Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sodium channel, voltage-gated, type IX, alpha subunit | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | steroid hormone receptor | 0.0218 | 0.0489 | 0.0769 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0218 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1452 | 0.6365 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0218 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0218 | 0.0489 | 0.0518 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | nuclear hormone receptor | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | nuclear hormone receptor | 0.0218 | 0.0489 | 0.0489 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0218 | 0.0489 | 0.0489 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0218 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | ecdysteroid receptor | 0.0218 | 0.0489 | 0.0769 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0218 | 0.0489 | 0.0489 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.0489 | 0.0518 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.135 | 0.5876 | 0.9231 |
Brugia malayi | nuclear receptor NHR-88 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.0489 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0218 | 0.0489 | 0.0489 |
Echinococcus granulosus | FTZ F1 alpha | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.2101 | 0.9452 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | nuclear hormone receptor | 0.1452 | 0.6365 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0218 | 0.0489 | 0.0489 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0218 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.0489 | 0.0489 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | steroid hormone receptor | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0218 | 0.0489 | 0.0769 |
Schistosoma mansoni | coup transcription factor | 0.0218 | 0.0489 | 0.0489 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.0489 | 0.0489 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0218 | 0.0489 | 0.0518 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0218 | 0.0489 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0218 | 0.0489 | 0.0769 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0218 | 0.0489 | 0.0769 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0218 | 0.0489 | 0.0518 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0218 | 0.0489 | 0.0769 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0218 | 0.0489 | 0.0518 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0218 | 0.0489 | 0.0518 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1568 | 0.6913 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0218 | 0.0489 | 0.0489 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0218 | 0.0489 | 0.0489 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0218 | 0.0489 | 0.0518 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 0.0489 | 0.0769 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.2757 | Inhibition of NaV1.7 ion channel (unknown origin) | ChEMBL. | 23177785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.