Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Canis familiaris | Transient receptor potential M8 protein | No references | |
Homo sapiens | transient receptor potential cation channel, subfamily M, member 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1114 aa | 24.9 % |
Echinococcus multilocularis | transient receptor potential cation channel | Transient receptor potential M8 protein | 1104 aa | 1108 aa | 25.5 % |
Echinococcus granulosus | transient receptor potential cation channel | transient receptor potential cation channel, subfamily M, member 8 | 1104 aa | 1115 aa | 24.8 % |
Schistosoma mansoni | transient receptor potential cation channel subfamily m member | Transient receptor potential M8 protein | 1104 aa | 1075 aa | 25.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | peroxisome assembly protein 26 | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.5571 | 0.5571 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.5571 | 0.5571 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Toxoplasma gondii | alpha tubulin TUBA1 | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0129 | 0.1296 | 0.1296 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.1672 | 0.1672 |
Brugia malayi | Tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha-1 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | tubulin subunit TubB | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0187 | 0.5571 | 0.5571 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1296 | 0.1296 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0129 | 0.1296 | 0.1296 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0134 | 0.1672 | 0.1672 |
Echinococcus multilocularis | peroxisome assembly protein 26 | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | Tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha-2 chain | 0.0187 | 0.5571 | 0.5571 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Trypanosoma brucei | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin isotype 2 | 0.0129 | 0.1296 | 0.1296 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | alpha-tubulin | 0.0187 | 0.5571 | 0.5571 |
Echinococcus multilocularis | hypothetical protein | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha 2 | 0.0129 | 0.1296 | 0.1296 |
Trypanosoma cruzi | alpha tubulin, putative | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin subunit TubB | 0.0187 | 0.5571 | 0.4682 |
Brugia malayi | tubulin alpha chain - mouse | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Toxoplasma gondii | alpha-tubulin I, putative | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0187 | 0.5571 | 0.5571 |
Plasmodium falciparum | alpha tubulin 1 | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin alpha chain | 0.0187 | 0.5571 | 0.5571 |
Echinococcus granulosus | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | tubulin alpha 1C chain | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha chain | 0.0187 | 0.5571 | 0.4682 |
Entamoeba histolytica | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Echinococcus granulosus | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Schistosoma mansoni | tubulin subunit alpha | 0.0187 | 0.5571 | 0.4682 |
Plasmodium vivax | tubulin alpha chain, putative | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Leishmania major | alpha tubulin | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | tubulin alpha 3 chain | 0.0187 | 0.5571 | 0.4682 |
Loa Loa (eye worm) | tubulin gamma chain | 0.0134 | 0.1672 | 0.1672 |
Plasmodium falciparum | alpha tubulin 2 | 0.0187 | 0.5571 | 0.4682 |
Echinococcus multilocularis | Tubulin alpha 1 chain | 0.0187 | 0.5571 | 0.4682 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0134 | 0.1672 | 0.1672 |
Trichomonas vaginalis | tubulin alpha-1 chain, putative | 0.0187 | 0.5571 | 0.5571 |
Giardia lamblia | Alpha-tubulin | 0.0187 | 0.5571 | 0.4682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.8 nM | Functional Assay | BINDINGDB. | No reference |
IC50 (binding) | = 1.1 nM | Patch Clamp Assay | BINDINGDB. | No reference |
IC50 (binding) | = 2.3 nM | Patch Clamp Assay | BINDINGDB. | No reference |
IC50 (binding) | = 4 nM | Inhibition of TRPM8 (unknown origin) | ChEMBL. | 23121096 |
IC50 (binding) | = 4 nM | Functional Assay | BINDINGDB. | No reference |
IC50 (binding) | = 5 nM | Functional Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.