Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0331 | 0.1969 | 0.1958 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0153 | 0.0601 | 0.0789 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0153 | 0.0601 | 0.0588 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0153 | 0.0601 | 0.0588 |
Echinococcus multilocularis | neuropeptide receptor | 0.0813 | 0.5674 | 0.7609 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0601 | 0.1037 |
Mycobacterium leprae | 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) | 0.1157 | 0.832 | 0.5 |
Echinococcus granulosus | neuropeptide receptor | 0.0813 | 0.5674 | 0.7609 |
Mycobacterium tuberculosis | 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) | 0.1157 | 0.832 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0601 | 0.0588 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0601 | 0.1037 |
Echinococcus granulosus | GPCR family 2 | 0.0153 | 0.0601 | 0.0789 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0813 | 0.5674 | 0.7609 |
Trichomonas vaginalis | rotamase, putative | 0.0077 | 0.0014 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0601 | 0.1037 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0484 | 0.3148 | 0.3138 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0077 | 0.0014 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0153 | 0.0601 | 0.0789 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.1044 | 0.7453 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0153 | 0.0601 | 0.0789 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0153 | 0.0601 | 0.0588 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0331 | 0.1969 | 0.1958 |
Schistosoma mansoni | hypothetical protein | 0.0153 | 0.0601 | 0.1037 |
Schistosoma mansoni | neuropeptide receptor | 0.0813 | 0.5674 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0484 | 0.3148 | 0.3138 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.1044 | 0.7453 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 0.1969 | 0.3453 |
Mycobacterium ulcerans | 3-dehydroquinate dehydratase | 0.1157 | 0.832 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.6021 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.