TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.855 | Formula: C24H17ClN2O5
H donors: 1 H acceptors: 4 LogP: 4.19 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C1N(c2ccc(cc2)C(=O)O)C(=O)[C@@H]2[C@H]1ON([C@@H]2c1ccccc1Cl)c1ccccc1
InChi: 1S/C24H17ClN2O5/c25-18-9-5-4-8-17(18)20-19-21(32-27(20)16-6-2-1-3-7-16)23(29)26(22(19)28)15-12-10-14(11-13-15)24(30)31/h1-13,19-21H,(H,30,31)/t19-,20+,21+/m0/s1
InChiKey: FWEQFXQLNOGMMH-PWRODBHTSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0454	0.3024	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	g-protein coupled receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide s receptor	0.0016	0.0017	0.0017
Brugia malayi	MAP kinase sur-1	0.0454	0.3024	0.3024
Loa Loa (eye worm)	NAK/GAK protein kinase	0.0087	0.0504	0.0504
Echinococcus granulosus	activated cdc42 kinase 1	0.0383	0.2534	0.2534
Onchocerca volvulus		0.0016	0.0017	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	somatostatin receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0017	0.0017
Echinococcus granulosus	somatostatin receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0017	0.0017
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0796	0.5372	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0016	0.0017	1
Brugia malayi	GnHR receptor homolog	0.0016	0.0017	0.0017
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0016	0.0017	0.0017
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0264	0.1718	0.1718
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Brugia malayi	Serotonin receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0017	0.0017
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0016	0.0017	1
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	G protein-coupled receptor F59B2.13	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0016	0.0017	0.0017
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0016	0.0017	0.0017
Schistosoma mansoni	amine GPCR	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	mitogen activated protein kinase 3	0.0454	0.3024	0.3024
Echinococcus multilocularis	cyclin g associated kinase	0.0087	0.0504	0.0504
Echinococcus granulosus	7tm_1 domain containing protein	0.0016	0.0017	0.0017
Echinococcus granulosus	g-protein coupled receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	camk/dcamkl protein kinase	0.0142	0.0881	0.0881
Loa Loa (eye worm)	hypothetical protein	0.0379	0.251	0.251
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0017	0.0017
Brugia malayi	Doublecortin family protein	0.0142	0.0881	0.0881
Schistosoma mansoni	amine GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	activated cdc42 kinase 1	0.0383	0.2534	0.2534
Schistosoma mansoni	growth hormone secretagogue receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	carbonic anhydrase	0.0796	0.5372	0.5372
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Brugia malayi	Carboxylesterase family protein	0.0082	0.0467	0.0467
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	Protein kinase domain containing protein	0.0383	0.2534	0.2534
Schistosoma mansoni	adenoreceptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	carbonic anhydrase-related	0.0796	0.5372	0.5372
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0017	0.0017
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Brugia malayi	G protein-coupled receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	neuropeptide F receptor	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	carbonic anhydrase	0.0796	0.5372	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0017	0.0017
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0796	0.5372	0.5372
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0016	0.0017	0.0017
Schistosoma mansoni	myosin xvIII	0.0016	0.0017	0.0017
Schistosoma mansoni	carbonic anhydrase-related	0.0796	0.5372	0.5372
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.3024	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0017	0.0017
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.0467	0.0467
Schistosoma mansoni	opsin-like receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	melatonin receptor type 1A	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	carbonic anhydrase	0.0796	0.5372	0.5372
Echinococcus granulosus	carbonic anhydrase	0.0796	0.5372	0.5372
Echinococcus granulosus	dro:myosuppressin receptor	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	carboxylesterase	0.0082	0.0467	0.0467
Onchocerca volvulus		0.0016	0.0017	1
Echinococcus multilocularis	sex peptide receptor	0.0016	0.0017	0.0017
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0796	0.5372	0.5372
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	fmrfamide receptor	0.0016	0.0017	0.0017
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.3024	1
Brugia malayi	neuropeptide F receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	neuropeptide f receptor 76f	0.0016	0.0017	0.0017
Echinococcus granulosus	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	orexin receptor type 2	0.0016	0.0017	0.0017
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0016	0.0017	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0017	0.0017
Brugia malayi	AKH receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	ORL1-like opioid receptor	0.0016	0.0017	0.0017
Brugia malayi	G-protein coupled receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	amine GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.026	0.1694	0.1694
Loa Loa (eye worm)	eukaryotic-type carbonic anhydrase	0.0796	0.5372	0.5372
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	G protein coupled receptor 139	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0017	0.0017
Brugia malayi	follicle stimulating hormone receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0796	0.5372	0.5372
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0796	0.5372	0.5372
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide receptor A26	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	serotonin receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	fmrfamide receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	serotonin receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	carboxylesterase 5A	0.0082	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	putative neuropeptide receptor NPR1	0.0016	0.0017	0.0017
Echinococcus granulosus	acetylcholinesterase	0.0082	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	biogenic amine receptor	0.0016	0.0017	0.0017
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.3024	1
Echinococcus granulosus	sex peptide receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Toxoplasma gondii	hypothetical protein	0.0796	0.5372	1
Giardia lamblia	Kinase, CMGC MAPK	0.0454	0.3024	0.5
Echinococcus multilocularis	carbonic anhydrase	0.0796	0.5372	0.5372
Brugia malayi	sulfakinin receptor protein	0.0016	0.0017	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0087	0.0504	0.0504
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	Dopamine receptor protein 2	0.0016	0.0017	0.0017
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	G protein coupled receptor 139	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	transfer RNA-Thr	0.0383	0.2534	0.2534
Schistosoma mansoni	neuropeptide receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	serotonin receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0264	0.1718	0.1718
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0016	0.0017	0.0017
Brugia malayi	Dopamine receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0796	0.5372	0.5372
Onchocerca volvulus		0.0016	0.0017	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Schistosoma mansoni	carbonic anhydrase-related	0.0796	0.5372	0.5372
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	cyclin g associated kinase	0.0087	0.0504	0.0504
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0016	0.0017	0.0017
Brugia malayi	Serotonin receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptides capa receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	allatostatin A receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0467	0.0467
Echinococcus multilocularis	neuropeptides capa receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Brugia malayi	RE15519p	0.0016	0.0017	0.0017
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0454	0.3024	0.3024
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0082	0.0467	0.0467
Echinococcus multilocularis	allatostatin A receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	biogenic amine 5HT receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide receptor A26	0.0016	0.0017	0.0017
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0264	0.1718	0.1718
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide Y receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	amine GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	mitogen activated protein kinase	0.0454	0.3024	0.3024
Loa Loa (eye worm)	TYRA-2 protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	g protein coupled receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	serine/threonine protein kinase	0.0454	0.3024	0.3024
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0016	0.0017	0.0017
Echinococcus multilocularis	carbonic anhydrase	0.0796	0.5372	0.5372
Brugia malayi	Eukaryotic-type carbonic anhydrase family protein	0.0796	0.5372	0.5372
Echinococcus granulosus	g protein coupled receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	neuropeptide receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0016	0.0017	0.0017
Echinococcus granulosus	carboxylesterase 5A	0.0082	0.0467	0.0467
Schistosoma mansoni	neuropeptide F-like receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	tyrosine kinase	0.0264	0.1718	0.1718
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0016	0.0017	0.0017
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus granulosus	mitogen activated protein kinase	0.0454	0.3024	0.3024
Schistosoma mansoni	histamine h1 receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	acetylcholinesterase	0.0082	0.0467	0.0467
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide s receptor	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0017	0.0017
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Brugia malayi	Dopamine receptor protein 1	0.0016	0.0017	0.0017
Brugia malayi	Carbonic anhydrase like protein 2 precursor	0.0796	0.5372	0.5372
Loa Loa (eye worm)	hypothetical protein	0.0383	0.2534	0.2534
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0016	0.0017	0.0017
Brugia malayi	hypothetical protein	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	acetylcholinesterase 1	0.0082	0.0467	0.0467
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide FF receptor 2	0.0016	0.0017	0.0017
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0016	0.0017	0.0017
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0016	0.0017	0.0017
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0796	0.5372	0.5372
Echinococcus multilocularis	dro:myosuppressin receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	opsin-like receptor	0.0016	0.0017	0.0017
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0016	0.0017	0.0017
Echinococcus granulosus	7TM GPCR rhodopsin	0.0016	0.0017	0.0017
Schistosoma mansoni	amine GPCR	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0016	0.0017	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0016	0.0017	0.0017
Echinococcus granulosus	activated cdc42 kinase 1	0.0383	0.2534	0.2534
Echinococcus granulosus	acetylcholinesterase	0.0082	0.0467	0.0467
Echinococcus granulosus	carbonic anhydrase	0.0796	0.5372	0.5372
Brugia malayi	Protein kinase domain containing protein	0.0087	0.0504	0.0504
Brugia malayi	putative neuropeptide receptor	0.0016	0.0017	0.0017
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Echinococcus multilocularis	orexin receptor type 2	0.0016	0.0017	0.0017
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0016	0.0017	0.0017
Brugia malayi	Melatonin receptor type 1A	0.0016	0.0017	0.0017
Echinococcus granulosus	neuropeptide receptor	0.0016	0.0017	0.0017
Brugia malayi	G-protein coupled receptor	0.0016	0.0017	0.0017
Brugia malayi	larval opioid receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0016	0.0017	0.0017
Echinococcus granulosus	rhodopsin orphan GPCR	0.0016	0.0017	0.0017
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	G-protein coupled receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Trichomonas vaginalis	CMGC family protein kinase	0.0454	0.3024	1
Brugia malayi	Carboxylesterase family protein	0.0082	0.0467	0.0467
Loa Loa (eye worm)	hypothetical protein	0.026	0.1694	0.1694
Loa Loa (eye worm)	neuropeptide F receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0016	0.0017	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Onchocerca volvulus		0.0016	0.0017	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0017	0.0017
Plasmodium falciparum	carbonic anhydrase	0.0796	0.5372	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0016	0.0017	0.0017
Schistosoma mansoni	opsin-like receptor	0.0016	0.0017	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0016	0.0017	0.0017

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2324783

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1726145