Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0597 | 0.5069 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0597 | 0.5069 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0597 | 0.5069 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0912 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0597 | 0.5069 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0597 | 0.5069 | 0.5 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0912 | 1 | 1 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Onchocerca volvulus | 0.0274 | 0 | 0.5 | |
Echinococcus granulosus | dihydrofolate reductase | 0.0912 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0912 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0912 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0912 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0597 | 0.5069 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0912 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0912 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0912 | 1 | 0.5 |
Onchocerca volvulus | 0.0274 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand | ChEMBL. | 12372513 |
Ki (binding) | = 271 nM | Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand | ChEMBL. | 12372513 |
Ki (binding) | = 5 uM | Binding affinity towards Dopamine type 4 receptor was determined by competitive displacement assays using [3H]-YM 09151 as the competitive ligand | ChEMBL. | 12372513 |
Ki (binding) | = 271 uM | Binding affinity towards Dopamine type 2 receptor was determined by displacement assays using [3H]-YM 09151 as the competitive ligand | ChEMBL. | 12372513 |
Ki (binding) | = 2177 uM | Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand | ChEMBL. | 12372513 |
Ki (binding) | = 2177 uM | Binding affinity towards Alpha-1 adrenergic receptor was determined by competitive displacement assays using rat brain homogenate with [3H]-prazosin as the competitive ligand | ChEMBL. | 12372513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.