Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | diacylglycerol O-acyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | ecdysteroid receptor | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | thyroid hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | steroid hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | nuclear hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.7767 | 0.7767 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0072 | 0.2933 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | nuclear receptor NHR-88 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0072 | 0.2933 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0072 | 0.2933 | 0.2933 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0072 | 0.2933 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0072 | 0.2933 | 0.2933 |
Onchocerca volvulus | 0.0072 | 0.2933 | 0.5 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | nuclear hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | thyroid hormone receptor | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0072 | 0.2933 | 0.2933 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0072 | 0.2933 | 0.2933 |
Echinococcus granulosus | FTZ F1 alpha | 0.0072 | 0.2933 | 0.2933 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0072 | 0.2933 | 0.2933 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0072 | 0.2933 | 0.2933 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0072 | 0.2933 | 0.2933 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 460 nM | Inhibition of human DGAT1 expressed in Sf9 cells using 1,2-dioleoyl-sn-glycerol and [14C]-palmitoyl-Co A substrates incubated for 2 hrs by scintillation counting method | ChEMBL. | 23317570 |
Inhibition (functional) | Reduction in plasma triglyceride levels in C57BL/6J mouse at 3 mg/kg, po by colorimetric method based postprandial triglyceride assay | ChEMBL. | 23317570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.