Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | Smad1 | 0.0036 | 0.0011 | 0.0011 |
Brugia malayi | MH2 domain containing protein | 0.0036 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0036 | 0.0011 | 0.0011 |
Echinococcus granulosus | serine:threonine protein kinase mig 15 | 0.5272 | 0.9964 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.012 | 0.017 | 0.5037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0067 | 0.007 | 0.1803 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4316 |
Mycobacterium tuberculosis | Probable chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase) | 0.1341 | 0.2493 | 0.5 |
Leishmania major | target of rapamycin (TOR) kinase 2, putative | 0.02 | 0.0323 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0156 | 0.024 | 0.0241 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor1 | 0.02 | 0.0323 | 0.1067 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.0168 | 0.4963 |
Brugia malayi | hypothetical protein | 0.1559 | 0.2906 | 0.2906 |
Mycobacterium leprae | Chorismate synthase AroF (5-enolpyruvylshikimate-3-phosphate phospholyase). | 0.1341 | 0.2493 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.011 | 0.0152 | 0.0152 |
Echinococcus granulosus | smad | 0.0036 | 0.0011 | 0.0011 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0156 | 0.024 | 0.0334 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0067 | 0.007 | 0.0192 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0159 | 0.0245 | 0.7477 |
Loa Loa (eye worm) | STE/STE20/KHS protein kinase | 0.1578 | 0.2943 | 0.2953 |
Chlamydia trachomatis | chorismate synthase | 0.272 | 0.5114 | 0.5 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0067 | 0.007 | 0.0071 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0085 | 0.0085 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0038 | 0.0015 | 0.0015 |
Trypanosoma cruzi | phosphatidylinositol 3-related kinase, putative | 0.0067 | 0.007 | 0.0192 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.02 | 0.0323 | 0.0323 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0067 | 0.007 | 0.0192 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.02 | 0.0323 | 0.0449 |
Onchocerca volvulus | 0.1559 | 0.2906 | 1 | |
Entamoeba histolytica | phosphatidylinositol3-kinaseTor2, putative | 0.02 | 0.0323 | 1 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.012 | 0.017 | 0.5037 |
Brugia malayi | RNA binding protein | 0.0075 | 0.0085 | 0.0085 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1578 | 0.2943 | 0.409 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0085 | 0.0085 |
Brugia malayi | MH1 domain containing protein | 0.0036 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0023 | 0.0023 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.1578 | 0.2943 | 0.2953 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0036 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0527 | 0.0944 | 0.0947 |
Schistosoma mansoni | vam6/vps39 related | 0.1559 | 0.2906 | 0.2906 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0049 | 0.0049 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0054 | 0.0045 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.1559 | 0.2906 | 0.2917 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0085 | 0.0085 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0036 | 0.0011 | 0.0011 |
Schistosoma mansoni | protein kinase | 0.3732 | 0.7037 | 0.7037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0067 | 0.007 | 0.1803 |
Schistosoma mansoni | smad1 5 8 and | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.02 | 0.0323 | 1 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1559 | 0.2906 | 1 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0038 | 0.0015 | 0.0015 |
Brugia malayi | MH2 domain containing protein | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.012 | 0.017 | 0.5037 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Echinococcus multilocularis | tumor protein p63 | 0.0753 | 0.1373 | 0.1909 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.0049 | 0.0049 |
Entamoeba histolytica | FKBP-rapamycin associated protein (FRAP), putative | 0.02 | 0.0323 | 1 |
Echinococcus granulosus | Smad4 | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4316 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0067 | 0.007 | 0.1803 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0067 | 0.007 | 0.007 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Brugia malayi | TAR-binding protein | 0.0075 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.1559 | 0.2906 | 0.2917 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0067 | 0.007 | 0.1803 |
Leishmania major | target of rapamycin kinase (TOR) kinase 3 | 0.0159 | 0.0246 | 0.6934 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0.024 | 0.7306 |
Schistosoma mansoni | protein kinase | 0.5291 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0753 | 0.1373 | 0.1378 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0067 | 0.007 | 0.1803 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0023 | 0.0266 |
Trypanosoma brucei | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1559 | 0.2906 | 1 |
Trypanosoma brucei | Phosphatidylinositol 3-kinase tor1 | 0.02 | 0.0323 | 0.1067 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.1578 | 0.2943 | 0.409 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0036 | 0.0011 | 0.0015 |
Trypanosoma cruzi | target of rapamycin kinase 3 | 0.0159 | 0.0246 | 0.0799 |
Echinococcus multilocularis | Smad4 | 0.0036 | 0.0011 | 0.0015 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1578 | 0.2943 | 0.2953 |
Schistosoma mansoni | Smad4 | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0118 | 0.0168 | 0.4963 |
Onchocerca volvulus | 0.011 | 0.0152 | 0.0523 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0085 | 0.0085 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Toxoplasma gondii | target of rapamycin (TOR), putative | 0.0149 | 0.0226 | 0.0414 |
Trypanosoma brucei | phosphatidylinositol 3-kinase tor, putative | 0.0095 | 0.0123 | 0.0374 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.013 | 0.019 | 0.5673 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.0049 | 0.0049 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0038 | 0.0015 | 0.002 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4327 |
Trypanosoma cruzi | Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative | 0.1559 | 0.2906 | 1 |
Giardia lamblia | GTOR | 0.02 | 0.0323 | 0.5 |
Schistosoma mansoni | fkbp-rapamycin associated protein | 0.0038 | 0.0015 | 0.0015 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.02 | 0.0323 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.3815 | 0.7194 | 0.7194 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.02 | 0.0323 | 0.0324 |
Echinococcus multilocularis | tar DNA binding protein | 0.0075 | 0.0085 | 0.0118 |
Echinococcus granulosus | GTPase activating Rap:RanGAP domain 3 | 0.1559 | 0.2906 | 0.2917 |
Echinococcus granulosus | protein kinase | 0.3732 | 0.7037 | 0.7062 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1559 | 0.2906 | 0.2906 |
Loa Loa (eye worm) | hypothetical protein | 0.5272 | 0.9964 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0015 | 0.0015 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0156 | 0.024 | 0.024 |
Trypanosoma cruzi | Phosphatidylinositol 3-kinase tor2 | 0.02 | 0.0323 | 0.1067 |
Loa Loa (eye worm) | hypothetical protein | 0.1559 | 0.2906 | 0.2917 |
Trypanosoma brucei | phosphatidylinositol 4-kinase, putative | 0.02 | 0.0323 | 0.1067 |
Echinococcus granulosus | tar DNA binding protein | 0.0075 | 0.0085 | 0.0085 |
Toxoplasma gondii | non-specific serine/threonine protein kinase | 0.0042 | 0.0023 | 0.0016 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.1578 | 0.2943 | 0.409 |
Toxoplasma gondii | chorismate synthase, putative | 0.272 | 0.5114 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0075 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | TAR-binding protein | 0.0075 | 0.0085 | 0.0085 |
Plasmodium vivax | chorismate synthase | 0.272 | 0.5114 | 0.5 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0038 | 0.0015 | 0.0015 |
Leishmania major | target of rapamycin (TOR) kinase 1, putative | 0.02 | 0.0323 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0036 | 0.0011 | 0.0011 |
Schistosoma mansoni | rap gtpase-activating protein | 0.1559 | 0.2906 | 0.2906 |
Echinococcus granulosus | Vam6:Vps39 protein | 0.1559 | 0.2906 | 0.2917 |
Schistosoma mansoni | hypothetical protein | 0.1559 | 0.2906 | 0.2906 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0075 | 0.0085 | 0.0085 |
Brugia malayi | Protein kinase domain containing protein | 0.1578 | 0.2943 | 0.2943 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0.024 | 0.7306 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.02 | 0.0323 | 0.0323 |
Schistosoma mansoni | smad1 5 8 and | 0.0036 | 0.0011 | 0.0011 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0527 | 0.0944 | 0.0947 |
Trypanosoma brucei | target of rapamycin kinase 3, putative | 0.0159 | 0.0246 | 0.0799 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0159 | 0.0245 | 0.7477 |
Schistosoma mansoni | hypothetical protein | 0.0156 | 0.024 | 0.024 |
Echinococcus multilocularis | smad | 0.0036 | 0.0011 | 0.0015 |
Schistosoma mansoni | smad | 0.0036 | 0.0011 | 0.0011 |
Brugia malayi | MH2 domain containing protein | 0.0527 | 0.0944 | 0.0944 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0067 | 0.007 | 0.0098 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0159 | 0.0245 | 0.7477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0036 | 0.0011 | 0.0015 |
Brugia malayi | Temporarily assigned gene name protein 59 | 0.1559 | 0.2906 | 0.2906 |
Echinococcus granulosus | serine:threonine protein kinase SMG1 | 0.0038 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.002 | 0.002 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0015 | 0.0015 |
Plasmodium falciparum | chorismate synthase | 0.272 | 0.5114 | 0.5 |
Echinococcus multilocularis | 0.3732 | 0.7037 | 0.9781 | |
Echinococcus multilocularis | microtubule associated protein 2 | 0.3815 | 0.7194 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.3815 | 0.7194 | 0.722 |
Loa Loa (eye worm) | STE/STE20/MSN protein kinase | 0.3732 | 0.7037 | 0.7062 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0134 | 0.0198 | 0.594 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0159 | 0.0245 | 0.7477 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4327 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4327 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1578 | 0.2943 | 0.2943 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0067 | 0.007 | 0.0071 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0036 | 0.0011 | 0.0011 |
Trypanosoma brucei | phosphatidylinositol 3-related kinase, putative | 0.0067 | 0.007 | 0.0192 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.0152 | 0.0153 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0.024 | 0.7306 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0159 | 0.0245 | 0.7477 |
Mycobacterium ulcerans | chorismate synthase | 0.272 | 0.5114 | 0.5 |
Echinococcus granulosus | serine protein kinase ATM | 0.0038 | 0.0015 | 0.0015 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.02 | 0.0323 | 0.0324 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0149 | 0.0226 | 0.684 |
Brugia malayi | MH1 domain containing protein | 0.0036 | 0.0011 | 0.0011 |
Entamoeba histolytica | hypothetical protein | 0.0156 | 0.024 | 0.7306 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0015 | 0.0015 |
Echinococcus multilocularis | GTPase activating Rap:RanGAP domain 3 | 0.1559 | 0.2906 | 0.404 |
Schistosoma mansoni | protein kinase | 0.1578 | 0.2943 | 0.2943 |
Loa Loa (eye worm) | RNA binding protein | 0.0075 | 0.0085 | 0.0085 |
Schistosoma mansoni | tar DNA-binding protein | 0.0075 | 0.0085 | 0.0085 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1578 | 0.2943 | 0.2943 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0015 | 0.0015 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.0049 | 0.0049 |
Trypanosoma brucei | FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative | 0.0083 | 0.0101 | 0.0298 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.02 | 0.0323 | 1 |
Brugia malayi | hypothetical protein | 0.0156 | 0.024 | 0.024 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0108 | 0.0148 | 0.4327 |
Echinococcus multilocularis | serine:threonine protein kinase SMG1 | 0.0038 | 0.0015 | 0.002 |
Schistosoma mansoni | smad1 5 8 and | 0.0036 | 0.0011 | 0.0011 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0171 | 0.0268 | 0.8197 |
Schistosoma mansoni | mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 | 0.1559 | 0.2906 | 0.2906 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0067 | 0.007 | 0.007 |
Brugia malayi | Smad1 | 0.0036 | 0.0011 | 0.0011 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.1578 | 0.2943 | 0.2953 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth inhibition (functional) | = 15 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
Growth inhibition (functional) | = 15 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Aspergillus fumigatus (AF-27) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Sporothrix schenck ii (SS-1) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Trichophyton mentagrophytes (A-280) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.