Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0059 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0059 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0059 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0059 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0059 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0059 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0059 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0059 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0059 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0059 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0059 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0059 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0059 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0059 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0059 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.7 | Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | = 2.45 | Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | = 3.04 | Inhibition of mouse mGAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 3.42 | Inhibition of mouse mGAT4 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 3.48 | Inhibition of mouse mGAT3 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 4.02 | Inhibition of mouse mGAT2 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 50 uM | Inhibition of [3H]GABA uptake at mouse GAT2 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | = 94.9 uM | Inhibition of mouse mGAT2 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 281 uM | Inhibition of [3H]GABA uptake at mouse GAT3 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 300 uM | Inhibition of [3H]GABA uptake at mouse GAT4 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | > 300 uM | Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysis | ChEMBL. | 23398473 |
IC50 (binding) | = 328 uM | Inhibition of mouse mGAT3 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 380 uM | Inhibition of mouse mGAT4 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
IC50 (binding) | = 917 uM | Inhibition of mouse mGAT1 expressed in HEK293 cells assessed as inhibition of [3H]GABA uptake after 3 mins incubation by TopCount microplate scintillation counting analysis | ChEMBL. | 25882526 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.