Detailed information for compound 1727485

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 579.601 | Formula: C28H31F2N9O3
  • H donors: 2 H acceptors: 6 LogP: 2.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: Oc1ccc(cc1)C[C@@H](C(=O)N1CCN(CC1)c1nc(nc(n1)n1c(nc2c1cccc2)C(F)F)N1CCOCC1)N
  • InChi: 1S/C28H31F2N9O3/c29-23(30)24-32-21-3-1-2-4-22(21)39(24)28-34-26(33-27(35-28)38-13-15-42-16-14-38)37-11-9-36(10-12-37)25(41)20(31)17-18-5-7-19(40)8-6-18/h1-8,20,23,40H,9-17,31H2/t20-/m0/s1
  • InChiKey: MHGMEBPPOVMOGK-FQEVSTJZSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta Starlite/ChEMBL References
Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania mexicana phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania infantum phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative Get druggable targets OG5_127444 All targets in OG5_127444
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide Get druggable targets OG5_127444 All targets in OG5_127444
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative Get druggable targets OG5_127444 All targets in OG5_127444
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase Get druggable targets OG5_127444 All targets in OG5_127444
Schistosoma japonicum ko:K00922 phosphatidylinositol-4,5-bisphosphate 3-kinase [EC2.7.1.153], putative Get druggable targets OG5_127444 All targets in OG5_127444
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127444 All targets in OG5_127444
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative Get druggable targets OG5_127444 All targets in OG5_127444
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444
Leishmania donovani phosphatidylinositol 3-kinase 2, putative Get druggable targets OG5_127444 All targets in OG5_127444

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 582 aa 491 aa 25.2 %
Entamoeba histolytica phosphatidylinositol 3-kinase, putative phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1068 aa 927 aa 29.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei epsilon tubulin 0.0293 0.2733 0.3261
Echinococcus multilocularis Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Plasmodium falciparum alpha tubulin 1 0.0391 0.4486 0.3521
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Trichomonas vaginalis tubulin, putative 0.0572 0.7711 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0493 0.6291 0.8078
Echinococcus granulosus Tubulin beta 2C chain 0.0572 0.7711 0.6974
Leishmania major beta tubulin 0.0572 0.7711 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0572 0.7711 1
Leishmania major beta tubulin 0.0572 0.7711 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) tubulin alpha-3 chain 0.0226 0.1537 0.1782
Echinococcus multilocularis beta tubulin 0.0572 0.7711 0.6974
Leishmania major beta tubulin 0.0572 0.7711 1
Trypanosoma cruzi beta tubulin, putative 0.0572 0.7711 1
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0493 0.6291 0.8159
Trichomonas vaginalis tubulin epsilon chain, putative 0.0572 0.7711 1
Leishmania major beta tubulin 0.0572 0.7711 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0572 0.7711 0.6974
Echinococcus granulosus alpha tubulin 0.0391 0.4486 0.2712
Echinococcus granulosus tubulin beta 1 chain 0.0572 0.7711 0.6974
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Echinococcus granulosus Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Echinococcus multilocularis tubulin alpha chain 0.0391 0.4486 0.2712
Brugia malayi Tubulin beta-1 chain 0.0572 0.7711 1
Plasmodium falciparum tubulin beta chain 0.0572 0.7711 1
Leishmania major beta tubulin 0.0572 0.7711 1
Echinococcus granulosus tubulin alpha chain 0.0391 0.4486 0.2712
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Echinococcus multilocularis tubulin subunit TubB 0.0391 0.4486 0.2712
Giardia lamblia Alpha-tubulin 0.0391 0.4486 0.3521
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Toxoplasma gondii alpha tubulin TUBA1 0.0391 0.4486 0.3521
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Entamoeba histolytica tubulin family protein 0.0572 0.7711 1
Echinococcus granulosus Tubulin beta 2C chain 0.0572 0.7711 0.6974
Echinococcus granulosus tubulin alpha 0.0293 0.2733 0.0395
Echinococcus multilocularis tubulin beta 1 chain 0.0572 0.7711 0.6974
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0493 0.6291 0.8159
Trichomonas vaginalis tubulin epsilon chain, putative 0.0391 0.4486 0.5634
Loa Loa (eye worm) tubulin beta-1 chain 0.0572 0.7711 0.8941
Echinococcus multilocularis tubulin alpha 0.0293 0.2733 0.0395
Schistosoma mansoni alpha tubulin 0.0391 0.4486 0.4301
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Echinococcus granulosus tubulin alpha 1C chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) tubulin alpha chain 0.0391 0.4486 0.5201
Leishmania major beta tubulin 0.0572 0.7711 1
Trypanosoma brucei beta tubulin 0.0572 0.7711 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0391 0.4486 0.5634
Toxoplasma gondii beta tubulin 0.0572 0.7711 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0493 0.6291 0.8078
Giardia lamblia Beta tubulin 0.0572 0.7711 1
Loa Loa (eye worm) BEN-1 protein 0.0572 0.7711 0.8941
Giardia lamblia Beta tubulin 0.0572 0.7711 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) hypothetical protein 0.0276 0.2434 0.2822
Echinococcus multilocularis hypothetical protein 0.0391 0.4486 0.2712
Entamoeba histolytica hypothetical protein 0.0415 0.4915 0.6216
Loa Loa (eye worm) tubulin alpha-2 chain 0.0391 0.4486 0.5201
Brugia malayi Tubulin beta chain 0.0166 0.0471 0.0198
Giardia lamblia Beta tubulin 0.0572 0.7711 1
Entamoeba histolytica tubulin gamma chain 0.0293 0.2733 0.3261
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0157 0.0324 0.042
Schistosoma mansoni tubulin subunit epsilon 0.0293 0.2733 0.249
Loa Loa (eye worm) phosphatidylinositol 3 0.0624 0.8624 1
Trypanosoma cruzi epsilon tubulin, putative 0.0293 0.2733 0.3545
Leishmania major beta tubulin 0.0572 0.7711 1
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Loa Loa (eye worm) hypothetical protein 0.0217 0.1379 0.1599
Leishmania major beta tubulin 0.0572 0.7711 1
Trypanosoma brucei alpha tubulin 0.0391 0.4486 0.5634
Leishmania major beta tubulin 0.0572 0.7711 1
Trypanosoma brucei alpha tubulin 0.0391 0.4486 0.5634
Schistosoma mansoni tubulin subunit alpha 0.0391 0.4486 0.4301
Echinococcus granulosus tubulin beta 4A class IVa 0.0572 0.7711 0.6974
Echinococcus multilocularis Tubulin beta 2C chain 0.0572 0.7711 0.6974
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0226 0.1537 0.1642
Echinococcus multilocularis Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Echinococcus multilocularis tubulin epsilon chain 0.0293 0.2733 0.0395
Echinococcus multilocularis peroxisome assembly protein 26 0.0391 0.4486 0.2712
Leishmania major beta tubulin 0.0572 0.7711 1
Trypanosoma brucei beta tubulin 0.0572 0.7711 1
Loa Loa (eye worm) alpha-tubulin 0.0391 0.4486 0.5201
Loa Loa (eye worm) tubulin beta chain 0.0572 0.7711 0.8941
Brugia malayi beta-tubulin, identical 0.0572 0.7711 1
Onchocerca volvulus 0.0166 0.0471 0.5
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0166 0.0471 0.0198
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0374 0.4181 0.5222
Brugia malayi tubulin alpha-2 chain 0.0391 0.4486 0.5634
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0471 0.0198
Trypanosoma brucei beta tubulin 0.0572 0.7711 1
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Echinococcus granulosus tubulin alpha 1C chain 0.0391 0.4486 0.2712
Leishmania major beta tubulin 0.0572 0.7711 1
Plasmodium vivax tubulin beta chain, putative 0.0572 0.7711 1
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0297 0.2805 0.0145
Brugia malayi alpha-tubulin 0.0391 0.4486 0.5634
Echinococcus granulosus Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) hypothetical protein 0.0264 0.2223 0.2578
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Echinococcus granulosus tubulin epsilon chain 0.0293 0.2733 0.0395
Echinococcus granulosus beta tubulin 0.0572 0.7711 0.6974
Trichomonas vaginalis tubulin, putative 0.0166 0.0471 0.0198
Trypanosoma cruzi tubulin gamma chain 0.0293 0.2733 0.3545
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0208 0.1231 0.1227
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0276 0.2434 0.2856
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Schistosoma mansoni alpha tubulin 0.0391 0.4486 0.4301
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0493 0.6291 0.8078
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0391 0.4486 0.5634
Echinococcus granulosus Tubulin beta 2C chain 0.0572 0.7711 0.6974
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Trypanosoma brucei tubulin gamma chain 0.0293 0.2733 0.3261
Echinococcus multilocularis tubulin subunit beta 0.0572 0.7711 0.6974
Brugia malayi Tubulin alpha-2 chain 0.0391 0.4486 0.5634
Giardia lamblia Alpha-tubulin 0.0391 0.4486 0.3521
Schistosoma mansoni tubulin subunit beta 0.0572 0.7711 0.7634
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0199 0.1058 0.0994
Trichomonas vaginalis tubulin alpha chain, putative 0.0293 0.2733 0.3261
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0474 0.5967 0.764
Loa Loa (eye worm) tubulin alpha 2 0.0264 0.2223 0.2578
Loa Loa (eye worm) tubulin beta-2A chain 0.0572 0.7711 0.8941
Entamoeba histolytica tubulin alpha chain, putative 0.0391 0.4486 0.5634
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Echinococcus granulosus tubulin subunit TubB 0.0391 0.4486 0.2712
Echinococcus granulosus tubulin alpha 3 chain 0.0391 0.4486 0.2712
Entamoeba histolytica tubulin family protein 0.0572 0.7711 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0293 0.2733 0.3261
Trypanosoma brucei alpha tubulin 0.0391 0.4486 0.5634
Echinococcus multilocularis tubulin alpha chain 0.0391 0.4486 0.2712
Trypanosoma brucei alpha tubulin 0.0391 0.4486 0.5634
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0572 0.7711 0.6974
Brugia malayi tubulin alpha chain - mouse 0.0391 0.4486 0.5634
Schistosoma mansoni tubulin subunit alpha 0.0391 0.4486 0.4301
Echinococcus multilocularis Tubulin beta 2C chain 0.0572 0.7711 0.6974
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0471 0.0198
Echinococcus multilocularis Tubulin beta 2C chain 0.0572 0.7711 0.6974
Echinococcus multilocularis tubulin alpha 3 chain 0.0391 0.4486 0.2712
Trypanosoma cruzi alpha tubulin, putative 0.0391 0.4486 0.5817
Trichomonas vaginalis tubulin, putative 0.0166 0.0471 0.0198
Echinococcus granulosus peroxisome assembly protein 26 0.0391 0.4486 0.2712
Plasmodium falciparum alpha tubulin 2 0.0391 0.4486 0.3521
Echinococcus granulosus tubulin alpha chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) beta-tubulin 0.0572 0.7711 0.8941
Loa Loa (eye worm) alpha-tubulin 0.0391 0.4486 0.5201
Loa Loa (eye worm) tubulin alpha 2 0.0264 0.2223 0.2578
Loa Loa (eye worm) tubulin beta-4 chain 0.0572 0.7711 0.8941
Leishmania major beta tubulin 0.0572 0.7711 1
Brugia malayi Tubulin alpha chain 0.0391 0.4486 0.5634
Echinococcus multilocularis tubulin alpha 1C chain 0.0391 0.4486 0.2712
Toxoplasma gondii beta-1 tubulin, putative 0.0572 0.7711 1
Brugia malayi Tubulin gamma chain 0.0293 0.2733 0.3261
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0264 0.2223 0.2571
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Toxoplasma gondii alpha-tubulin I, putative 0.0391 0.4486 0.3521
Entamoeba histolytica tubulin alpha-1 chain 0.0391 0.4486 0.5634
Echinococcus granulosus tubulin alpha chain 0.0391 0.4486 0.2712
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0374 0.4181 0.5222
Echinococcus multilocularis Tubulin alpha 1 chain 0.0391 0.4486 0.2712
Trypanosoma brucei epsilon tubulin 0.0293 0.2733 0.3261
Echinococcus granulosus tubulin subunit beta 0.0572 0.7711 0.6974
Schistosoma mansoni alpha tubulin 0.0391 0.4486 0.4301
Leishmania major beta tubulin 0.0572 0.7711 1
Plasmodium vivax tubulin alpha chain, putative 0.0391 0.4486 0.3521
Trypanosoma brucei beta tubulin 0.0293 0.2733 0.3261
Leishmania major beta tubulin 0.0572 0.7711 1
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0493 0.6291 0.8078
Trypanosoma brucei alpha tubulin, putative 0.0166 0.0471 0.0198
Trypanosoma cruzi epsilon tubulin, putative 0.0293 0.2733 0.3545
Echinococcus multilocularis Tubulin beta 2C chain 0.0572 0.7711 0.6974
Leishmania major beta tubulin 0.0572 0.7711 1
Echinococcus granulosus tubulin alpha chain 0.0391 0.4486 0.2712
Loa Loa (eye worm) hypothetical protein 0.0226 0.1537 0.1782
Echinococcus multilocularis tubulin alpha chain 0.0391 0.4486 0.2712
Echinococcus granulosus tubulin gamma 1 chain 0.0293 0.2733 0.0395
Toxoplasma gondii beta-tubulin, putative 0.0572 0.7711 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0572 0.7711 1
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Echinococcus granulosus beta tubulin 0.0572 0.7711 0.6974
Echinococcus granulosus tubulin alpha chain 0.0391 0.4486 0.2712
Trichomonas vaginalis tubulin gamma chain, putative 0.0293 0.2733 0.3261
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Loa Loa (eye worm) hypothetical protein 0.0391 0.4486 0.5201
Leishmania major beta tubulin 0.0572 0.7711 1
Leishmania major beta tubulin 0.0572 0.7711 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0415 0.4915 0.6216
Echinococcus multilocularis tubulin alpha chain 0.0391 0.4486 0.2712
Schistosoma mansoni tubulin subunit alpha 0.0391 0.4486 0.4301
Echinococcus granulosus Tubulin beta 2C chain 0.0572 0.7711 0.6974
Trypanosoma brucei beta tubulin 0.0572 0.7711 1
Brugia malayi Tubulin alpha-2 chain 0.0391 0.4486 0.5634
Trichomonas vaginalis tubulin epsilon chain, putative 0.0572 0.7711 1
Echinococcus multilocularis beta tubulin 0.0572 0.7711 0.6974
Trichomonas vaginalis tubulin beta chain, putative 0.0166 0.0471 0.0198
Echinococcus multilocularis tubulin alpha 1C chain 0.0391 0.4486 0.2712
Echinococcus multilocularis tubulin gamma 1 chain 0.0293 0.2733 0.0395
Loa Loa (eye worm) BEN-1 protein 0.0572 0.7711 0.8941
Leishmania major beta tubulin 0.0572 0.7711 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0166 0.0471 0.0198
Trichomonas vaginalis tubulin beta chain, putative 0.0391 0.4486 0.5634
Leishmania major alpha tubulin 0.0391 0.4486 0.3521
Trypanosoma brucei epsilon tubulin 0.0293 0.2733 0.3261
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0264 0.2223 0.2578
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0493 0.6291 0.8078
Loa Loa (eye worm) tubulin gamma chain 0.0293 0.2733 0.3169
Loa Loa (eye worm) tubulin alpha chain 0.0391 0.4486 0.5201
Plasmodium vivax tubulin alpha chain, putative 0.0391 0.4486 0.3521
Schistosoma mansoni tubulin subunit gamma 0.0293 0.2733 0.249
Echinococcus granulosus Tubulin beta 2C chain 0.0572 0.7711 0.6974
Echinococcus multilocularis tubulin alpha chain 0.0391 0.4486 0.2712
Echinococcus granulosus tubulin alpha 3 chain 0.0391 0.4486 0.2712
Trichomonas vaginalis tubulin beta chain, putative 0.0572 0.7711 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 220 nM Inhibition of PI3K-beta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate measured after 60 mins by luminescence assay ChEMBL. 23795239
IC50 (binding) = 1200 nM Inhibition of PI3K-delta (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate measured after 60 mins by luminescence assay ChEMBL. 23795239
IC50 (binding) = 3300 nM Inhibition of PI3K-alpha (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate measured after 60 mins by luminescence assay ChEMBL. 23795239
IC50 (binding) > 10 uM Inhibition of PI3K-gamma (unknown origin) assessed as decrease in ATP consumption using phosphatidylinositol bisphosphate and 10 uM ATP as substrate measured after 60 mins by luminescence assay ChEMBL. 23795239

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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