TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 821.863 | Formula: C43H51NO15
H donors: 5 H acceptors: 10 LogP: 1.54 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: CC(=O)O[C@@]12CO[C@@H]1C[C@@H]([C@@]1([C@@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@@H]([C@@H](N3C(=O)OC(C3O)(C)C)c3ccccc3)O)C(=C(C2(C)C)[C@H](C1=O)O)C)C)O
InChi: 1S/C43H51NO15/c1-21-25(56-36(51)31(48)29(23-14-10-8-11-15-23)44-37(52)40(5,6)59-38(44)53)19-43(54)34(57-35(50)24-16-12-9-13-17-24)32-41(7,33(49)30(47)28(21)39(43,3)4)26(46)18-27-42(32,20-55-27)58-22(2)45/h8-17,25-27,29-32,34,37,46-48,52,54H,18-20H2,1-7H3/t25-,26-,27+,29-,30+,31+,32-,34-,37?,41+,42-,43+/m0/s1
InChiKey: MZGHWPNTSVYFCV-APYNTUORSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0424	0.0441
Echinococcus multilocularis	sex peptide receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	allatostatin A receptor	0.0028	0.0562	0.0636
Onchocerca volvulus		0.0037	0.0955	0.0773
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Echinococcus granulosus	7TM GPCR rhodopsin	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	N-terminal motif family protein	0.0176	0.7297	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	latrophilin 2 splice variant baaae	0.0077	0.2789	0.3822
Brugia malayi	sulfakinin receptor protein	0.0028	0.0562	0.077
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0955	1
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0028	0.0562	0.0636
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0037	0.0955	0.1028
Plasmodium vivax	hypothetical protein, conserved	0.0025	0.0424	0.038
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Trichomonas vaginalis	hypothetical protein	0.0198	0.8315	1
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0424	0.0441
Echinococcus multilocularis	neuropeptide receptor A26	0.0028	0.0562	0.0636
Mycobacterium tuberculosis	Probable hydrolase	0.0037	0.0955	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	neuropeptide F receptor	0.0028	0.0562	0.077
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0028	0.0562	0.0636
Toxoplasma gondii	hypothetical protein	0.0025	0.0424	0.038
Brugia malayi	Serotonin receptor	0.0028	0.0562	0.077
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.0581
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus multilocularis	allatostatin A receptor	0.0028	0.0562	0.0636
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.0581
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0424	0.0441
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0028	0.0562	0.0636
Schistosoma mansoni	adenoreceptor	0.0028	0.0562	0.0636
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0028	0.0562	0.077
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0562	0.0636
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.038
Brugia malayi	follicle stimulating hormone receptor	0.0028	0.0562	0.077
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.038
Plasmodium falciparum	amino acid transporter, putative	0.0025	0.0424	0.038
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	beta-lactamase	0.0037	0.0955	0.1173
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Mycobacterium ulcerans	beta-lactamase	0.0037	0.0955	0.1028
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0036	0.0902	0.1118
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0028	0.0562	0.0636
Mycobacterium ulcerans	lipase LipD	0.0037	0.0955	0.1028
Onchocerca volvulus		0.0148	0.6034	0.8163
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0397	0.0347
Echinococcus granulosus	neuropeptide FF receptor 2	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	GPCR, family 2	0.0036	0.0902	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	fmrfamide receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0562	0.0625
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0037	0.0955	0.1173
Onchocerca volvulus		0.0028	0.0562	0.02
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide f receptor 76f	0.0028	0.0562	0.0636
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.0434
Schistosoma mansoni	hypothetical protein	0.0036	0.0902	0.1118
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Echinococcus granulosus	beta LACTamase domain containing family member	0.0037	0.0955	0.1193
Loa Loa (eye worm)	serotonin transporter b	0.0148	0.6034	0.8243
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Onchocerca volvulus		0.0028	0.0562	0.02
Onchocerca volvulus		0.0037	0.0955	0.0773
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0148	0.6034	0.8384
Schistosoma mansoni	hypothetical protein	0.0028	0.0562	0.0636
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Mycobacterium tuberculosis	Probable lipase LipE	0.0037	0.0955	0.0852
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	sodium/chloride dependent transporter	0.0148	0.6034	0.8384
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	Serotonin receptor	0.0028	0.0562	0.077
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0397	0.3373
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0562	0.0636
Onchocerca volvulus		0.0028	0.0562	0.02
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0562	0.0625
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	neuropeptide receptor	0.0028	0.0562	0.0636
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0955	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0148	0.6034	0.8243
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0176	0.7297	1
Schistosoma mansoni	myosin xvIII	0.0028	0.0562	0.0636
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0562	0.0636
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0025	0.0424	0.0441
Echinococcus granulosus	somatostatin receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Toxoplasma gondii	hypothetical protein	0.0025	0.0424	0.038
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0562	0.0636
Onchocerca volvulus		0.0028	0.0562	0.02
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0955	0.0852
Brugia malayi	AKH receptor	0.0028	0.0562	0.077
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0025	0.0424	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	hypothetical protein	0.0028	0.0562	0.0636
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0424	0.0441
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	serotonin receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Brugia malayi	neuropeptide F receptor	0.0028	0.0562	0.077
Brugia malayi	GnHR receptor homolog	0.0028	0.0562	0.077
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0424	0.0441
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0562	0.0636
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0113	0.4414	0.6049
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0036	0.0902	0.1099
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0028	0.0562	0.02
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0028	0.0562	0.0636
Onchocerca volvulus		0.0028	0.0562	0.02
Toxoplasma gondii	enoyl-acyl carrier reductase ENR	0.0198	0.8315	1
Mycobacterium ulcerans	hypothetical protein	0.0037	0.0955	0.1028
Brugia malayi	ORL1-like opioid receptor	0.0028	0.0562	0.077
Echinococcus granulosus	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0028	0.0562	0.0636
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	hypothetical protein	0.0036	0.0902	0.1118
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0562	0.0636
Trypanosoma brucei	hypothetical protein, conserved	0.0037	0.0955	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0028	0.0562	0.0625
Brugia malayi	RE15519p	0.0028	0.0562	0.077
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	geminin	0.0173	0.7176	1
Mycobacterium tuberculosis	NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase)	0.0198	0.8315	0.8296
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0036	0.0902	0.1237
Echinococcus granulosus	g-protein coupled receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0955	0.1028
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	neuropeptide F receptor	0.0028	0.0562	0.0625
Echinococcus multilocularis	serotonin receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	GPCR family 2	0.0036	0.0902	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Chlamydia trachomatis	enoyl-acyl-carrier protein reductase	0.0198	0.8315	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus granulosus	serotonin transporter	0.0148	0.6034	0.8384
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0028	0.0562	0.077
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	Latrophilin receptor protein 2	0.0036	0.0902	0.1237
Wolbachia endosymbiont of Brugia malayi	enoyl-ACP reductase	0.0198	0.8315	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	somatostatin receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	amine GPCR	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	dro:myosuppressin receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0562	0.0636
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Treponema pallidum	sodium- and chloride- dependent transporter	0.0148	0.6034	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0397	0.3373
Echinococcus multilocularis	G protein coupled receptor 139	0.0028	0.0562	0.0636
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0176	0.7297	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0037	0.0955	0.1309
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0028	0.0562	0.0636
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0018	0.0113	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Onchocerca volvulus		0.0028	0.0562	0.02
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0562	0.0636
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0955	0.1193
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.0434
Brugia malayi	putative neuropeptide receptor NPR1	0.0028	0.0562	0.077
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0025	0.0397	0.0544
Plasmodium falciparum	enoyl-acyl carrier reductase	0.0198	0.8315	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	neuropeptides capa receptor	0.0028	0.0562	0.0636
Mycobacterium tuberculosis	Probable lipase LipD	0.0037	0.0955	0.0852
Onchocerca volvulus		0.0028	0.0562	0.02
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0113	0.4414	0.6049
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0955	0.1028
Loa Loa (eye worm)	hypothetical protein	0.0148	0.6034	0.8243
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	dro:myosuppressin receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0028	0.0562	0.0625
Trichomonas vaginalis	D-aminoacylase, putative	0.0037	0.0955	0.1028
Echinococcus granulosus	7tm_1 domain containing protein	0.0028	0.0562	0.0636
Echinococcus granulosus	g protein coupled receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	opsin-like receptor	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Plasmodium vivax	amine transporter, putative	0.0025	0.0424	0.038
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0028	0.0562	0.0625
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0028	0.0562	0.0636
Schistosoma mansoni	hypothetical protein	0.0173	0.7176	1
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0025	0.0424	0.0441
Brugia malayi	G protein-coupled receptor	0.0028	0.0562	0.077
Schistosoma mansoni	hypothetical protein	0.0036	0.0902	0.1118
Brugia malayi	beta-lactamase	0.0037	0.0955	0.1309
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0037	0.0955	0.0852
Brugia malayi	putative neuropeptide receptor	0.0028	0.0562	0.077
Loa Loa (eye worm)	hypothetical protein	0.0148	0.6034	0.8243
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0397	0.3373
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0397	0.3373
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus granulosus	sodium and chloride dependent glycine	0.0025	0.0424	0.0441
Brugia malayi	beta-lactamase family protein	0.0037	0.0955	0.1309
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0018	0.0113	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	G protein-coupled receptor F59B2.13	0.0028	0.0562	0.077
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0028	0.0562	0.077
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	TYRA-2 protein	0.0028	0.0562	0.0625
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0036	0.0902	0.1118
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0028	0.0562	0.077
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0562	0.0636
Brugia malayi	beta-lactamase family protein	0.0037	0.0955	0.1309
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Loa Loa (eye worm)	melatonin receptor type 1A	0.0028	0.0562	0.0625
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0028	0.0562	0.077
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0028	0.0562	0.0636
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0028	0.0562	0.0636
Mycobacterium leprae	NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE)	0.0198	0.8315	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0562	0.0636
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Brugia malayi	Dopamine receptor	0.0028	0.0562	0.077
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0028	0.0562	0.0636
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0028	0.0562	0.0636
Plasmodium vivax	enoyl-acyl carrier protein reductase	0.0198	0.8315	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0036	0.0902	0.1118
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	hypothetical protein	0.0028	0.0562	0.0636
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0113	0.4414	0.5987
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0025	0.0424	0.0441
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Leishmania major	hypothetical protein, conserved	0.0037	0.0955	1
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0955	0.0852
Onchocerca volvulus		0.0028	0.0562	0.02
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0562	0.0636
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0397	0.0347
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Echinococcus granulosus	serotonin receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0562	0.0636
Brugia malayi	G-protein coupled receptor	0.0028	0.0562	0.077
Toxoplasma gondii	ABC1 family protein	0.0037	0.0955	0.1028
Brugia malayi	hypothetical protein	0.0025	0.0424	0.0581
Onchocerca volvulus		0.0028	0.0562	0.02
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	geminin	0.0173	0.7176	1
Loa Loa (eye worm)	hypothetical protein	0.0077	0.2789	0.3725
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Trypanosoma cruzi	hypothetical protein, conserved	0.0037	0.0955	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0113	0.4414	0.5987
Onchocerca volvulus		0.0037	0.0955	0.0773
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0424	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0902	0.1099
Echinococcus granulosus	G protein coupled receptor 139	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Echinococcus multilocularis	g protein coupled receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0028	0.0562	0.0636
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0148	0.6034	0.827
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0037	0.0955	0.1193
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	amine GPCR	0.0028	0.0562	0.0636
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0397	0.0347
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0037	0.0955	0.0852
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0028	0.0562	0.077
Mycobacterium tuberculosis	Probable esterase LipL	0.0037	0.0955	0.0852
Echinococcus granulosus	sex peptide receptor	0.0028	0.0562	0.0636
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0037	0.0955	0.0852
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Schistosoma mansoni	hypothetical protein	0.0077	0.2789	0.3789
Trichomonas vaginalis	esterase, putative	0.0037	0.0955	0.1028
Onchocerca volvulus		0.0028	0.0562	0.02
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0025	0.0424	0.0581
Echinococcus granulosus	tm gpcr rhodopsin	0.0028	0.0562	0.0636
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0028	0.0562	0.0636
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0397	0.0347
Schistosoma mansoni	growth hormone secretagogue receptor	0.0028	0.0562	0.0636
Plasmodium falciparum	transporter, putative	0.0025	0.0424	0.038
Brugia malayi	larval opioid receptor	0.0028	0.0562	0.077
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0025	0.0424	0.0581
Echinococcus multilocularis	neuropeptide s receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	neuropeptide F-like receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	sodium/chloride dependent transporter	0.0025	0.0424	0.0441
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	hypothetical protein	0.0028	0.0562	0.0636
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	hypothetical protein	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0025	0.0424	0.0441
Echinococcus granulosus	neuropeptides capa receptor	0.0028	0.0562	0.0636
Plasmodium vivax	hypothetical protein, conserved	0.0037	0.0955	0.1028
Schistosoma mansoni	hypothetical protein	0.0173	0.7176	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0902	0.1118
Onchocerca volvulus		0.0028	0.0562	0.02
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0397	0.0396
Brugia malayi	Dopamine receptor protein 1	0.0028	0.0562	0.077
Brugia malayi	Melatonin receptor type 1A	0.0028	0.0562	0.077
Trichomonas vaginalis	penicillin-binding protein, putative	0.0037	0.0955	0.1028
Schistosoma mansoni	histamine h1 receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Loa Loa (eye worm)	norepinephrine transporter	0.0148	0.6034	0.8243
Schistosoma mansoni	amine GPCR	0.0028	0.0562	0.0636
Echinococcus multilocularis	neuropeptide Y receptor	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0028	0.0562	0.0636
Echinococcus granulosus	neuropeptide s receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Mycobacterium ulcerans	enoyl-(acyl carrier protein) reductase	0.0198	0.8315	1
Brugia malayi	G-protein coupled receptor	0.0028	0.0562	0.077
Schistosoma mansoni	opsin-like receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	amine GPCR	0.0028	0.0562	0.0636
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0028	0.0562	0.0636
Echinococcus granulosus	fmrfamide receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0955	0.1173
Schistosoma mansoni	opsin-like receptor	0.0028	0.0562	0.0636
Echinococcus granulosus	orexin receptor type 2	0.0028	0.0562	0.0636
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0028	0.0562	0.0625
Echinococcus granulosus	biogenic amine 5HT receptor	0.0028	0.0562	0.0636
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0028	0.0562	0.0636
Brugia malayi	hypothetical protein	0.0028	0.0562	0.077
Echinococcus multilocularis	orexin receptor type 2	0.0028	0.0562	0.0636
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0036	0.0902	0.1118
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Brugia malayi	exodeoxyribonuclease III family protein	0.0018	0.0113	0.0154
Mycobacterium tuberculosis	Conserved protein	0.0037	0.0955	0.0852
Onchocerca volvulus		0.0028	0.0562	0.02
Schistosoma mansoni	biogenic amine receptor	0.0028	0.0562	0.0636
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus granulosus	neuropeptide receptor A26	0.0028	0.0562	0.0636
Echinococcus multilocularis	serotonin transporter	0.0148	0.6034	0.8384
Echinococcus granulosus	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0028	0.0562	0.02
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0028	0.0562	0.0636
Mycobacterium ulcerans	esterase/lipase LipP	0.0037	0.0955	0.1028
Schistosoma mansoni	amine GPCR	0.0028	0.0562	0.0636
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0028	0.0562	0.0636
Brugia malayi	Dopamine receptor protein 2	0.0028	0.0562	0.077
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0025	0.0424	0.0441
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0148	0.6034	0.8243
Echinococcus granulosus	neuropeptide Y receptor	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0028	0.0562	0.0636
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0028	0.0562	0.0636
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0562	0.0625
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0037	0.0955	0.1193
Echinococcus multilocularis	g-protein coupled receptor	0.0028	0.0562	0.0636

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3706532

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1729350