Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0082 | 0.0014 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0067 | 0.0067 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0553 | 0.6779 | 1 |
Loa Loa (eye worm) | fibroinase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0553 | 0.6779 | 0.6779 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0082 | 0.0014 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0082 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0553 | 0.6779 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0075 | 0.0775 | 0.1035 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0553 | 0.6779 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0082 | 0.0082 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Trypanosoma brucei | protein kinase, putative | 0.0553 | 0.6779 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.0569 | 0.084 |
Entamoeba histolytica | cysteine protease, putative | 0.002 | 0.0082 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0082 | 0.0014 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0553 | 0.6779 | 0.6779 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0553 | 0.6779 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0775 | 0.1035 |
Onchocerca volvulus | Cathepsin L homolog | 0.002 | 0.0082 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.002 | 0.0082 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0775 | 0.1035 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Loa Loa (eye worm) | cysteine protease | 0.002 | 0.0082 | 0.012 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0068 | 0.0693 | 0.0913 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0082 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0553 | 0.6779 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.0337 | 0.0497 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0067 | 0.0099 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0082 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0775 | 0.1035 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.002 | 0.0082 | 0.0014 |
Loa Loa (eye worm) | ctsf protein | 0.002 | 0.0082 | 0.012 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0553 | 0.6779 | 1 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0059 | 0.0573 | 0.0734 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.0569 | 0.084 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0553 | 0.6779 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.002 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0775 | 0.1035 |
Onchocerca volvulus | Cathepsin F homolog | 0.002 | 0.0082 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0337 | 0.0337 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0553 | 0.6779 | 0.6757 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0067 | 0.0067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0067 | 0.0099 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.002 | 0.0082 | 0.5 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0553 | 0.6779 | 0.6779 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0553 | 0.6779 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0553 | 0.6779 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0553 | 0.6779 | 0.6757 |
Brugia malayi | MAP kinase sur-1 | 0.0553 | 0.6779 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.002 | 0.0082 | 0.012 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0067 | 0.0099 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.0569 | 0.084 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0553 | 0.6779 | 1 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.002 | 0.0082 | 0.0014 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.002 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Plasmodium vivax | vivapain-2 | 0.002 | 0.0082 | 0.5 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.002 | 0.0082 | 0.012 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.002 | 0.0082 | 0.0014 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0553 | 0.6779 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Onchocerca volvulus | 0.002 | 0.0082 | 1 | |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0075 | 0.0775 | 0.1035 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0553 | 0.6779 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0553 | 0.6779 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0337 | 0.0497 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.002 | 0.0082 | 0.5 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.002 | 0.0082 | 0.0082 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0553 | 0.6779 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.0569 | 0.084 |
Leishmania major | cathepsin L-like protease | 0.0075 | 0.0775 | 0.1035 |
Entamoeba histolytica | cysteine proteinase, putative | 0.002 | 0.0082 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0082 | 0.012 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0067 | 0.0067 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0067 | 0.0067 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.002 | 0.0082 | 0.0082 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0067 | 0.0099 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.002 | 0.0082 | 0.012 |
Brugia malayi | Cathepsin L-like precursor | 0.002 | 0.0082 | 0.012 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 0 % | Cytoprotective activity against shiga toxin-induced cytotoxicity in human HeLa cells at 30 uM incubated for 4 hrs prior to shiga toxin addition measured after 20 hrs by liquid scintillation counting analysis relative to Retro-2 | ChEMBL. | 23517565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.