Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosine kinase, non-receptor, 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | alpha tubulin, putative | 0.0203 | 0.6567 | 0.4682 |
Trypanosoma brucei | epsilon tubulin | 0.0145 | 0.3544 | 0.3392 |
Trypanosoma brucei | alpha tubulin | 0.0203 | 0.6567 | 0.6486 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.014 | 0.3252 | 0.3252 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.014 | 0.3252 | 0.3252 |
Echinococcus multilocularis | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | alpha-tubulin | 0.0203 | 0.6567 | 0.6567 |
Schistosoma mansoni | alpha tubulin | 0.0203 | 0.6567 | 0.6567 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0203 | 0.6567 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0203 | 0.6567 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0145 | 0.3544 | 0.3392 |
Brugia malayi | alpha-tubulin | 0.0203 | 0.6567 | 0.6486 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.014 | 0.3252 | 0.3252 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0203 | 0.6567 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0203 | 0.6567 | 0.6567 |
Trypanosoma brucei | alpha tubulin | 0.0203 | 0.6567 | 0.6486 |
Brugia malayi | tubulin alpha chain - mouse | 0.0203 | 0.6567 | 0.6486 |
Trypanosoma brucei | tubulin gamma chain | 0.0145 | 0.3544 | 0.3392 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Echinococcus granulosus | alpha tubulin | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0203 | 0.6567 | 0.6486 |
Trypanosoma brucei | epsilon tubulin | 0.0145 | 0.3544 | 0.3392 |
Schistosoma mansoni | tubulin subunit alpha | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0145 | 0.3544 | 0.3544 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0203 | 0.6567 | 0.6486 |
Schistosoma mansoni | tubulin subunit alpha | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0203 | 0.6567 | 0.6567 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha | 0.0145 | 0.3544 | 0.3544 |
Echinococcus granulosus | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Brugia malayi | Protein kinase domain containing protein | 0.02 | 0.6448 | 0.6365 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Echinococcus granulosus | tubulin epsilon chain | 0.0145 | 0.3544 | 0.3544 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0145 | 0.3544 | 0.3544 |
Echinococcus multilocularis | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0145 | 0.3544 | 0.3392 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0145 | 0.3544 | 0.3544 |
Schistosoma mansoni | alpha tubulin | 0.0203 | 0.6567 | 0.6567 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Echinococcus multilocularis | hypothetical protein | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.02 | 0.6448 | 0.6448 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Plasmodium falciparum | alpha tubulin 2 | 0.0203 | 0.6567 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0203 | 0.6567 | 0.6567 |
Loa Loa (eye worm) | hypothetical protein | 0.0121 | 0.2247 | 0.2247 |
Onchocerca volvulus | 0.0082 | 0.0229 | 0.5 | |
Loa Loa (eye worm) | tubulin gamma chain | 0.0145 | 0.3544 | 0.3544 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0203 | 0.6567 | 0.6567 |
Schistosoma mansoni | tubulin subunit alpha | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0203 | 0.6567 | 0.6567 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0203 | 0.6567 | 0.4682 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0203 | 0.6567 | 0.6486 |
Echinococcus multilocularis | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0203 | 0.6567 | 0.6486 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Echinococcus multilocularis | tubulin alpha | 0.0145 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.0203 | 0.6567 | 0.6567 |
Trypanosoma brucei | alpha tubulin | 0.0203 | 0.6567 | 0.6486 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0203 | 0.6567 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.6394 | 0.6394 |
Echinococcus multilocularis | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0203 | 0.6567 | 0.6486 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.6448 | 0.6448 |
Trypanosoma brucei | epsilon tubulin | 0.0145 | 0.3544 | 0.3392 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Brugia malayi | Tubulin gamma chain | 0.0145 | 0.3544 | 0.3392 |
Brugia malayi | Tubulin alpha-2 chain | 0.0203 | 0.6567 | 0.6486 |
Echinococcus multilocularis | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Brugia malayi | Tubulin alpha-2 chain | 0.0203 | 0.6567 | 0.6486 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0203 | 0.6567 | 0.6567 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Giardia lamblia | Alpha-tubulin | 0.0203 | 0.6567 | 0.4682 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0145 | 0.3544 | 0.3544 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.014 | 0.3252 | 0.3094 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0203 | 0.6567 | 0.6567 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0145 | 0.3544 | 0.3392 |
Brugia malayi | tubulin alpha-2 chain | 0.0203 | 0.6567 | 0.6486 |
Leishmania major | alpha tubulin | 0.0203 | 0.6567 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0121 | 0.2247 | 0.2066 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.6448 | 0.6448 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.6448 | 0.6448 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0203 | 0.6567 | 0.6567 |
Schistosoma mansoni | tubulin subunit gamma | 0.0145 | 0.3544 | 0.3544 |
Loa Loa (eye worm) | hypothetical protein | 0.014 | 0.3252 | 0.3252 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0121 | 0.2247 | 0.2247 |
Echinococcus multilocularis | transfer RNA-Thr | 0.02 | 0.6448 | 0.6448 |
Trypanosoma brucei | beta tubulin | 0.0145 | 0.3544 | 0.3392 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0203 | 0.6567 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0203 | 0.6567 | 0.6486 |
Schistosoma mansoni | alpha tubulin | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0203 | 0.6567 | 0.6567 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0203 | 0.6567 | 0.6567 |
Giardia lamblia | Alpha-tubulin | 0.0203 | 0.6567 | 0.4682 |
Plasmodium falciparum | alpha tubulin 1 | 0.0203 | 0.6567 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0203 | 0.6567 | 0.6567 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 238 nM | BindingDB_Patents: AlphaScreen Assay. AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity. | ChEMBL. | No reference |
IC50 (binding) | = 0.24 uM | Inhibition of ACK1 (unknown origin) by biochemical assay | ChEMBL. | 23317569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.