Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) | 0.0125 | 0.0087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0125 | 0.0087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1031 | 0.4006 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Echinococcus granulosus | defective proboscis extension response | 0.0148 | 0.0188 | 0.0256 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.1031 | 0.4006 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.2257 | 0.9313 | 1 |
Mycobacterium ulcerans | 3-isopropylmalate dehydrogenase | 0.0125 | 0.0087 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0148 | 0.0188 | 0.0468 |
Schistosoma mansoni | cell adhesion molecule | 0.0197 | 0.0397 | 0.0991 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.0397 | 0.0312 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.1031 | 0.4006 | 0.3953 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.1031 | 0.4006 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.0561 | 0.0478 |
Schistosoma mansoni | unc-13 (munc13) | 0.0125 | 0.0087 | 0.0218 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0148 | 0.0188 | 0.0468 |
Echinococcus granulosus | roundabout 2 | 0.0235 | 0.0561 | 0.1208 |
Echinococcus granulosus | twitchin | 0.0186 | 0.0351 | 0.0674 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1031 | 0.4006 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.1031 | 0.4006 | 0.5 |
Schistosoma mansoni | nephrin | 0.0186 | 0.0351 | 0.0877 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0148 | 0.0188 | 0.0101 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Schistosoma mansoni | vesicular amine transporter | 0.0148 | 0.0188 | 0.0468 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0197 | 0.0397 | 0.079 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0125 | 0.0087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.0561 | 0.0478 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.1031 | 0.4006 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0235 | 0.0561 | 0.1208 |
Echinococcus multilocularis | neuroglian | 0.0186 | 0.0351 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Echinococcus multilocularis | Immunoglobulin | 0.0148 | 0.0188 | 0.0256 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.1031 | 0.4006 | 0.5 |
Brugia malayi | Fibronectin type III domain containing protein | 0.0148 | 0.0188 | 0.0101 |
Brugia malayi | Isocitrate dehydrogenase | 0.1031 | 0.4006 | 0.3953 |
Echinococcus granulosus | neuroglian | 0.0186 | 0.0351 | 0.0674 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0125 | 0.0087 | 0.5 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.1031 | 0.4006 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.1031 | 0.4006 | 0.3953 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0125 | 0.0087 | 0.0218 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1031 | 0.4006 | 0.5 |
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0125 | 0.0087 | 0.0218 |
Echinococcus multilocularis | Immunoglobulin | 0.0148 | 0.0188 | 0.0256 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.2416 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.1031 | 0.4006 | 0.5 |
Echinococcus multilocularis | basement membrane specific heparan sulfate | 0.0148 | 0.0188 | 0.0256 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.1031 | 0.4006 | 1 |
Brugia malayi | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.0188 | 0.0101 |
Echinococcus granulosus | Immunoglobulin | 0.0148 | 0.0188 | 0.0256 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.1031 | 0.4006 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD50 (functional) | = 6.6 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.58 when administered subcutaneously. | ChEMBL. | 2296025 |
CD50 (functional) | = 6.6 mg kg-1 | Trypanocidal Activity at I.C.E. value 0.58 when administered subcutaneously. | ChEMBL. | 2296025 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.