Detailed information for compound 1729569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.476 | Formula: C25H25FN2O3
  • H donors: 2 H acceptors: 2 LogP: 2 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCNCc1ccc(cc1)/C(=N/OCc1ccc(cc1F)c1ccccc1)/C
  • InChi: 1S/C25H25FN2O3/c1-18(20-9-7-19(8-10-20)16-27-14-13-25(29)30)28-31-17-23-12-11-22(15-24(23)26)21-5-3-2-4-6-21/h2-12,15,27H,13-14,16-17H2,1H3,(H,29,30)/b28-18+
  • InChiKey: IOGFZDMRKKVGJF-MTDXEUNCSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0004 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0004 0.5 0.5
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0004 0.5 0.5
Trypanosoma brucei oxidoreductase-like protein 0.0004 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Leishmania major short chain dehydrogenase-like protein 0.0004 0.5 0.5
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0004 0.5 0.5
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0004 0.5 0.5
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0004 0.5 0.5
Onchocerca volvulus Sepiapterin reductase homolog 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0004 0.5 0.5
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0004 0.5 0.5
Echinococcus multilocularis conserved hypothetical protein 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 9 0.0004 0.5 0.5
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.5 0.5
Leishmania major 3-keto-dihydrosphingosine reductase 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Plasmodium vivax steroid dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0004 0.5 0.5
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0004 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0004 0.5 0.5
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0004 0.5 0.5
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0004 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 2 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Plasmodium vivax hypothetical protein, conserved 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis oxidoreductase 0.0004 0.5 0.5
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase, putative 0.0004 0.5 0.5
Echinococcus granulosus WW domain containing oxidoreductase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0004 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0004 0.5 0.5
Giardia lamblia Short-chain dehydrogenase, putative 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.5 0.5
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Echinococcus granulosus hypothetical protein 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0004 0.5 0.5
Giardia lamblia Reductase, putative 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type oxidoreductase 0.0004 0.5 0.5
Brugia malayi dehydrogenases, short chain protein 2 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Brugia malayi hypothetical protein 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0004 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0004 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.5 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium leprae Probable oxidoreductase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Toxoplasma gondii carbonyl reductase 1, putative 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Echinococcus granulosus steroid dehydrogenase 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Echinococcus granulosus oxidoreductase 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0004 0.5 0.5
Giardia lamblia Hypothetical protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible oxidoreductase 0.0004 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 11 0.0004 0.5 0.5
Entamoeba histolytica hypothetical protein 0.0004 0.5 0.5
Echinococcus multilocularis transient receptor potential cation channel 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0004 0.5 0.5
Echinococcus multilocularis carbonyl reductase 1 0.0004 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0004 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Brugia malayi hypothetical protein 0.0004 0.5 0.5
Echinococcus multilocularis retinol dehydrogenase 13 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.5 0.5
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.5 0.5
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0004 0.5 0.5
Loa Loa (eye worm) dehydrogenase 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable oxidoreductase 0.0004 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0004 0.5 0.5
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Mycobacterium ulcerans dehydrogenase/reductase 0.0004 0.5 0.5
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0004 0.5 0.5
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Leishmania major short chain dehydrogenase, putative 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, putative 0.0004 0.5 0.5
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0004 0.5 0.5
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0004 0.5 0.5
Mycobacterium ulcerans ketoacyl reductase 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0004 0.5 0.5
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis steroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0004 0.5 0.5
Leishmania major pteridine reductase 1 0.0004 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0004 0.5 0.5
Leishmania major dehydrogenase-like protein 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0004 0.5 0.5
Brugia malayi Dehydrogenases, short chain protein 30 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Entamoeba histolytica short chain dehydrogenase family protein 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0004 0.5 0.5
Entamoeba histolytica hypothetical protein, conserved 0.0004 0.5 0.5
Brugia malayi oxidoreductase 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Mycobacterium ulcerans carveol-like dehydrogenase 0.0004 0.5 0.5
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0004 0.5 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0004 0.5 0.5
Mycobacterium ulcerans oxidoreductase 0.0004 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0004 0.5 0.5
Leishmania major hypothetical protein, conserved 0.0004 0.5 0.5
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0004 0.5 0.5
Schistosoma mansoni steroid dehydrogenase 0.0004 0.5 0.5
Loa Loa (eye worm) hypothetical protein 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0004 0.5 0.5
Leishmania major oxidoreductase-like protein 0.0004 0.5 0.5
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0004 0.5 0.5
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0004 0.5 0.5
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0004 0.5 0.5
Loa Loa (eye worm) oxidoreductase 0.0004 0.5 0.5
Leishmania major short chain dehydrogenase/reductase, putative 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain dehydrogenase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Schistosoma mansoni retinal dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Schistosoma mansoni short chain dehydrogenase 0.0004 0.5 0.5
Onchocerca volvulus 0.0004 0.5 0.5
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0004 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.5 0.5
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0004 0.5 0.5
Trichomonas vaginalis steroid dehydrogenase, putative 0.0004 0.5 0.5
Schistosoma mansoni carbonyl reductase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0004 0.5 0.5
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0004 0.5 0.5
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0004 0.5 0.5
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0004 0.5 0.5
Brugia malayi Retinol dehydrogenase 12 0.0004 0.5 0.5
Echinococcus granulosus retinol dehydrogenase 11 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Mycobacterium ulcerans short chain dehydrogenase 0.0004 0.5 0.5
Echinococcus granulosus carbonyl reductase 1 0.0004 0.5 0.5
Plasmodium falciparum steroid dehydrogenase, putative 0.0004 0.5 0.5
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0004 0.5 0.5

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.12 uM Agonist activity at human S1P1 receptor transfected in CHO cells incubated for 10 to 15 mins prior to GTPgamma35S addition measured after 120 mins by GTPgamma35S binding assay ChEMBL. 24900670

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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