Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | histone deacetylase | 0.0636 | 0.9243 | 0.8817 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.044 | 0.3599 | 0.3894 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0636 | 0.9243 | 1 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0593 | 0.8012 | 0.6895 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0636 | 0.9243 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Giardia lamblia | Histone deacetylase | 0.0636 | 0.9243 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0636 | 0.9243 | 0.8817 |
Trypanosoma brucei | histone deacetylase 1 | 0.0636 | 0.9243 | 1 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0636 | 0.9243 | 0.8817 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.044 | 0.3599 | 0.3894 |
Echinococcus granulosus | histone deacetylase 1 | 0.0636 | 0.9243 | 0.8817 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0593 | 0.8012 | 0.6895 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0593 | 0.8012 | 0.6895 |
Echinococcus granulosus | histone deacetylase 6 | 0.0593 | 0.8012 | 0.6895 |
Leishmania major | histone deacetylase, putative | 0.0636 | 0.9243 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0636 | 0.9243 | 0.8817 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0636 | 0.9243 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0384 | 0.1988 | 0.2151 |
Brugia malayi | Histone deacetylase family protein | 0.0593 | 0.8012 | 0.782 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.044 | 0.3599 | 0.3894 |
Echinococcus multilocularis | histone deacetylase | 0.0593 | 0.8012 | 0.6895 |
Echinococcus granulosus | histone deacetylase 6 | 0.0593 | 0.8012 | 0.6895 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0636 | 0.9243 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0636 | 0.9243 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0593 | 0.8012 | 0.6895 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.044 | 0.3599 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0636 | 0.9243 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.044 | 0.3599 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Echinococcus granulosus | histone deacetylase 7 | 0.0593 | 0.8012 | 0.6895 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.044 | 0.3599 | 0.3894 |
Echinococcus granulosus | histone deacetylase 3 | 0.0636 | 0.9243 | 0.8817 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.044 | 0.3599 | 0.3894 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0593 | 0.8012 | 0.8669 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0636 | 0.9243 | 0.5 |
Loa Loa (eye worm) | histone deacetylase | 0.0593 | 0.8012 | 0.8669 |
Plasmodium falciparum | histone deacetylase 1 | 0.0636 | 0.9243 | 1 |
Onchocerca volvulus | 0.044 | 0.3599 | 0.5 | |
Brugia malayi | Histone deacetylase family protein | 0.0593 | 0.8012 | 0.782 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0636 | 0.9243 | 1 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Brugia malayi | Histone deacetylase 1 | 0.0636 | 0.9243 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0593 | 0.8012 | 0.6895 |
Loa Loa (eye worm) | hypothetical protein | 0.044 | 0.3599 | 0.3894 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.044 | 0.3599 | 0.5 |
Loa Loa (eye worm) | steroid hormone receptor | 0.044 | 0.3599 | 0.3894 |
Leishmania major | histone deacetylase, putative | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.044 | 0.3599 | 0.3894 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0636 | 0.9243 | 1 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0593 | 0.8012 | 0.6895 |
Loa Loa (eye worm) | hypothetical protein | 0.0636 | 0.9243 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.044 | 0.3599 | 0.3894 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 10 % | Inhibition of 17beta-HSD1 in human placental cytosolic fraction using [3H]E1 as substrate after 10 mins at 1 uM by HPLC analysis | ChEMBL. | 23145773 |
Inhibition (binding) | = 40 % | Inhibition of 17beta-HSD2 in human placental microsomal fraction using [3H]E2 as substrate at 1 uM after 20 mins by HPLC analysis | ChEMBL. | 23145773 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.