Detailed information for compound 172882

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 533.058 | Formula: C16H17Br3N6
  • H donors: 2 H acceptors: 0 LogP: 5.29 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=N)N/N=C/c1ccc(cc1)c1[n+](C)c2n(c1Br)cccc2.[Br-].Br
  • InChi: 1S/C16H16BrN6.2BrH/c1-22-13-4-2-3-9-23(13)15(17)14(22)12-7-5-11(6-8-12)10-20-21-16(18)19;;/h2-10H,1H3,(H4,18,19,21);2*1H/q+1;;/p-1/b20-10+;;
  • InChiKey: GDQTXTQFCMZKGX-QOFFZXOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0329 0.1159 0.1159
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus protein tyrosine kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis FL cytokine receptor 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Loa Loa (eye worm) serine/threonine protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0329 0.1159 0.1159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Onchocerca volvulus Tyrosine kinase homolog 0.0201 0.0683 1
Toxoplasma gondii isocitrate dehydrogenase 0.2712 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/Met protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0078 0.0078
Echinococcus granulosus protein kinase 0.0038 0.0078 0.0078
Brugia malayi Isocitrate dehydrogenase 0.2712 1 1
Echinococcus granulosus natriuretic peptide receptor 1 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1479 0.5427 0.5427
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.2712 1 1
Echinococcus multilocularis insulin receptor 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FAK protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus activated cdc42 kinase 1 0.0038 0.0078 0.0078
Giardia lamblia Kinase, NEK 0.0038 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/ACK protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.1479 0.5427 0.5427
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.1518 0.5568 0.5568
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0038 0.0078 0.0078
Echinococcus multilocularis natriuretic peptide receptor 1 0.0038 0.0078 0.0078
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.2712 1 1
Echinococcus multilocularis integrin linked protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0078 0.0078
Schistosoma mansoni tyrosine kinase 0.0044 0.0101 0.0024
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.2712 1 1
Echinococcus granulosus tyrosine protein kinase shark 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0038 0.0078 0.0078
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0329 0.1159 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0038 0.0078 0.0078
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis activated cdc42 kinase 1 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.1479 0.5427 0.5427
Echinococcus multilocularis c src tyrosine kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) SRC-1 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0041 0.0088 0.0088
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Abl 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.2712 1 1
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0329 0.1159 0.5
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.2712 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.2712 1 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0329 0.1159 0.1159
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0329 0.1159 0.1089
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/INSR protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0041 0.0088 0.0088
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Echinococcus multilocularis epidermal growth factor receptor 0.0038 0.0078 0.0078
Echinococcus multilocularis ephrin type A receptor 4 A 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0038 0.0078 0.0078
Echinococcus granulosus fibroblast growth factor receptor 4 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0078 0.0078
Echinococcus granulosus raf serine:threonine protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis protein KINase family member (kin 25) 0.0038 0.0078 0.0078
Schistosoma mansoni unc-13 (munc13) 0.0329 0.1159 0.1089
Echinococcus granulosus insulin receptor 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.0078 0.0078
Echinococcus granulosus epidermal growth factor receptor 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1479 0.5427 0.5427
Echinococcus multilocularis epidermal growth factor receptor 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0078 0.0078
Giardia lamblia Kinase, NEK 0.0038 0.0078 0.5
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0329 0.1159 0.1159
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.2712 1 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0038 0.0078 0.0078
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.2712 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase HCK 0.0038 0.0078 0.0078
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0038 0.0078 0.0078
Echinococcus multilocularis protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0329 0.1159 0.1159
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/CSK protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/RYK protein kinase 0.0038 0.0078 0.0078
Brugia malayi Protein kinase domain containing protein 0.1518 0.5568 0.5534
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus c src tyrosine kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis kinase suppressor of Ras 1 0.0038 0.0078 0.0078
Echinococcus multilocularis kinase protein 0.1479 0.5427 0.5427
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0329 0.1159 0.1089
Echinococcus granulosus tyrosine kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase shark 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/EPH protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.2712 1 1
Echinococcus granulosus kinase suppressor of Ras 1 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis raf serine:threonine protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0038 0.0078 0.0078
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Trypanosoma brucei isocitrate dehydrogenase, putative 0.2712 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0038 0.0078 0.0078
Echinococcus granulosus integrin linked protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0038 0.0078 0.0078
Leishmania major isocitrate dehydrogenase, putative 0.0329 0.1159 0.1089
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0038 0.0078 0.0078
Echinococcus granulosus activated cdc42 kinase 1 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/ALK protein kinase 0.0038 0.0078 0.0078
Entamoeba histolytica tartrate dehydrogenase, putative 0.0329 0.1159 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Giardia lamblia Kinase 0.0038 0.0078 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.2712 1 1
Loa Loa (eye worm) TK/ROR protein kinase 0.0041 0.0088 0.0088
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.1518 0.5568 0.5568
Toxoplasma gondii isocitrate dehydrogenase 0.2712 1 1
Onchocerca volvulus 0.016 0.0532 0.7495
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 0.2712 1 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0038 0.0078 0.0078
Echinococcus multilocularis protein tyrosine kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0038 0.0078 0.0078
Brugia malayi Probable isocitrate dehydrogenase 0.0329 0.1159 0.1089
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0041 0.0088 0.0088
Echinococcus granulosus tyrosine kinase 0.0038 0.0078 0.0078
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.2712 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase pr2 0.0038 0.0078 0.0078
Echinococcus multilocularis activin receptor type 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1518 0.5568 0.5568
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis receptor type guanylyl cyclase 0.0038 0.0078 0.0078
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0329 0.1159 1
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0213 0.0726 0.0726
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.1479 0.5427 0.5427
Echinococcus multilocularis kinase protein 0.1479 0.5427 0.5427
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase pr2 0.0038 0.0078 0.0078
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0078 0.0078
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0329 0.1159 0.1159
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Echinococcus granulosus retinal guanylyl cyclase 2 0.0038 0.0078 0.0078
Echinococcus multilocularis transfer RNA-Thr 0.0038 0.0078 0.0078
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.1479 0.5427 0.5427
Loa Loa (eye worm) TK/ABL protein kinase 0.0038 0.0078 0.0078
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.2712 1 1
Loa Loa (eye worm) TK/EGFR protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.2712 1 1
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.2712 1 1
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0329 0.1159 0.1089
Loa Loa (eye worm) TK/DDR protein kinase 0.0038 0.0078 0.0078
Brugia malayi Probable isocitrate dehydrogenase 0.0329 0.1159 0.1089
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine kinase 0.0038 0.0078 0.0078
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0329 0.1159 0.5
Echinococcus multilocularis protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0038 0.0078 0.0078
Loa Loa (eye worm) RGC/RGC protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0078 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0041 0.0088 0.001
Echinococcus granulosus ephrin type A receptor 4 A 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Brugia malayi Immunoglobulin I-set domain containing protein 0.0213 0.0726 0.0654
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Loa Loa (eye worm) protein kinase domain-containing protein 0.0038 0.0078 0.0078
Echinococcus granulosus receptor type guanylyl cyclase 0.0038 0.0078 0.0078
Schistosoma mansoni isocitrate dehydrogenase 0.0329 0.1159 0.1089
Giardia lamblia Protein 21.1 0.0038 0.0078 0.5
Echinococcus multilocularis heat shock protein 70 0.0038 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.0078 0.0078
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0329 0.1159 0.1089
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK/FER protein kinase 0.0038 0.0078 0.0078
Echinococcus granulosus activin receptor type 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase ABL1 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0078 0.0078
Loa Loa (eye worm) TK protein kinase 0.0038 0.0078 0.0078
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine kinase 0.0038 0.0078 0.0078
Echinococcus granulosus epidermal growth factor receptor 0.0038 0.0078 0.0078
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0038 0.0078 0.0078
Echinococcus multilocularis tyrosine protein kinase csk 0.0038 0.0078 0.0078
Echinococcus granulosus tyrosine protein kinase Srms 0.0038 0.0078 0.0078
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0038 0.0078 0.0078

Activities

Activity type Activity value Assay description Source Reference
CD50 (functional) = 1.6 mg kg-1 Trypanocidal Activity at I.C.E. value 0.32 when administered subcutaneously. ChEMBL. 2296025
CD50 (functional) = 1.6 mg kg-1 Trypanocidal Activity at I.C.E. value 0.32 when administered subcutaneously. ChEMBL. 2296025
CD50 (functional) = 26 mg kg-1 Trypanocidal Activity at I.C.E. value 0.43 when administered perorally. ChEMBL. 2296025
CD50 (functional) = 26 mg kg-1 Trypanocidal Activity at I.C.E. value 0.43 when administered perorally. ChEMBL. 2296025

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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