Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0208 | 0.0456 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.0456 | 0.0274 |
Brugia malayi | Isocitrate dehydrogenase | 0.171 | 0.7044 | 0.6987 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0561 | 0.038 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial | 0.0208 | 0.0456 | 0.0274 |
Echinococcus multilocularis | neuroglian | 0.0184 | 0.0351 | 0.0239 |
Echinococcus granulosus | isocitrate dehydrogenase NAD | 0.0208 | 0.0456 | 0.0392 |
Echinococcus granulosus | twitchin | 0.0184 | 0.0351 | 0.0239 |
Echinococcus granulosus | roundabout 2 | 0.0231 | 0.0561 | 0.0544 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0194 | 0.0397 | 0.0305 |
Echinococcus multilocularis | roundabout 2 | 0.0231 | 0.0561 | 0.0544 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.171 | 0.7044 | 0.5 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0208 | 0.0456 | 0.5 |
Schistosoma mansoni | nephrin | 0.0184 | 0.0351 | 0.0499 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.171 | 0.7044 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.171 | 0.7044 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.171 | 0.7044 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0208 | 0.0456 | 0.0648 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.0397 | 0.0213 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0208 | 0.0456 | 0.0648 |
Brugia malayi | isocitrate dehydrogenase | 0.171 | 0.7044 | 0.6987 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0208 | 0.0456 | 0.0274 |
Brugia malayi | Probable isocitrate dehydrogenase | 0.0208 | 0.0456 | 0.0274 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD) subunit | 0.0208 | 0.0456 | 0.0392 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.171 | 0.7044 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.2384 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.0561 | 0.038 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.171 | 0.7044 | 0.5 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0208 | 0.0456 | 0.5 |
Echinococcus granulosus | isocitrate dehydrogenase NAD subunit | 0.0208 | 0.0456 | 0.0392 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0194 | 0.0397 | 0.0563 |
Brugia malayi | isocitrate dehydrogenase [NAD] subunit beta, mitochondrial | 0.0208 | 0.0456 | 0.0274 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0208 | 0.0456 | 0.5 |
Schistosoma mansoni | vesicular amine transporter | 0.0146 | 0.0188 | 0.0266 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.171 | 0.7044 | 0.6987 |
Loa Loa (eye worm) | isocitrate dehydrogenase gamma subunit | 0.0208 | 0.0456 | 0.0274 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.171 | 0.7044 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.171 | 0.7044 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0184 | 0.0351 | 0.0239 |
Brugia malayi | Isocitrate dehydrogenase subunit gamma, mitochondrial precursor | 0.0208 | 0.0456 | 0.0274 |
Echinococcus multilocularis | isocitrate dehydrogenase (NAD+) | 0.0208 | 0.0456 | 0.0392 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.2227 | 0.9313 | 1 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0146 | 0.0188 | 0.0266 |
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0208 | 0.0456 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.171 | 0.7044 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.171 | 0.7044 | 0.5 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.171 | 0.7044 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0208 | 0.0456 | 0.0648 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0146 | 0.0188 | 0.0266 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.171 | 0.7044 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | = 106 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.24 when administered subcutaneously. | ChEMBL. | 2296025 |
CD50 (functional) | = 106 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.24 when administered subcutaneously. | ChEMBL. | 2296025 |
CD50 (functional) | = 424 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.06 when administered perorally. | ChEMBL. | 2296025 |
CD50 (functional) | = 424 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.06 when administered perorally. | ChEMBL. | 2296025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.