Detailed information for compound 172867

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.4 | Formula: C16H25N5O5
  • H donors: 5 H acceptors: 7 LogP: -0.17 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](Nc1ncnc2c1ncn2C1OC(C(C1O)O)CO)CC(C)C
  • InChi: 1S/C16H25N5O5/c1-8(2)3-9(4-22)20-14-11-15(18-6-17-14)21(7-19-11)16-13(25)12(24)10(5-23)26-16/h6-10,12-13,16,22-25H,3-5H2,1-2H3,(H,17,18,20)/t9-,10?,12?,13?,16?/m1/s1
  • InChiKey: IFXXETIETNTLBL-SGGKBPMUSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax vivapain-3 0.045 0.3944 0.3927
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Schistosoma mansoni RNA binding protein 0.0396 0.3457 0.3438
Echinococcus granulosus SWI:SNF matrix associated 0.1114 1 1
Echinococcus multilocularis pyruvate kinase 0.0065 0.0438 0.0411
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1361 0.134
Schistosoma mansoni hypothetical protein 0.0042 0.0223 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.0065 0.0438 0.0415
Trypanosoma cruzi WLM domain containing protein, putative 0.0396 0.3457 0.447
Schistosoma mansoni brg-1 associated factor 0.1114 1 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0865 0.7732 0.7726
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0126 0.0099
Onchocerca volvulus 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Onchocerca volvulus Cathepsin L homolog 0.0865 0.7732 0.7726
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.1361 0.1338
Plasmodium falciparum pyruvate kinase 2 0.0033 0.0148 0.0121
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0396 0.3457 0.4451
Onchocerca volvulus 0.0396 0.3457 0.3438
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Plasmodium vivax serine-repeat antigen (SERA) 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.013 0.0106
Echinococcus multilocularis cathepsin L cysteine protease 0.0865 0.7732 0.7726
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Plasmodium falciparum hexose transporter 0.0101 0.0766 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.005 0.0022
Echinococcus multilocularis cysteine protease 0.0865 0.7732 0.7726
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Plasmodium vivax serine-repeat antigen (SERA) 0.0166 0.1361 0.1338
Echinococcus granulosus Zinc finger RanBP2 type 0.0396 0.3457 0.3438
Giardia lamblia Hypothetical protein 0.0166 0.1361 0.6372
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Onchocerca volvulus 0.0396 0.3457 0.3438
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0438 0.0414
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0166 0.1361 0.134
Onchocerca volvulus 0.0865 0.7732 0.7726
Entamoeba histolytica cysteine proteinase, putative 0.0865 0.7732 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0166 0.1361 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.025 0.2121 0.2717
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0126 0.0099
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0223 0.0196
Echinococcus multilocularis pyruvate kinase 0.0065 0.0438 0.0411
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Toxoplasma gondii cathepsin CPC1 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin F (C01 family) 0.0582 0.5149 0.5136
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis ion channel nompc, putative 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.0865 0.7732 1
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Trypanosoma cruzi hexose transporter 0.0031 0.013 0.0168
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0163 0.1334 0.131
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0109 0.0081
Loa Loa (eye worm) ctsf protein 0.0865 0.7732 0.7726
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Echinococcus multilocularis cathepsin L 0.045 0.3944 0.3927
Echinococcus multilocularis cysteine protease 0.0865 0.7732 0.7726
Trypanosoma brucei glucose transporter 2A 0.0031 0.013 0.0133
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0126 0.0099
Trichomonas vaginalis sex-determining protein fem-1, putative 0.002 0.0027 0.0003
Onchocerca volvulus 0.0396 0.3457 0.3438
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Toxoplasma gondii cathepsin CPL 0.0865 0.7732 0.7726
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0396 0.3457 0.447
Onchocerca volvulus 0.0865 0.7732 0.7726
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Loa Loa (eye worm) brahma associated protein 0.1114 1 1
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0166 0.0215
Schistosoma mansoni hypothetical protein 0.1114 1 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.002 0.0027 0.0003
Mycobacterium leprae Probable pyruvate kinase PykA 0.0065 0.0438 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0582 0.5149 0.666
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0865 0.7732 0.7726
Loa Loa (eye worm) hypothetical protein 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica cysteine proteinase, putative 0.0865 0.7732 1
Brugia malayi B-box zinc finger family protein 0.002 0.0027 0.0004
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.005 0.0022
Echinococcus granulosus pyruvate kinase 0.0065 0.0438 0.0411
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Brugia malayi SWIB/MDM2 domain containing protein 0.1114 1 1
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0166 0.1361 0.1341
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0126 0.0099
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Echinococcus granulosus cathepsin b 0.0436 0.3817 0.38
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0109 0.0081
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0865 0.7732 0.7726
Echinococcus multilocularis cathepsin b 0.0436 0.3817 0.38
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Brugia malayi Sugar transporter family protein 0.0101 0.0766 0.0744
Toxoplasma gondii cathepsin B 0.025 0.2121 0.2099
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0126 0.0099
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0396 0.3457 0.447
Brugia malayi cathepsin L-like cysteine proteinase 0.0166 0.1361 0.1341
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Plasmodium vivax hexose transporter 0.0101 0.0766 0.074
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0223 0.0196
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Brugia malayi RING zinc finger protein 0.002 0.0027 0.0004
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0166 0.1361 0.1338
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Leishmania major cysteine peptidase A (CPA) 0.0865 0.7732 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi Cathepsin L-like cysteine proteinase 0.0582 0.5149 0.5138
Echinococcus multilocularis pyruvate kinase 0.0051 0.0312 0.0286
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0126 0.0128
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Brugia malayi RING finger protein 20 0.002 0.0027 0.0004
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0283 0.2426 0.2406
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0865 0.7732 0.7726
Trichomonas vaginalis conserved hypothetical protein 0.1114 1 1
Schistosoma mansoni fusion 0.0396 0.3457 0.3438
Schistosoma mansoni cathepsin C 0.0166 0.1361 0.1338
Trypanosoma cruzi cruzipain precursor, putative 0.0283 0.2426 0.3138
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.005 0.0022
Plasmodium falciparum pyruvate kinase 0.0065 0.0438 0.0411
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Schistosoma mansoni cathepsin s 0.0283 0.2426 0.2406
Plasmodium falciparum serine repeat antigen 8 0.0166 0.1361 0.1338
Plasmodium vivax CDK-related protein kinase 6, putative 0.0429 0.3758 0.374
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0166 0.1361 0.134
Leishmania major glucose transporter/membrane transporter D2, putative 0.0031 0.013 0.0133
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Schistosoma mansoni hypothetical protein 0.1114 1 1
Schistosoma mansoni pyruvate kinase 0.0065 0.0438 0.0411
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0065 0.0438 1
Trichomonas vaginalis glucose transporter, putative 0.0031 0.013 0.0106
Schistosoma mansoni pyruvate kinase 0.0033 0.0148 0.0121
Brugia malayi cathepsin Z-like cysteine proteinase 0.0166 0.1361 0.1341
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0093
Loa Loa (eye worm) fibroinase 0.0865 0.7732 0.7726
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Brugia malayi brahma associated protein 60 kDa 0.1114 1 1
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.002 0.0027 0.0003
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Plasmodium falciparum serine repeat antigen 3 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Trypanosoma brucei pyruvate kinase 1, putative 0.0065 0.0438 0.0532
Echinococcus granulosus General substrate transporter 0.0087 0.0636 0.061
Trichomonas vaginalis glucose transporter, putative 0.0031 0.013 0.0106
Brugia malayi fibroinase precursor 0.0166 0.1361 0.1341
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.005 0.0105
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.005 0.0022
Schistosoma mansoni pyruvate kinase 0.0065 0.0438 0.0411
Giardia lamblia Hypothetical protein 0.0166 0.1361 0.6372
Schistosoma mansoni cathepsin F (C01 family) 0.0865 0.7732 0.7726
Schistosoma mansoni hypothetical protein 0.0396 0.3457 0.3438
Brugia malayi Cathepsin L-like precursor 0.0582 0.5149 0.5138
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1114 1 1
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Echinococcus multilocularis SWI:SNF matrix associated 0.1114 1 1
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.005 0.0029
Chlamydia trachomatis pyruvate kinase 0.0065 0.0438 0.039
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0766 0.0744
Giardia lamblia Kinase, NEK 0.0022 0.0045 0.0084
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0166 0.1361 0.1338
Echinococcus granulosus cathepsin L cysteine proteinase 0.0865 0.7732 0.7726
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Echinococcus granulosus cathepsin L 0.0166 0.1361 0.1338
Entamoeba histolytica pyruvate kinase, putative 0.0045 0.0258 0.0299
Entamoeba histolytica hypothetical protein 0.0166 0.1361 0.1731
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0035 0.0166 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Echinococcus multilocularis cathepsin L 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0065 0.0438 0.0411
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Onchocerca volvulus 0.0865 0.7732 0.7726
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi hypothetical protein, conserved 0.0396 0.3457 0.447
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi Cathepsin L-like precursor 0.0582 0.5149 0.5138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0045 0.0018
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0396 0.3457 0.3438
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0028 0.0036
Echinococcus granulosus cathepsin b 0.0436 0.3817 0.38
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.5149 0.5138
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0223 0.0196
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0126 0.0103
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0283 0.2426 0.2409
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Leishmania major pyruvate kinase 0.0065 0.0438 0.0532
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0396 0.3457 0.3438
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Giardia lamblia Kinase 0.0022 0.0045 0.0084
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.005 0.0022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.025 0.2121 0.2743
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Trypanosoma cruzi cysteine proteinase, putative 0.045 0.3944 0.5101
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0045 0.0258 0.0231
Chlamydia trachomatis DNA topoisomerase I 0.1114 1 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.003 0.012 0.0097
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1114 1 1
Brugia malayi YY1-associated factor 2 0.0396 0.3457 0.3441
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi cathepsin F-like cysteine proteinase 0.0283 0.2426 0.2409
Trypanosoma cruzi cysteine protease, putative 0.045 0.3944 0.5101
Echinococcus granulosus cathepsin l cysteine peptidase 0.0865 0.7732 0.7726
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.002 0.0028 0.0036
Toxoplasma gondii pyruvate kinase PyK1 0.0065 0.0438 0.0411
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Plasmodium vivax unspecified product 0.045 0.3944 0.3927
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1114 1 1
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Echinococcus multilocularis General substrate transporter 0.0087 0.0636 0.061
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Plasmodium vivax pyruvate kinase 2, putative 0.0033 0.0148 0.0121
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0166 0.1361 0.1338
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Schistosoma mansoni TRABID protein (C64 family) 0.0396 0.3457 0.3438
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.003 0.012 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Plasmodium vivax unspecified product 0.0166 0.1361 0.1338
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Toxoplasma gondii ran binding protein 0.0396 0.3457 0.3438
Plasmodium vivax vivapain-1 0.045 0.3944 0.3927
Onchocerca volvulus Cathepsin L homolog 0.0865 0.7732 0.7726
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0126 0.0099
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus ring and YY1 binding protein 0.0396 0.3457 0.3438
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0436 0.3817 0.38
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0126 0.0099
Toxoplasma gondii preprocathepsin c precursor, putative 0.0166 0.1361 0.1338
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Schistosoma mansoni cathepsin S (C01 family) 0.0166 0.1361 0.1338
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.005 0.0064
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0166 0.1361 0.1338
Leishmania major glucose transporter, lmgt2 0.0031 0.013 0.0133
Plasmodium vivax hypothetical protein, conserved 0.1114 1 1
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.003 0.012 0.012
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0126 0.0102
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.005 0.0022
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0126 0.0099
Loa Loa (eye worm) hypothetical protein 0.003 0.012 0.0093
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Loa Loa (eye worm) sugar transporter 0.0101 0.0766 0.074
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0436 0.3817 0.38
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trypanosoma cruzi cysteine proteinase, putative 0.045 0.3944 0.5101
Brugia malayi Cathepsin L-like precursor 0.0283 0.2426 0.2409
Onchocerca volvulus Cathepsin L homolog 0.0166 0.1361 0.1338
Brugia malayi Zinc finger, C2H2 type family protein 0.002 0.0027 0.0004
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0166 0.1361 0.1338
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Plasmodium falciparum serine repeat antigen 6 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0166 0.1361 0.1338
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Trypanosoma cruzi cysteine peptidase, putative 0.045 0.3944 0.5101
Schistosoma mansoni protein kinase 0.0031 0.0126 0.0099
Trypanosoma brucei glucose transporter 1E 0.0031 0.013 0.0133
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1114 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Brugia malayi Pyruvate kinase, muscle isozyme 0.0065 0.0438 0.0415
Schistosoma mansoni hypothetical protein 0.0101 0.0766 0.074
Brugia malayi Cam kinase protein 1 0.0031 0.0126 0.0103
Loa Loa (eye worm) hypothetical protein 0.0283 0.2426 0.2406
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1114 1 1
Plasmodium falciparum serine repeat antigen 5 0.0166 0.1361 0.1338
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0126 0.0099
Trichomonas vaginalis ankyrin, putative 0.002 0.0027 0.0003
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Brugia malayi Zinc finger protein 183 homolog 0.002 0.0027 0.0004
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Giardia lamblia Pyruvate kinase 0.0033 0.0148 0.0578
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.0766 0.074
Echinococcus granulosus cysteine protease 0.045 0.3944 0.3927
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0126 0.0099
Plasmodium falciparum proline--tRNA ligase 0.0035 0.0166 0.0139
Entamoeba histolytica cysteine proteinase 2 0.045 0.3944 0.5083
Schistosoma mansoni glucose transport protein 0.0101 0.0766 0.074
Leishmania major glucose transporter, lmgt1 0.0031 0.013 0.0133
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.045 0.3944 0.5083
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Brugia malayi cathepsin B-like cysteine proteinase 0.0436 0.3817 0.3803
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.025 0.2121 0.2099
Giardia lamblia Pyruvate kinase 0.0065 0.0438 0.1959
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Echinococcus granulosus pyruvate kinase 0.0065 0.0438 0.0411
Entamoeba histolytica protein kinase, putative 0.0031 0.0126 0.0128
Onchocerca volvulus Cathepsin F homolog 0.0865 0.7732 0.7726
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0166 0.1361 0.1338
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi cysteine peptidase, putative 0.0283 0.2426 0.3138
Brugia malayi Papain family cysteine protease containing protein 0.045 0.3944 0.393
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0166 0.1361 0.1338
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.045 0.3944 0.5101
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0396 0.3457 0.447
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0166 0.1361 0.1338
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0438 0.0566
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0396 0.3457 0.3438
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.0766 0.074
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0166 0.1361 0.1731
Plasmodium falciparum cysteine proteinase falcipain 1 0.045 0.3944 0.3927
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0035 0.0166 0.0215
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Loa Loa (eye worm) cysteine protease 0.0865 0.7732 0.7726
Echinococcus multilocularis cathepsin L cysteine protease 0.0865 0.7732 0.7726
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin L precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0166 0.1361 0.1338
Echinococcus granulosus cathepsin l1 0.0582 0.5149 0.5136
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.002 0.0027 0.0003
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Entamoeba histolytica cysteine proteinase, putative 0.0582 0.5149 0.6648
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Schistosoma mansoni cathepsin B (C01 family) 0.0166 0.1361 0.1338
Onchocerca volvulus 0.0865 0.7732 0.7726
Brugia malayi cathepsin F-like cysteine proteinase 0.0166 0.1361 0.1341
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.1361 0.1761
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Toxoplasma gondii protein kinase, putative 0.0286 0.2449 0.2428
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0166 0.1361 0.1341
Trypanosoma cruzi cruzipain precursor, putative 0.0865 0.7732 1
Echinococcus multilocularis cathepsin b 0.0436 0.3817 0.38
Brugia malayi cathepsin L-like precursor 0.0582 0.5149 0.5138
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0436 0.3817 0.4937
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Plasmodium vivax proline--tRNA ligase, putative 0.0035 0.0166 0.0139
Plasmodium falciparum protein kinase 6 0.0429 0.3758 0.374
Entamoeba histolytica protein kinase, putative 0.0031 0.0126 0.0128
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0166 0.1361 0.6372
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Giardia lamblia Prolyl-tRNA synthetase 0.003 0.012 0.0443
Trichomonas vaginalis sugar transporter, putative 0.0031 0.013 0.0106
Brugia malayi hypothetical protein 0.0042 0.0223 0.02
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0166 0.1361 0.1338
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0126 0.0099
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Entamoeba histolytica hypothetical protein 0.0042 0.0223 0.0254
Trypanosoma brucei cysteine peptidase C (CPC) 0.025 0.2121 0.2717
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0396 0.3457 0.3438
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Leishmania major protein kinase, putative 0.0031 0.0126 0.0128
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1114 1 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0396 0.3457 0.4451
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trypanosoma brucei glucose transporter, putative 0.0031 0.013 0.0133
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.003 0.012 0.0093
Loa Loa (eye worm) hypothetical protein 0.0582 0.5149 0.5136
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.005 0.0029
Schistosoma mansoni hypothetical protein 0.1114 1 1
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.005 0.074
Loa Loa (eye worm) cathepsin B 0.025 0.2121 0.2099
Toxoplasma gondii cathepsin CPC2 0.0166 0.1361 0.1338
Trypanosoma brucei THT1 - hexose transporter, putative 0.0031 0.013 0.0133
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Onchocerca volvulus 0.0865 0.7732 0.7726
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Echinococcus granulosus pyruvate kinase 0.0033 0.0148 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Echinococcus granulosus zinc finger protein Ran binding 0.0396 0.3457 0.3438
Trypanosoma cruzi cysteine peptidase, putative 0.0865 0.7732 1
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Plasmodium falciparum protein kinase 7 0.0286 0.2449 0.2428
Trypanosoma brucei pyruvate kinase 1 0.0065 0.0438 0.0532
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.045 0.3944 0.393
Leishmania major glucose transporter, lmgt3 0.0031 0.013 0.0133
Schistosoma mansoni zinc finger protein 0.0396 0.3457 0.3438
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.005 0.0022
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Trypanosoma brucei hypothetical protein, conserved 0.0396 0.3457 0.4451
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0166 0.1361 0.1338
Echinococcus granulosus cathepsin L 0.045 0.3944 0.3927
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.025 0.2121 0.2102
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0396 0.3457 0.447
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Onchocerca volvulus 0.1114 1 1
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0163 0.1334 0.131
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Echinococcus multilocularis pyruvate kinase 0.0033 0.0148 0.0121
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0865 0.7732 0.7727
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Leishmania major pyruvate kinase 0.0065 0.0438 0.0532
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.045 0.3944 0.3927
Chlamydia trachomatis SWIB complex protein 0.1114 1 1
Trypanosoma cruzi hypothetical protein 0.002 0.0027 0.0036
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0166 0.1361 0.1338
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0099
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0035 0.0166 0.018
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Brugia malayi Papain family cysteine protease containing protein 0.0865 0.7732 0.7727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Trichomonas vaginalis conserved hypothetical protein 0.0166 0.1361 0.134
Plasmodium vivax unspecified product 0.0283 0.2426 0.2406
Trypanosoma brucei hypothetical protein, conserved 0.0396 0.3457 0.4451
Onchocerca volvulus 0.0865 0.7732 0.7726
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Plasmodium falciparum serine repeat antigen 9 0.0166 0.1361 0.1338
Echinococcus multilocularis ring and YY1 binding protein 0.0396 0.3457 0.3438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.045 0.3944 0.5083
Onchocerca volvulus Pyruvate kinase homolog 0.0065 0.0438 0.0411
Loa Loa (eye worm) hypothetical protein 0.0436 0.3817 0.38
Giardia lamblia Cysteine protease 0.0166 0.1361 0.6372
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0126 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.013 0.0106
Giardia lamblia Cathepsin L-like protease 0.0166 0.1361 0.6372
Trypanosoma cruzi major cysteine proteinase, putative 0.0166 0.1361 0.1761
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.003 0.012 0.0096
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1114 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0865 0.7732 1
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0166 0.1361 0.1338
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Brugia malayi Neuralized family protein 0.002 0.0027 0.0004
Plasmodium falciparum serine repeat antigen 7 0.0166 0.1361 0.1338
Plasmodium vivax pyruvate kinase, putative 0.0065 0.0438 0.0411
Giardia lamblia Cathepsin B precursor 0.025 0.2121 1
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.045 0.3944 0.393
Onchocerca volvulus 0.0865 0.7732 0.7726
Giardia lamblia Encystation-specific protease 0.0166 0.1361 0.6372
Plasmodium falciparum serine repeat antigen 4 0.0166 0.1361 0.1338
Giardia lamblia Kinase, NEK 0.0022 0.0045 0.0084
Loa Loa (eye worm) pyruvate kinase 0.0065 0.0438 0.0411
Plasmodium vivax vivapain-2 0.0865 0.7732 0.7726
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.012 0.0093
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0126 0.0099
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0126 0.0099
Trichomonas vaginalis pyruvate kinase, putative 0.0065 0.0438 0.0414
Plasmodium falciparum serine repeat antigen 2 0.0166 0.1361 0.1338
Plasmodium vivax vivapain-2 0.0865 0.7732 0.7726
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.003 0.012 0.243
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.005 0.0025
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0396 0.3457 0.3438
Entamoeba histolytica cysteine proteinase 1, putative 0.045 0.3944 0.5083
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Entamoeba histolytica hypothetical protein 0.0023 0.005 0.0029
Plasmodium falciparum serine repeat antigen 1 0.0166 0.1361 0.1338
Trypanosoma cruzi pyruvate kinase 2, putative 0.0065 0.0438 0.0566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Loa Loa (eye worm) hypothetical protein 0.0396 0.3457 0.3438
Trichomonas vaginalis hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Echinococcus multilocularis zinc finger protein Ran binding 0.0396 0.3457 0.3438
Trypanosoma cruzi hypothetical protein 0.002 0.0027 0.0036
Trypanosoma cruzi WLM domain containing protein, putative 0.0396 0.3457 0.447
Toxoplasma gondii pyruvate kinase PyKII 0.0033 0.0148 0.0121
Brugia malayi Papain family cysteine protease containing protein 0.045 0.3944 0.393
Loa Loa (eye worm) hypothetical protein 0.0166 0.1361 0.1338
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.002 0.0027 0.0004
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0126 0.0099
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0582 0.5149 0.5138
Brugia malayi Cathepsin L-like precursor 0.0865 0.7732 0.7727
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0166 0.1361 0.134
Brugia malayi lysyl-tRNA synthetase 0.0023 0.005 0.0026
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0396 0.3457 0.447
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0766 0.074
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0865 0.7732 0.7727
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1114 1 1
Trypanosoma cruzi hexose transporter, putative 0.0031 0.013 0.0168
Giardia lamblia Cathepsin B precursor 0.0166 0.1361 0.6372
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.002 0.0027 0.0003
Brugia malayi cathepsin L precursor 0.0166 0.1361 0.1341
Schistosoma mansoni cathepsin F (C01 family) 0.0865 0.7732 0.7726
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.003 0.012 0.0093
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0166 0.1361 0.134
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi Papain family cysteine protease containing protein 0.0166 0.1361 0.1341
Onchocerca volvulus 0.0396 0.3457 0.3438
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0865 0.7732 0.7726
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0166 0.1361 0.134
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0166 0.1361 0.1731
Entamoeba histolytica cysteine proteinase, putative 0.045 0.3944 0.5083
Loa Loa (eye worm) pyruvate kinase-PB 0.0045 0.0258 0.0231
Entamoeba histolytica cysteine protease, putative 0.045 0.3944 0.5083
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.002 0.0027 0.0003
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Giardia lamblia Cathepsin L-like protease 0.0166 0.1361 0.6372
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0036
Plasmodium falciparum mitogen-activated protein kinase 2 0.0163 0.1334 0.131
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0396 0.3457 0.3438
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0166 0.1361 0.1338
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0166 0.1361 0.6372
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.003 0.012 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0003
Brugia malayi hypothetical protein 0.002 0.0027 0.0004
Entamoeba histolytica cysteine protease, putative 0.0166 0.1361 0.1731
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.002 0.0027 0.0036
Echinococcus granulosus cathepsin L cysteine protease 0.045 0.3944 0.3927
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0396 0.3457 0.3441
Onchocerca volvulus 0.0582 0.5149 0.5136
Mycobacterium ulcerans pyruvate kinase 0.0065 0.0438 1
Leishmania major cathepsin L-like protease 0.0865 0.7732 1
Leishmania major hypothetical protein, conserved 0.0396 0.3457 0.4451
Echinococcus granulosus cathepsin l1 0.0865 0.7732 0.7726
Brugia malayi hypothetical protein 0.002 0.0027 0.0004

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 224 nM Binding affinity at Adenosine A1 receptor in rat brain membranes by [3H]-(R)-PIA displacement. ChEMBL. No reference
Ki (binding) = 30300 nM Displacement of [3H]-CGS- 21680 from Adenosine A2 receptor of rat striatal membranes ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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