Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | porcupine homolog (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Loa Loa (eye worm) | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma japonicum | ko:K00181 porcupine, putative | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Schistosoma mansoni | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Brugia malayi | MBOAT family protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus granulosus | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Echinococcus multilocularis | zinc finger protein | Get druggable targets OG5_133309 | All targets in OG5_133309 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0144 | 0.3653 | 0.3653 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0053 | 0.0461 | 0.0506 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0053 | 0.0461 | 0.0506 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0061 | 0.072 | 0.0791 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0053 | 0.0461 | 0.0506 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0144 | 0.3653 | 0.4011 |
Brugia malayi | MBOAT family protein | 0.0299 | 0.9107 | 1 |
Loa Loa (eye worm) | MBCTL1 | 0.0061 | 0.072 | 0.0791 |
Echinococcus multilocularis | acetylcholinesterase | 0.0144 | 0.3653 | 0.4011 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0061 | 0.072 | 0.0791 |
Echinococcus granulosus | carboxylesterase 5A | 0.0144 | 0.3653 | 0.4011 |
Echinococcus granulosus | acetylcholinesterase | 0.0144 | 0.3653 | 0.4011 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0053 | 0.0461 | 0.0506 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3653 | 0.4011 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.3653 | 0.4011 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0061 | 0.072 | 0.0791 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0061 | 0.072 | 0.0791 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0061 | 0.072 | 0.0791 |
Onchocerca volvulus | 0.0053 | 0.0461 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 0.3653 | 0.4011 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0053 | 0.0461 | 0.0461 |
Loa Loa (eye worm) | MBOAT family protein | 0.0299 | 0.9107 | 1 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0461 | 0.0506 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0299 | 0.9107 | 1 |
Echinococcus granulosus | zinc finger protein | 0.0273 | 0.82 | 0.9004 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.764 | 1 |
Echinococcus multilocularis | zinc finger protein | 0.0273 | 0.82 | 0.9004 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.021 | 0.5984 | 0.657 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0461 | 0.0506 |
Echinococcus granulosus | acetylcholinesterase | 0.0144 | 0.3653 | 0.4011 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0461 | 0.0461 |
Schistosoma mansoni | zinc finger protein | 0.0299 | 0.9107 | 0.9107 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0144 | 0.3653 | 0.4011 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0053 | 0.0461 | 0.0461 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0053 | 0.0461 | 1 |
Brugia malayi | mbt repeat family protein | 0.0053 | 0.0461 | 0.0506 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.021 | 0.5984 | 0.657 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0299 | 0.9107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.072 | 0.0791 |
Brugia malayi | Carboxylesterase family protein | 0.0144 | 0.3653 | 0.4011 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0061 | 0.072 | 0.072 |
Echinococcus multilocularis | acetylcholinesterase | 0.0144 | 0.3653 | 0.4011 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0053 | 0.0461 | 0.0506 |
Loa Loa (eye worm) | carboxylesterase | 0.0144 | 0.3653 | 0.4011 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.5 nM | Inhibition of porcupine-mediated Wnt signalling in mouse L cells after 24 hrs by SpringerImages-Topflash reporter assay | ChEMBL. | 23477365 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.