Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | biogenic amine (octopamine/dopamine) receptor | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | ko:K04165 Oamb gene product from transcript, putative | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Schistosoma japonicum | 5-hydroxytryptamine receptor, putative | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | Get druggable targets OG5_141128 | All targets in OG5_141128 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133680 | All targets in OG5_133680 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | AT19640p | 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled | 390 aa | 335 aa | 21.8 % |
Echinococcus multilocularis | serotonin receptor | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled | 366 aa | 399 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | protein kinase, putative | 0.312 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.312 | 1 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.312 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.312 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.312 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.312 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.312 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.312 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.312 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.312 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.016 | 0.016 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.312 | 1 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.312 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.016 | 0.016 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.312 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.312 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.312 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.312 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.312 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.312 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.312 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.312 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 3.2 nM | In vitro binding affinity of the compound was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor | ChEMBL. | 12825944 |
Ki (binding) | = 3.2 nM | In vitro binding affinity of the compound was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1B receptor | ChEMBL. | 12825944 |
Ki (binding) | = 3.8 nM | In vitro binding affinity of the compound was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor | ChEMBL. | 12825944 |
Ki (binding) | = 3.8 nM | In vitro binding affinity of the compound was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1D receptor | ChEMBL. | 12825944 |
Ki (binding) | = 11 nM | In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor | ChEMBL. | 12825944 |
Ki (binding) | = 11 nM | In vitro binding affinity was determined by radioligand binding assay using cell line expressing human 5-hydroxytryptamine 1F receptor | ChEMBL. | 12825944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.