Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2805 | 0.2805 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Echinococcus granulosus | carboxylesterase 5A | 0.048 | 0.3288 | 0.9865 |
Schistosoma mansoni | voltage-gated potassium channel | 0.053 | 0.3701 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0491 | 0.0491 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0141 | 0.0491 | 0.1326 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0096 | 0.0123 | 0.037 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0453 | 0.307 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0141 | 0.0491 | 0.1326 |
Echinococcus multilocularis | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0141 | 0.0491 | 0.1472 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0123 | 0.0123 |
Echinococcus granulosus | voltage gated potassium channel | 0.0141 | 0.0491 | 0.1472 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0485 | 0.3333 | 0.3333 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Echinococcus multilocularis | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0141 | 0.0491 | 0.1472 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0141 | 0.0491 | 0.1472 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.3288 | 0.3288 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0096 | 0.0123 | 0.0401 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | carboxylesterase 5A | 0.048 | 0.3288 | 0.9865 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0812 | 0.2193 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus granulosus | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.048 | 0.3288 | 0.3288 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Brugia malayi | Carboxylesterase family protein | 0.048 | 0.3288 | 0.9865 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.3288 | 0.3288 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Brugia malayi | Carboxylesterase family protein | 0.048 | 0.3288 | 0.9865 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0453 | 0.307 | 1 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0096 | 0.0123 | 0.037 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0096 | 0.0123 | 0.0401 |
Loa Loa (eye worm) | carboxylesterase | 0.048 | 0.3288 | 0.3288 |
Schistosoma mansoni | voltage-gated potassium channel | 0.053 | 0.3701 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0485 | 0.3333 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.048 | 0.3288 | 0.8885 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0485 | 0.3333 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0485 | 0.3333 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.018 | 0.0812 | 0.5 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.0123 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0141 | 0.0491 | 0.1472 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0096 | 0.0123 | 0.037 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.715 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.623 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.551 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.477 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.465 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.312 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.244 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.154 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.003 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.