Detailed information for compound 1729613

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1423.83 | Formula: C75H118N14O13
  • H donors: 14 H acceptors: 13 LogP: 6.79 Rotable bonds: 41
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H](NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)[C@H]1CCC[C@@H]1NC(=O)C)CC(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N[C@H]1CCC[C@@H]1C(=O)N
  • InChi: 1S/C75H118N14O13/c1-40(90)78-54-28-5-17-43(54)67(94)83-58-32-9-21-47(58)71(98)86-60-34-11-23-49(60)73(100)88-62-36-13-25-51(62)75(102)89-63-37-14-26-52(63)74(101)87-61-35-12-24-50(61)72(99)85-59-33-10-22-48(59)70(97)82-56-30-7-19-45(56)66(93)79-41(15-2-3-38-76)39-64(91)80-55-29-6-18-44(55)68(95)84-57-31-8-20-46(57)69(96)81-53-27-4-16-42(53)65(77)92/h41-63H,2-39,76H2,1H3,(H2,77,92)(H,78,90)(H,79,93)(H,80,91)(H,81,96)(H,82,97)(H,83,94)(H,84,95)(H,85,99)(H,86,98)(H,87,101)(H,88,100)(H,89,102)/t41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-,63-/m0/s1
  • InChiKey: CVKZVCYNZJQRBT-RWVDNASCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus lamin 0.0026 0.0083 0.0083
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0273 0.0257
Trypanosoma cruzi cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0059 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0197 0.0197
Echinococcus granulosus adenine phosphoribosyltransferase 0.0381 0.2282 0.2282
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.021
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Brugia malayi hypothetical protein 0.0227 0.1329 0.1322
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0381 0.2282 0.2173
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0017 0.0031 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0053 0.0044
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.014 0.0109
Loa Loa (eye worm) hypothetical protein 0.0118 0.0651 0.2582
Schistosoma mansoni lamin 0.0026 0.0083 0.0067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0044
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0215 0.0199
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.014 0.0123
Entamoeba histolytica peptidase, C54 family 0.0022 0.0059 0.0885
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.014 0.014
Brugia malayi beta-lactamase family protein 0.0035 0.014 0.0131
Schistosoma mansoni hypothetical protein 0.0048 0.022 0.0204
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.014 0.0161
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0381 0.2282 0.2971
Trichomonas vaginalis maltase-glucoamylase, putative 0.0069 0.0353 0.0323
Brugia malayi Peptidase family C54 containing protein 0.0057 0.0273 0.0265
Leishmania major phosphatidylinositol 3-kinase, putative 0.0017 0.0031 0.0014
Schistosoma mansoni BC026374 protein (S09 family) 0.0047 0.0215 0.0199
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0381 0.2282 0.2258
Echinococcus multilocularis microtubule associated protein 2 0.0773 0.4715 0.4715
Schistosoma mansoni hypothetical protein 0.0048 0.022 0.0204
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0381 0.2282 0.2856
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0381 0.2282 0.2282
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0053 0.0036
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0197 0.0779
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0017 0.0031 0.0031
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0083 0.0066
Toxoplasma gondii autophagy-related cysteine peptidase atg4, putative 0.0022 0.0059 0.0043
Onchocerca volvulus Huntingtin homolog 0.0118 0.0651 0.0602
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0015
Leishmania major adenine phosphoribosyltransferase 0.0381 0.2282 0.2269
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0279 0.1653 0.6553
Echinococcus multilocularis GPCR, family 2 0.0048 0.022 0.022
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.014 0.0161
Echinococcus multilocularis musashi 0.0026 0.0083 0.0083
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0381 0.2282 0.9047
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.0044
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0381 0.2282 0.2269
Schistosoma mansoni hypothetical protein 0.0035 0.0138 0.0122
Brugia malayi Latrophilin receptor protein 2 0.0048 0.022 0.0211
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.3331
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0071 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0044
Echinococcus granulosus intermediate filament protein 0.0026 0.0083 0.0083
Echinococcus multilocularis acetylcholinesterase 0.0279 0.1653 0.1653
Brugia malayi intermediate filament protein 0.0026 0.0083 0.0075
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1309 0.1695
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0071 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0114
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0791 0.0775
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.014 0.0109
Trypanosoma brucei glucosidase, putative 0.0069 0.0353 0.0337
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.021
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0017 0.0031 0.0031
Echinococcus multilocularis neutral alpha glucosidase AB 0.0069 0.0353 0.0353
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.014 0.0109
Echinococcus multilocularis lysosomal alpha glucosidase 0.0313 0.1861 0.1861
Brugia malayi Carboxylesterase family protein 0.0047 0.0215 0.0207
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.014 0.0109
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0083 0.0052
Loa Loa (eye worm) hypothetical protein 0.0088 0.047 0.1863
Echinococcus multilocularis Peptidase C54 0.0057 0.0273 0.0273
Loa Loa (eye worm) carboxylesterase 0.0047 0.0215 0.0852
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.014 0.0161
Trichomonas vaginalis maltase-glucoamylase, putative 0.0026 0.0083 0.0052
Schistosoma mansoni hypothetical protein 0.0048 0.022 0.0204
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0381 0.2282 0.9047
Echinococcus multilocularis neuroligin 0.0047 0.0215 0.0215
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0178 0.0162
Schistosoma mansoni lamin 0.0026 0.0083 0.0067
Echinococcus multilocularis lamin dm0 0.0026 0.0083 0.0083
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.0353 1
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0157 0.3907
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0051 0.0034
Entamoeba histolytica peptidase, C54 family 0.0022 0.0059 0.0885
Echinococcus granulosus neutral alpha glucosidase AB 0.0069 0.0353 0.0353
Plasmodium falciparum orotate phosphoribosyltransferase 0.0381 0.2282 0.2269
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0157 0.014
Schistosoma mansoni hypothetical protein 0.0104 0.0565 0.0549
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0053 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0053 0.0044
Entamoeba histolytica hypothetical protein 0.0024 0.0071 0.1257
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.1245 0.7641 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0197 0.0188
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0381 0.2282 0.2971
Echinococcus multilocularis BC026374 protein (S09 family) 0.0047 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.0165 0.0944 0.0929
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0053 0.0053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0053 0.0053
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0009 0.0034
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0017 0.0031 0.0014
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0017 0.0031 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.0044
Treponema pallidum adenine phosphoribosyltransferase 0.0381 0.2282 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.014 0.0109
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0053 0.0053
Schistosoma mansoni alpha-glucosidase 0.0269 0.1591 0.1577
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0328
Schistosoma mansoni gliotactin 0.0047 0.0215 0.0199
Schistosoma mansoni acetylcholinesterase 0.0047 0.0215 0.0199
Schistosoma mansoni family C54 unassigned peptidase (C54 family) 0.0057 0.0273 0.0257
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.0044
Echinococcus granulosus uridine 5' monophosphate synthase 0.0381 0.2282 0.2282
Brugia malayi Carboxylesterase family protein 0.0279 0.1653 0.1646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.021
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Conserved protein 0.0035 0.014 0.0161
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0273 0.0243
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0071 0.0055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0178 0.0162
Echinococcus granulosus lamin dm0 0.0026 0.0083 0.0083
Schistosoma mansoni survival motor neuron protein 0.0046 0.0209 0.0193
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0071 0.0071
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0053 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.02
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0381 0.2282 0.2269
Brugia malayi nuclear hormone receptor 0.0021 0.0053 0.0044
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0157 0.0126
Loa Loa (eye worm) hypothetical protein 0.0279 0.1653 0.6553
Onchocerca volvulus 0.0026 0.0083 0.003
Toxoplasma gondii orotate phosphoribosyltransferase 0.0381 0.2282 0.2269
Echinococcus multilocularis lamin 0.0026 0.0083 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0083 0.0329
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0053 0.0053
Brugia malayi hypothetical protein 0.0118 0.0651 0.0643
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0381 0.2282 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0114
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.0353 0.0323
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Mycobacterium ulcerans hypothetical protein 0.0381 0.2282 0.2173
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0069 0.0353 0.1398
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.014 0.0123
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0053 0.0053
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0138 0.0138
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0381 0.2282 0.2173
Mycobacterium tuberculosis Conserved protein 0.0381 0.2282 0.2971
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0279 0.1653 0.1639
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0178 0.0147
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0381 0.2282 0.2856
Brugia malayi ecdysteroid receptor 0.0021 0.0053 0.0044
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) acetyltransferase 0.014 0.0791 0.3135
Brugia malayi Carboxylesterase family protein 0.0279 0.1653 0.1646
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0178 0.0147
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0053 0.0036
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.014 0.014
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.013 0.013
Echinococcus granulosus BC026374 protein S09 family 0.0047 0.0215 0.0215
Brugia malayi Glycosyl hydrolases family 31 protein 0.0026 0.0083 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0053 0.0044
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0031 0.0022
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0273 0.0243
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.3331
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Schistosoma mansoni autophagin-1 (C54 family) 0.0057 0.0273 0.0257
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0273 0.0243
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0317
Echinococcus multilocularis geminin 0.0165 0.0944 0.0944
Trypanosoma brucei cysteine peptidase, Clan CA, family C54, putative 0.0022 0.0059 0.0043
Onchocerca volvulus Phospholipase A2 homolog 0.0419 0.2522 0.2482
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0083 0.0052
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0017
Echinococcus multilocularis para nitrobenzyl esterase 0.0047 0.0215 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.014 0.0123
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0017 0.0031 0.0014
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0565 0.0557
Echinococcus multilocularis survival motor neuron protein 1 0.0227 0.1329 0.1329
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0053 0.0053
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0017 0.0031 0.0014
Onchocerca volvulus 0.0035 0.014 0.0087
Schistosoma mansoni hypothetical protein 0.0046 0.0209 0.0193
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0053 0.0044
Loa Loa (eye worm) hypothetical protein 0.0118 0.0651 0.2582
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0353 0.0323
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0083 0.0052
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0791 0.0783
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.018
Echinococcus granulosus cysteine protease atg4b 0.0057 0.0273 0.0273
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0381 0.2282 0.2971
Onchocerca volvulus 0.0047 0.0215 0.0163
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0017 0.0031 0.0014
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0381 0.2282 0.2269
Onchocerca volvulus 0.0033 0.013 0.0077
Schistosoma mansoni alpha-glucosidase 0.0269 0.1591 0.1577
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0031 0.0123
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0017 0.0031 0.0014
Schistosoma mansoni alpha glucosidase 0.0069 0.0353 0.0337
Schistosoma mansoni neuroligin 3 (S09 family) 0.0047 0.0215 0.0199
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0053 0.0036
Onchocerca volvulus 0.0026 0.0083 0.003
Leishmania major glycosyl hydrolase-like protein 0.0026 0.0083 0.0066
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Brugia malayi Carboxylesterase family protein 0.0047 0.0215 0.0207
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0178 0.0178
Echinococcus granulosus microtubule associated protein 2 0.0773 0.4715 0.4715
Echinococcus multilocularis acetylcholinesterase 0.0279 0.1653 0.1653
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0273 0.0243
Brugia malayi Carboxylesterase family protein 0.0047 0.0215 0.0207
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0381 0.2282 0.5
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0178 0.0162
Echinococcus granulosus GPCR family 2 0.0048 0.022 0.022
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0017 0.0031 0.0014
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0381 0.2282 0.2258
Brugia malayi isocitrate dehydrogenase 0.0015 0.0017 0.0008
Schistosoma mansoni uracil phosphoribosyltransferase 0.0381 0.2282 0.2269
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.022 0.022
Loa Loa (eye worm) carboxylesterase 0.0047 0.0215 0.0852
Echinococcus granulosus acetylcholinesterase 0.0279 0.1653 0.1653
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.022 0.0871
Loa Loa (eye worm) hypothetical protein 0.0057 0.0273 0.1084
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0017 0.0031 0.0014
Plasmodium vivax hypothetical protein, conserved 0.0035 0.014 0.0123
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0083 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.0862 0.0854
Loa Loa (eye worm) hypothetical protein 0.0104 0.0565 0.2239
Schistosoma mansoni hypothetical protein 0.0165 0.0944 0.0929
Brugia malayi Pre-SET motif family protein 0.0033 0.013 0.0121
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0031 0.0014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0017
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0017 0.0031 0.0014
Onchocerca volvulus 0.0035 0.014 0.0087
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0313 0.1861 0.7378
Trichomonas vaginalis set domain proteins, putative 0.0265 0.1568 0.1541
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.1368 0.5423
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0353 0.0323
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.3331
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0353 0.0323
Trichomonas vaginalis sucrase-isomaltase, putative 0.0069 0.0353 0.0323
Plasmodium falciparum cysteine protease ATG4, putative 0.0022 0.0059 0.0043
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0083 0.0075
Loa Loa (eye worm) MH2 domain-containing protein 0.0115 0.0633 0.2509
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.018
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0053 0.0044
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0138 0.0122
Brugia malayi orotate phosphoribosyltransferase family protein 0.0381 0.2282 0.2275
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0381 0.2282 0.2173
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0069 0.0353 0.0323
Mycobacterium tuberculosis Conserved protein 0.0035 0.014 0.0161
Entamoeba histolytica peptidase, C54 family 0.0022 0.0059 0.0885
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0071 0.0055
Onchocerca volvulus 0.0265 0.1568 0.1523
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.0862 0.3417
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0017 0.0031 0.0014
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0044
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0026 0.0083 0.1612
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0069 0.0353 0.0337
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0778 0.4746 0.4746
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0215 0.0199
Loa Loa (eye worm) acetylcholinesterase 1 0.0279 0.1653 0.6553
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0215 0.026
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0871
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Brugia malayi hypothetical protein 0.0047 0.0215 0.0207
Onchocerca volvulus 0.0047 0.0215 0.0163
Schistosoma mansoni coup transcription factor 0.0021 0.0053 0.0036
Onchocerca volvulus 0.0047 0.0215 0.0163
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.013 0.0114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.022 0.0211
Onchocerca volvulus Phospholipase A2 homolog 0.0088 0.047 0.0419
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Echinococcus granulosus para nitrobenzyl esterase 0.0047 0.0215 0.0215
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0197 0.0197
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.014 0.0161
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0083 0.0329
Loa Loa (eye worm) beta-lactamase 0.0035 0.014 0.0553
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0047 0.0215 0.0199
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0381 0.2282 0.2173
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0053 0.0036
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0017 0.0017
Onchocerca volvulus 0.0047 0.0215 0.0163
Brugia malayi Glycosyl hydrolases family 31 protein 0.0069 0.0353 0.0344
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0053 0.021
Echinococcus granulosus acetylcholinesterase 0.0279 0.1653 0.1653
Loa Loa (eye worm) hypothetical protein 0.0033 0.013 0.0515
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0053 0.0036
Brugia malayi Glycosyl hydrolases family 31 protein 0.0313 0.1861 0.1854
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0017 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Loa Loa (eye worm) transcription factor SMAD2 0.0115 0.0633 0.2509
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0047 0.0215 0.026
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0026 0.0083 0.0066
Toxoplasma gondii target of rapamycin (TOR), putative 0.0017 0.0031 0.0014
Loa Loa (eye worm) phosphatidylinositol 3 0.0017 0.0031 0.0123
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.014 0.0161
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0209 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.014 0.0123
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0059 0.0043
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0353 0.0337
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0017 0.0031 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0353 0.0323
Brugia malayi MH2 domain containing protein 0.0115 0.0633 0.0625
Brugia malayi Adenine phosphoribosyltransferase 0.0381 0.2282 0.2275
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0017 0.0031 0.0014
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0053 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0053 0.0053
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.013 0.013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0053 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0053 0.021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.014 0.0553
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0026 0.0083 0.0052
Brugia malayi Phospholipase A2 family protein 0.0088 0.047 0.0462
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0047 0.0215 0.0215
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.1245 0.7641 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.014 0.0131
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0138 0.0138
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0083 0.0052
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0381 0.2282 0.2282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.013 0.0114
Trypanosoma cruzi hypothetical protein, conserved 0.0069 0.0353 0.0337
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0017 0.0008
Onchocerca volvulus Huntingtin homolog 0.0118 0.0651 0.0602
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0026 0.0083 0.003
Mycobacterium ulcerans carboxylesterase, LipT 0.0047 0.0215 0.0076
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.013 0.013
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0017 0.0066
Trichomonas vaginalis esterase, putative 0.0035 0.014 0.0109
Trypanosoma brucei AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0273 0.0257
Brugia malayi Carboxylesterase family protein 0.0047 0.0215 0.0207
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0071 0.0055
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.022 0.022
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.013 0.0114
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Entamoeba histolytica peptidase, C54 family 0.0057 0.0273 0.7536
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0381 0.2282 0.2971
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.014 0.0161
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0053 0.021
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0381 0.2282 0.5
Loa Loa (eye worm) hypothetical protein 0.0419 0.2522 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0017 0.0031 0.0014
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0053 0.0036
Trichomonas vaginalis spcc417.12 protein, putative 0.0047 0.0215 0.0185
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.022 0.022
Echinococcus granulosus geminin 0.0165 0.0944 0.0944
Brugia malayi steroid hormone receptor 0.0021 0.0053 0.0044
Mycobacterium tuberculosis Conserved protein 0.0035 0.014 0.0161
Trypanosoma cruzi target of rapamycin kinase 3 0.0017 0.0031 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0053 0.021
Leishmania major hypothetical protein, conserved 0.0035 0.014 0.0123
Trypanosoma cruzi AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0273 0.0257
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0053 0.0036
Leishmania major alpha glucosidase II subunit, putative 0.0069 0.0353 0.0337
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0791 0.0791
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0047 0.0215 0.0215
Treponema pallidum hypothetical protein 0.0381 0.2282 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0197 0.0197
Mycobacterium tuberculosis Conserved protein 0.0381 0.2282 0.2971
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0047 0.0215 0.0185
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Entamoeba histolytica peptidase, C54 family 0.0022 0.0059 0.0885
Trichomonas vaginalis alpha-glucosidase, putative 0.0069 0.0353 0.0323
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0381 0.2282 0.2241
Schistosoma mansoni hypothetical protein 0.0048 0.022 0.0204
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0022 0.0059 0.0043
Onchocerca volvulus 0.0035 0.014 0.0087
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0381 0.2282 0.2269
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0053 0.0053
Onchocerca volvulus 0.0046 0.0209 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0053 0.0044
Echinococcus granulosus lysosomal alpha glucosidase 0.0313 0.1861 0.1861
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Echinococcus multilocularis carboxylesterase 5A 0.0279 0.1653 0.1653
Giardia lamblia Adenine phosphoribosyltransferase 0.0381 0.2282 0.2258
Mycobacterium tuberculosis Carboxylesterase LipT 0.0047 0.0215 0.026
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0071 0.0071
Brugia malayi beta-lactamase 0.0035 0.014 0.0131
Brugia malayi Pre-SET motif family protein 0.0233 0.1368 0.1361
Trichomonas vaginalis Clan CA, family C54, ATG4-like cysteine peptidase 0.0057 0.0273 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0053 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0053 0.0044
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0031 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.014 0.0123
Loa Loa (eye worm) hypothetical protein 0.0026 0.0083 0.0329
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0053 0.021
Onchocerca volvulus 0.0181 0.1044 0.0996
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0197 0.0197
Schistosoma mansoni microtubule-associated protein tau 0.0773 0.4715 0.4706
Toxoplasma gondii ABC1 family protein 0.0035 0.014 0.0123
Loa Loa (eye worm) hypothetical protein 0.0227 0.1329 0.527
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0053 0.0036
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0381 0.2282 0.2269
Loa Loa (eye worm) carboxylesterase 0.0279 0.1653 0.6553
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.0862 0.0854
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.014 0.0161
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0017 0.0031 0.0022
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0069 0.0353 1
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0053 0.0053
Trypanosoma brucei glycosyl hydrolase-like protein 0.0026 0.0083 0.0066
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0381 0.2282 0.2269
Schistosoma mansoni intermediate filament proteins 0.0026 0.0083 0.0067
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0053 0.0044
Plasmodium vivax SET domain protein, putative 0.0033 0.013 0.0114
Loa Loa (eye worm) hypothetical protein 0.0035 0.014 0.0553
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.022 0.022
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0053 0.0036
Entamoeba histolytica hypothetical protein 0.0035 0.0138 0.3331
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0017 0.0017
Echinococcus granulosus neuroligin 0.0047 0.0215 0.0215
Trichomonas vaginalis alpha-glucosidase, putative 0.0026 0.0083 0.0052
Echinococcus multilocularis lysosomal alpha glucosidase 0.0313 0.1861 0.1861
Onchocerca volvulus 0.0047 0.0215 0.0163
Echinococcus granulosus carboxylesterase 5A 0.0279 0.1653 0.1653
Leishmania major AUT2/APG4/ATG4 cysteine peptidase, putative 0.0057 0.0273 0.0257
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0071 0.0041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0766 0.0766
Echinococcus granulosus survival motor neuron protein 1 0.0227 0.1329 0.1329
Echinococcus multilocularis cysteine protease atg4b 0.0057 0.0273 0.0273
Brugia malayi nuclear receptor NHR-88 0.0021 0.0053 0.0044
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0017 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0215 0.0852
Brugia malayi beta-lactamase family protein 0.0035 0.014 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0053 0.0053
Mycobacterium tuberculosis Conserved hypothetical protein 0.0381 0.2282 0.2971
Echinococcus granulosus Peptidase C54 0.0057 0.0273 0.0273
Brugia malayi hypothetical protein 0.0035 0.0138 0.013
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0381 0.2282 0.2269
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0197 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.021
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0151 0.0862 0.3417

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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