TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 254.33 | Formula: C15H18N4
H donors: 1 H acceptors: 2 LogP: 3.16 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: Cn1nc(c2c1cnc1c2cc[nH]1)C1CCCCC1
InChi: 1S/C15H18N4/c1-19-12-9-17-15-11(7-8-16-15)13(12)14(18-19)10-5-3-2-4-6-10/h7-10H,2-6H2,1H3,(H,16,17)
InChiKey: ITJOPOBKLBQUJE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	fms-related tyrosine kinase 3	Starlite/ChEMBL	References
Homo sapiens	tyrosine kinase 2	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References
Homo sapiens	aurora kinase A	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 1	Starlite/ChEMBL	References
Homo sapiens	protein kinase C, alpha	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	IPR000477,RNA-directed DNA polymerase (Reverse transcriptase),domain-containing	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	protein kinase C gamma type	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	Protein kinase C, brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Schistosoma japonicum	Calcium-dependent protein kinase C, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	serine threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Protein kinase C gamma type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	Protein kinase C brain isozyme	Get druggable targets OG5_129482	All targets in OG5_129482
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_129482	All targets in OG5_129482
Brugia malayi	Protein kinase c protein 2	Get druggable targets OG5_129482	All targets in OG5_129482
Echinococcus multilocularis	telomerase reverse transcriptase subunit	Get druggable targets OG5_129482	All targets in OG5_129482
Candida albicans	protein kinase C similar to S. cerevisiae PKC1 (YBL105C)	Get druggable targets OG5_129482	All targets in OG5_129482
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Protein kinase C alpha type, putative	Get druggable targets OG5_129482	All targets in OG5_129482
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis	RNA directed DNA polymerase	Get druggable targets OG5_129482	All targets in OG5_129482
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	protein kinase, putative	0.0011	0.0039	0.0099
Brugia malayi	protein-tyrosine kinase	0.0016	0.0275	0.0237
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Onchocerca volvulus		0.0167	0.7839	0.9242
Echinococcus multilocularis	Immunoglobulin	0.003	0.0994	0.3386
Entamoeba histolytica	protein kinase, putative	0.0011	0.0039	0.0099
Trypanosoma cruzi	aurora B kinase, putative	0.0068	0.2916	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0016	0.0275	0.091
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0275	0.0237
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0016	0.0275	0.091
Leishmania major	protein kinase, putative	0.0068	0.2916	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Brugia malayi	Variant SH3 domain containing protein	0.0013	0.0163	0.0125
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0011	0.0039	0.0099
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0016	0.0275	0.091
Loa Loa (eye worm)	TK protein kinase	0.0012	0.0115	0.0076
Schistosoma mansoni	nephrin	0.0033	0.1138	0.3881
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0011	0.0039	0.0099
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0011	0.0039	0.0099
Entamoeba histolytica	protein kinase, putative	0.0068	0.2916	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0275	0.0237
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Schistosoma mansoni	tyrosine kinase	0.0016	0.0298	0.0991
Echinococcus multilocularis	RNA directed DNA polymerase	0.0048	0.1879	0.6429
Entamoeba histolytica	protein kinase domain containing protein	0.0068	0.2916	1
Echinococcus granulosus	aurora kinase A	0.0068	0.2916	1
Toxoplasma gondii	aurora kinase	0.0068	0.2916	1
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.2916	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0016	0.0275	0.0237
Echinococcus multilocularis	serine threonine protein kinase	0.006	0.2499	0.8565
Echinococcus multilocularis	c src tyrosine kinase	0.0016	0.0275	0.091
Schistosoma mansoni	vav2	0.0013	0.0163	0.0526
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Schistosoma mansoni	serine/threonine kinase	0.0011	0.0039	0.0099
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0016	0.0275	0.091
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0275	0.0237
Echinococcus granulosus	defective proboscis extension response	0.003	0.0994	0.3386
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Brugia malayi	serine/threonine kinase 12	0.0068	0.2916	0.2889
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Echinococcus multilocularis	tyrosine protein kinase shark	0.0016	0.0275	0.091
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0016	0.0275	0.091
Entamoeba histolytica	protein kinase, putative	0.0011	0.0039	0.0099
Onchocerca volvulus	Tyrosine kinase homolog	0.0179	0.846	1
Echinococcus granulosus	tyrosine kinase	0.0016	0.0275	0.091
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0016	0.0314	0.1044
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0016	0.0275	0.091
Echinococcus multilocularis	neuroglian	0.0033	0.1138	0.3881
Echinococcus granulosus	tyrosine protein kinase Blk	0.0016	0.0275	0.091
Trypanosoma brucei	aurora B kinase	0.0068	0.2916	1
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0275	0.0237
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0011	0.0039	0.0099
Echinococcus multilocularis	Immunoglobulin	0.003	0.0994	0.3386
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.2865	0.9822
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0012	0.0115	0.0076
Schistosoma mansoni	serine/threonine protein kinase	0.002	0.048	0.1617
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0016	0.0275	0.091
Brugia malayi	RhoGAP domain containing protein	0.0013	0.0163	0.0125
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Entamoeba histolytica	protein kinase , putative	0.0068	0.2916	1
Echinococcus granulosus	NDR protein kinase	0.0011	0.0039	0.0099
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Entamoeba histolytica	protein kinase, putative	0.0011	0.0039	0.0099
Entamoeba histolytica	protein kinase, putative	0.0068	0.2916	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0012	0.0115	0.036
Loa Loa (eye worm)	TK/ABL protein kinase	0.0016	0.0275	0.0237
Schistosoma mansoni	cell adhesion molecule	0.0034	0.1178	0.4018
Echinococcus granulosus	raf serine:threonine protein kinase	0.0017	0.0337	0.1123
Giardia lamblia	Aurora kinase	0.0068	0.2916	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0275	0.0237
Echinococcus granulosus	tyrosine protein kinase Srms	0.0016	0.0275	0.091
Echinococcus granulosus	roundabout 2	0.0036	0.1322	0.4512
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.2865	0.9822
Brugia malayi	hypothetical protein	0.0016	0.0275	0.0237
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Echinococcus multilocularis	tyrosine kinase	0.0016	0.0275	0.091
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1322	0.1288
Brugia malayi	Fibronectin type III domain containing protein	0.003	0.0994	0.0959
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0013	0.0163	0.0526
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0068	0.2916	1
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0011	0.0039	0.0099
Brugia malayi	hypothetical protein	0.003	0.0994	0.0959
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.2916	1
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.2916	0.2889
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0039	0.0099
Echinococcus granulosus	N chimaerin	0.0013	0.0163	0.0526
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Brugia malayi	protein kinase C II.	0.002	0.048	0.0443
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0016	0.0275	0.091
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Echinococcus multilocularis	protein kinase c epsilon type	0.002	0.048	0.1617
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Schistosoma mansoni	atypical protein kinase C	0.0018	0.0405	0.1356
Brugia malayi	Protein kinase domain containing protein	0.0016	0.0275	0.0237
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0068	0.2916	1
Brugia malayi	serine/threonine protein kinase 6	0.0068	0.2916	0.2889
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.003	0.0994	0.3386
Loa Loa (eye worm)	TK/ROR protein kinase	0.0012	0.0115	0.0076
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0016	0.0275	0.091
Loa Loa (eye worm)	hypothetical protein	0.0055	0.2244	0.2214
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0068	0.2916	1
Echinococcus granulosus	twitchin	0.0034	0.1177	0.4015
Schistosoma mansoni	protein kinase	0.0068	0.2916	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.2916	0.2889
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0337	0.1123
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0011	0.0039	0.0099
Echinococcus granulosus	protein kinase c iota type	0.0018	0.0405	0.1356
Echinococcus granulosus	neuroglian	0.0033	0.1138	0.3881
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0039	0.0099
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.2916	1
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0013	0.0163	0.0125
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0067	0.2865	0.9822
Echinococcus granulosus	tyrosine protein kinase shark	0.0016	0.0275	0.091
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0016	0.0275	0.091
Loa Loa (eye worm)	hypothetical protein	0.0048	0.1879	0.1847
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0016	0.0275	0.091
Loa Loa (eye worm)	SRC-1	0.0016	0.0275	0.0237
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0011	0.0039	0.0099
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0048	0.1879	0.6429
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0012	0.0115	0.036
Brugia malayi	Protein kinase c protein 2	0.0057	0.2359	0.2329
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0016	0.0275	0.091
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0016	0.0275	0.091
Brugia malayi	serine/threonine-protein kinase 6	0.0068	0.2916	0.2889
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0013	0.0163	0.0526
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0034	0.1178	0.4018
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0016	0.0275	0.091
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0068	0.2916	1
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.005	0.1993	0.1962
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0017	0.0337	0.1123
Loa Loa (eye worm)	hypothetical protein	0.0036	0.1322	0.1288
Echinococcus granulosus	tyrosine kinase	0.0016	0.0275	0.091
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0016	0.0275	0.091
Loa Loa (eye worm)	TK/FER protein kinase	0.0016	0.0275	0.0237
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0016	0.0275	0.091
Echinococcus multilocularis	protein kinase c iota type	0.0018	0.0405	0.1356
Echinococcus granulosus	Immunoglobulin	0.003	0.0994	0.3386
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.2916	1
Brugia malayi	SH2 domain containing protein	0.0016	0.0275	0.0237
Brugia malayi	SRC-1	0.0016	0.0275	0.0237
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0068	0.2916	1
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0011	0.0039	0.0099
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0016	0.0275	0.091
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Loa Loa (eye worm)	hypothetical protein	0.0034	0.1178	0.1143
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Echinococcus multilocularis	N chimaerin	0.0013	0.0163	0.0526
Loa Loa (eye worm)	TK protein kinase	0.0016	0.0275	0.0237
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0016	0.0275	0.091
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0068	0.2916	0.5
Brugia malayi	SH2 domain containing protein	0.0016	0.0275	0.0237
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0039	0.0099
Echinococcus granulosus	Protein kinase C brain isozyme	0.0067	0.2865	0.9822
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Loa Loa (eye worm)	hypothetical protein	0.003	0.0994	0.0959
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.003	0.0994	0.3386
Echinococcus multilocularis	roundabout 2	0.0036	0.1322	0.4512
Schistosoma mansoni	vesicular amine transporter	0.003	0.0994	0.3386
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0013	0.0163	0.0526
Trichomonas vaginalis	AGC family protein kinase	0.0011	0.0039	0.0134
Echinococcus granulosus	RNA directed DNA polymerase	0.0048	0.1879	0.6429
Schistosoma mansoni	serine/threonine protein kinase	0.0068	0.2916	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0013	0.0163	0.0526
Echinococcus granulosus	protein kinase c epsilon type	0.002	0.048	0.1617
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.002	0.048	0.0443
Loa Loa (eye worm)	AUR protein kinase	0.0068	0.2916	0.2889
Echinococcus granulosus	serine:threonine protein kinase N2	0.0011	0.0039	0.0099
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0011	0.0039	0.0099
Toxoplasma gondii	AGC kinase	0.0011	0.0039	0.0099
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0016	0.0275	0.091
Schistosoma mansoni	tyrosine kinase	0.0016	0.0275	0.091
Echinococcus granulosus	protein kinase C gamma type	0.006	0.2499	0.8565
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0011	0.0039	0.0099
Brugia malayi	Immunoglobulin I-set domain containing protein	0.003	0.0994	0.0959
Schistosoma mansoni	serine/threonine protein kinase	0.0011	0.0039	0.0099
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0068	0.2916	1
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.003	0.0994	0.3386
Echinococcus granulosus	c src tyrosine kinase	0.0016	0.0275	0.091
Echinococcus multilocularis	aurora kinase A	0.0068	0.2916	1

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.89 uM	Inhibition of JAK2 in human UT7 cells assessed as inhibition of Epo-dependent STAT5 phosphorylation	ChEMBL.	23265875
EC50 (binding)	= 1.2 uM	Inhibition of JAK1 in human TF1 cells assessed as inhibition of IL6-dependent STAT3 phosphorylation	ChEMBL.	23265875
IC50 (binding)	= 0.05 uM	Inhibition of JAK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 0.09 uM	Inhibition of JAK1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 0.16 uM	Inhibition of KDR (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 0.3 uM	Inhibition of TYK2 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 0.34 uM	Inhibition of Aurora 1 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 0.44 uM	Inhibition of FLT3 (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 1000 uM ATP	ChEMBL.	23265875
IC50 (binding)	= 2.6 uM	Inhibition of PKCalpha (unknown origin) after 2.5 hrs by time-resolved fluorescence resonance energy transfer assay in presence of 100 uM ATP	ChEMBL.	23265875

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2322136

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1728987