Detailed information for compound 1725659

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 468.59 | Formula: C29H32N4O2
  • H donors: 0 H acceptors: 4 LogP: 4.31 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)C1CCN(CC1)c1ncnc2c1CN(CC2)C(=O)c1ccc(cc1)c1ccccc1
  • InChi: 1S/C29H32N4O2/c1-2-6-27(34)23-13-16-32(17-14-23)28-25-19-33(18-15-26(25)30-20-31-28)29(35)24-11-9-22(10-12-24)21-7-4-3-5-8-21/h3-5,7-12,20,23H,2,6,13-19H2,1H3
  • InChiKey: CJZGRIRZVHNUSM-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium channel, subfamily K, member 9 Starlite/ChEMBL References
Homo sapiens potassium channel, subfamily K, member 3 Starlite/ChEMBL References
Homo sapiens potassium voltage-gated channel, subfamily H (eag-related), member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum Potassium voltage-gated channel subfamily H member 2, putative Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus multilocularis Two pore potassium channel protein sup 9 Get druggable targets OG5_130595 All targets in OG5_130595
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130595 All targets in OG5_130595
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog Get druggable targets OG5_130595 All targets in OG5_130595
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130595 All targets in OG5_130595
Loa Loa (eye worm) voltage and ligand gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus Two pore potassium channel protein sup 9 Get druggable targets OG5_130595 All targets in OG5_130595
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma mansoni twik family of potassium channels-related Get druggable targets OG5_130595 All targets in OG5_130595
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog Get druggable targets OG5_128858 All targets in OG5_128858
Trichomonas vaginalis voltage and ligand gated potassium channel, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128858 All targets in OG5_128858
Echinococcus granulosus potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K05323 potassium channel, subfamily K, invertebrate, putative Get druggable targets OG5_130595 All targets in OG5_130595
Echinococcus multilocularis potassium voltage gated channel subfamily H Get druggable targets OG5_128858 All targets in OG5_128858
Schistosoma japonicum ko:K04910 potassium voltage-gated channel, Eag-related subfamily H, member 7, putative Get druggable targets OG5_128858 All targets in OG5_128858
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130595 All targets in OG5_130595

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 potassium channel, subfamily K, member 3 394 aa 450 aa 24.2 %
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 potassium channel, subfamily K, member 9 374 aa 309 aa 22.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.0871 0.1885
Loa Loa (eye worm) hypothetical protein 0.0175 0.3304 0.3225
Leishmania major beta tubulin 0.0231 0.4622 1
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus granulosus beta tubulin 0.0231 0.4622 0.4482
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus granulosus tubulin alpha chain 0.0175 0.3304 0.3129
Echinococcus multilocularis tubulin alpha chain 0.0175 0.3304 0.3129
Giardia lamblia Beta tubulin 0.0231 0.4622 1
Loa Loa (eye worm) alpha-tubulin 0.0175 0.3304 0.3225
Trypanosoma brucei alpha tubulin 0.0175 0.3304 0.6814
Trichomonas vaginalis tubulin, putative 0.0054 0.0486 0.1051
Schistosoma mansoni tubulin subunit epsilon 0.0125 0.2144 0.1859
Plasmodium falciparum tubulin epsilon chain, putative 0.0125 0.2144 0.4008
Echinococcus granulosus tubulin alpha chain 0.0175 0.3304 0.3129
Leishmania major beta tubulin 0.0231 0.4622 1
Leishmania major beta tubulin 0.0231 0.4622 1
Loa Loa (eye worm) beta-tubulin 0.0231 0.4622 0.4558
Trichomonas vaginalis tubulin epsilon chain, putative 0.0175 0.3304 0.7149
Trypanosoma brucei alpha tubulin 0.0175 0.3304 0.6814
Loa Loa (eye worm) tubulin beta-4 chain 0.0231 0.4622 0.4558
Echinococcus granulosus tubulin subunit beta 0.0231 0.4622 0.4482
Echinococcus multilocularis beta tubulin 0.0231 0.4622 0.4482
Loa Loa (eye worm) tubulin gamma chain 0.0125 0.2144 0.2051
Echinococcus multilocularis Tubulin beta 2C chain 0.0231 0.4622 0.4482
Toxoplasma gondii beta-tubulin, putative 0.0231 0.4622 1
Echinococcus multilocularis tubulin alpha chain 0.0175 0.3304 0.3129
Toxoplasma gondii beta tubulin 0.0231 0.4622 1
Leishmania major beta tubulin 0.0231 0.4622 1
Trypanosoma brucei beta tubulin 0.0231 0.4622 1
Entamoeba histolytica tubulin family protein 0.0231 0.4622 1
Loa Loa (eye worm) tubulin beta-1 chain 0.0231 0.4622 0.4558
Echinococcus multilocularis hypothetical protein 0.0175 0.3304 0.3129
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0054 0.0486 0.5
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Echinococcus multilocularis Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Echinococcus multilocularis tubulin alpha 3 chain 0.0175 0.3304 0.3129
Schistosoma mansoni alpha tubulin 0.0175 0.3304 0.3061
Plasmodium falciparum alpha tubulin 1 0.0175 0.3304 0.6814
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Plasmodium vivax tubulin gamma chain, putative 0.0125 0.2144 0.4008
Trypanosoma cruzi beta tubulin, putative 0.0231 0.4622 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0175 0.3304 0.7149
Echinococcus granulosus tubulin alpha chain 0.0175 0.3304 0.3129
Plasmodium falciparum tubulin beta chain 0.0231 0.4622 1
Echinococcus granulosus tubulin alpha 0.0125 0.2144 0.1939
Loa Loa (eye worm) tubulin alpha chain 0.0175 0.3304 0.3225
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0104 0.1646 0.3561
Echinococcus multilocularis tubulin alpha 0.0125 0.2144 0.1939
Trichomonas vaginalis tubulin gamma chain, putative 0.0054 0.0486 0.1051
Echinococcus granulosus Tubulin beta 2C chain 0.0231 0.4622 0.4482
Echinococcus multilocularis tubulin subunit beta 0.0231 0.4622 0.4482
Loa Loa (eye worm) tubulin beta-2A chain 0.0231 0.4622 0.4558
Echinococcus granulosus Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Echinococcus granulosus Tubulin beta 2C chain 0.0231 0.4622 0.4482
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0486 0.1051
Echinococcus multilocularis tubulin alpha 3 chain 0.0175 0.3304 0.3129
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0231 0.4622 0.4482
Echinococcus multilocularis tubulin beta 1 chain 0.0231 0.4622 0.4482
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0071 0.0871 0.1885
Entamoeba histolytica tubulin alpha-1 chain 0.0175 0.3304 0.4682
Trichomonas vaginalis tubulin epsilon chain, putative 0.0231 0.4622 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0231 0.4622 1
Brugia malayi Tubulin beta chain 0.0054 0.0486 0.0237
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus granulosus tubulin epsilon chain 0.0125 0.2144 0.1939
Loa Loa (eye worm) hypothetical protein 0.0434 0.9351 0.9343
Trichomonas vaginalis tubulin alpha chain, putative 0.0125 0.2144 0.4638
Schistosoma mansoni tubulin subunit delta 0.0054 0.0486 0.0141
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0121 0.2032 0.1938
Echinococcus granulosus Tubulin beta 2C chain 0.0231 0.4622 0.4482
Loa Loa (eye worm) tubulin beta chain 0.0054 0.0486 0.0373
Echinococcus multilocularis tubulin alpha 1C chain 0.0175 0.3304 0.3129
Echinococcus multilocularis peroxisome assembly protein 26 0.0175 0.3304 0.3129
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0486 0.1051
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0231 0.4622 0.4482
Plasmodium vivax tubulin beta chain, putative 0.0231 0.4622 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0125 0.2144 0.1939
Trichomonas vaginalis tubulin beta chain, putative 0.0231 0.4622 1
Echinococcus granulosus tubulin subunit TubB 0.0175 0.3304 0.3129
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus granulosus tubulin delta chain 0.0054 0.0486 0.0237
Trypanosoma brucei tubulin gamma chain 0.0125 0.2144 0.4008
Echinococcus multilocularis tubulin alpha chain 0.0175 0.3304 0.3129
Trichomonas vaginalis tubulin, putative 0.0231 0.4622 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0835 0.1807
Brugia malayi Tubulin beta-1 chain 0.0231 0.4622 0.4482
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0054 0.0486 0.1051
Echinococcus multilocularis Tubulin beta 2C chain 0.0231 0.4622 0.4482
Leishmania major beta tubulin 0.0231 0.4622 1
Plasmodium vivax tubulin alpha chain, putative 0.0175 0.3304 0.6814
Trypanosoma cruzi tubulin gamma chain 0.0125 0.2144 0.4008
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0175 0.3304 0.7149
Trypanosoma brucei alpha tubulin, putative 0.0071 0.0871 0.0932
Leishmania major beta tubulin 0.0231 0.4622 1
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Brugia malayi Tubulin alpha-2 chain 0.0175 0.3304 0.3129
Echinococcus multilocularis tubulin delta chain 0.0054 0.0486 0.0237
Echinococcus granulosus alpha tubulin 0.0175 0.3304 0.3129
Trypanosoma cruzi epsilon tubulin, putative 0.0125 0.2144 0.4008
Leishmania major beta tubulin 0.0231 0.4622 1
Schistosoma mansoni alpha tubulin 0.0175 0.3304 0.3061
Plasmodium vivax tubulin alpha chain, putative 0.0175 0.3304 0.6814
Brugia malayi Tubulin alpha-2 chain 0.0175 0.3304 0.3129
Brugia malayi Tubulin beta chain 0.0071 0.0871 0.0633
Loa Loa (eye worm) tubulin alpha-3 chain 0.0104 0.1646 0.1547
Echinococcus multilocularis tubulin epsilon chain 0.0125 0.2144 0.1939
Echinococcus granulosus Tubulin beta 2C chain 0.0231 0.4622 0.4482
Schistosoma mansoni tubulin subunit beta 0.0054 0.0486 0.0141
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0125 0.2144 0.4008
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Trichomonas vaginalis tubulin, putative 0.0071 0.0871 0.1885
Echinococcus granulosus tubulin alpha 3 chain 0.0175 0.3304 0.3129
Plasmodium falciparum alpha tubulin 2 0.0175 0.3304 0.6814
Trypanosoma cruzi epsilon tubulin, putative 0.0125 0.2144 0.4008
Echinococcus granulosus tubulin alpha chain 0.0175 0.3304 0.3129
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Toxoplasma gondii alpha tubulin TUBA1 0.0175 0.3304 0.6814
Trypanosoma brucei epsilon tubulin 0.0125 0.2144 0.4008
Giardia lamblia Alpha-tubulin 0.0175 0.3304 0.6814
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.0871 0.1885
Trichomonas vaginalis tubulin epsilon chain, putative 0.0231 0.4622 1
Giardia lamblia Alpha-tubulin 0.0175 0.3304 0.6814
Schistosoma mansoni tubulin subunit gamma 0.0125 0.2144 0.1859
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0835 0.1807
Echinococcus multilocularis tubulin alpha chain 0.0175 0.3304 0.3129
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Echinococcus multilocularis beta tubulin 0.0231 0.4622 0.4482
Trichomonas vaginalis tubulin gamma chain, putative 0.0125 0.2144 0.4638
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Echinococcus granulosus tubulin beta 4A class IVa 0.0231 0.4622 0.4482
Echinococcus multilocularis Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Echinococcus multilocularis tubulin alpha 1C chain 0.0175 0.3304 0.3129
Trypanosoma brucei beta tubulin 0.0231 0.4622 1
Schistosoma mansoni tubulin subunit alpha 0.0175 0.3304 0.3061
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Schistosoma mansoni alpha tubulin 0.0175 0.3304 0.3061
Loa Loa (eye worm) alpha-tubulin 0.0175 0.3304 0.3225
Echinococcus granulosus tubulin alpha 1C chain 0.0175 0.3304 0.3129
Giardia lamblia Gamma tubulin 0.0125 0.2144 0.4008
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Leishmania major beta tubulin 0.0231 0.4622 1
Loa Loa (eye worm) tubulin beta chain 0.0231 0.4622 0.4558
Trichomonas vaginalis tubulin beta chain, putative 0.0071 0.0871 0.1885
Echinococcus granulosus Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Loa Loa (eye worm) BEN-1 protein 0.0231 0.4622 0.4558
Echinococcus granulosus tubulin alpha 1C chain 0.0175 0.3304 0.3129
Trypanosoma brucei alpha tubulin 0.0175 0.3304 0.6814
Echinococcus granulosus Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Loa Loa (eye worm) tubulin alpha 2 0.005 0.0374 0.026
Brugia malayi alpha-tubulin 0.0175 0.3304 0.3129
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Treponema pallidum cell division protein FtsZ 0.0054 0.0486 0.5
Brugia malayi Cell division protein ftsZ 0.0054 0.0486 0.0237
Echinococcus multilocularis Tubulin beta 2C chain 0.0231 0.4622 0.4482
Echinococcus multilocularis Tubulin beta 2C chain 0.0231 0.4622 0.4482
Leishmania major beta tubulin 0.0231 0.4622 1
Giardia lamblia Beta tubulin 0.0231 0.4622 1
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Trypanosoma brucei epsilon tubulin 0.0125 0.2144 0.4008
Echinococcus multilocularis tubulin alpha chain 0.0175 0.3304 0.3129
Leishmania major epsilon tubulin, putative 0.0125 0.2144 0.4008
Brugia malayi tubulin alpha chain - mouse 0.0175 0.3304 0.3129
Trypanosoma brucei epsilon tubulin 0.0125 0.2144 0.4008
Trypanosoma cruzi alpha tubulin, putative 0.0175 0.3304 0.6814
Plasmodium falciparum tubulin gamma chain 0.0125 0.2144 0.4008
Onchocerca volvulus 0.0071 0.0871 0.5
Loa Loa (eye worm) tubulin alpha 2 0.0121 0.2032 0.1938
Brugia malayi beta-tubulin, identical 0.0231 0.4622 0.4482
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Schistosoma mansoni tubulin subunit alpha 0.0175 0.3304 0.3061
Trichomonas vaginalis tubulin alpha chain, putative 0.0071 0.0871 0.1885
Leishmania major beta tubulin 0.0231 0.4622 1
Echinococcus granulosus beta tubulin 0.0231 0.4622 0.4482
Trypanosoma brucei beta tubulin 0.0125 0.2144 0.4008
Schistosoma mansoni tubulin subunit alpha 0.0054 0.0486 0.0141
Echinococcus granulosus peroxisome assembly protein 26 0.0175 0.3304 0.3129
Leishmania major beta tubulin 0.0231 0.4622 1
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Loa Loa (eye worm) hypothetical protein 0.0104 0.1646 0.1547
Toxoplasma gondii alpha-tubulin I, putative 0.0175 0.3304 0.6814
Entamoeba histolytica tubulin alpha chain, putative 0.0175 0.3304 0.4682
Leishmania major beta tubulin 0.0231 0.4622 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0231 0.4622 1
Loa Loa (eye worm) tubulin alpha chain 0.0175 0.3304 0.3225
Echinococcus granulosus tubulin alpha 3 chain 0.0175 0.3304 0.3129
Trichomonas vaginalis tubulin epsilon chain, putative 0.0054 0.0486 0.1051
Loa Loa (eye worm) hypothetical protein 0.0121 0.2032 0.1938
Trypanosoma brucei alpha tubulin 0.0175 0.3304 0.6814
Giardia lamblia Beta tubulin 0.0231 0.4622 1
Brugia malayi tubulin alpha-2 chain 0.0175 0.3304 0.3129
Entamoeba histolytica tubulin family protein 0.0231 0.4622 1
Toxoplasma gondii beta-1 tubulin, putative 0.0231 0.4622 1
Plasmodium vivax tubulin epsilon chain, putative 0.0125 0.2144 0.4008
Leishmania major beta tubulin 0.0231 0.4622 1
Loa Loa (eye worm) BEN-1 protein 0.0231 0.4622 0.4558
Loa Loa (eye worm) tubulin alpha 2 0.0121 0.2032 0.1938
Loa Loa (eye worm) tubulin alpha-2 chain 0.0175 0.3304 0.3225
Mycobacterium ulcerans cell division protein FtsZ 0.0054 0.0486 0.5
Trypanosoma brucei beta tubulin 0.0231 0.4622 1
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Trypanosoma brucei beta tubulin 0.0231 0.4622 1
Echinococcus granulosus Tubulin beta 2C chain 0.0231 0.4622 0.4482
Schistosoma mansoni tubulin subunit alpha 0.0175 0.3304 0.3061
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0254 0.0139
Trichomonas vaginalis tubulin beta chain, putative 0.0175 0.3304 0.7149
Schistosoma mansoni tubulin subunit beta 0.0231 0.4622 0.4427
Leishmania major gamma-tubulin 0.0125 0.2144 0.4008
Mycobacterium leprae cell division protein FtsZ 0.0054 0.0486 0.5
Echinococcus granulosus tubulin beta 1 chain 0.0231 0.4622 0.4482
Echinococcus multilocularis Tubulin alpha 1 chain 0.0175 0.3304 0.3129
Trichomonas vaginalis tubulin gamma chain, putative 0.0125 0.2144 0.4638
Brugia malayi Tubulin alpha chain 0.0175 0.3304 0.3129
Leishmania major alpha tubulin 0.0175 0.3304 0.6814
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0121 0.2032 0.4396
Echinococcus granulosus tubulin alpha chain 0.0175 0.3304 0.3129
Brugia malayi Tubulin alpha chain 0.0054 0.0486 0.0237
Trichomonas vaginalis tubulin, putative 0.0071 0.0871 0.1885
Echinococcus multilocularis tubulin subunit TubB 0.0175 0.3304 0.3129
Echinococcus granulosus tubulin gamma 1 chain 0.0125 0.2144 0.1939
Brugia malayi Tubulin gamma chain 0.0125 0.2144 0.1939
Mycobacterium tuberculosis Cell division protein FtsZ 0.0054 0.0486 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 35 nM Inhibition of TASK-3 (unknown origin) ChEMBL. 23121096
IC50 (binding) = 300 nM Inhibition of TASK-1 (unknown origin) ChEMBL. 23121096
IC50 (binding) = 300 nM Inhibition of TASK-1 (unknown origin) expressed in CHO cells by thallium flux assay ChEMBL. 25017033
IC50 (functional) 0.021 uM PubChem BioAssay. SAR Analysis for the identification of inhibitors of the two-pore domain potassium channel TASK1 (KCNK3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 0.14 uM PubChem BioAssay. SAR analysis for compounds that inhibit the two-pore domain potassium channel TASK1- Selectivity assay against TASK3 (KCNK9): FluxOR Assay CRC. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.68 uM PubChem BioAssay. SAR Analysis for the identification of selective inhibitors of the two-pore domain potassium channel TASK1 in hERG expressing cells: FluxOR Assay CRC. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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