Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.136 | 0.2333 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0272 | 0.2557 | 0.4945 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0472 | 0.4873 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0119 | 0.0782 | 0.1506 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0129 | 0.0905 | 0.1599 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0272 | 0.2557 | 0.4163 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0472 | 0.4873 | 0.472 |
Onchocerca volvulus | 0.0272 | 0.2557 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0169 | 0.136 | 0.1101 |
Brugia malayi | thymidylate synthase | 0.0272 | 0.2557 | 0.519 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.309 | 0.5627 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0272 | 0.2557 | 0.4945 |
Echinococcus granulosus | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0272 | 0.2557 | 0.3432 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0472 | 0.4873 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Loa Loa (eye worm) | thymidylate synthase | 0.0272 | 0.2557 | 0.519 |
Echinococcus granulosus | geminin | 0.0169 | 0.136 | 0.2333 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0151 | 0.115 | 0.205 |
Schistosoma mansoni | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0168 | 0.1347 | 0.1113 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0472 | 0.4873 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.0291 | 0.0485 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0472 | 0.4873 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0129 | 0.0905 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0119 | 0.0782 | 0.1506 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0472 | 0.4873 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0119 | 0.0782 | 0.1506 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0318 | 0.309 | 0.5627 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0318 | 0.309 | 0.4499 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.0291 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0318 | 0.309 | 0.4499 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0523 | 0.5463 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0472 | 0.4873 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 0.5 |
Brugia malayi | hypothetical protein | 0.0129 | 0.0905 | 0.176 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.136 | 0.2333 |
Echinococcus multilocularis | thymidylate synthase | 0.0272 | 0.2557 | 0.2334 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0523 | 0.5463 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 163000 nM | Viral Plaque Reduction Assay | BINDINGDB. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.