Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | adenosine deaminase | 0.0085 | 0.4929 | 0.5 |
Schistosoma mansoni | adenosine deaminase-related | 0.0085 | 0.4929 | 0.0873 |
Onchocerca volvulus | Adenosine deaminase homolog | 0.0085 | 0.4929 | 0.5 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.4929 | 0.4929 |
Schistosoma mansoni | adenosine deaminase | 0.0085 | 0.4929 | 0.0873 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.4929 | 0.3791 |
Trichomonas vaginalis | adenosine deaminase, putative | 0.0085 | 0.4929 | 0.4929 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Time (functional) | = 13.8 s | Analgesic activity in mouse assessed as increase in paw withdrawal latency at 100 mg/kg after 120 mins by hot plate test (Rvb = 6.07 +/- 0.057 secs) | ChEMBL. | 23357631 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.