Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tyrosine kinase, non-receptor, 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Brugia malayi | tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.7221 | 0.7221 |
Echinococcus granulosus | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0128 | 0.3046 | 0.3046 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Brugia malayi | tubulin alpha chain - mouse | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin epsilon chain | 0.0134 | 0.3347 | 0.3306 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin gamma 1 chain | 0.0134 | 0.3347 | 0.3306 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.006 | 0.006 |
Plasmodium falciparum | alpha tubulin 2 | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.3347 | 0.1672 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.6462 | 0.6462 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.02 | 0.7281 | 0.7281 |
Loa Loa (eye worm) | tubulin alpha-3 chain | 0.0111 | 0.2011 | 0.2011 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Brugia malayi | Protein kinase domain containing protein | 0.02 | 0.7281 | 0.5913 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Plasmodium falciparum | alpha tubulin 1 | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Brugia malayi | alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0128 | 0.3046 | 0.1296 |
Brugia malayi | Tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin epsilon chain | 0.0134 | 0.3347 | 0.3306 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Brugia malayi | Tubulin alpha chain | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0128 | 0.3046 | 0.3046 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | transfer RNA-Thr | 0.02 | 0.7281 | 0.7264 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.6462 | 0.6462 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0134 | 0.3347 | 0.3347 |
Echinococcus granulosus | tubulin alpha | 0.0134 | 0.3347 | 0.3306 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin gamma 1 chain | 0.0134 | 0.3347 | 0.3306 |
Schistosoma mansoni | tubulin subunit alpha | 0.0186 | 0.6462 | 0.644 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.6462 | 0.6462 |
Schistosoma mansoni | alpha tubulin | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus granulosus | tubulin subunit TubB | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.2011 | 0.2011 |
Echinococcus multilocularis | tubulin alpha | 0.0134 | 0.3347 | 0.3306 |
Echinococcus multilocularis | hypothetical protein | 0.0186 | 0.6462 | 0.644 |
Trypanosoma brucei | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | tubulin subunit gamma | 0.0134 | 0.3347 | 0.3306 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0186 | 0.6462 | 0.644 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.3046 | 0.3046 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0186 | 0.6462 | 0.5571 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0134 | 0.3347 | 0.1672 |
Loa Loa (eye worm) | alpha-tubulin | 0.0186 | 0.6462 | 0.6462 |
Echinococcus granulosus | tubulin alpha chain | 0.0186 | 0.6462 | 0.644 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0186 | 0.6462 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0186 | 0.6462 | 0.6462 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Echinococcus multilocularis | activated cdc42 kinase 1 | 0.02 | 0.7281 | 0.7264 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0186 | 0.6462 | 0.4682 |
Schistosoma mansoni | tubulin subunit epsilon | 0.0134 | 0.3347 | 0.3306 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.3347 | 0.1672 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0186 | 0.6462 | 0.6462 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0128 | 0.3046 | 0.3046 |
Leishmania major | alpha tubulin | 0.0186 | 0.6462 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0186 | 0.6462 | 0.5571 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0186 | 0.6462 | 0.644 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 369.4 nM | BindingDB_Patents: AlphaScreen Assay. AlphaScreen (amplified luminescent proximity homogeneous assay) assay was used to test for ACK1 inhibitory activity. | ChEMBL. | No reference |
IC50 (binding) | = 0.37 uM | Inhibition of ACK1 (unknown origin) by biochemical assay | ChEMBL. | 23317569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.