Detailed information for compound 1728205

Basic information

Technical information
  • TDR Targets ID: 1728205
  • Name: 4-[methyl-(5,5,8,8-tetramethyl-6,7-dihydronap hthalen-2-yl)amino]benzoic acid
  • MW: 337.455 | Formula: C22H27NO2
  • H donors: 1 H acceptors: 2 LogP: 6.26 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc2c(c1)C(C)(C)CCC2(C)C)c1ccc(cc1)C(=O)O
  • InChi: 1S/C22H27NO2/c1-21(2)12-13-22(3,4)19-14-17(10-11-18(19)21)23(5)16-8-6-15(7-9-16)20(24)25/h6-11,14H,12-13H2,1-5H3,(H,24,25)
  • InChiKey: HATHCUUYHJQEAP-UHFFFAOYSA-N  

Network

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Synonyms

  • 4-[methyl-(1,1,4,4-tetramethyltetralin-6-yl)amino]benzoic acid
  • 4-[methyl-(1,1,4,4-tetramethyl-6-tetralinyl)amino]benzoic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0159 0.3317 0.3276
Trypanosoma cruzi aldo-keto reductase 0.0199 0.4603 0.457
Brugia malayi Cell division protein ftsZ 0.0079 0.0754 0.0698
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0199 0.4603 0.457
Loa Loa (eye worm) hypothetical protein 0.0238 0.5863 0.5863
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Schistosoma mansoni alpha tubulin 0.0238 0.5863 0.5837
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.1208 0.1154
Brugia malayi alpha-tubulin 0.0238 0.5863 0.5837
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.1208 0.1154
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin alpha chain 0.0238 0.5863 0.5837
Loa Loa (eye worm) tubulin alpha chain 0.0238 0.5863 0.5863
Mycobacterium ulcerans oxidoreductase 0.0199 0.4603 0.55
Echinococcus multilocularis peroxisome assembly protein 26 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin gamma chain, putative 0.0079 0.0754 0.0698
Onchocerca volvulus 0.0199 0.4603 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Treponema pallidum cell division protein FtsZ 0.0079 0.0754 0.5
Echinococcus granulosus aldehyde reductase 0.0141 0.2751 0.2706
Mycobacterium ulcerans cell division protein FtsZ 0.0079 0.0754 0.084
Trypanosoma brucei alpha tubulin 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin alpha 1C chain 0.0238 0.5863 0.5837
Plasmodium falciparum tubulin delta chain, putative 0.0079 0.0754 0.0698
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0199 0.4603 0.457
Loa Loa (eye worm) tubulin alpha-2 chain 0.0238 0.5863 0.5863
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Trypanosoma brucei zeta tubulin, putative 0.0079 0.0754 0.0698
Brugia malayi Tubulin alpha chain 0.0238 0.5863 0.5837
Echinococcus granulosus Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Toxoplasma gondii alpha tubulin TUBA1 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin delta chain 0.0079 0.0754 0.0698
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Echinococcus granulosus Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin epsilon chain, putative 0.0079 0.0754 0.0698
Plasmodium falciparum tubulin gamma chain 0.0182 0.4071 0.4035
Brugia malayi Tubulin beta chain 0.0079 0.0754 0.0698
Schistosoma mansoni hypothetical protein 0.0166 0.3554 0.3515
Loa Loa (eye worm) tubulin alpha chain 0.0238 0.5863 0.5863
Trichomonas vaginalis tubulin alpha chain, putative 0.0103 0.1526 0.1474
Trypanosoma cruzi tubulin gamma chain 0.0182 0.4071 0.4035
Trypanosoma brucei epsilon tubulin 0.0182 0.4071 0.4035
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0754 0.0698
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin alpha chain, putative 0.0103 0.1526 0.1474
Schistosoma mansoni tubulin subunit alpha 0.0238 0.5863 0.5837
Entamoeba histolytica hypothetical protein 0.0289 0.7492 0.7477
Echinococcus granulosus tubulin alpha 0.0182 0.4071 0.4035
Echinococcus granulosus tubulin alpha chain 0.0238 0.5863 0.5837
Loa Loa (eye worm) oxidoreductase 0.0199 0.4603 0.4603
Loa Loa (eye worm) tubulin alpha 2 0.0159 0.3317 0.3317
Onchocerca volvulus 0.0199 0.4603 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Trypanosoma cruzi aldo/keto reductase, putative 0.0199 0.4603 0.457
Echinococcus granulosus geminin 0.0166 0.3554 0.3515
Giardia lamblia Alpha-tubulin 0.0238 0.5863 0.5525
Schistosoma mansoni hypothetical protein 0.0289 0.7492 0.7477
Echinococcus multilocularis tubulin alpha 3 chain 0.0238 0.5863 0.5837
Echinococcus multilocularis protoporphyrinogen oxidase 0.0314 0.8318 0.8308
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.1526 0.1474
Trichomonas vaginalis aldo/keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin gamma chain, putative 0.0182 0.4071 0.4035
Leishmania major epsilon tubulin, putative 0.0182 0.4071 0.4035
Trypanosoma brucei epsilon tubulin 0.0182 0.4071 0.4035
Schistosoma mansoni tubulin subunit epsilon 0.0182 0.4071 0.4035
Giardia lamblia Gamma tubulin 0.0182 0.4071 0.3588
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Brugia malayi tubulin alpha chain - mouse 0.0238 0.5863 0.5837
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Trypanosoma cruzi tubulin delta chain 0.0079 0.0754 0.0698
Brugia malayi Tubulin alpha-2 chain 0.0238 0.5863 0.5837
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0314 0.8318 1
Brugia malayi Tubulin gamma chain 0.0182 0.4071 0.4035
Trypanosoma brucei alpha tubulin, putative 0.0103 0.1526 0.1474
Trypanosoma cruzi alpha tubulin, putative 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Echinococcus granulosus tubulin alpha 1C chain 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin alpha chain, putative 0.0182 0.4071 0.4035
Loa Loa (eye worm) oxidoreductase 0.0199 0.4603 0.4603
Echinococcus multilocularis aldo keto reductase 0.0199 0.4603 0.457
Brugia malayi Tubulin alpha chain 0.0079 0.0754 0.0698
Brugia malayi Tubulin beta chain 0.0103 0.1526 0.1474
Echinococcus granulosus Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Loa Loa (eye worm) tubulin gamma chain 0.0182 0.4071 0.4071
Loa Loa (eye worm) alpha-tubulin 0.0238 0.5863 0.5863
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0199 0.4603 0.457
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0314 0.8318 1
Toxoplasma gondii aldose reductase, putative 0.0199 0.4603 0.457
Entamoeba histolytica aldose reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Entamoeba histolytica tubulin alpha-1 chain 0.0238 0.5863 0.5837
Schistosoma mansoni tubulin subunit beta 0.0079 0.0754 0.0698
Loa Loa (eye worm) hypothetical protein 0.0159 0.3317 0.3317
Trypanosoma brucei alpha tubulin 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0079 0.0754 0.0698
Echinococcus granulosus tubulin gamma 1 chain 0.0182 0.4071 0.4035
Schistosoma mansoni transcription factor LCR-F1 0.0289 0.7492 0.7477
Echinococcus multilocularis aldo keto reductase 0.0199 0.4603 0.457
Loa Loa (eye worm) alpha-tubulin 0.0238 0.5863 0.5863
Echinococcus multilocularis aldehyde reductase 0.0141 0.2751 0.2706
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin, putative 0.0103 0.1526 0.1474
Trichomonas vaginalis tubulin, putative 0.0103 0.1526 0.1474
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Echinococcus granulosus tubulin alpha chain 0.0238 0.5863 0.5837
Plasmodium vivax tubulin alpha chain, putative 0.0238 0.5863 0.5837
Onchocerca volvulus 0.0103 0.1526 0.3226
Echinococcus granulosus tubulin epsilon chain 0.0182 0.4071 0.4035
Echinococcus granulosus tubulin alpha 3 chain 0.0238 0.5863 0.5837
Entamoeba histolytica hypothetical protein 0.0289 0.7492 0.7477
Echinococcus multilocularis hypothetical protein 0.0238 0.5863 0.5837
Leishmania major gamma-tubulin 0.0182 0.4071 0.4035
Plasmodium vivax delta tubulin, putative 0.0079 0.0754 0.0698
Giardia lamblia Aldose reductase 0.0199 0.4603 0.4162
Schistosoma mansoni aldo-keto reductase 0.0199 0.4603 0.457
Plasmodium vivax tubulin gamma chain, putative 0.0182 0.4071 0.4035
Entamoeba histolytica aldose reductase, putative 0.0199 0.4603 0.457
Trypanosoma brucei alpha tubulin 0.0238 0.5863 0.5837
Plasmodium vivax tubulin alpha chain, putative 0.0238 0.5863 0.5837
Mycobacterium tuberculosis Cell division protein FtsZ 0.0079 0.0754 0.1001
Trypanosoma cruzi zeta tubulin, putative 0.0079 0.0754 0.0698
Trypanosoma brucei zeta tubulin 0.0079 0.0754 0.0698
Onchocerca volvulus 0.0199 0.4603 1
Plasmodium falciparum alpha tubulin 2 0.0238 0.5863 0.5837
Echinococcus granulosus tubulin subunit TubB 0.0238 0.5863 0.5837
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Loa Loa (eye worm) tubulin beta chain 0.0079 0.0754 0.0754
Trichomonas vaginalis tubulin gamma chain, putative 0.0182 0.4071 0.4035
Trichomonas vaginalis tubulin epsilon chain, putative 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0289 0.7492 0.7477
Plasmodium falciparum alpha tubulin 1 0.0238 0.5863 0.5837
Entamoeba histolytica hypothetical protein 0.0289 0.7492 0.7477
Echinococcus granulosus alpha tubulin 0.0238 0.5863 0.5837
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0289 0.7492 0.7477
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0238 0.5863 0.5837
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Echinococcus multilocularis tubulin alpha 1C chain 0.0238 0.5863 0.5837
Schistosoma mansoni aldo-keto reductase 0.0199 0.4603 0.457
Echinococcus multilocularis kelch ECH associated protein 1 0.0093 0.1208 0.1154
Onchocerca volvulus 0.0199 0.4603 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0079 0.0754 0.0698
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0199 0.4603 0.457
Echinococcus multilocularis tubulin alpha chain 0.0238 0.5863 0.5837
Brugia malayi tubulin alpha-2 chain 0.0238 0.5863 0.5837
Schistosoma mansoni tubulin subunit alpha 0.0238 0.5863 0.5837
Echinococcus granulosus tubulin alpha 3 chain 0.0238 0.5863 0.5837
Trypanosoma brucei epsilon tubulin 0.0182 0.4071 0.4035
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0079 0.0754 0.5
Giardia lamblia Aldose reductase 0.0199 0.4603 0.4162
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Trichomonas vaginalis aldo/keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin epsilon chain, putative 0.0238 0.5863 0.5837
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0058 0.0061 0.0061
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0273 0.6988 1
Chlamydia trachomatis protoporphyrinogen oxidase 0.0314 0.8318 0.5
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0159 0.3317 0.3317
Echinococcus granulosus hypothetical protein 0.0199 0.4603 0.457
Mycobacterium leprae Conserved hypothetical protein 0.0141 0.2751 0.3257
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Loa Loa (eye worm) oxidoreductase 0.0199 0.4603 0.4603
Trypanosoma cruzi zeta tubulin, putative 0.0079 0.0754 0.0698
Loa Loa (eye worm) tubulin alpha-3 chain 0.0135 0.2545 0.2545
Loa Loa (eye worm) tubulin alpha 2 0.0159 0.3317 0.3317
Plasmodium vivax tubulin epsilon chain, putative 0.0182 0.4071 0.4035
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0314 0.8318 0.8308
Leishmania major prostaglandin f synthase, putative 0.0199 0.4603 0.457
Echinococcus multilocularis tubulin alpha chain 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Echinococcus granulosus kelch ECH associated protein 1 like 0.0093 0.1208 0.1154
Entamoeba histolytica tubulin alpha chain, putative 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo/keto reductase, putative 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Leishmania major aldo-keto reductase-like protein 0.0199 0.4603 0.457
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Trypanosoma brucei tubulin delta chain 0.0079 0.0754 0.0698
Trypanosoma cruzi tubulin delta chain 0.0079 0.0754 0.0698
Brugia malayi hypothetical protein 0.0289 0.7492 0.7477
Schistosoma mansoni alpha tubulin 0.0238 0.5863 0.5837
Loa Loa (eye worm) hypothetical protein 0.0199 0.4603 0.4603
Leishmania major zeta tubulin, putative 0.0079 0.0754 0.0698
Trypanosoma brucei prostaglandin f synthase 0.0199 0.4603 0.457
Schistosoma mansoni tubulin subunit gamma 0.0182 0.4071 0.4035
Echinococcus multilocularis geminin 0.0166 0.3554 0.3515
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0199 0.4603 0.457
Schistosoma mansoni hypothetical protein 0.0093 0.1216 0.1163
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Trypanosoma brucei tubulin gamma chain 0.0182 0.4071 0.4035
Schistosoma mansoni tubulin subunit alpha 0.0238 0.5863 0.5837
Trichomonas vaginalis tubulin, putative 0.0079 0.0754 0.0698
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0199 0.4603 0.457
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Echinococcus granulosus aldo keto reductase 0.0199 0.4603 0.457
Entamoeba histolytica tubulin gamma chain 0.0182 0.4071 0.4035
Toxoplasma gondii alpha-tubulin I, putative 0.0238 0.5863 0.5837
Loa Loa (eye worm) oxidoreductase 0.0199 0.4603 0.4603
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0199 0.4603 0.457
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Brugia malayi Tubulin alpha-2 chain 0.0238 0.5863 0.5837
Trypanosoma brucei alpha tubulin 0.0238 0.5863 0.5837
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Echinococcus multilocularis Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Echinococcus granulosus protoporphyrinogen oxidase 0.0273 0.6988 0.697
Loa Loa (eye worm) oxidoreductase 0.0199 0.4603 0.4603
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Echinococcus granulosus tubulin delta chain 0.0079 0.0754 0.0698
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0079 0.0754 0.0698
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Leishmania major delta tubulin, putative 0.0079 0.0754 0.0698
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0182 0.4071 0.4035
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0754 0.0698
Echinococcus granulosus tubulin alpha chain 0.0238 0.5863 0.5837
Echinococcus multilocularis aldo keto reductase 0.0199 0.4603 0.457
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Trypanosoma brucei aldo-keto reductase, putative 0.0199 0.4603 0.457
Echinococcus multilocularis Tubulin alpha 1 chain 0.0238 0.5863 0.5837
Schistosoma mansoni hypothetical protein 0.0166 0.3554 0.3515
Giardia lamblia Alpha-tubulin 0.0238 0.5863 0.5525
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin alpha chain, putative 0.0103 0.1526 0.1474
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0199 0.4603 0.457
Entamoeba histolytica hypothetical protein 0.0289 0.7492 0.7477
Onchocerca volvulus 0.0199 0.4603 1
Echinococcus multilocularis aldo keto reductase 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0103 0.1526 0.1474
Echinococcus multilocularis Kelch repeat type 1 0.0093 0.1216 0.1163
Schistosoma mansoni tubulin subunit delta 0.0079 0.0754 0.0698
Trypanosoma cruzi epsilon tubulin, putative 0.0182 0.4071 0.4035
Trypanosoma brucei beta tubulin 0.0182 0.4071 0.4035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0199 0.4603 0.457
Echinococcus granulosus aldo keto reductase 0.0199 0.4603 0.457
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin alpha chain 0.0238 0.5863 0.5837
Entamoeba histolytica aldose reductase, putative 0.0199 0.4603 0.457
Echinococcus granulosus aldo keto reductase 0.0199 0.4603 0.457
Trypanosoma cruzi epsilon tubulin, putative 0.0182 0.4071 0.4035
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Mycobacterium tuberculosis Probable oxidoreductase 0.0199 0.4603 0.6556
Echinococcus multilocularis tubulin alpha chain 0.0238 0.5863 0.5837
Mycobacterium leprae cell division protein FtsZ 0.0079 0.0754 0.084
Echinococcus granulosus peroxisome assembly protein 26 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Onchocerca volvulus 0.0199 0.4603 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Leishmania major alpha tubulin 0.0238 0.5863 0.5837
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0199 0.4603 0.457
Echinococcus granulosus tubulin alpha chain 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin alpha 3 chain 0.0238 0.5863 0.5837
Schistosoma mansoni pol-related 0.0199 0.4603 0.457
Plasmodium falciparum tubulin epsilon chain, putative 0.0182 0.4071 0.4035
Echinococcus granulosus tubulin alpha chain 0.0238 0.5863 0.5837
Echinococcus granulosus tubulin alpha 1C chain 0.0238 0.5863 0.5837
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Echinococcus granulosus kelch ECH associated protein 1 0.0093 0.1208 0.1154
Schistosoma mansoni tubulin subunit alpha 0.0079 0.0754 0.0698
Echinococcus multilocularis tubulin subunit TubB 0.0238 0.5863 0.5837
Echinococcus multilocularis tubulin gamma 1 chain 0.0182 0.4071 0.4035
Echinococcus multilocularis tubulin alpha 0.0182 0.4071 0.4035
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Trichomonas vaginalis aldo-keto reductase, putative 0.0199 0.4603 0.457
Echinococcus multilocularis tubulin epsilon chain 0.0182 0.4071 0.4035
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0135 0.2545 0.25
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0199 0.4603 0.55
Loa Loa (eye worm) hypothetical protein 0.0135 0.2545 0.2545
Schistosoma mansoni alpha tubulin 0.0238 0.5863 0.5837
Leishmania major alpha tubulin 0.0238 0.5863 0.5837

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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