Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0124 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0124 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0124 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 | |
Brugia malayi | SH2 domain containing protein | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0124 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 | |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0124 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0124 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0124 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0124 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0124 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0124 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Growth inhibition (functional) | = 30 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
Growth inhibition (functional) | = 30 % | An vitro anti-leishmanial activity against Leishmania donovani promastigotes (25 microM) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Aspergillus fumigatus (AF-27) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Sporothrix schenck ii (SS-1) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | In vitro for antifungal activity against Trichophyton mentagrophytes (A-280) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Antifungal activity against Candida albicans (SKF) | ChEMBL. | No reference |
MIC (functional) | > 100 ug ml-1 | Atifungal activity against Cryptococcus neoformans (CN-17) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.