Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0658 | 0.4543 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Echinococcus multilocularis | poly (ADP ribose) polymerase | 0.0316 | 0.1047 | 0.0663 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0757 | 0.5566 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0658 | 0.4543 | 0.4459 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0658 | 0.4543 | 0.5 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.1156 | 0.9646 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0257 | 0.0437 | 0.0453 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0658 | 0.4543 | 0.8006 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0658 | 0.4543 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Echinococcus granulosus | WGR domain containing protein | 0.0428 | 0.2194 | 0.2274 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0658 | 0.4543 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.0658 | 0.4543 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0658 | 0.4543 | 0.8006 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0658 | 0.4543 | 0.4459 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0658 | 0.4543 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0757 | 0.5566 | 0.7563 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0428 | 0.2194 | 0.2274 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.1156 | 0.9646 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0757 | 0.5566 | 1 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0257 | 0.0437 | 0.0453 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0257 | 0.0437 | 0.0453 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0658 | 0.4543 | 0.0048 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0757 | 0.5566 | 0.5771 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0757 | 0.5566 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0658 | 0.4543 | 0.5 |
Brugia malayi | WGR domain containing protein | 0.0757 | 0.5566 | 0.557 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0757 | 0.5566 | 0.2043 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.6273 | 1 |
Brugia malayi | WGR domain containing protein | 0.1156 | 0.9646 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0757 | 0.5566 | 0.557 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.1156 | 0.9646 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.1156 | 0.9646 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0658 | 0.4543 | 0.8006 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0257 | 0.0437 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.451 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.