Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0012 | 0.2195 | 0.2941 |
Loa Loa (eye worm) | fatty acid synthase | 0.0017 | 0.4253 | 0.4318 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0017 | 0.4144 | 0.5551 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0014 | 0.3102 | 0.4155 |
Mycobacterium ulcerans | thioesterase | 0.0015 | 0.3283 | 0.4398 |
Mycobacterium ulcerans | polyketide synthase | 0.0018 | 0.4337 | 0.581 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0026 | 0.7465 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0019 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0016 | 0.3922 | 0.5254 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0013 | 0.2515 | 0.3708 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0018 | 0.4337 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0018 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0018 | 0.4337 | 0.581 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0014 | 0.3102 | 0.4155 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0032 | 0.9413 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0015 | 0.3283 | 0.4398 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.8637 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0019 | 0.473 | 0.6337 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0018 | 0.4337 | 0.581 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0014 | 0.3102 | 0.4155 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0014 | 0.3185 | 0.4267 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0018 | 0.4337 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.1557 | 0.0823 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0015 | 0.3283 | 0.4398 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0019 | 0.473 | 0.6337 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0019 | 0.473 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0019 | 0.473 | 0.6337 |
Onchocerca volvulus | 0.0031 | 0.9021 | 0.9285 | |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0006 | 0.0188 | 0.0251 |
Mycobacterium ulcerans | thioesterase TesA | 0.0015 | 0.3283 | 0.4398 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0026 | 0.7465 | 1 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.001 | 0.1609 | 0.2155 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0019 | 0.473 | 0.6337 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0012 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0026 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0018 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0012 | 0.2195 | 0.2941 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0018 | 0.4337 | 0.581 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0018 | 0.4337 | 0.0684 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0013 | 0.2556 | 0.3424 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0019 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0018 | 0.4337 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0018 | 0.4337 | 0.581 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0026 | 0.7465 | 1 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0019 | 0.473 | 0.6337 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0016 | 0.3922 | 0.3889 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0017 | 0.4144 | 0.5551 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0011 | 0.2116 | 0.2574 |
Mycobacterium ulcerans | polyketide synthase | 0.0019 | 0.473 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0007 | 0.0571 | 0.0765 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0019 | 0.473 | 0.6337 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.