274 0.0274
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0108 0.0274 0.0274
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0045 0.0045
Schistosoma mansoni vesicular amine transporter 0.0225 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0116 0.0304 0.0304
Echinococcus granulosus BTB:POZ domain containing protein 0.0116 0.0304 0.0304
Brugia malayi conserved hypotetical protein 0.0048 0.0045 0.0045
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0045 0.0045
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0225 0.0716 0.0716
Schistosoma mansoni voltage-gated cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0108 0.0274 0.0274
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0125 0.0336 0.0336
Echinococcus multilocularis ryanodine receptor 44f 0.0108 0.0274 0.0274
Echinococcus granulosus transient receptor potential gamma protein 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0114 0.0295 0.0335
Echinococcus granulosus chromobox protein 1 0.0074 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0269 0.0885 0.0885
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0154 0.0445 0.0445
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0108 0.0274 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0023 0.0023
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0269 0.0885 0.0885
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0045 0.0045
Brugia malayi mKIAA0176 protein 0.0116 0.0304 0.0304
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0172 0.0515 0.0515
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0125 0.0336 0.0336
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Schistosoma mansoni chromobox protein 0.0074 0.0143 0.0143
Schistosoma mansoni transient receptor potential channel 4 0.0108 0.0274 0.0274
Schistosoma mansoni calcium-activated potassium channel 0.0108 0.0274 0.0274
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0125 0.0336 0.0336
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0108 0.0274 0.0274
Brugia malayi hypothetical protein 0.0048 0.0045 0.0045
Echinococcus granulosus carbonic anhydrase 0.0269 0.0885 0.0885
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Leishmania major hypothetical protein, conserved 0.0116 0.0304 0.0148
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0172 0.0515 0.0515
Echinococcus multilocularis hyperpolarization activated cyclic 0.0108 0.0274 0.0274
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0108 0.0274 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0125 0.0336 0.0336
Echinococcus multilocularis potassium voltage gated channel protein 0.0108 0.0274 0.0274
Brugia malayi voltage-dependent calcium channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Echinococcus multilocularis BTB:POZ domain containing protein 0.0116 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0108 0.0274 0.0274
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0269 0.0885 0.0885
Brugia malayi K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.0304
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0108 0.0274 0.0274
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Trypanosoma brucei btb/poz domain containing protein, putative 0.0116 0.0304 0.0836
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0045 0.0041
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Brugia malayi hypothetical protein 0.0108 0.0274 0.0274
Plasmodium vivax kelch protein K13, putative 0.0116 0.0304 0.5
Loa Loa (eye worm) hypothetical protein 0.0269 0.0885 0.0885
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0116 0.0304 0.0491
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0125 0.0336 0.0336
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0642 0.2298 0.2298
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0642 0.2298 0.2298
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.027 0.0886 0.1398
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0125 0.0336 0.0336
Schistosoma mansoni nuclear receptor 0.0048 0.0045 0.0045
Brugia malayi RNA recognition motif domain containing protein 0.0042 0.0023 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0225 0.0716 0.0716
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0108 0.0274 0.0698
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0108 0.0274 0.0411
Onchocerca volvulus 0.0116 0.0304 0.0459
Trypanosoma brucei carbonic anhydrase-like protein 0.0642 0.2298 1
Echinococcus multilocularis two pore calcium channel protein 2 0.0108 0.0274 0.0274
Plasmodium falciparum carbonic anhydrase 0.0269 0.0885 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0153 0.0153
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0225 0.0716 0.0716
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0125 0.0336 0.0336
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0108 0.0274 0.0274
Loa Loa (eye worm) voltage-gated potassium channel 0.0225 0.0716 0.0716
Brugia malayi RNA, U transporter 1 0.0067 0.0118 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0125 0.0336 0.0336
Echinococcus multilocularis voltage dependent calcium channel 0.0108 0.0274 0.0274
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0108 0.0274 0.0274
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0125 0.0336 0.0336
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0154 0.0445 0.0445
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus multilocularis potassium voltage gated channel protein 0.0225 0.0716 0.0716
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Echinococcus granulosus potassium large conductance calcium activated 0.0108 0.0274 0.0274
Brugia malayi cation channel family protein 0.0108 0.0274 0.0274
Loa Loa (eye worm) steroid hormone receptor 0.0125 0.0336 0.0336
Echinococcus granulosus FTZ F1 alpha 0.0125 0.0336 0.0336
Trypanosoma cruzi potassium voltage-gated channel 0.0116 0.0304 0.0148
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0108 0.0274 0.0274
Loa Loa (eye worm) voltage-gated potassium channel 0.0108 0.0274 0.0274
Schistosoma mansoni transient receptor potential channel 0.0108 0.0274 0.0274
Echinococcus granulosus two pore calcium channel protein 1 0.0108 0.0274 0.0274
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0225 0.0716 0.0716
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.5
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0125 0.0336 0.0336
Brugia malayi tailless protein 0.0048 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0108 0.0274 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0125 0.0336 0.0336
Toxoplasma gondii hypothetical protein 0.0269 0.0885 1
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0116 0.0304 0.0304
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0125 0.0336 0.0336
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus granulosus tar DNA binding protein 0.0042 0.0023 0.0023
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0045 0.0045
Echinococcus multilocularis short transient receptor potential channel 6 0.0108 0.0274 0.0274
Schistosoma mansoni transient receptor potential channel 0.0108 0.0274 0.0274
Schistosoma mansoni steroid hormone receptor ad4bp 0.0125 0.0336 0.0336
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0108 0.0274 1
Schistosoma mansoni hypothetical protein 0.0108 0.0274 0.0274
Schistosoma mansoni chromobox protein 0.0074 0.0143 0.0143
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0125 0.0336 0.0336
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0108 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0253 0.0821 0.0821
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0269 0.0885 0.0885
Brugia malayi chromobox protein homolog 3 0.0041 0.002 0.002
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0108 0.0274 0.0274
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0108 0.0274 0.0274
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0125 0.0336 0.0336
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0045 0.0045
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0045 0.0045
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0153 0.0153
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Brugia malayi nuclear hormone receptor 0.0048 0.0045 0.0045
Loa Loa (eye worm) DR-78 0.0048 0.0045 0.0045
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0108 0.0274 0.0274
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0045 0.0045
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0116 0.0304 0.0148
Echinococcus granulosus Dipeptidyl peptidase 9 0.0154 0.0445 0.0445
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0225 0.0716 0.2185
Onchocerca volvulus Bile acid receptor homolog 0.1674 0.6213 1
Leishmania major hypothetical protein, conserved 0.0116 0.0304 0.0148
Brugia malayi K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.0304
Schistosoma mansoni tar DNA-binding protein 0.0042 0.0023 0.0023
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0125 0.0336 0.0336
Schistosoma mansoni voltage-gated potassium channel 0.0116 0.0304 0.0304
Echinococcus multilocularis potassium voltage gated channel protein 0.0225 0.0716 0.0716
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Brugia malayi Nuclear hormone receptor-like 1 0.0077 0.0153 0.0153
Echinococcus multilocularis snurportin 1 0.0253 0.0821 0.0821
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0225 0.0716 0.0716
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0108 0.0274 0.0274
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0108 0.0274 0.0274
Loa Loa (eye worm) prolyl oligopeptidase 0.027 0.0886 0.0886
Schistosoma mansoni transient receptor potential channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0041 0.002 0.002
Schistosoma mansoni hypothetical protein 0.0269 0.0885 0.0885
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0077 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Schistosoma mansoni voltage-gated potassium channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis potassium large conductance calcium activated 0.0108 0.0274 0.0274
Trypanosoma brucei btb/poz domain containing protein, putative 0.0116 0.0304 0.0836
Brugia malayi hypothetical protein 0.0077 0.0153 0.0153
Brugia malayi Transient-receptor-potential like protein 0.0108 0.0274 0.0274
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0108 0.0274 0.0274
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0077 0.0153 0.0153
Echinococcus multilocularis sodium leak channel non selective protein 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0125 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Brugia malayi nuclear receptor NHR-88 0.0125 0.0336 0.0336
Loa Loa (eye worm) heterochromatin protein 1 0.0074 0.0143 0.0143
Loa Loa (eye worm) carbonic anhydrase 3 0.0642 0.2298 0.2298
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0116 0.0304 0.0304
Brugia malayi nuclear hormone receptor 0.0125 0.0336 0.0336
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0108 0.0274 0.0274
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0125 0.0336 0.0336
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0045 0.0045
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0045 0.0045
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.027 0.0886 0.0886
Echinococcus multilocularis short transient receptor potential channel 6 0.0108 0.0274 0.0274
Loa Loa (eye worm) ion channel NompC 0.0108 0.0274 0.0274
Echinococcus multilocularis chromobox protein 1 0.0074 0.0143 0.0143
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.0274 0.0274
Echinococcus multilocularis transfer RNA-Gly 0.0225 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0269 0.0885 0.0885
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0045 0.0045
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0108 0.0274 0.0274
Brugia malayi olfactory channel protein osm-9 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0108 0.0274 0.0274
Echinococcus granulosus short transient receptor potential channel 6 0.0108 0.0274 0.0274
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0108 0.0274 0.0274
Echinococcus granulosus carbonic anhydrase 0.0269 0.0885 0.0885
Echinococcus multilocularis voltage gated potassium channel 0.0225 0.0716 0.0716
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0108 0.0274 0.0274
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0225 0.0716 0.0716
Echinococcus multilocularis thyroid hormone receptor alpha 0.0125 0.0336 0.0336
Echinococcus granulosus snurportin 1 0.0253 0.0821 0.0821
Leishmania major carbonic anhydrase-like protein 0.0642 0.2298 1
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Brugia malayi hypothetical protein 0.0077 0.0153 0.0153
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0045 0.0045
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0045 0.0045
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0108 0.0274 0.0274
Brugia malayi K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.0304
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0125 0.0336 0.0336
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0125 0.0336 0.0336
Echinococcus multilocularis carbonic anhydrase II 0.0642 0.2298 0.2298
Schistosoma mansoni ryanodine receptor related 0.0108 0.0274 0.0274
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0154 0.0445 0.1483
Echinococcus multilocularis transient receptor potential gamma protein 0.0108 0.0274 0.0274
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.0304 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0125 0.0336 0.0336
Echinococcus multilocularis voltage gated potassium channel 0.0108 0.0274 0.0274
Trichomonas vaginalis chromobox protein, putative 0.0074 0.0143 0.4837
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0045 0.0045
Echinococcus multilocularis transient receptor potential cation channel 0.0108 0.0274 0.0274
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0116 0.0304 0.0304
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0116 0.0304 0.0491
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0125 0.0336 0.0336
Echinococcus granulosus voltage dependent calcium channel 0.0108 0.0274 0.0274
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0125 0.0336 0.0336
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0125 0.0336 0.0336
Echinococcus granulosus transient receptor potential cation channel 0.0108 0.0274 0.0274
Trypanosoma brucei btb/poz domain containing protein, putative 0.0116 0.0304 0.0836
Schistosoma mansoni thyroid hormone receptor 0.0125 0.0336 0.0336
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0108 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0167 0.0495 0.0495
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0045 0.0045
Onchocerca volvulus 0.0108 0.0274 0.0411
Brugia malayi nuclear receptor NHR-67 0.0048 0.0045 0.0045
Brugia malayi cation channel family protein 0.0108 0.0274 0.0274
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0125 0.0336 0.0336
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0045 0.0045
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0225 0.0716 0.0716
Brugia malayi ion channel NompC 0.0108 0.0274 0.0274
Onchocerca volvulus 0.0125 0.0336 0.0511
Brugia malayi hypothetical protein 0.0048 0.0045 0.0045
Schistosoma mansoni nuclear receptor 0.0048 0.0045 0.0045
Schistosoma mansoni edp1-related 0.0116 0.0304 0.0304
Echinococcus multilocularis shaker cognate 0.0225 0.0716 0.0716
Echinococcus granulosus shaker cognate 0.0225 0.0716 0.0716
Loa Loa (eye worm) hypothetical protein 0.0048 0.0045 0.0045

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 180 uM Inhibition of human recombinant CDK4/Cyclin D1 using fluoresceinyl-Ahx-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly tracer peptide as substrate after 45 mins by fluorescent polarization binding assay ChEMBL. 23323521
IC50 (binding) > 180 uM Inhibition of human recombinant CDK2/Cyclin A2 using fluoresceinyl-Ahx-Pro-Val-Lys-Arg-Arg-Leu-Phe-Gly tracer peptide as substrate after 45 mins by fluorescent polarization binding assay ChEMBL. 23323521

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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