Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Nitric-oxide synthase, brain | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | multidrug resistance protein 1 | 0.0024 | 0.5606 | 0.5606 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 0.6787 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0027 | 0.6787 | 0.6787 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0027 | 0.6787 | 1 |
Plasmodium vivax | flavodoxin domain containing protein | 0.0024 | 0.5498 | 0.5498 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0027 | 0.6787 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0027 | 0.6787 | 1 |
Echinococcus multilocularis | ATP binding cassette sub family B | 0.0034 | 0.9841 | 0.9841 |
Brugia malayi | flavodoxin family protein | 0.0027 | 0.6787 | 0.6787 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0017 | 0.2449 | 0.2449 |
Brugia malayi | FAD binding domain containing protein | 0.0017 | 0.2449 | 0.2449 |
Echinococcus granulosus | multidrug resistance protein 1 | 0.0024 | 0.5606 | 0.5606 |
Echinococcus multilocularis | methionine synthase reductase | 0.0017 | 0.2449 | 0.2449 |
Leishmania major | p450 reductase, putative | 0.0027 | 0.6787 | 0.6787 |
Schistosoma mansoni | diflavin oxidoreductase | 0.0013 | 0.1074 | 0.1074 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 0.6787 | 0.6787 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.6787 | 1 |
Giardia lamblia | Hypothetical protein | 0.0024 | 0.5498 | 1 |
Trichomonas vaginalis | ATP-binding cassette transporter, putative | 0.0024 | 0.5606 | 0.5606 |
Leishmania major | cytochrome P450 reductase, putative | 0.0024 | 0.5498 | 0.5498 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0027 | 0.6787 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0027 | 0.6787 | 0.6787 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0014 | 0.116 | 0.116 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0027 | 0.6787 | 0.6787 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0017 | 0.2449 | 0.2449 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0027 | 0.6787 | 0.6787 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0027 | 0.6787 | 0.6787 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0027 | 0.6787 | 0.6787 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0027 | 0.6787 | 0.6787 |
Echinococcus granulosus | methionine synthase reductase | 0.0017 | 0.2449 | 0.2449 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0027 | 0.6787 | 0.6787 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.9841 | 0.9841 |
Trichomonas vaginalis | NADPH fad oxidoreductase, putative | 0.0024 | 0.5498 | 0.5498 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0027 | 0.6787 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.0027 | 0.6787 | 0.6787 |
Trypanosoma cruzi | p450 reductase, putative | 0.0027 | 0.6787 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0027 | 0.6787 | 1 |
Echinococcus multilocularis | multidrug resistance protein 1 | 0.0024 | 0.5606 | 0.5606 |
Echinococcus granulosus | 5'partial|ATP binding cassette sub family B | 0.0034 | 0.9841 | 0.9841 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0027 | 0.6787 | 0.6787 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0.1074 | 0.1074 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0024 | 0.5498 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.6787 | 0.6787 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0013 | 0.1074 | 0.1074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.11 uM | Inhibition of rat recombinant nNOS expressed in Escherichia coli using L-arginine as substrate | ChEMBL. | 23451760 |
Ki (binding) | = 21.9 uM | Inhibition of mouse recombinant iNOS expressed in Escherichia coli using L-arginine as substrate | ChEMBL. | 23451760 |
Ki (binding) | = 33.4 uM | Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate | ChEMBL. | 23451760 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.