Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0052 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0052 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0052 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0052 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0052 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0052 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0052 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0052 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0052 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0052 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0052 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 131 uM | Inhibition of human neuraminidase 2 expressed in Escherichia coli using 4MU-NANA as substrate after 30 mins by fluorescence assay | ChEMBL. | 23530623 |
IC50 (binding) | = 300 uM | Inhibition of human neuraminidase 4 using 4MU-NANA as substrate after 30 mins by fluorescence assay | ChEMBL. | 23530623 |
IC50 (binding) | = 440 uM | Inhibition of human neuraminidase 3 expressed in Escherichia coli using 4MU-NANA as substrate after 30 mins by fluorescence assay | ChEMBL. | 23530623 |
IC50 (binding) | > 1000 uM | Inhibition of Vibrio cholerae neuraminidase | ChEMBL. | 23530623 |
IC50 (binding) | > 1000 uM | Inhibition of human neuraminidase 1 using 4MU-NANA as substrate after 30 mins by fluorescence assay | ChEMBL. | 23530623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.