Detailed information for compound 1725522

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 383.355 | Formula: C19H17N3O6
  • H donors: 1 H acceptors: 4 LogP: 1.08 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@@H]1OC(=O)N2[C@H]1COc1c2ccc(c1)c1ccc(nc1)N1CCOC1=O
  • InChi: 1S/C19H17N3O6/c23-9-16-14-10-27-15-7-11(1-3-13(15)22(14)19(25)28-16)12-2-4-17(20-8-12)21-5-6-26-18(21)24/h1-4,7-8,14,16,23H,5-6,9-10H2/t14-,16-/m0/s1
  • InChiKey: GGGXTTVFLQYHFN-HOCLYGCPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0918 0.2218
Brugia malayi Eukaryotic aspartyl protease family protein 0.0033 0.0304 0.0734
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0079 0.1195 0.4178
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0392
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0075 0.0063
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1101 0.2004
Onchocerca volvulus 0.0065 0.0918 0.2772
Plasmodium falciparum plasmepsin VII 0.0033 0.0304 0.0876
Brugia malayi nuclear hormone receptor 0.002 0.0062 0.015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0062 0.015
Brugia malayi nuclear receptor NHR-88 0.002 0.0062 0.015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0561 0.1021
Plasmodium vivax plasmepsin V, putative 0.0033 0.0304 0.0876
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Echinococcus granulosus microsomal glutathione S transferase 3 0.011 0.1798 0.3274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0062 0.0113
Onchocerca volvulus 0.0041 0.047 0.1321
Plasmodium vivax aspartyl protease, putative 0.0033 0.0304 0.0876
Echinococcus granulosus acetylcholinesterase 0.0035 0.0336 0.0612
Loa Loa (eye worm) hypothetical protein 0.0033 0.0304 0.0554
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0062 0.0113
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0041 0.047 0.0856
Plasmodium falciparum plasmepsin I 0.0033 0.0304 0.0876
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.047 0.3569
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0119 0.1963 0.7094
Entamoeba histolytica Ran family GTPase 0.0021 0.0068 0.0244
Schistosoma mansoni BC026374 protein (S09 family) 0.0035 0.0336 0.0336
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.003 0.0251 0.1627
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.048 0.8968 0.8968
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Echinococcus multilocularis carboxylesterase 5A 0.0035 0.0336 0.0612
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0918 0.1672
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0108 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0062 0.015
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.016 0.2767 1
Loa Loa (eye worm) acetylcholinesterase 1 0.0035 0.0336 0.0612
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0251 0.0907
Onchocerca volvulus Peroxidase homolog 0.0065 0.0918 0.2772
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0287 0.1948
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.047 0.3569
Brugia malayi Peroxidasin 0.0065 0.0918 0.2218
Schistosoma mansoni cathepsin D (A01 family) 0.0033 0.0304 0.0304
Schistosoma mansoni thyroid hormone receptor 0.002 0.0062 0.0062
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0865 0.0865
Schistosoma mansoni rotamase 0.0033 0.0302 0.0302
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0062 0.0113
Onchocerca volvulus 0.0035 0.0336 0.0888
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0028 0.0212 0.0385
Loa Loa (eye worm) blistered cuticle protein 3 0.0065 0.0918 0.1672
Schistosoma mansoni peroxidasin 0.0065 0.0918 0.0918
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0918 0.2218
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.1935 0.3488
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0062 0.015
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0075 0.0136
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0062 0.0113
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0062 0.0062
Brugia malayi Pepsin A precursor 0.0033 0.0304 0.0734
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.047 0.3569
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2767 1
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0865 0.2089
Brugia malayi Thioredoxin reductase 0.0046 0.0561 0.1355
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Brugia malayi hypothetical protein 0.0033 0.0304 0.0734
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0918 0.2772
Onchocerca volvulus Dual oxidase homolog 0.0065 0.0918 0.2772
Giardia lamblia Nitric oxide synthase, inducible 0.007 0.1022 0.3691
Loa Loa (eye worm) flavodoxin family protein 0.003 0.0251 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0062 0.015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0062 0.0113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0287 0.1948
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.016 0.2767 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0041 0.047 0.3569
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0068 0.0244
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0287 0.1948
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.1101 0.3977
Schistosoma mansoni hypothetical protein 0.0301 0.5491 0.5491
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0041 0.047 0.1491
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0865 0.0865
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0079 0.1195 1
Schistosoma mansoni diflavin oxidoreductase 0.0039 0.0425 0.0425
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.016 0.2767 1
Brugia malayi glutathione reductase 0.0046 0.0561 0.1355
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0062 0.015
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0068 0.0123
Loa Loa (eye worm) glutathione reductase 0.0046 0.0561 0.1021
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1101 0.9159
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0041 0.047 0.0856
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.1935 0.3488
Onchocerca volvulus Bile acid receptor homolog 0.018 0.315 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0062 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0062 0.0062
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0068 0.0123
Leishmania major cytochrome P450 reductase, putative 0.007 0.1022 0.8458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0062 0.0113
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1101 0.1101
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0041 0.047 0.1698
Plasmodium falciparum glutathione reductase 0.0046 0.0561 0.1827
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0108 0.0392
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0251 0.1627
Brugia malayi hypothetical protein 0.0065 0.0918 0.2218
Mycobacterium tuberculosis Carboxylesterase LipT 0.0303 0.5546 1
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0496 0.0904
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.047 0.3569
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0041 0.047 0.0856
Toxoplasma gondii aspartyl protease ASP1 0.0033 0.0304 0.1548
Trypanosoma brucei trypanothione reductase 0.0046 0.0561 0.4372
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0041 0.047 0.3569
Schistosoma mansoni ap endonuclease 0.0021 0.0075 0.0075
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0918 0.1672
Plasmodium falciparum plasmepsin III 0.0033 0.0304 0.0876
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0033 0.0304 0.0554
Schistosoma mansoni alpha-amylase 0.0072 0.1064 0.1064
Leishmania major p450 reductase, putative 0.0079 0.1195 1
Schistosoma mansoni alpha-amylase 0.0072 0.1064 0.1064
Echinococcus granulosus importin subunit beta 1 0.0028 0.0212 0.0385
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.1935 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.1707 0.3078
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Toxoplasma gondii MAPEG family protein 0.011 0.1798 0.9156
Trichomonas vaginalis spcc417.12 protein, putative 0.0035 0.0336 0.1214
Onchocerca volvulus Chorion peroxidase homolog 0.0065 0.0918 0.2772
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0062 0.0062
Schistosoma mansoni neuroligin 3 (S09 family) 0.0035 0.0336 0.0336
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.1064 0.257
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0251 0.0907
Plasmodium falciparum plasmepsin IX 0.0033 0.0304 0.0876
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0212 0.1078
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Plasmodium falciparum plasmepsin X 0.0033 0.0304 0.0876
Echinococcus granulosus lamin 0.0026 0.0176 0.0321
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.003 0.0251 0.068
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0068 0.0163
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.1935 0.3488
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0062 0.0113
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0033 0.0304 0.0554
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0062 0.0113
Brugia malayi flavodoxin family protein 0.003 0.0251 0.0606
Brugia malayi flavodoxin family protein 0.0079 0.1195 0.2888
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0062 0.0062
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0062 0.0113
Echinococcus granulosus BC026374 protein S09 family 0.0035 0.0336 0.0612
Echinococcus granulosus snurportin 1 0.0301 0.5491 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0336 0.0336
Echinococcus multilocularis alpha glucosidase 0.0072 0.1064 0.1937
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0075 0.0135
Plasmodium vivax aspartyl protease, putative 0.0033 0.0304 0.0876
Plasmodium falciparum plasmepsin IV 0.0033 0.0304 0.0876
Echinococcus granulosus alpha glucosidase 0.0072 0.1064 0.1937
Giardia lamblia Hypothetical protein 0.007 0.1022 0.3691
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0033 0.0304 0.1098
Brugia malayi RNA, U transporter 1 0.008 0.1218 0.2942
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0075 0.0026
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0079 0.1195 0.2177
Chlamydia trachomatis sulfite reductase 0.0049 0.061 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0062 0.0062
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0251 0.0907
Onchocerca volvulus Peroxidasin homolog 0.0065 0.0918 0.2772
Schistosoma mansoni alpha-amylase 0.0072 0.1064 0.1064
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0425 0.2164
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0062 0.015
Schistosoma mansoni acetylcholinesterase 0.0035 0.0336 0.0336
Echinococcus multilocularis acetylcholinesterase 0.0035 0.0336 0.0612
Brugia malayi RNA binding protein 0.0062 0.0865 0.2089
Mycobacterium tuberculosis Probable reductase 0.0105 0.1707 0.3078
Leishmania major importin beta-1 subunit, putative 0.0023 0.0108 0.0362
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.007 0.1022 0.3691
Echinococcus granulosus expressed protein 0.0033 0.0302 0.055
Echinococcus multilocularis microsomal glutathione S transferase 3 0.011 0.1798 0.3274
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0062 0.015
Loa Loa (eye worm) aspartyl protease 6 0.0033 0.0304 0.0554
Trichomonas vaginalis ran, putative 0.0021 0.0068 0.0244
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0561 0.1011
Plasmodium falciparum plasmepsin V 0.0033 0.0304 0.0876
Leishmania major hypothetical protein, conserved 0.003 0.0251 0.1627
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0079 0.1195 0.2156
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0062 0.0113
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0496 0.0904
Toxoplasma gondii hypothetical protein 0.0041 0.047 0.2394
Schistosoma mansoni ran 0.0021 0.0068 0.0068
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0865 0.1575
Entamoeba histolytica oligo-1,6-glucosidase, putative 0.0072 0.1064 0.3843
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0075 0.0136
Plasmodium falciparum thioredoxin reductase 0.0046 0.0561 0.1827
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0035 0.0336 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0062 0.015
Loa Loa (eye worm) alpha amylase 0.0072 0.1064 0.1937
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0062 0.0113
Plasmodium falciparum plasmepsin VIII, putative 0.0033 0.0304 0.0876
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0865 0.0865
Toxoplasma gondii exonuclease III APE 0.0021 0.0075 0.038
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0075 0.027
Onchocerca volvulus 0.0035 0.0336 0.0888
Giardia lamblia Rab geranylgeranyltransferase 0.016 0.2767 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0041 0.047 0.0856
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0865 0.1575
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0251 0.0907
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Trypanosoma cruzi p450 reductase, putative 0.0079 0.1195 1
Brugia malayi TAR-binding protein 0.0062 0.0865 0.2089
Plasmodium vivax glutathione reductase, putative 0.0046 0.0561 0.1827
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Brugia malayi aspartic protease BmAsp-1, identical 0.0033 0.0304 0.0734
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.1195 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.016 0.2767 0.504
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0062 0.0113
Echinococcus multilocularis snurportin 1 0.0301 0.5491 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0075 0.0063
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0075 0.5
Schistosoma mansoni cytochrome P450 reductase 0.0079 0.1195 0.1195
Echinococcus granulosus acetylcholinesterase 0.0035 0.0336 0.0612
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0062 0.0113
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0041 0.047 0.047
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1101 0.2659
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.4139 0.7538
Schistosoma mansoni alpha-amylase 0.0072 0.1064 0.1064
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0251 0.0907
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0336 0.0336
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0075 0.027
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0049 0.061 0.061
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Loa Loa (eye worm) FAD binding domain-containing protein 0.0079 0.1195 0.2177
Loa Loa (eye worm) hypothetical protein 0.0026 0.0176 0.0321
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0033 0.0304 0.0554
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0212 0.0385
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.1195 1
Brugia malayi Blistered cuticle protein 3 0.0065 0.0918 0.2218
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0062 0.0113
Plasmodium falciparum importin beta, putative 0.0028 0.0212 0.0534
Toxoplasma gondii thioredoxin reductase 0.0046 0.0561 0.2856
Toxoplasma gondii hypothetical protein 0.0119 0.1963 1
Onchocerca volvulus 0.0033 0.0304 0.0783
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0176 0.0321
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0918 0.1672
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0075 0.0135
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0918 0.2218
Echinococcus multilocularis acetylcholinesterase 0.0035 0.0336 0.0612
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0062 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0079 0.1195 0.2177
Trichomonas vaginalis rotamase, putative 0.0032 0.0287 0.1038
Echinococcus granulosus intermediate filament protein 0.0026 0.0176 0.0321
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0336 0.0606
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0068 0.0344
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0041 0.047 0.1698
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0865 0.1575
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Treponema pallidum flavodoxin 0.003 0.0251 1
Echinococcus granulosus lamin dm0 0.0026 0.0176 0.0321
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0062 0.015
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0251 0.0907
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0287 0.1463
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1101 0.2004
Mycobacterium tuberculosis Probable alpha-glucosidase AglA (maltase) (glucoinvertase) (glucosidosucrase) (maltase-glucoamylase) (lysosomal alpha-glucosidas 0.0072 0.1064 0.1918
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0035 0.0336 0.0606
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Plasmodium vivax aspartyl proteinase, putative 0.0033 0.0304 0.0876
Echinococcus multilocularis neuroligin 0.0035 0.0336 0.0612
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.1277
Onchocerca volvulus 0.0026 0.0176 0.037
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.1707 0.3078
Trichomonas vaginalis sulfite reductase, putative 0.0079 0.1195 0.432
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0035 0.0336 0.0612
Loa Loa (eye worm) animal heme peroxidase 0.0065 0.0918 0.1672
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0062 0.0062
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0251 0.0907
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0075 0.0063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0033 0.0304 0.0554
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0287 0.1038
Brugia malayi Carboxylesterase family protein 0.0035 0.0336 0.0812
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.003 0.0251 0.1627
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0561 0.1021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.1707 0.3078
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0041 0.047 0.3569
Echinococcus multilocularis lamin dm0 0.0026 0.0176 0.0321
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0041 0.047 0.1136
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0041 0.047 0.0856
Schistosoma mansoni microsomal glutathione s-transferase 0.011 0.1798 0.1798
Plasmodium vivax importin-beta 2, putative 0.0028 0.0212 0.0534
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0302 0.1092
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0561 0.1021
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0062 0.0113
Brugia malayi aspartic protease BmAsp-2, identical 0.0033 0.0304 0.0734
Trichomonas vaginalis rotamase, putative 0.0033 0.0302 0.1092
Echinococcus granulosus methionine synthase reductase 0.0049 0.061 0.1112
Schistosoma mansoni lamin 0.0026 0.0176 0.0176
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Echinococcus multilocularis lamin 0.0026 0.0176 0.0321
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0336 0.0336
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0062 0.0113
Mycobacterium tuberculosis Trehalose synthase TreS 0.0072 0.1064 0.1918
Brugia malayi hypothetical protein 0.0035 0.0336 0.0812
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0079 0.1195 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.016 0.2767 0.504
Giardia lamblia Rab geranylgeranyltransferase 0.0041 0.047 0.1698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0062 0.0113
Onchocerca volvulus 0.0065 0.0918 0.2772
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0035 0.0336 0.0336
Plasmodium vivax hypothetical protein, conserved 0.003 0.0251 0.068
Echinococcus multilocularis musashi 0.0026 0.0176 0.0321
Onchocerca volvulus Peroxidase homolog 0.0065 0.0918 0.2772
Brugia malayi steroid hormone receptor 0.002 0.0062 0.015
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0079 0.1195 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0176 0.0426
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0561 0.1827
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0033 0.0304 0.1548
Onchocerca volvulus 0.0035 0.0336 0.0888
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1101 0.9159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0075 0.0063
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.1707 0.7385
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0302 0.073
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.016 0.2767 0.6687
Loa Loa (eye worm) hypothetical protein 0.0033 0.0304 0.0554
Leishmania major trypanothione reductase 0.0046 0.0561 0.4372
Loa Loa (eye worm) hypothetical protein 0.0033 0.0304 0.0554
Plasmodium falciparum nitric oxide synthase, putative 0.0079 0.1195 0.4178
Echinococcus granulosus FTZ F1 alpha 0.002 0.0062 0.0113
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0918 0.2218
Echinococcus granulosus tar DNA binding protein 0.0062 0.0865 0.1575
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.016 0.2767 0.2767
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.5491 1
Loa Loa (eye worm) hypothetical protein 0.018 0.315 0.5737
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0561 0.4372
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.1707 0.3078
Schistosoma mansoni NADPH flavin oxidoreductase 0.004 0.0437 0.0437
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Schistosoma mansoni cathepsin D (A01 family) 0.0033 0.0304 0.0304
Brugia malayi Importin beta-1 subunit 0.0028 0.0212 0.0511
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0068 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0062 0.0113
Loa Loa (eye worm) carboxylesterase 0.0035 0.0336 0.0612
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.047 0.3569
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0062 0.015
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0033 0.0304 0.1548
Loa Loa (eye worm) RNA binding protein 0.0062 0.0865 0.1575
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0041 0.047 0.1491
Toxoplasma gondii aspartyl protease 0.0033 0.0304 0.1548
Plasmodium vivax flavodoxin domain containing protein 0.007 0.1022 0.3534
Schistosoma mansoni importin beta-1 0.0028 0.0212 0.0212
Brugia malayi follicle stimulating hormone receptor 0.0231 0.4139 1
Echinococcus multilocularis methionine synthase reductase 0.0049 0.061 0.1112
Loa Loa (eye worm) FAD binding domain-containing protein 0.0049 0.061 0.1112
Entamoeba histolytica type A flavoprotein, putative 0.003 0.0251 0.0907
Loa Loa (eye worm) carboxylesterase 0.0035 0.0336 0.0612
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0287 0.1948
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0062 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0062 0.015
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0062 0.015
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0302 0.055
Plasmodium falciparum plasmepsin VI 0.0033 0.0304 0.0876
Brugia malayi ecdysteroid receptor 0.018 0.315 0.7611
Loa Loa (eye worm) hypothetical protein 0.0079 0.1195 0.2177
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1101 0.9159
Loa Loa (eye worm) carboxylesterase 0.0035 0.0336 0.0612
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1101 0.9159
Brugia malayi FAD binding domain containing protein 0.0079 0.1195 0.2888
Onchocerca volvulus 0.0026 0.0176 0.037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0167 0.0304
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Echinococcus multilocularis BC026374 protein (S09 family) 0.0035 0.0336 0.0612
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0075 0.027
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0079 0.1195 0.2177
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0079 0.1195 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0041 0.047 0.3569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Brugia malayi hypothetical protein 0.0033 0.0304 0.0734
Schistosoma mansoni alpha-amylase 0.0072 0.1064 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0062 0.015
Schistosoma mansoni peroxidasin 0.0065 0.0918 0.0918
Onchocerca volvulus 0.0035 0.0336 0.0888
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0062 0.0113
Plasmodium falciparum plasmepsin II 0.0033 0.0304 0.0876
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0062 0.0113
Mycobacterium ulcerans trehalose synthase TreS 0.0072 0.1064 0.1918
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0176 0.0321
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Echinococcus granulosus carboxylesterase 5A 0.0035 0.0336 0.0612
Echinococcus multilocularis peroxidasin 0.0065 0.0918 0.1672
Schistosoma mansoni ran 0.0021 0.0068 0.0068
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0865 0.0865
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0251 0.1627
Echinococcus granulosus peroxidasin 0.0065 0.0918 0.1672
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Schistosoma mansoni gliotactin 0.0035 0.0336 0.0336
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0392
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.016 0.2767 1
Plasmodium vivax plasmepsin IV, putative 0.0033 0.0304 0.0876
Schistosoma mansoni lamin 0.0026 0.0176 0.0176
Brugia malayi Alpha amylase, catalytic domain containing protein 0.0072 0.1064 0.257
Schistosoma mansoni thyroid hormone receptor 0.002 0.0062 0.0062
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0079 0.1195 1
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0079 0.1195 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0075 0.027
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.047 0.3569
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0865 0.0865
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0035 0.0336 0.1214
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0079 0.1195 0.2177
Mycobacterium ulcerans carboxylesterase, LipT 0.0303 0.5546 1
Echinococcus granulosus neuroligin 0.0035 0.0336 0.0612
Loa Loa (eye worm) alpha amylase 0.0072 0.1064 0.1937
Loa Loa (eye worm) hypothetical protein 0.0035 0.0336 0.0612
Schistosoma mansoni intermediate filament proteins 0.0026 0.0176 0.0176
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0062 0.0062
Schistosoma mansoni coup transcription factor 0.002 0.0062 0.0062
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0108 0.0362
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0075 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0062 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0062 0.015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0062 0.015
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.1707 0.3078
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1101 0.2004
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.003 0.0251 0.068
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0062 0.0062
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0033 0.0304 0.0304
Plasmodium vivax aspartyl protease, putative 0.0033 0.0304 0.0876
Loa Loa (eye worm) hypothetical protein 0.002 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.016 0.2767 0.504
Toxoplasma gondii aspartyl protease ASP3 0.0033 0.0304 0.1548
Brugia malayi Animal haem peroxidase family protein 0.0065 0.0918 0.2218
Onchocerca volvulus 0.0065 0.0918 0.2772
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.016 0.2767 0.504
Toxoplasma gondii flavodoxin domain-containing protein 0.0039 0.0425 0.2164
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0065 0.0918 0.1672
Echinococcus multilocularis expressed protein 0.0033 0.0302 0.055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0062 0.0113
Brugia malayi FAD binding domain containing protein 0.0049 0.061 0.1475
Onchocerca volvulus 0.0033 0.0304 0.0783
Echinococcus multilocularis para nitrobenzyl esterase 0.0035 0.0336 0.0612
Trichomonas vaginalis NADPH cytochrome P450, putative 0.003 0.0251 0.0907
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0075 0.0136
Echinococcus granulosus para nitrobenzyl esterase 0.0035 0.0336 0.0612
Plasmodium vivax aspartyl proteinase, putative 0.0033 0.0304 0.0876
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0212 0.1277
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0075 0.018
Brugia malayi intermediate filament protein 0.0026 0.0176 0.0426
Onchocerca volvulus 0.0035 0.0336 0.0888
Plasmodium vivax prenyltransferase alpha subunit, putative 0.016 0.2767 1
Schistosoma mansoni ap endonuclease 0.0021 0.0075 0.0075

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 13.3 % Inhibition of human ERG at 30 uM relative to control ChEMBL. 23428155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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