Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0421 | 0.2805 | 0.2805 |
Echinococcus multilocularis | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.048 | 0.3288 | 0.8885 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0141 | 0.0491 | 0.1472 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0141 | 0.0491 | 0.1472 |
Brugia malayi | Carboxylesterase family protein | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | voltage-gated potassium channel | 0.053 | 0.3701 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.048 | 0.3288 | 0.9865 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.0491 | 0.0491 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Brugia malayi | Cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Echinococcus multilocularis | potassium:sodium hyperpolarization activated | 0.0096 | 0.0123 | 0.037 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0096 | 0.0123 | 0.0401 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0453 | 0.307 | 1 |
Echinococcus granulosus | cyclic nucleotide gated cation channel alpha 3 | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | carboxylesterase 5A | 0.048 | 0.3288 | 0.9865 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0812 | 0.2193 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0141 | 0.0491 | 0.1326 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0141 | 0.0491 | 0.1326 |
Echinococcus granulosus | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Trypanosoma brucei | RNA helicase, putative | 0.018 | 0.0812 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0485 | 0.3333 | 0.3333 |
Echinococcus multilocularis | hyperpolarization activated cyclic | 0.0096 | 0.0123 | 0.037 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0453 | 0.307 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel alpha 3 | 0.0096 | 0.0123 | 0.037 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.3288 | 0.3288 |
Echinococcus granulosus | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | carboxylesterase 5A | 0.048 | 0.3288 | 0.9865 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0485 | 0.3333 | 1 |
Schistosoma mansoni | cyclic-nucleotide-gated cation channel | 0.0096 | 0.0123 | 0.0333 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0485 | 0.3333 | 1 |
Loa Loa (eye worm) | cyclic-nucleotide gated cation channel | 0.0096 | 0.0123 | 0.0123 |
Echinococcus granulosus | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Schistosoma mansoni | voltage-gated potassium channel | 0.053 | 0.3701 | 1 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0141 | 0.0491 | 0.1472 |
Loa Loa (eye worm) | hypothetical protein | 0.048 | 0.3288 | 0.3288 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0141 | 0.0491 | 0.1472 |
Echinococcus multilocularis | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | acetylcholinesterase | 0.048 | 0.3288 | 0.9865 |
Echinococcus granulosus | voltage gated potassium channel | 0.0141 | 0.0491 | 0.1472 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0485 | 0.3333 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.048 | 0.3288 | 0.3288 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0096 | 0.0123 | 0.0401 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0123 | 0.0123 |
Echinococcus multilocularis | cyclic nucleotide gated cation channel | 0.0096 | 0.0123 | 0.037 |
Echinococcus granulosus | potassium:sodium hyperpolarization activated | 0.0096 | 0.0123 | 0.037 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.048 | 0.3288 | 0.3288 |
Schistosoma mansoni | hyperpolarization activated cyclic nucleotide-gated potassium channel | 0.0096 | 0.0123 | 0.0333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.815 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.68 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.564 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.556 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.53 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.523 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.48 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.448 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.284 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.211 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.2 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.