Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0018 | 0.5004 | 0.5 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0018 | 0.5004 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0018 | 0.5004 | 0.5 |
Echinococcus multilocularis | lamin | 0.0027 | 0.9924 | 1 |
Onchocerca volvulus | 0.0027 | 0.9924 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.5004 | 0.4883 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.9643 | 0.9631 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0018 | 0.5004 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0018 | 0.5004 | 0.4883 |
Trichomonas vaginalis | r2r3-MYB transcription factor, putative | 0.001 | 0.0026 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0018 | 0.5004 | 0.4883 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0018 | 0.5004 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0014 | 0.2784 | 0.2554 |
Giardia lamblia | Myb 1-like protein | 0.001 | 0.0025 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0018 | 0.5004 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0018 | 0.5004 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.9924 | 1 |
Loa Loa (eye worm) | cytochrome P450 | 0.0018 | 0.5004 | 0.4844 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0018 | 0.5004 | 0.5 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.2784 | 0.2554 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0018 | 0.5004 | 0.5 |
Onchocerca volvulus | 0.0027 | 0.9924 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.1968 | 0.1711 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1686 | 0.1421 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.9924 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.9924 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.9924 | 0.9922 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.9924 | 0.9922 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0018 | 0.5004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.1686 | 0.1421 |
Schistosoma mansoni | lamin | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0018 | 0.5004 | 0.5 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.1968 | 0.1725 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0018 | 0.5004 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0018 | 0.5004 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.9924 | 0.9922 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.5004 | 0.4844 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9924 | 0.9922 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0.5004 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0018 | 0.5004 | 0.4844 |
Trichomonas vaginalis | MYB, putative | 0.001 | 0.0026 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0018 | 0.5004 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.1968 | 0.1725 |
Schistosoma mansoni | lamin | 0.0027 | 0.9924 | 1 |
Echinococcus multilocularis | 0.0018 | 0.5004 | 0.4883 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.9924 | 0.9922 |
Echinococcus granulosus | lamin | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0018 | 0.5004 | 0.5 |
Echinococcus multilocularis | musashi | 0.0027 | 0.9924 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0018 | 0.5004 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.9924 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.