Detailed information for compound 1728804

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.599 | Formula: C30H30N6O
  • H donors: 1 H acceptors: 4 LogP: 4.8 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccc(cc1)C1CCN(CC1)C(=O)c1cc(ccc1C)c1nc2c([nH]1)cnc(c2)N1CCCC1
  • InChi: 1S/C30H30N6O/c1-20-4-7-24(29-33-26-17-28(32-19-27(26)34-29)35-12-2-3-13-35)16-25(20)30(37)36-14-10-23(11-15-36)22-8-5-21(18-31)6-9-22/h4-9,16-17,19,23H,2-3,10-15H2,1H3,(H,33,34)
  • InChiKey: HWQONTIWVVHWEW-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Fatty acid synthase Starlite/ChEMBL References
Homo sapiens fatty acid synthase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks5 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks8 Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum Soraphen polyketide synthase A, related Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase, putative Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Fatty acid synthase homolog Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks2 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 Get druggable targets OG5_126633 All targets in OG5_126633
Onchocerca volvulus Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii AMP-binding enzyme domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks7 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) acyl carrier protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable polyketide synthase Pks1 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB Get druggable targets OG5_126633 All targets in OG5_126633
Neospora caninum KR domain domain-containing protein, putative Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks15 Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable polyketide synthase Pks9 Get druggable targets OG5_126633 All targets in OG5_126633
Cryptosporidium parvum type I fatty acid synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks13 Get druggable targets OG5_126633 All targets in OG5_126633
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans Type I modular polyketide synthase Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD Get druggable targets OG5_126633 All targets in OG5_126633
Mycobacterium tuberculosis Polyketide synthase Pks12 Get druggable targets OG5_126633 All targets in OG5_126633
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126633 All targets in OG5_126633

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Fatty acid synthase   2505 aa 2611 aa 43.0 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.3352 0.3261
Plasmodium falciparum tyrosine kinase-like protein 0.0052 0.3352 0.5
Leishmania major hypothetical protein, conserved 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.3352 0.3352
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Trichomonas vaginalis STE family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase Srms 0.0087 0.6956 1
Brugia malayi Variant SH3 domain containing protein 0.0035 0.1607 0.1607
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni serine/threonine RGC 0.0052 0.3352 0.3261
Leishmania major protein kinase, putative 0.0052 0.3352 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus fibroblast growth factor receptor 4 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase HCK 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Loa Loa (eye worm) TK/ACK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0052 0.3352 0.3103
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi Receptor family ligand binding region containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica ankyrin repeat protein 0.0052 0.3352 0.3261
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Echinococcus multilocularis ephrin type A receptor 4 A 0.0052 0.3352 0.3261
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.1607 0.0811
Trypanosoma brucei Flagellum attachment zone protein 20 0.0052 0.3352 0.5
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Toxoplasma gondii type I fatty acid synthase, putative 0.0064 0.4587 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) SRC-1 0.0087 0.6956 0.784
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0087 0.6956 1
Brugia malayi Raf kinase 0.0052 0.3352 0.3352
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Probable thioesterase TesA 0.0053 0.3416 0.4619
Echinococcus granulosus natriuretic peptide receptor 1 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Schistosoma mansoni tyrosine protein kinase 0.0052 0.3352 0.3261
Brugia malayi Tensin 0.0035 0.1607 0.1607
Mycobacterium ulcerans polyketide synthase Pks13 0.0091 0.7396 1
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi Tyrosine-protein kinase PR2 0.0052 0.3352 0.3352
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase Src64B 0.0087 0.6956 1
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK/EPH protein kinase 0.0052 0.3352 0.3103
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0087 0.6956 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.006 0.4183 0.563
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase Srms 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) hypothetical protein 0.0032 0.1327 0.0443
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.2607 0.2125
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0035 0.1607 0.0811
Onchocerca volvulus 0.0052 0.3352 0.2152
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Brugia malayi Protein kinase domain containing protein 0.0087 0.6956 0.6956
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.6956 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0052 0.3352 0.3103
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Echinococcus granulosus tyrosine kinase 0.0087 0.6956 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0059 0.4072 0.5506
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0061 0.43 0.5814
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi integrin-linked kinase 0.0052 0.3352 0.3352
Onchocerca volvulus 0.0087 0.6956 0.6599
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0035 0.1607 0.0811
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0045 0.2669 0.3609
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.3352 0.3261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2607 0.1868
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Plasmodium falciparum protein kinase, putative 0.0052 0.3352 0.5
Echinococcus granulosus tyrosine protein kinase pr2 0.0052 0.3352 0.3261
Onchocerca volvulus 0.0087 0.6956 0.6599
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.3352 0.3103
Echinococcus multilocularis protein kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0052 0.3352 0.3103
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Giardia lamblia Kinase, NEK 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0087 0.6956 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/Met protein kinase 0.0052 0.3352 0.3103
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FAK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) TK/CSK protein kinase 0.0052 0.3352 0.3103
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0041 0.2217 0.2821
Brugia malayi Tyrosine-protein kinase abl-1 0.0087 0.6956 0.6956
Brugia malayi ephrin receptor 1 precursor 0.0052 0.3352 0.3352
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Brugia malayi STAT protein, DNA binding domain containing protein 0.0035 0.1607 0.1607
Brugia malayi SH2 domain containing protein 0.0087 0.6956 0.6956
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Echinococcus multilocularis tyrosine protein kinase pr2 0.0052 0.3352 0.3261
Echinococcus multilocularis activin receptor type 0.0052 0.3352 0.3261
Onchocerca volvulus 0.0052 0.3352 0.2152
Loa Loa (eye worm) hypothetical protein 0.0103 0.86 1
Leishmania major protein kinase, putative 0.0052 0.3352 0.5
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0087 0.6956 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0087 0.6956 0.6956
Echinococcus granulosus tyrosine kinase 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) STAT protein 0.0035 0.1607 0.0811
Loa Loa (eye worm) TK protein kinase 0.0087 0.6956 0.784
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.3352 0.3261
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.3352 0.3261
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0087 0.6956 1
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0061 0.43 0.5814
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis epidermal growth factor receptor 0.0052 0.3352 0.3261
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Trypanosoma cruzi protein kinase, putative 0.0052 0.3352 0.5
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.3352 0.3103
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0087 0.6956 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0035 0.1607 0.0811
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0091 0.7396 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.4183 0.5656
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase Src42A 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Onchocerca volvulus 0.0087 0.6956 0.6599
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Onchocerca volvulus 0.0052 0.3352 0.2152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2607 0.1868
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0052 0.3352 0.3261
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0052 0.3352 0.3261
Echinococcus granulosus receptor type guanylyl cyclase 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.3352 0.3261
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.1607 0.0811
Brugia malayi RhoGAP domain containing protein 0.0035 0.1607 0.1607
Schistosoma mansoni ephrin receptor 0.0052 0.3352 0.3261
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0052 0.3352 0.2152
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.3352 0.3261
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0064 0.4587 0.6202
Echinococcus multilocularis tyrosine protein kinase HCK 0.0052 0.3352 0.3261
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Mycobacterium ulcerans polyketide synthase Pks9 0.0039 0.1983 0.2681
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2607 0.1868
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0052 0.3352 0.6258
Plasmodium falciparum protein kinase, putative 0.0052 0.3352 0.5
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Loa Loa (eye worm) TK/ALK protein kinase 0.0052 0.3352 0.3103
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Entamoeba histolytica hypothetical protein, conserved 0.0052 0.3352 0.3261
Echinococcus granulosus integrin linked protein kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK/RYK protein kinase 0.0052 0.3352 0.3103
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.6956 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.3352 0.3352
Echinococcus granulosus tyrosine kinase 0.0052 0.3352 0.3261
Brugia malayi Variant SH3 domain containing protein 0.0035 0.1607 0.1607
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.3352 0.3103
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Echinococcus multilocularis epidermal growth factor receptor 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0036 0.1696 0.2293
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Brugia malayi AMP-binding enzyme family protein 0.0059 0.4072 0.4072
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus multilocularis transfer RNA-Thr 0.0052 0.3352 0.3261
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0048 0.2914 0.394
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0039 0.1983 0.2638
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Onchocerca volvulus 0.0052 0.3352 0.2152
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0052 0.3352 0.3261
Echinococcus multilocularis protein kinase 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi hypothetical protein 0.0087 0.6956 0.6956
Echinococcus multilocularis tyrosine protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Plasmodium falciparum tyrosine kinase-like protein 0.0052 0.3352 0.5
Trypanosoma brucei protein kinase, putative 0.0052 0.3352 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Echinococcus granulosus ephrin type A receptor 4 A 0.0052 0.3352 0.3261
Plasmodium vivax tyrosine kinase-like protein, putative 0.0052 0.3352 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2607 0.1868
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0052 0.3352 0.3103
Onchocerca volvulus 0.0052 0.3352 0.2152
Giardia lamblia Kinase, NEK 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Mycobacterium ulcerans fatty acid synthase Fas 0.002 0.0043 0.0059
Echinococcus granulosus tyrosine protein kinase Lyn 0.0087 0.6956 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.006 0.4183 0.5656
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.6956 1
Echinococcus granulosus tyrosine protein kinase Blk 0.0087 0.6956 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.4183 0.5656
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Echinococcus granulosus epidermal growth factor receptor 0.0052 0.3352 0.3261
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0052 0.3352 0.5
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0052 0.3352 0.3103
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.006 0.4183 0.5656
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0052 0.3352 0.5
Brugia malayi tRNA modification GTPase TrmE family protein 0.0035 0.1607 0.1607
Loa Loa (eye worm) TK/INSR protein kinase 0.0052 0.3352 0.3103
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Loa Loa (eye worm) protein kinase domain-containing protein 0.0052 0.3352 0.3103
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus granulosus protein tyrosine kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0087 0.6956 1
Echinococcus multilocularis FL cytokine receptor 0.0052 0.3352 0.3261
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0052 0.3352 0.3352
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Onchocerca volvulus 0.011 0.931 0.9502
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.3352 0.3103
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0064 0.4587 0.6202
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.3352 0.3261
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0035 0.1607 0.0811
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica ankyrin repeat protein 0.0052 0.3352 0.3261
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0087 0.6956 1
Echinococcus multilocularis tyrosine kinase 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0064 0.4587 0.6202
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3352 0.3261
Schistosoma mansoni hypothetical protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0052 0.3352 0.6258
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Brugia malayi protein-tyrosine kinase 0.0087 0.6956 0.6956
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Onchocerca volvulus Tyrosine kinase homolog 0.0052 0.3352 0.2152
Schistosoma mansoni protein tyrosine kinase 0.0052 0.3352 0.3261
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica cysteine surface protein, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0064 0.4587 0.6202
Trichomonas vaginalis protein tyrosine kinase, putative 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase Abl 0.0087 0.6956 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0052 0.3352 0.3352
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0052 0.3352 0.3261
Loa Loa (eye worm) RGC/RGC protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0052 0.3352 0.3261
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.006 0.4183 0.5656
Brugia malayi Protein kinase domain containing protein 0.0087 0.6956 0.6956
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0052 0.3352 0.6258
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi SH2 domain containing protein 0.0087 0.6956 0.6956
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Giardia lamblia Kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.6956 1
Onchocerca volvulus 0.0052 0.3352 0.2152
Echinococcus granulosus tyrosine protein kinase csk 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Mycobacterium ulcerans polyketide synthase 0.0064 0.4587 0.6202
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0026 0.063 0.0851
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0087 0.6956 1
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0048 0.2914 0.394
Brugia malayi hypothetical protein 0.0052 0.3352 0.3352
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0087 0.6956 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0052 0.3352 0.3261
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Brugia malayi hypothetical protein 0.0052 0.3352 0.3352
Echinococcus multilocularis protein KINase family member (kin 25) 0.0052 0.3352 0.3261
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0053 0.3416 0.4587
Echinococcus multilocularis heat shock protein 70 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase shark 0.0087 0.6956 1
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.2627 0.4063
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.2607 0.2607
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0064 0.4587 0.6179
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TK family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Mycobacterium ulcerans thioesterase 0.0053 0.3416 0.4619
Entamoeba histolytica receptor protein kinase, putative 0.0052 0.3352 0.3261
Onchocerca volvulus 0.0087 0.6956 0.6599
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0087 0.6956 1
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Echinococcus granulosus activin receptor type 0.0052 0.3352 0.3261
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0052 0.3352 0.3352
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Onchocerca volvulus 0.0087 0.6956 0.6599
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.006 0.4183 0.563
Entamoeba histolytica receptor protein kinase, putative 0.0052 0.3352 0.3261
Onchocerca volvulus 0.0052 0.3352 0.2152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.2607 0.1868
Mycobacterium ulcerans thioesterase TesA 0.0053 0.3416 0.4619
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0087 0.6956 1
Giardia lamblia Protein 21.1 0.0052 0.3352 0.5
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0052 0.3352 0.3261
Loa Loa (eye worm) fatty acid synthase 0.0062 0.4412 0.4497
Brugia malayi Protein kinase domain containing protein 0.0087 0.6956 0.6956
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0052 0.3352 0.3352
Brugia malayi Protein kinase domain containing protein 0.0087 0.6956 0.6956
Loa Loa (eye worm) TK/EGFR protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0059 0.4072 0.405
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Echinococcus granulosus kinase suppressor of Ras 1 0.0052 0.3352 0.3261
Echinococcus multilocularis activated cdc42 kinase 1 0.0052 0.3352 0.3261
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica serine/threonine kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis integrin linked protein kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.3352 0.3261
Mycobacterium leprae Polyketide synthase Pks13 0.0091 0.7396 1
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Brugia malayi C-terminal src kinase protein 1 0.0052 0.3352 0.3352
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0035 0.1607 0.1607
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0052 0.3352 0.3103
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0064 0.4587 0.6202
Onchocerca volvulus 0.0052 0.3352 0.2152
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0087 0.6956 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Echinococcus granulosus raf serine:threonine protein kinase 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.006 0.4183 0.4183
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Trypanosoma brucei Pseudokinase, putative 0.0052 0.3352 0.5
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi Variant SH3 domain containing protein 0.0035 0.1607 0.1607
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0052 0.3352 0.3261
Echinococcus granulosus tyrosine protein kinase ABL1 0.0087 0.6956 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0035 0.1607 0.0811
Echinococcus multilocularis natriuretic peptide receptor 1 0.0052 0.3352 0.3261
Brugia malayi Guanylyl cyclase protein 23 0.0052 0.3352 0.3352
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0039 0.1983 0.2681
Toxoplasma gondii STE kinase 0.0052 0.3352 0.6258
Mycobacterium ulcerans polyketide synthase 0.006 0.4183 0.5656
Echinococcus multilocularis c src tyrosine kinase 0.0087 0.6956 1
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Echinococcus granulosus c src tyrosine kinase 0.0087 0.6956 1
Toxoplasma gondii protein kinase domain-containing protein 0.0052 0.3352 0.6258
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0052 0.3352 0.3261
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0052 0.3352 0.3261
Brugia malayi SRC-1 0.0087 0.6956 0.6956
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Brugia malayi Immunoglobulin I-set domain containing protein 0.0052 0.3352 0.3352
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica hypothetical protein 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0091 0.7396 1
Plasmodium vivax protein kinase, putative 0.0052 0.3352 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Loa Loa (eye worm) hypothetical protein 0.0052 0.3352 0.3103
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis receptor type guanylyl cyclase 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0052 0.3352 0.3261
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase csk 0.0052 0.3352 0.3261
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Echinococcus multilocularis protein tyrosine kinase 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Onchocerca volvulus Fatty acid synthase homolog 0.0114 0.9713 1
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK protein kinase 0.0052 0.3352 0.3103
Brugia malayi hypothetical protein 0.0035 0.1607 0.1607
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus protein kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus retinal guanylyl cyclase 2 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.6956 1
Loa Loa (eye worm) TK/FER protein kinase 0.0052 0.3352 0.3103
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis kinase suppressor of Ras 1 0.0052 0.3352 0.3261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.2607 0.1868
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.2607 0.1868
Plasmodium vivax tyrosine kinase-like protein, putative 0.0052 0.3352 0.5
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.1607 0.0811
Plasmodium falciparum protein kinase, putative 0.0052 0.3352 0.5
Schistosoma mansoni ephrin receptor 0.0052 0.3352 0.3261
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.006 0.4183 0.5656
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Trichomonas vaginalis AGC family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus multilocularis insulin receptor 0.0052 0.3352 0.3261
Schistosoma mansoni protein kinase 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0064 0.4587 0.6179
Brugia malayi bone morphogenetic protein type 1 receptor 0.0052 0.3352 0.3352
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0052 0.3352 0.3103
Onchocerca volvulus 0.0059 0.4072 0.3041
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0052 0.3352 0.3103
Loa Loa (eye worm) serine/threonine protein kinase 0.0052 0.3352 0.3103
Brugia malayi Variant SH3 domain containing protein 0.0035 0.1607 0.1607
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0052 0.3352 0.3261
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.3352 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Mycobacterium leprae Probable polyketide synthase Pks1 0.0064 0.4587 0.6179
Toxoplasma gondii protein kinase 0.0052 0.3352 0.6258
Loa Loa (eye worm) TK/ABL protein kinase 0.0087 0.6956 0.784
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Echinococcus granulosus tyrosine protein kinase 0.0052 0.3352 0.3261
Echinococcus granulosus insulin receptor 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0052 0.3352 0.3261
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Entamoeba histolytica tyrosine kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.6956 1
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0049 0.3 0.4056
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Brugia malayi Protein kinase domain containing protein 0.0052 0.3352 0.3352
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0087 0.6956 1
Trichomonas vaginalis protein kinase atn1, putative 0.0052 0.3352 0.5
Echinococcus multilocularis raf serine:threonine protein kinase 0.0052 0.3352 0.3261
Echinococcus multilocularis tyrosine protein kinase Blk 0.0087 0.6956 1
Echinococcus multilocularis tyrosine kinase 0.0052 0.3352 0.3261
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.3352 0.5
Entamoeba histolytica tyrosin kinase, putative 0.0052 0.3352 0.3261
Brugia malayi SH2 domain containing protein 0.0035 0.1607 0.1607
Trypanosoma cruzi protein kinase, putative 0.0052 0.3352 0.5
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0052 0.3352 0.2152
Onchocerca volvulus 0.0052 0.3352 0.2152
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.3352 0.3261
Loa Loa (eye worm) TK/FER protein kinase 0.0087 0.6956 0.784
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0052 0.3352 0.5
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.002 0.0043 0.0059
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0048 0.2914 0.3904
Loa Loa (eye worm) SH2 domain-containing protein 0.0035 0.1607 0.0811
Brugia malayi cytokine inducible SH2-containing protein 5 0.0035 0.1607 0.1607
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0052 0.3352 0.5
Onchocerca volvulus 0.0087 0.6956 0.6599
Schistosoma mansoni tyrosine kinase 0.0052 0.3352 0.3261
Schistosoma mansoni tyrosine kinase 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Echinococcus granulosus tyrosine protein kinase shark 0.0087 0.6956 1
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.1607 0.0811
Brugia malayi Sex muscle abnormal protein 5 0.0035 0.1607 0.1607
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Mycobacterium ulcerans Type I modular polyketide synthase 0.006 0.4183 0.5656
Trichomonas vaginalis TKL family protein kinase 0.0052 0.3352 0.5
Loa Loa (eye worm) hypothetical protein 0.0087 0.6956 0.784
Brugia malayi Furin-like cysteine rich region family protein 0.0052 0.3352 0.3352
Entamoeba histolytica protein kinase, putative 0.0052 0.3352 0.3261
Entamoeba histolytica protein kinase domain containing protein 0.0052 0.3352 0.3261

Activities

Activity type Activity value Assay description Source Reference
CC50 (ADMET) = 8.6 uM Cytotoxicity against human HuH7 cells after 72 hrs by celltiter glo assay ChEMBL. 24900571
IC50 (binding) = 60 nM BindingDB_Patents: Biochemical Assay. The FASN enzyme was isolated from SKBr3 cells. SKBr3 is a human breast cancer cell-line with high levels of FASN expression. It is estimated that FASN comprises about 25% of the cytosolic proteins in this cell line. SKBr3 cells were homogenized in a dounce homogenizer then centrifuged for 15 minutes at 4C. to remove particulate matter. The supernatant was then analyzed for protein content, diluted to the appropriate concentration, and used to measure FASN activity. The presence of FASN was confirmed by western blot analysis. A similar method for isolation of FASN from SKBr3 cells is described in Teresa, P. et al. (Clin. Cancer Res. 2009; 15(24), 7608-7615).FASN activity of the SKBr3 cell extract was determined by measuring either NADPH oxidation or the amount of thiol-containing coenzyme A (CoA) released during the fatty acid synthase reaction. The dye CPM (7-diethylamino-3-(4â-maleimidyl-phenyl)-4-methylcoumarin) contains a thiol reactive group that increases its fluorescence emission. ChEMBL. No reference
IC50 (binding) = 0.06 uM Inhibition of human FASN assessed as release of co-enzyme A ChEMBL. 24900571
IC50 (binding) = 0.635 uM Inhibition of rat FASN assessed as release of co-enzyme A ChEMBL. 24900571

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.