Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 526 aa | 518 aa | 22.4 % |
Dictyostelium discoideum | amine oxidase | Monoamine oxidase A | 526 aa | 491 aa | 31.0 % |
Brugia malayi | amine oxidase, flavin-containing family protein | Monoamine oxidase A | 526 aa | 464 aa | 21.6 % |
Dictyostelium discoideum | hypothetical protein | Monoamine oxidase A | 526 aa | 524 aa | 22.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Brugia malayi | thymidylate synthase | 0.0789 | 0.3523 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Onchocerca volvulus | 0.0789 | 0.3523 | 0.5 | |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0789 | 0.3523 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0789 | 0.3523 | 0.3433 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0789 | 0.3523 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0375 | 0.0137 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0789 | 0.3523 | 0.3523 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 34 nM | Inhibition of MAO-A in Sprague-Dawley rat brain mitochondrial suspension using kynuramine as substrate incubated for 5 mins prior to substrate addition measured for 5 mins by spectrophotometry | ChEMBL. | 23437843 |
Inhibition (binding) | = 0 % | Inhibition of MAO-B in Sprague-Dawley rat brain mitochondrial suspension using kynuramine as substrate at 10 uM incubated for 5 mins prior to substrate addition measured for 5 mins by spectrophotometry | ChEMBL. | 23437843 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.