TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 286.175 | Formula: C13H27BN2O4
H donors: 4 H acceptors: 4 LogP: -1.94 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: OB(CCCC[C@](C(=O)O)(CCN1CCCCC1)N)O
InChi: 1S/C13H27BN2O4/c15-13(12(17)18,6-2-3-8-14(19)20)7-11-16-9-4-1-5-10-16/h19-20H,1-11,15H2,(H,17,18)/t13-/m1/s1
InChiKey: CHPILBYRQPOXMV-CYBMUJFWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arginase 2	Starlite/ChEMBL	References
Homo sapiens	arginase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis		Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium falciparum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania donovani	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus multilocularis	arginase 2, mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium knowlesi	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania braziliensis	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania infantum	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma mansoni	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium berghei	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	conserved hypothetical protein	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Trichomonas vaginalis	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania mexicana	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Candida albicans	likely arginase similar to S. cerevisiae CAR1 (YPL111W) involved in arginine catabolism to ornithine	Get druggable targets OG5_128245	All targets in OG5_128245
Schistosoma japonicum	ko:K01476 arginase [EC3.5.3.1], putative	Get druggable targets OG5_128245	All targets in OG5_128245
Leishmania major	arginase	Get druggable targets OG5_128245	All targets in OG5_128245
Entamoeba histolytica	Arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium vivax	arginase, putative	Get druggable targets OG5_128245	All targets in OG5_128245
Plasmodium yoelii	arginase	Get druggable targets OG5_128245	All targets in OG5_128245

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	ATP-binding cassette protein subfamily C, member 2, putative	0.0008	0.0044	0.0091
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Mycobacterium tuberculosis	Probable drugs-transport transmembrane ATP-binding protein ABC transporter	0.0008	0.0044	0.1788
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0003	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Echinococcus multilocularis	ATP binding cassette sub family B	0.0008	0.0044	0.0044
Echinococcus multilocularis	neutral sphingomyelinase	0.0004	0.0003	0.0003
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0245	0.0508
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Leishmania major	hypothetical protein, conserved	0.0004	0.0003	0.0005
Trypanosoma cruzi	ABC transporter, mitochondrial, putative	0.0008	0.0044	0.0254
Giardia lamblia	hypothetical protein	0.0004	0.0003	0.0127
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0008	0.0044	0.0091
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Plasmodium falciparum	ABC transporter B family member 7, putative	0.0008	0.0044	0.0091
Brugia malayi	ABC transporter	0.0008	0.0044	0.0152
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0245	0.0245
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.483	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0202	0.0418
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0003	0.0006
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0062	0.0124
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0245	0.0245
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Echinococcus multilocularis	multidrug resistance associated protein 7	0.0008	0.0044	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0009
Echinococcus multilocularis	survival motor neuron protein 1	0.0249	0.2882	0.2882
Trypanosoma brucei	multidrug resistance protein E	0.0008	0.0044	0.0254
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.0245	0.0245
Schistosoma mansoni	hypothetical protein	0.0191	0.2203	0.4388
Echinococcus granulosus	neutral sphingomyelinase	0.0004	0.0003	0.0005
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Entamoeba histolytica	P-glycoprotein 5, putative	0.0025	0.0245	0.0508
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0004	0.0003	0.0005
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Leishmania major	agmatinase-like protein	0.0151	0.1727	0.3575
Onchocerca volvulus	Putative neutral sphingomyelinase	0.0004	0.0003	0.0047
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Brugia malayi	hypothetical protein	0.0249	0.2882	1
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0008	0.0044	0.2171
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0202	0.0701
Loa Loa (eye worm)	ABC transporter	0.0008	0.0044	0.0152
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0157	0.0312
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Plasmodium falciparum	multidrug resistance-associated protein 2	0.0008	0.0044	0.0091
Entamoeba histolytica	inositol polyphosphate 5-phosphatase, putative	0.0004	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0245	0.0851
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0004	0.0003	0.0005
Mycobacterium tuberculosis	Iron-regulated transporter IrtA	0.0008	0.0044	0.1788
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0004	0.0003	0.0015
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Trichomonas vaginalis	type IV inositol 5-phosphatase, putative	0.0004	0.0003	0.0005
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0044	0.0087
Leishmania major	inositol/phosphatidylinositol phosphatase, putative	0.0004	0.0003	0.0005
Leishmania major	ATP-binding cassette protein subfamily C, member 6, putative	0.0008	0.0044	0.0091
Plasmodium falciparum	ABC transporter B family member 5, putative	0.0008	0.0044	0.0091
Trypanosoma cruzi	arginase, putative	0.0151	0.1727	1
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Leishmania major	endonuclease/exonuclease protein-like protein	0.0004	0.0003	0.0005
Brugia malayi	ABC transporter	0.0008	0.0041	0.0141
Echinococcus granulosus	multidrug resistance associated protein 1	0.0008	0.0044	0.0087
Leishmania major	hypothetical protein, conserved	0.0004	0.0003	0.0005
Leishmania major	ATP-binding cassette protein subfamily C, member 1, putative	0.0008	0.0044	0.0091
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0245	0.0489
Trypanosoma cruzi	endonuclease/exonuclease/phosphatase, putative	0.0004	0.0003	0.0015
Echinococcus multilocularis	multidrug resistance associated protein 1	0.0008	0.0044	0.0044
Giardia lamblia	Multidrug resistance-associated protein Mrp2	0.0008	0.0041	0.2013
Leishmania major	inositol phosphosphingolipid phospholipase C-Like	0.0004	0.0003	0.0005
Schistosoma mansoni	cpg binding protein	0.0032	0.0328	0.0654
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Echinococcus multilocularis		0.0008	0.0044	0.0044
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0008	0.0044	0.0091
Echinococcus granulosus	5'partial\|ATP binding cassette sub family B	0.0025	0.0242	0.0482
Leishmania major	ATP-binding cassette protein subfamily B, member 3, putative	0.0008	0.0044	0.0091
Giardia lamblia	Multidrug resistance-associated protein 1	0.0008	0.0044	0.2171
Entamoeba histolytica	Arginase, putative	0.0414	0.483	1
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0245	0.0245
Trypanosoma brucei	ABC transporter of the mitochondrion, putative	0.0008	0.0044	0.0254
Trichomonas vaginalis	Arginase, putative	0.0414	0.483	1
Trichomonas vaginalis	ocrl type II inositol 5-phosphatase, putative	0.0004	0.0003	0.0005
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.0041	0.0041
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0041	0.0081
Plasmodium falciparum	arginase	0.0414	0.483	1
Toxoplasma gondii	ATP-binding cassette transporter ABC.B1	0.0025	0.0245	0.3916
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0017	0.0157	0.0325
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Onchocerca volvulus		0.003	0.0308	0.5602
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0245	0.0489
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0004	0.0003	0.0005
Schistosoma mansoni	hypothetical protein	0.0004	0.0003	0.0005
Toxoplasma gondii	exonuclease III APE	0.0021	0.0202	0.3224
Giardia lamblia	Multidrug resistance-associated protein 1	0.0008	0.0044	0.2171
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Echinococcus granulosus	geminin	0.0191	0.2203	0.4388
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0021	0.0202	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0202	1
Plasmodium vivax	ABC transporter B family member 5, putative	0.0008	0.0044	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0009
Echinococcus granulosus	arginase 2 mitochondrial	0.0414	0.483	0.962
Trypanosoma cruzi	agmatinase, putative	0.0151	0.1727	1
Brugia malayi	multidrug Resistance Protein family member (mrp-5), putative	0.0008	0.0044	0.0152
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0008	0.0041	0.0084
Schistosoma mansoni	hypothetical protein	0.0191	0.2203	0.4388
Schistosoma mansoni	synaptojanin	0.0004	0.0003	0.0005
Plasmodium falciparum	carbon catabolite repressor protein 4, putative	0.0004	0.0003	0.0005
Schistosoma mansoni	carbon catabolite repressor protein	0.0004	0.0003	0.0005
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0245	0.0489
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	abcb9, putative	0.0025	0.0245	0.0508
Trypanosoma brucei	agmatinase, putative	0.0151	0.1727	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0033	0.0068
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0008	0.0041	0.0084
Plasmodium falciparum	ABC transporter B family member 3, putative	0.0008	0.0044	0.0091
Trypanosoma cruzi	multidrug resistance protein E, putative	0.0008	0.0044	0.0254
Trichomonas vaginalis	taga, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Trichomonas vaginalis	type II inositol 5-phosphatase, putative	0.0004	0.0003	0.0005
Trichomonas vaginalis	skeletal muscle/kidney enriched inositol 5-phosphatase, putative	0.0004	0.0003	0.0005
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Plasmodium vivax	ABC transporter B family member 6, putative	0.0008	0.0044	0.0091
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0064	0.0707	0.1408
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.0025	0.0245	0.0508
Wolbachia endosymbiont of Brugia malayi	ABC-type protease secretion system, ATPase and permease component, AprD	0.0008	0.0044	0.2171
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Trypanosoma brucei	inositol/phosphatidylinositol phosphatase, putative	0.0004	0.0003	0.0015
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Brugia malayi	hypothetical protein	0.0008	0.0044	0.0152
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Trypanosoma cruzi	arginase, putative	0.0151	0.1727	1
Schistosoma mansoni	smdr2	0.0025	0.0245	0.0489
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0044	0.0087
Brugia malayi	ABC transporter transmembrane region family protein	0.0008	0.0044	0.0152
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0245	0.0489
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0202	0.0701
Brugia malayi	ABC transporter family protein	0.0008	0.0044	0.0152
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Entamoeba histolytica	P-glycoprotein-2, putative	0.0025	0.0245	0.0508
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0008	0.0044	1
Plasmodium vivax	multidrug resistance-associated protein 2, putative	0.0008	0.0044	0.0091
Brugia malayi	P-glycoprotein-like protein	0.0008	0.0044	0.0152
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0202	0.0202
Mycobacterium ulcerans	component linked with the assembly of cytochrome transport transmembrane ATP-binding protein ABC transporter CydD	0.0008	0.0044	0.2171
Echinococcus multilocularis	arginase 2, mitochondrial	0.0414	0.483	0.483
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0245	0.0508
Giardia lamblia	Multidrug resistance-associated protein 1	0.0008	0.0041	0.2013
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0044	0.0087
Onchocerca volvulus		0.0025	0.0245	0.4461
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0245	0.0508
Leishmania major	p-glycoprotein e	0.0008	0.0044	0.0091
Schistosoma mansoni	synaptojanin	0.0004	0.0003	0.0005
Echinococcus multilocularis		0.0414	0.483	0.483
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0202	0.0418
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0003	0.0005
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0062	0.0062
Trypanosoma cruzi	inositol 5-phosphatase 1, putative	0.0004	0.0003	0.0015
Leishmania major	arginase	0.0414	0.483	1
Mycobacterium leprae	PROBABLE DRUGS-TRANSPORT TRANSMEMBRANE ATP-BINDING PROTEIN ABC TRANSPORTER	0.0008	0.0044	1
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0245	0.0489
Loa Loa (eye worm)	multidrug resistance protein 3	0.0025	0.0245	0.0851
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0025	0.0245	0.3916
Echinococcus granulosus	dnaJ subfamily B	0.043	0.502	1
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Trichomonas vaginalis	abcb9, putative	0.0025	0.0245	0.0508
Plasmodium vivax	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0003	0.0005
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0245	0.0508
Mycobacterium tuberculosis	Probable exported protein	0.0004	0.0003	0.0105
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0245	0.0508
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0033	0.0068
Echinococcus granulosus	ATP binding cassette sub family B	0.0008	0.0044	0.0087
Echinococcus granulosus	ATP binding cassette sub family B	0.0008	0.0041	0.0081
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0009
Entamoeba histolytica	inositol polyphosphate-5-phosphatase, putative	0.0004	0.0003	0.0005
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Echinococcus granulosus	3'partial\|arginase 2 mitochondrial	0.0414	0.483	0.962
Trypanosoma brucei	Inositol phosphosphingolipids phospholipase C	0.0004	0.0003	0.0015
Schistosoma mansoni	survival motor neuron protein	0.0051	0.055	0.1095
Leishmania major	ATP-binding cassette protein subfamily C, member 5, putative	0.0008	0.0044	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0041	0.0141
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Schistosoma mansoni	ATP-binding cassette sub-family B member 7 mitochondrial precursor (abc7)	0.0008	0.0044	0.0087
Plasmodium falciparum	ABC transporter B family member 6, putative	0.0008	0.0044	0.0091
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Schistosoma mansoni	arginase	0.0414	0.483	0.962
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.0245	0.0508
Trypanosoma cruzi	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0057	0.0626	1
Plasmodium vivax	multidrug resistance protein 1, putative	0.0025	0.0245	0.0508
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0041	0.0141
Echinococcus multilocularis	geminin	0.0191	0.2203	0.2203
Schistosoma mansoni	ATP-binding cassette sub-family B member 6 mitochondrial precursor (abc6)	0.0008	0.0041	0.0081
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Trypanosoma brucei	Endonuclease/Exonuclease/phosphatase family, putative	0.0004	0.0003	0.0015
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0004	0.0003	0.0015
Plasmodium vivax	ABC transporter B family member 4, putative	0.0008	0.0044	0.0091
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0003	0.0009
Schistosoma mansoni	cpg binding protein	0.0032	0.0328	0.0654
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0003	0.0009
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0202	0.0418
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0008	0.0044	0.2171
Leishmania major	pentamidine resistance protein 1	0.0008	0.0044	0.0091
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Echinococcus multilocularis	multidrug resistance protein 1	0.0017	0.0157	0.0157
Entamoeba histolytica	P-glycoprotein-1	0.0025	0.0245	0.0508
Toxoplasma gondii	ABC transporter family protein	0.0008	0.0044	0.07
Brugia malayi	ABC transporter family protein	0.0025	0.0245	0.0851
Onchocerca volvulus		0.0004	0.0003	0.0047
Schistosoma mansoni	hypothetical protein	0.0051	0.055	0.1095
Brugia malayi	CCR4	0.0004	0.0003	0.0009
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0025	0.0245	1
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0044	0.0152
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0202	0.1169
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0061	0.0211
Onchocerca volvulus		0.0004	0.0003	0.0047
Plasmodium vivax	ABC transporter B family member 3, putative	0.0008	0.0044	0.0091
Loa Loa (eye worm)	ABC transporter	0.0008	0.0044	0.0152
Echinococcus multilocularis	multidrug resistance protein 1	0.0025	0.0245	0.0245
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0003	0.0009
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0041	0.0081
Entamoeba histolytica	multidrug resistance protein, putative	0.0008	0.0044	0.0091
Brugia malayi	ABC transporter family protein	0.0008	0.0044	0.0152
Echinococcus multilocularis	synaptojanin 1	0.0004	0.0003	0.0003
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0004	0.0003	0.0015
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0245	0.0508
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0062	0.0216
Plasmodium falciparum	multidrug resistance protein 1	0.0025	0.0245	0.0508
Echinococcus granulosus	synaptojanin 1	0.0004	0.0003	0.0005
Leishmania major	ATP-binding cassette protein subfamily B, member 2, putative	0.0025	0.0245	0.0508
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0202	0.1169
Trypanosoma brucei	inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative	0.0004	0.0003	0.0015
Trypanosoma cruzi	mitochondrial protein 99, putative	0.0004	0.0003	0.0015
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0245	0.0245
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0004	0.0003	0.0003
Trichomonas vaginalis	abcb9, putative	0.0025	0.0245	0.0508
Schistosoma mansoni	nocturnin	0.0004	0.0003	0.0005
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0021	0.0202	0.0418
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.0041	0.0081
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0044	0.0087
Trypanosoma cruzi	Inositol phosphosphingolipids phospholipase C	0.0004	0.0003	0.0015
Echinococcus granulosus	survival motor neuron protein 1	0.0249	0.2882	0.5741
Plasmodium vivax	multidrug resistance protein 2, putative	0.0008	0.0044	0.0091
Schistosoma mansoni	smdr1	0.0008	0.0044	0.0087
Onchocerca volvulus		0.0051	0.055	1
Trypanosoma cruzi	pantothenate kinase subunit, putative	0.0004	0.0003	0.0015
Leishmania major	ATP-binding cassette protein subfamily C, member 8, putative	0.0008	0.0044	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0044	0.0152
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0245	0.0489
Schistosoma mansoni	cpg binding protein	0.003	0.0308	0.0614
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Trypanosoma brucei	RNA editing exonuclease 2	0.0004	0.0003	0.0015
Plasmodium vivax	hypothetical protein, conserved	0.0004	0.0003	0.0005
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0202	0.8234
Schistosoma mansoni	ap endonuclease	0.0021	0.0202	0.0402
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0003	0.0009
Schistosoma mansoni	multidrug resistance protein	0.0025	0.0245	0.0489
Giardia lamblia	ABC transporter, putative	0.0008	0.0044	0.2171
Plasmodium vivax	ABC transporter B family member 7, putative	0.0008	0.0044	0.0091
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0008	0.0044	0.0254
Entamoeba histolytica	endonuclease/exonuclease/phosphatase domain containing protein	0.0004	0.0003	0.0005
Entamoeba histolytica	hypothetical protein	0.0008	0.0044	0.0091
Schistosoma mansoni	cript-related	0.0004	0.0003	0.0005
Loa Loa (eye worm)	ABC transporter transmembrane region family protein	0.0008	0.0044	0.0152
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0025	0.0245	0.0851
Trypanosoma brucei	p-glycoprotein	0.0008	0.0044	0.0254
Leishmania major	p-glycoprotein	0.0025	0.0245	0.0508
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0003	0.0005
Entamoeba histolytica	P-glycoprotein-5	0.0025	0.0245	0.0508
Wolbachia endosymbiont of Brugia malayi	ABC-type multidrug transport system, ATPase and permease component	0.0008	0.0044	0.2171
Leishmania major	pantothenate kinase subunit, putative	0.0004	0.0003	0.0005
Trichomonas vaginalis	Phospholipase C precursor, putative	0.0004	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0249	0.2882	1
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0245	0.0489
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0021	0.0202	0.0418
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0202	0.0402
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.0041	0.0041
Trypanosoma cruzi	agmatinase, putative	0.0151	0.1727	1
Entamoeba histolytica	ABC transporter, putative	0.0008	0.0044	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Brugia malayi	ABC transporter transmembrane region family protein	0.0008	0.0041	0.0141
Trichomonas vaginalis	sphingomyelinase C 2 precursor, putative	0.0004	0.0003	0.0005
Trypanosoma cruzi	RNA-editing complex protein MP100, putative	0.0004	0.0003	0.0015
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0202	1
Trichomonas vaginalis	ABC transporter, putative	0.0025	0.0245	0.0508
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0008	0.0044	0.0254
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0003	0.0005
Plasmodium falciparum	multidrug resistance protein 2	0.0008	0.0044	0.0091
Trypanosoma cruzi	multidrug resistance-associated protein, putative	0.0008	0.0044	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0242	0.084
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0308	0.1069
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Trypanosoma cruzi	ABC transporter of the mitochondrion, putative	0.0008	0.0044	0.0254
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0008	0.0044	0.0091
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Trypanosoma brucei	multidrug resistance-associated protein, putative	0.0008	0.0044	0.0254
Loa Loa (eye worm)	hypothetical protein	0.0004	0.0003	0.0009
Plasmodium vivax	multidrug resistance-associated protein 1, putative	0.0008	0.0044	0.0091
Trypanosoma brucei	ABC transporter, mitochondrial, putative	0.0008	0.0044	0.0254
Entamoeba histolytica	P-glycoprotein 5, putative	0.0008	0.0041	0.0084
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0004	0.0003	0.0003
Toxoplasma gondii	ABC transporter, putative	0.0008	0.0044	0.07
Plasmodium vivax	arginase, putative	0.0414	0.483	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0033	0.0068
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508
Echinococcus multilocularis	ATP binding cassette sub family B	0.0008	0.0044	0.0044
Schistosoma mansoni	ap endonuclease	0.0021	0.0202	0.0402
Giardia lamblia	Hypothetical protein	0.0008	0.0041	0.2013
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0202	0.0418
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0003	0.0003
Plasmodium falciparum	exodeoxyribonuclease III, putative	0.0004	0.0003	0.0005
Entamoeba histolytica	P-glycoprotein 6, putative	0.0008	0.0044	0.0091
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0021	0.0202	1
Toxoplasma gondii	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0041
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0004	0.0003	0.0005
Entamoeba histolytica	P-glyco protein 6, putative	0.0025	0.0245	0.0508
Giardia lamblia	Inositol 5-phosphatase 4	0.0004	0.0003	0.0127
Toxoplasma gondii	ATP-binding cassette sub-family B member 5	0.0008	0.0044	0.07
Trichomonas vaginalis	carbon catabolite repressor protein, putative	0.0004	0.0003	0.0005
Toxoplasma gondii	ABC transporter transmembrane region domain-containing protein	0.0008	0.0044	0.07
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.055	0.1908
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0004	0.0003	0.0009
Brugia malayi	ABC transporter family protein	0.0008	0.0044	0.0152
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0033	0.0068
Echinococcus multilocularis	ATP binding cassette sub family B	0.0025	0.0242	0.0242
Schistosoma mansoni	hypothetical protein	0.043	0.502	1
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0004	0.0003	0.0009
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0025	0.0245	0.5
Schistosoma mansoni	multidrug resistance protein	0.0008	0.0044	0.0087
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0025	0.0245	0.0508
Entamoeba histolytica	P-glycoprotein-2, putative	0.0008	0.0041	0.0084
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0004	0.0003	0.0009
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.0041	0.0081
Schistosoma mansoni	neutral sphingomyelinase	0.0004	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0245	0.0851
Plasmodium falciparum	multidrug resistance-associated protein 1	0.0008	0.0044	0.0091
Echinococcus multilocularis	ATP binding cassette sub family B	0.0008	0.0044	0.0044
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0008	0.0044	0.0091
Echinococcus granulosus	multidrug resistance protein 1	0.0025	0.0245	0.0489
Echinococcus multilocularis	dnaJ subfamily B	0.043	0.502	0.502
Entamoeba histolytica	ATP-binding cassette protein, putative	0.0008	0.0044	0.0091
Entamoeba histolytica	sphingomyelinase C precursor, putative	0.0004	0.0003	0.0005
Leishmania major	ABC-thiol transporter	0.0008	0.0044	0.0091
Entamoeba histolytica	P-glycoprotein-2	0.0025	0.0245	0.0508
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0025	0.0245	0.0245
Plasmodium falciparum	endonuclease/exonuclease/phosphatase family protein, putative	0.0004	0.0003	0.0005
Mycobacterium ulcerans	transmembrane ABC transporter ATP-binding protein	0.0008	0.0044	0.2171
Echinococcus granulosus	traf and tnf receptor associated protein	0.0004	0.0003	0.0005
Plasmodium falciparum	DNase I-like protein, putative	0.0004	0.0003	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0414	0.483	1
Echinococcus granulosus	multidrug resistance associated protein 7	0.0008	0.0044	0.0087
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0202	0.1169
Echinococcus multilocularis	cpg binding protein	0.0032	0.0328	0.0328
Brugia malayi	CXXC zinc finger family protein	0.003	0.0308	0.1069
Plasmodium vivax	exodeoxyribonuclease III, putative	0.0004	0.0003	0.0005
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0025	0.0245	0.0489
Leishmania major	ATP-binding cassette protein subfamily B, member 1, putative	0.0008	0.0044	0.0091
Echinococcus granulosus	ATP binding cassette sub family B	0.0008	0.0044	0.0087
Leishmania major	RNA-editing complex protein MP100, putative	0.0004	0.0003	0.0005
Entamoeba histolytica	endonuclease/exonuclease/phosphatase family protein	0.0004	0.0003	0.0005
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.0025	0.0245	0.0508
Giardia lamblia	MRP-like ABC transporter	0.0008	0.0044	0.2171
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0004	0.0003	0.0003
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.0008	0.0041	0.0084
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0004	0.0003	0.0005
Echinococcus multilocularis	ATP binding cassette sub family B	0.0008	0.0044	0.0044
Echinococcus granulosus	multidrug resistance protein 1	0.0017	0.0157	0.0312
Entamoeba histolytica	P-glycoprotein 6, putative	0.0008	0.0044	0.0091
Trichomonas vaginalis	helicase, putative	0.0007	0.0033	0.0068
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0004	0.0003	0.0003
Brugia malayi	ABC transporter transmembrane region family protein	0.0008	0.0044	0.0152
Leishmania major	hypothetical protein, conserved	0.0004	0.0003	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0041	0.0084
Plasmodium falciparum	ABC transporter B family member 4, putative	0.0008	0.0044	0.0091
Trypanosoma brucei	DNA-(apurinic or apyrimidinic site) lyase, putative	0.0004	0.0003	0.0015
Loa Loa (eye worm)	ABC transporter	0.0008	0.0044	0.0152
Mycobacterium ulcerans	drugs-transport transmembrane ATP-binding protein ABC transporter	0.0008	0.0044	0.2171
Echinococcus granulosus	cpg binding protein	0.0032	0.0328	0.0654
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0044	0.0152
Brugia malayi	multidrug resistance protein 3	0.0025	0.0245	0.0851
Brugia malayi	multidrug resistance related protein 1	0.0008	0.0044	0.0152
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.0025	0.0245	0.0508

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 223 nM	Inhibition of human recombinant full length arginase I overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	ChEMBL.	23472952
IC50 (binding)	= 509 nM	Inhibition of human recombinant fully active truncated form of arginase 2 overexpressed in Escherichia coli BL21(DE3) assessed as inhibition of urea formation after 60 mins by spectrophotometric analysis	ChEMBL.	23472952
IC50 (binding)	= 3 uM	Inhibition of human arginase 1 transfected in CHO cells assessed as inhibition of urea formation after 24 hrs by spectrophotometric analysis	ChEMBL.	23472952
Ratio IC50 (binding)	= 50	Selectivity ratio of IC50 for human arginase 1 transfected in CHO cells to IC50 for human arginase 1	ChEMBL.	23472952

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2326089

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1727999