Detailed information for compound 1727757

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 353.369 | Formula: C20H19NO5
  • H donors: 0 H acceptors: 2 LogP: 2.72 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1c(OC)cc(cc1OC)C(=O)c1ccc2c(c1)c(C=O)cn2C
  • InChi: 1S/C20H19NO5/c1-21-10-14(11-22)15-7-12(5-6-16(15)21)19(23)13-8-17(24-2)20(26-4)18(9-13)25-3/h5-11H,1-4H3
  • InChiKey: WYVGABPGBUPWKI-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) Smad1 0.0016 0.0049 0.0222
Loa Loa (eye worm) hypothetical protein 0.0051 0.0309 0.1397
Leishmania major hypothetical protein, conserved 0.0051 0.0309 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0153 0.0276
Brugia malayi hypothetical protein 0.0304 0.2213 1
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0378 0.2766 0.3753
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Echinococcus multilocularis cpg binding protein 0.003 0.0152 0.0245
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0232 0.1016
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0185
Echinococcus multilocularis protein jagged 1 0.0017 0.0051 0.0083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0153 0.0247
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0167 0.5274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0232 0.1049
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0232 0.1049
Brugia malayi Cadherin domain containing protein 0.0017 0.0051 0.0195
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0011 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0053 0.0326 0.1475
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0087 0.0395
Leishmania major DNA polymerase kappa, putative 0.002 0.0075 0.1801
Schistosoma mansoni hypothetical protein 0.0023 0.0097 0.017
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0688 0.1305
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0586
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0269
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0232 0.0374
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0051 0.0195
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.007 0.0117
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.1801
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.1801
Schistosoma mansoni smad 0.0016 0.0049 0.0078
Echinococcus granulosus neurogenic locus protein delta 0.0017 0.0051 0.0097
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0167 0.5024
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0185
Schistosoma mansoni hypothetical protein 0.0297 0.2157 0.4083
Loa Loa (eye worm) blistered cuticle protein 3 0.0052 0.0315 0.1424
Onchocerca volvulus Dual oxidase homolog 0.0052 0.0315 0.1392
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Echinococcus granulosus GPCR family 2 0.0032 0.0167 0.0316
Echinococcus multilocularis expressed conserved protein 0.0095 0.0642 0.1034
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0087 0.0359
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0177 0.0623
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0014 0.0029 0.0092
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0269
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0232 0.0426
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.0713
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0232 0.1016
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0023 0.0109
Brugia malayi conserved hypotetical protein 0.0019 0.007 0.0281
Echinococcus multilocularis heat shock protein 90 0.0033 0.0177 0.0285
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0315 0.1392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Onchocerca volvulus Huntingtin homolog 0.0126 0.0874 0.3929
Trypanosoma brucei trypanothione reductase 0.0038 0.0208 0.647
Echinococcus granulosus protein jagged 2 0.0017 0.0051 0.0097
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0177 0.538
Onchocerca volvulus 0.0041 0.0232 0.1016
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Brugia malayi Thioredoxin reductase 0.0038 0.0208 0.0907
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0232 0.044
Trichomonas vaginalis MYB, putative 0.0011 0.0005 0.0002
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0126 0.0239
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Schistosoma mansoni hypothetical protein 0.0042 0.0241 0.0442
Schistosoma mansoni DNA polymerase eta 0.002 0.0075 0.0127
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0075 0.1801
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0232 0.044
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.0571 0.0633
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0232 0.044
Mycobacterium tuberculosis Probable reductase 0.0086 0.0571 0.0767
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0276
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0075 0.0142
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0153 0.0291
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0126 0.0874 0.3952
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0014 0.0029 0.0054
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0281
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.007 0.0113
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0023 0.0503
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.007 0.0113
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0075 0.0072
Toxoplasma gondii EGF family domain-containing protein 0.0017 0.0051 0.0167
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Trypanosoma brucei heat shock protein 84, putative 0.0014 0.0029 0.0179
Brugia malayi nuclear receptor RXR 0.0019 0.007 0.0281
Brugia malayi Peroxidasin 0.0052 0.0315 0.1392
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0395
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.0962 0.716 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.1801
Echinococcus multilocularis tumor protein p63 0.0339 0.2475 0.3987
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0011 0.0008 0.0037
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0177 0.538
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0232 0.1016
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0011 0.0008 0.0016
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.0571 0.0767
Schistosoma mansoni cpg binding protein 0.003 0.0152 0.0274
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0078
Brugia malayi nuclear receptor RXR 0.0022 0.0087 0.0359
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0167 0.0269
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Echinococcus multilocularis dna polymerase kappa 0.002 0.0075 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0028 0.0177
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Echinococcus multilocularis heat shock protein 0.0033 0.0177 0.0285
Loa Loa (eye worm) pax transcription factor protein 2 0.0241 0.1741 0.787
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Echinococcus granulosus delta-like protein 1 0.0017 0.0051 0.0097
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0301
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0232 0.044
Brugia malayi isocitrate dehydrogenase 0.0032 0.0167 0.072
Toxoplasma gondii thioredoxin reductase 0.0038 0.0208 0.0736
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0029
Schistosoma mansoni endoplasmin 0.0033 0.0177 0.0321
Brugia malayi glutathione reductase 0.0038 0.0208 0.0907
Plasmodium falciparum heat shock protein 90 0.0033 0.0177 0.5613
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0309 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0133
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0253 0.0479
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0008 0.0013
Schistosoma mansoni microtubule-associated protein tau 0.0711 0.5271 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0309 1
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0051 0.0083
Onchocerca volvulus 0.0019 0.007 0.0281
Brugia malayi notch-like transmembrane receptor 0.0017 0.0051 0.0195
Brugia malayi Endoplasmin precursor 0.0033 0.0177 0.0766
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi hypothetical protein 0.0052 0.0315 0.1392
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0212 0.0342
Brugia malayi ecdysone receptor 0.0019 0.007 0.0281
Echinococcus granulosus smad 0.0016 0.0049 0.0093
Trypanosoma cruzi heat shock protein, putative 0.0014 0.0029 0.0179
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0101 0.0688 0.311
Toxoplasma gondii Hsp90 domain-containing protein 0.0014 0.0029 0.0085
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0315 0.1424
Plasmodium falciparum glutathione reductase 0.0038 0.0208 0.6648
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Loa Loa (eye worm) DR-78 0.0019 0.007 0.0317
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.0962 0.716 1
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0126 0.3586
Plasmodium vivax endoplasmin, putative 0.0033 0.0177 0.5613
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0075 0.0413
Echinococcus multilocularis protein patched 0.0044 0.0253 0.0407
Brugia malayi nuclear hormone receptor 0.0041 0.0232 0.1016
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0232 0.0374
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0017 0.0051 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0232 0.1049
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0232 0.044
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0075 0.1801
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Onchocerca volvulus Slit protein homolog 0.0017 0.0051 0.0195
Mycobacterium ulcerans heat shock protein 90 0.0027 0.0126 0.0103
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0315 0.1424
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0395
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0317
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.007 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0309 1
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0075 0.0127
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0049 0.0093
Echinococcus multilocularis microtubule associated protein 2 0.0711 0.5271 0.8492
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0232 0.0426
Echinococcus granulosus neurogenic locus notch protein 4 0.0017 0.0051 0.0097
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0309 1
Brugia malayi nuclear hormone receptor 0.0019 0.007 0.0281
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0027 0.0126 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0232 0.1049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0232 0.1016
Brugia malayi Hsp90 protein 0.0014 0.0029 0.0092
Echinococcus granulosus heat shock protein 0.0033 0.0177 0.0336
Echinococcus granulosus protein jagged 1 0.0017 0.0051 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0232 0.0426
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0232 0.1016
Loa Loa (eye worm) MH2 domain-containing protein 0.0242 0.1742 0.7874
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0097 0.0185
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0315 0.1392
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.0643 0.0868
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0049 0.0222
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0232 0.1016
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Schistosoma mansoni hypothetical protein 0.0042 0.0241 0.0442
Loa Loa (eye worm) hypothetical protein 0.002 0.0075 0.0338
Brugia malayi Muscle positioning protein 4 0.0017 0.0051 0.0195
Brugia malayi heat shock protein 90 0.0033 0.0177 0.0766
Plasmodium falciparum thioredoxin reductase 0.0013 0.0023 0.0503
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0167 0.0302
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0281
Schistosoma mansoni patched 1 0.0044 0.0253 0.0464
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Loa Loa (eye worm) hypothetical protein 0.003 0.0153 0.0693
Loa Loa (eye worm) endoplasmin 0.0033 0.0177 0.08
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0232 0.1016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.0571 0.0767
Echinococcus granulosus neural cadherin 0.0017 0.0051 0.0097
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0177 0.2522
Brugia malayi Cadherin domain containing protein 0.0017 0.0051 0.0195
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0078
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0232 0.0374
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0023 0.0109
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.007 0.0317
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0023 0.0066
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0309 1
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0023 0.0069
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0232 0.1049
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0232 0.0374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0232 0.044
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0177 0.538
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.07 0.1314
Trichomonas vaginalis heat shock protein, putative 0.0021 0.008 0.0442
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0011 0.0005 0.0002
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0051 0.0083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0232 0.0426
Onchocerca volvulus 0.0052 0.0315 0.1392
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Echinococcus multilocularis geminin 0.0346 0.2524 0.4067
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0395
Brugia malayi Pax transcription factor protein 2 0.0241 0.1741 0.7862
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.1801
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0232 0.1016
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.007 0.0281
Schistosoma mansoni heat shock protein 0.0014 0.0029 0.0038
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Trypanosoma brucei unspecified product 0.0014 0.0028 0.0177
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0688 0.1108
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0212 0.0402
Loa Loa (eye worm) Notch2 0.0017 0.0051 0.0232
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.007 0.0113
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0023 0.1059
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Trichomonas vaginalis set domain proteins, putative 0.0236 0.1702 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0232 0.1049
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0075 0.0127
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.0713
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0688 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0075 0.0052
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0177 0.538
Onchocerca volvulus Chorion peroxidase homolog 0.0052 0.0315 0.1392
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Plasmodium vivax heat shock protein 90, putative 0.0014 0.0029 0.0673
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0051 0.0195
Brugia malayi Pre-SET motif family protein 0.0208 0.1487 0.6707
Schistosoma mansoni heat shock protein 0.0033 0.0177 0.0321
Giardia lamblia High cysteine protein 0.0017 0.0051 0.268
Echinococcus multilocularis dna polymerase eta 0.002 0.0075 0.0121
Echinococcus multilocularis neural cadherin 0.0017 0.0051 0.0083
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.0571 0.0767
Echinococcus multilocularis notch 0.0017 0.0051 0.0083
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0185
Onchocerca volvulus 0.0017 0.0051 0.0195
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0167 0.0753
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0029 0.0673
Echinococcus granulosus heat shock protein 90 0.0033 0.0177 0.0336
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Echinococcus granulosus Smad4 0.0016 0.0049 0.0093
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0023 0.0503
Onchocerca volvulus 0.0052 0.0315 0.1392
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0378 0.2766 0.276
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0014 0.0029 0.0347
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Echinococcus multilocularis protein jagged 1 0.0017 0.0051 0.0083
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0301
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0167 0.5274
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.007 0.0117
Echinococcus granulosus peroxidasin 0.0052 0.0315 0.0598
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0315 0.1424
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0232 0.1016
Onchocerca volvulus 0.005 0.0299 0.1317
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0075 0.0413
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Onchocerca volvulus 0.0241 0.1741 0.7862
Schistosoma mansoni cpg binding protein 0.0029 0.014 0.0251
Loa Loa (eye worm) transcription factor SMAD2 0.0242 0.1742 0.7874
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0126 0.3586
Loa Loa (eye worm) hypothetical protein 0.0032 0.0167 0.0753
Leishmania major DNA polymerase eta, putative 0.002 0.0075 0.1801
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.007 0.0133
Brugia malayi CHE-14 protein 0.0044 0.0253 0.1109
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0167 0.0201
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0087 0.0166
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0341 0.1215
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.007 0.0281
Treponema pallidum heat shock protein 90 0.0027 0.0126 0.0103
Brugia malayi GCC2 and GCC3 family protein 0.0017 0.0051 0.0195
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0011 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Brugia malayi Pre-SET motif family protein 0.003 0.0153 0.0658
Echinococcus granulosus notch 0.0017 0.0051 0.0097
Loa Loa (eye worm) glutathione reductase 0.0038 0.0208 0.0941
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0051 0.0097
Echinococcus granulosus expressed conserved protein 0.0095 0.0642 0.1217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0153 0.0537
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.007 0.0133
Schistosoma mansoni hypothetical protein 0.0042 0.0241 0.0442
Echinococcus granulosus endoplasmin 0.0027 0.0126 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Brugia malayi hypothetical protein 0.0019 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0395
Echinococcus multilocularis neurogenic locus notch protein 4 0.0017 0.0051 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0023 0.0015
Brugia malayi hypothetical protein 0.0019 0.007 0.0281
Loa Loa (eye worm) hypothetical protein 0.0022 0.0087 0.0395
Echinococcus granulosus protein jagged 2 0.0017 0.0051 0.0097
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0208 0.6648
Schistosoma mansoni heat shock protein 0.0033 0.0177 0.0321
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Echinococcus granulosus cpg binding protein 0.003 0.0152 0.0289
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.1015 0.1926
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.014 0.0266
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0023 0.0503
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Giardia lamblia DINP protein human, muc B family 0.002 0.0075 0.4051
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0268
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Trypanosoma brucei unspecified product 0.002 0.0075 0.1801
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0014 0.0029 0.0046
Echinococcus granulosus slit 2 protein 0.0017 0.0051 0.0097
Plasmodium falciparum thioredoxin reductase 0.0038 0.0208 0.6648
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0688 0.3082
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0167 0.0718
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0232 0.1049
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0126 0.7018
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.007 0.0281
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0075 0.0072
Echinococcus multilocularis protein dispatched 1 0.005 0.0299 0.0481
Onchocerca volvulus Putative cubilin 0.0017 0.0051 0.0195
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0075 0.1801
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0049 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi steroid hormone receptor 0.0041 0.0232 0.1016
Brugia malayi tailless protein 0.0019 0.007 0.0281
Plasmodium falciparum glutathione reductase 0.0013 0.0023 0.0503
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0008 0.0013
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0075 0.1025
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0167 0.5024
Loa Loa (eye worm) hypothetical protein 0.005 0.0299 0.1349
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0185
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0023 0.0044
Echinococcus granulosus fibropellin Ia 0.0017 0.0051 0.0097
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0087 0.0359
Onchocerca volvulus 0.0019 0.007 0.0281
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0688 0.3084
Loa Loa (eye worm) animal heme peroxidase 0.0052 0.0315 0.1424
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.0643 0.0868
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0315 0.1392
Schistosoma mansoni Smad4 0.0016 0.0049 0.0078
Brugia malayi Blistered cuticle protein 3 0.0052 0.0315 0.1392
Onchocerca volvulus Peroxidasin homolog 0.0052 0.0315 0.1392
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0232 0.0426
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0028 0.0177
Onchocerca volvulus Neurogenic locus notch homolog 0.0017 0.0051 0.0195
Brugia malayi Nuclear hormone receptor E75 0.0019 0.007 0.0281
Schistosoma mansoni cpg binding protein 0.003 0.0152 0.0274
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0177 0.5613
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0177 0.08
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0835 0.6207 1
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0117
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0117
Onchocerca volvulus Huntingtin homolog 0.0126 0.0874 0.3929
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.5024
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0167 0.0269
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0167 0.0718
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.007 0.0133
Schistosoma mansoni laminin gamma-3 chain 0.0017 0.0051 0.0082
Echinococcus multilocularis neurogenic locus notch protein 0.0017 0.0051 0.0083
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Onchocerca volvulus 0.0017 0.0051 0.0195
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.007 0.0133
Schistosoma mansoni nuclear receptor 0.0019 0.007 0.0117
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0023 0.0066
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0177 0.0623
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.014 0.0633
Leishmania major heat shock protein, putative 0.0014 0.0029 0.0179
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0075 0.0302
Brugia malayi nuclear receptor NHR-88 0.0041 0.0232 0.1016
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0309 0.1101
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.1015 0.1636
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0208 0.0941
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.007 0.0317
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0232 0.1016
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0232 0.0426
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0017 0.0051 0.0082
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0167 0.072
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0177 0.538
Brugia malayi hypothetical protein 0.0022 0.0087 0.0359
Echinococcus granulosus SWI:SNF matrix associated 0.0011 0.0008 0.0016
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0688 0.3082
Onchocerca volvulus 0.0017 0.0051 0.0195
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0208 0.647
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.0643 0.0735
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0253 0.1142
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0023 0.0503
Toxoplasma gondii heat shock protein 75, putative 0.0014 0.0029 0.0085
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0315 0.1392
Onchocerca volvulus 0.0304 0.2213 1
Schistosoma mansoni hypothetical protein 0.0069 0.0446 0.0833
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0029 0.014
Echinococcus multilocularis X box binding protein 1 0.0297 0.2157 0.3475
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.0078
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0276
Echinococcus multilocularis protein jagged 2 0.0017 0.0051 0.0083
Plasmodium vivax heat shock protein, putative 0.0014 0.0029 0.0673
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0049 0.0222
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0232 0.0374
Echinococcus granulosus heat shock protein 90 0.0027 0.0126 0.0239
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0301
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0378 0.2766 1
Brugia malayi hypothetical protein 0.0051 0.0309 0.1365
Schistosoma mansoni endoplasmin 0.0033 0.0177 0.0321
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0126 0.3586
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0253 0.146
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0232 0.0374
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.007 0.0281
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0075 0.1801
Echinococcus multilocularis fat cadherin tumor suppressor 0.0017 0.0051 0.0083
Plasmodium vivax SET domain protein, putative 0.003 0.0153 0.4821
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0075 0.0338
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0232 0.0426
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0011 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0126 0.0874 0.3952
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.0643 0.0868
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0153 0.0247
Brugia malayi ecdysteroid receptor 0.0041 0.0232 0.1016
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0299 0.0552
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.007 0.0117
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1487 0.6719
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0253 0.0407
Loa Loa (eye worm) heat shock protein 75 0.0014 0.0029 0.0129
Echinococcus multilocularis GPCR, family 2 0.0032 0.0167 0.0268
Loa Loa (eye worm) hypothetical protein 0.0041 0.0232 0.1049
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0688 0.3108
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Brugia malayi MH2 domain containing protein 0.0242 0.1742 0.7866
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0028 0.0177
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.1801
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0087 0.015
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0075 0.1801
Plasmodium falciparum heat shock protein 90, putative 0.0014 0.0029 0.0673
Brugia malayi nuclear receptor NHR-88 0.0019 0.007 0.0281
Echinococcus multilocularis SWI:SNF matrix associated 0.0011 0.0008 0.0013
Schistosoma mansoni slit 0.0017 0.0051 0.0082
Echinococcus granulosus geminin 0.0346 0.2524 0.4789
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.5024
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0253 0.0479
Schistosoma mansoni peroxidasin 0.0052 0.0315 0.0583
Leishmania major trypanothione reductase 0.0038 0.0208 0.647
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.007 0.0317
Echinococcus multilocularis smad 0.0016 0.0049 0.0079
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0232 0.0374
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Onchocerca volvulus 0.0017 0.0051 0.0195
Echinococcus granulosus protein jagged 1 0.0017 0.0051 0.0097
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0049 0.0078
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0011 0.0005 0.0002
Brugia malayi EGF-like domain containing protein 0.0017 0.0051 0.0195
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0232 0.0426
Loa Loa (eye worm) hypothetical protein 0.0304 0.2213 1
Echinococcus multilocularis fibropellin Ia 0.0017 0.0051 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0232 0.1016
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0446 0.1988
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0049 0.0079
Schistosoma mansoni cell polarity protein 0.0017 0.0051 0.0082
Schistosoma mansoni hypothetical protein 0.0346 0.2524 0.4781
Echinococcus granulosus X box binding protein 1 0.0297 0.2157 0.4092
Schistosoma mansoni coup transcription factor 0.0041 0.0232 0.0426
Echinococcus multilocularis neurogenic locus protein delta 0.0017 0.0051 0.0083
Echinococcus multilocularis slit 2 protein 0.0017 0.0051 0.0083
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Brugia malayi Smad1 0.0016 0.0049 0.0185
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0017 0.0051 0.0195
Echinococcus multilocularis peroxidasin 0.0052 0.0315 0.0508
Echinococcus granulosus tumor protein p63 0.0339 0.2475 0.4695
Brugia malayi hypothetical protein 0.0033 0.0173 0.0748
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.0571 0.0767
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0232 0.0426
Schistosoma mansoni hypothetical protein 0.0032 0.0167 0.0301
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Brugia malayi nuclear receptor NHR-67 0.0019 0.007 0.0281
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0177 0.2522
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0232 0.1016
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0075 0.0302
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0075 0.1801
Schistosoma mansoni hypothetical protein 0.0042 0.0241 0.0442
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0316
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0232 0.1016
Loa Loa (eye worm) brahma associated protein 0.0011 0.0008 0.0037
Onchocerca volvulus 0.003 0.0153 0.0658
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Loa Loa (eye worm) hypothetical protein 0.0044 0.0253 0.1142
Brugia malayi CXXC zinc finger family protein 0.0029 0.014 0.0598
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0167 0.0268
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0097 0.0157
Schistosoma mansoni peroxidasin 0.0052 0.0315 0.0583
Echinococcus multilocularis endoplasmin 0.0027 0.0126 0.0203
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0232 0.1016
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0027 0.0126 0.0103
Echinococcus granulosus dna polymerase kappa 0.002 0.0075 0.0142
Schistosoma mansoni nuclear hormone receptor 0.0019 0.007 0.0117
Onchocerca volvulus 0.0017 0.0051 0.0195
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0315 0.1392
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0232 0.0374
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0087 0.0141
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0167 0.0754
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0232 0.1016
Trichomonas vaginalis endoplasmin, putative 0.0021 0.008 0.0442
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0378 0.2766 0.2749
Echinococcus granulosus neurogenic locus notch protein 0.0017 0.0051 0.0097
Onchocerca volvulus 0.0052 0.0315 0.1392
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0232 0.1016
Schistosoma mansoni notch 0.0017 0.0051 0.0082
Trypanosoma brucei unspecified product 0.0014 0.0028 0.0177
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0049 0.0093
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0177 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0232 0.1016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0232 0.044
Schistosoma mansoni septate junction protein 0.0017 0.0051 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0232 0.0374
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0167 0.0269
Brugia malayi Animal haem peroxidase family protein 0.0052 0.0315 0.1392
Onchocerca volvulus Peroxidase homolog 0.0052 0.0315 0.1392
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0153 0.0276
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0167 0.5024
Brugia malayi hypothetical protein 0.0126 0.0874 0.3929
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0232 0.1016
Brugia malayi Delta serrate ligand family protein 0.0017 0.0051 0.0195
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Trypanosoma brucei heat shock protein, putative 0.0033 0.0177 0.538
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0232 0.1016
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0052 0.0315 0.1424
Schistosoma mansoni hypothetical protein 0.0017 0.0051 0.0082
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0167 0.0586
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0232 0.044
Onchocerca volvulus Peroxidase homolog 0.0052 0.0315 0.1392
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0167 0.0316
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0208 0.0259
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0075 0.0121
Loa Loa (eye worm) notch protein 0.0017 0.0051 0.0232
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.007 0.0133
Brugia malayi Calcium binding EGF domain containing protein 0.0017 0.0051 0.0195
Plasmodium falciparum endoplasmin, putative 0.0021 0.008 0.2378
Echinococcus multilocularis Smad4 0.0016 0.0049 0.0079
Plasmodium vivax glutathione reductase, putative 0.0038 0.0208 0.6648
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.0571 0.0767
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0113
Onchocerca volvulus 0.0236 0.1702 0.7683
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0075 0.0052
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0232 0.044
Brugia malayi hypothetical protein 0.0022 0.0087 0.0359
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0069 0.0446 0.2018
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.007 0.0113
Schistosoma mansoni hypothetical protein 0.0346 0.2524 0.4781
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0232 0.0426
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0074 0.177
Loa Loa (eye worm) hypothetical protein 0.0101 0.0688 0.3108
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0087 0.015
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0126 0.0713
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0232 0.0426
Schistosoma mansoni zinc finger protein 0.0019 0.007 0.0117
Echinococcus granulosus microtubule associated protein 2 0.0711 0.5271 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0177 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0232 0.1049
Onchocerca volvulus 0.0029 0.014 0.0598
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0309 1
Giardia lamblia Grp94/Hsp90 0.0027 0.0126 0.7018
Leishmania major heat shock protein 83-1 0.0033 0.0177 0.538
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0232
Loa Loa (eye worm) hypothetical protein 0.0019 0.007 0.0317
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0232 0.0426
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0389 0.0724
Echinococcus multilocularis heat shock protein 90 0.0027 0.0126 0.0203
Echinococcus granulosus dna polymerase eta 0.002 0.0075 0.0142

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3000 nM Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by XTT assay ChEMBL. 23470139

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 23470139

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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